维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

5篇 您的检索式：作者名="Massimo Cirillo"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients.	Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio	2014	World Journal of Clinical Cases2014，2，12：	10
	2	Leptin Stimulated C-Reactive Protein Production by Human Coronary Artery Endothelial Cells显示文摘	De Rosa Salvatore Cirillo Plinio Pacileo Mario Di Palma Vito Paglia Antonella Chiariello Massimo	2009	Journal of Vascular Research2009，，6：	1
	3	Neopterin: From Forgotten Biomarker to Leading Actor in Cardiovascular Pathophysiology显示文摘	Salvatore De Rosa Plinio Cirillo Mario Pacileo Gianluca Petrillo Greta-Luana D’Ascoli Fabio Maresca Francesca Ziviello Massimo Chiariello	2011	Current Vascular Pharmacology2011，，2：	1
	4	Role of β2 Adrenergic Receptors in Human Atherosclerotic Coronary Arteries显示文摘	Emanuele Barbato Federico Piscione Jozef Bartunek Gennaro Galasso Plinio Cirillo Giuseppe De Luca Guido Iaccarino Bernard De Bruyne Massimo Chiariello William Wijns	2005	Circulation2005，，3：	1
	5	Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis显示文摘	Bakhtawar K Mahmoodi Kunihiro Matsushita Mark Woodward Peter J Blankestijn Massimo Cirillo Takayoshi Ohkubo Peter Rossing Mark J Sarnak Bénédicte Stengel Kazumasa Yamagishi Kentaro Yamashita Luxia Zhang Josef Coresh Paul E de Jong Brad C Astor	2012	2012 (9854)2012，，9854：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费