|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 2 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 3 | Metastable amorphous chromium-vanadium oxide nanoparticles with superior performance as a new lithium battery cathode显示文摘钒氧化物的主要缺点作为阴极材料是它的低传导性,低实际能力和差的骑车稳定性。补充说 Cr 能改进它的传导性和一个亚稳的非结晶的状态可以提供更高的能力和稳定性。在这个工作,亚稳的非结晶的 Cr-V-O nanoparticles 成功地通过反应由退火跟随了的灵巧的一起沉淀被准备了处理。作为为锂电池的阴极材料,亚稳的非结晶的 Cr-V-O nanoparticles 展览高度能力(在在 1.54 V 之间的 100 mA/g 的 260 mAh/g ) ,低能力损失(超过 80% 在 100 mA/g 在 200 个周期以后被保留) 并且高率能力(多达 3 A/g ) 。 | Jinzhi Sheng Qidong Li Qiulong Wei Pengfei Zhang Qinqin Wang Fan Lv Qinyou An Wei Chen Liqiang Mai | 2014 | Nano Research2014，7，11： | 5 |
| 4 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 5 | 关于中澳自由贸易协议潜在优势的分析模型——一份为中澳自由贸易协议可行性研究作准备的独立报告显示文摘1.2002年,为了促进双边贸易和投资,中国和澳大利亚建立了一个经济贸易框架。在这个框架下,一项关于未来中澳自由贸易协定(FTA)的联合可行性研究已经出炉。2.受澳大利亚外交贸易部委任,莫纳什大学的政策研究中心对关于中澳自由贸易协定所带来的潜在利益进行模型分析,并与来自中国社科院和南开大学的专家共同着手这项研究。3.在这项研究中,我们从三个方面对自由贸易协定进行模拟:消除商品贸易中的边境保护主义、投资自由化以及消除服务贸易壁垒。分析框架为一个多国家、多部门的可计算的一般均衡模型,即'莫纳什的多国家模型'。在我们的模拟中,假设基于自由贸易协定下的政策调整是于2006年开始贯彻落实的。4.在模拟FTA下政策调整所带来的冲击方面,我们首先模拟了一个常规发展模式(或称'基准模式'),基准模式描述了在中澳没有签订FTA情况下中国和澳大利亚经济的发展进程。与基准假设相比,其改变程度将被视为FTA下政策调整所带来的效应。5.从模型中,我们可以得出这样的结论:FTA使得中澳两国的产出增加并使得福利提高。据估计,FTA将提高中澳两国2006年至2015年期间的实际国内生产总值(GDP)和实际国民生产总值(GNP)的现值(见42页图表7.1),数值如下:澳大利亚实际GDP:180亿美元中国实际GDP:640亿美元澳大利亚实际GNP:220亿美元中国实际GNP:520亿美元6.从2005年至2015年期间的年均增长率方面来讲,FTA估计将使澳大利亚的实际GDP年均增长0.039个百分点,使中国的实际GDP年均增长0.042个百分点。7.两国实际GDP的增长主要归功于不断增加的资本、不断提高的生产率水平和得到优化利用的资源。澳大利亚实际GDP增长的一个潜在的重要因素就是贸易条件的改善。8.通过不断增长的双边贸易和投资,FTA强化了中澳双方的经济合作伙伴关系;就整体而言,它也在世界范围内创造了贸易:由于中澳FTA的签订,世界进口量相较于基线水平也相应增长。9.为了更好地利用资源,两国实现了各部门之间的劳动力调整,这主要是为了消除商品贸易边境保护主义。然而,由于两国之间的互补性,部门间的这种劳动力再分配还是更倾向于促进两国间已发生的自然调整进程。而且,与中澳两国在还没有自由贸易协定时的全球化中已发生的合作相比,这种调整只能属于小规模范畴的调整。10.澳大利亚从自由贸易协定获利最大的产业有谷物、羊毛织品、绒线、矿物和有色金属。中国获利最大的产业则是制造业,特别是纺织品、服装和其它杂项制成品(如玩具和体育用品等);而两国的服务部门则都能从FTA中获益。11.如果2006年至2010年期间,政策调整能够逐步实施,则至2015年FTA所带来的长期效应将和在2006年完全贯彻执行FTA的效果没有区别。然而,越早实施FTA将会使两国更早获益,而相比较而言,如果采取不急不愠的措施,那么其导致实际GDP和实际GNP获益的现值将减少。 | Yinhua MAI Philip ADAMS Mingtai FAN Ronglin LI Zhaoyang ZHENG 黄姗姗 郑秀莲 王思婷 熊爱宗 洪冬梅 | 2007 | 经济资料译丛2007，，3： | 3 |
| 6 | Author correction to‘Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsisinduced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice'[Acta Pharmaceutica Sinica B 13(2023)1164-1179]显示文摘The authors regret that there were some picture errors in Fig.7C and Supporting Information Fig.S10B owing to the negligence of the picture typesetting and careless mistakes.In Fig.7C,the H&E picture of PBS+Lipo+CLP group was the inverted picture of CLP group in Fig.5G.In Fig.7C,the H&E picture of Clo-Lipo+CLP group was zoom-in picture of L johnsoni+CLP group in Fig.8F.In Fig.SI0B,the H&E picture of ileum in CLP group was zoom-in picture of Anti-IL-10R+CLP group in Fig.S11C.The authors revise the H&E picture of liver in PBS+Lipo+CLP group and the H&E picture of liver in Clo-Lipo+CLP group in Fig.7C.Also,the H&E picture of ileum in CLP group of Fig.S10B have been revised.The correct figures are presented as below. | Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 2 |
| 7 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 8 | 查看详情显示文摘 | Fan T Y Mai Y W | | 0，，： | 1 |
| 9 | Hier- archical MnMoOJCoMoO4 heterostructured nanowires with enhanced supercapacitor performance 显示文摘 | MAI Li-qing YANG Fan ZHAO Yun-long | 2011 | Nature Communications2011，，2： | 1 |
| 10 | Molybdenum oxide nanowires: synthesis & properties显示文摘 | Liqiang Mai Fan Yang Yunlong Zhao Xu Xu Lin Xu Bin Hu Yanzhu Luo Hangyu Liu | 2011 | Materials Today2011，，7： | 1 |
| 11 | Elastiity theory, fracture mechan- ics,and some relevan thermal properties of quasi-crys- talline materials 显示文摘 | Fan T Y Mai Y W | 2004 | Applied Mechanics Reviews2004，57，： | 1 |
| 12 | Elasticity theory, fracture mechanics,and some relevant thermal properties of quasi-crystallinematerials 显示文摘 | Fan T Y Mai Y W | 2004 | Applied Mechanics Review2004，57，5： | 1 |
| 13 | A brief review on the lead element substitution in perovskite solar cells显示文摘Organic-inorganic halide perovskites have attracted huge attentions as the novel photoelectric function materials. So far, perovskite solar cells(PSCs) with prominent performance are still based on the lead halide perovskites, although they are potentially highly toxic. The issue of toxicity has become one of most crucial problems before its commercialization. Therefore, an increasing number of studies have focused on the lead element substitution in PSCs, and many excellent achievements have been reported.Alternative elements, e.g., Sn, Ge, Bi and Sb were successively used to fabricate lead-free perovskites,which provided potential possibility to tackle the toxicity issue. Recently, Sn–Pb hybrid perovskites were demonstrated to realize lead reduction without sacrificing the PCE. In addition, a new family of halide double-perovskites was explored and given high expectations. Here, we give a brief review on the lead substitution in PSCs, including theoretical explorations and experimental achievements, and finally we propose some perspectives. | Chong Liu Wenzhe Li Jiandong Fan Yaohua Mai | 2018 | Journal of Energy Chemistry2018，27，4： | 1 |
| 14 | Plane stress crack growing steadily in metal foams显示文摘 | RuiPing Guo YW Mai TianYou Fan | | 0，，1： | 1 |
| 15 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 16 | Plane stress crack growing steadily in metal foams 显示文摘 | GUO Rui-ping MAI Y W FAN Tian-you | 2004 | Materials Science and Engineering A2004，381，12： | 1 |
| 17 | Plane stress crack growing steadily in metal foams显示文摘 | RuiPing Guo Y.W Mai TianYou Fan GuanTing Liu M Maier | 2004 | Materials Science & Engineering A2004，，1： | 1 |
| 18 | Spectrum-shaped Si-perovskite hybrid photodetectors for hyperspectral bioimaging显示文摘Hyperspectral imaging(HSI)with rich spectral and spatial information holds potential for applications ranging from remote sensing to biomedicine.However,charge-coupled device(CCD)detectors used in conventional HSI systems suffer from inferior and unbalanced responsivity in the visible region,which is not a perfect choice for high-performance visible HSI.That is,conventional Si-based CCDs exhibit poor responsivity at short wavelengths(e.g.,400–600 nm)compared with that at longer wavelengths due to the nature of the indirect bandgap in silicon of around 1.1 e V.To solve this challenge,we introduce a Cs Pb Br_(3) perovskite layer to shape the spectrum of a Si/PEDOT:PSS heterojunction photodetector(PD),resulting in a fabricated Si-Cs Pb Br_(3) hybrid PD with enhanced responsivity at 400–600 nm.This results in an approximately flat spectral responsivity curve in the visible region(400–800 nm).Therefore,the stable Si-Cs Pb Br_(3) hybrid PD with a flat spectrum overcomes the shortcomings of traditional Si-based PDs and makes it more suitable for HSI.Further,we set up a first perovskite HSI system with high spectrum resolution and demonstrate potential applications for tumor detection and tissue identification.We believe that this perovskite optimization can be integrated into modern CCD,thus becoming a step in future CCD fabrication processes,which is a milestone for high-performance HSI systems. | YUJIN LIU ZHONG JI YAPING LI HONG JIN FAN WENJIE MAI | 2021 | Photonics Research2021，9，9： | 1 |
| 19 | Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice显示文摘Sepsis-induced liver injury(SILI)is an important cause of septicemia deaths.BaWeiBaiDuSan(BWBDS)was extracted from a formula of Panax ginseng C.A.Meyer,Lilium brownie F.E.Brown ex Miellez var.viridulum Baker,Polygonatum sibiricum Delar.ex Redoute,Lonicera japonica Thunb.,Hippophae rhamnoides Linn.,Amygdalus Communis Vas,Platycodon grandiflorus(Jacq.)A.DC.,and Cortex Phelloderdri.Herein,we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut microbiota.BWBDS protected mice against SILI,which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal integrity.BWBDS selectively promoted the growth of Lactobacillus johnsonii(L.johnsonii)in cecal ligation and puncture treated mice.Fecal microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis effects.Notably,L.johnsonii significantly reduced SILI by promoting macrophage anti-inflammatory activity,increasing interleukin-10+M2 macrophage production and enhancing intestinal integrity.Furthermore,heat inactivation L.johnsonii(HI-L.johnsonii)treatment promoted macrophage anti-inflammatory activity and alleviated SILI.Our findings revealed BWBDS and gut microbiota L.johnsonii as novel prebiotic and probiotic that may be used to treat SILI.The potential underlying mechanism was at least in part,via L.johnsonii-dependent immune regulation and interleukin-10+M2 macrophage production. | Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 20 | Zuogui Wan(左归丸) improves trabecular bone microarchitecture in ovariectomy-induced osteoporosis rats by regulating orexin-A and orexin receptors显示文摘OBJECTIVE:To investigate the protective effects of Zuogui Wan(左归丸,ZGW)on bone loss induced by ovariectomy(OVX)and its mechanism via orexin-A and orexin receptors in the osteoporosis rat model.METHODS:Fifty Sprague-Dawley female rats were randomly divided into sham-operated(sham)group and four OVX subgroups.Rats subjected to sham and OVX were treated with the vehicle(OVX,1 mL/100 g weight,n=10),17β-estradiol(E2,50μg·kg-1·d-1),and ZGW at the doses of 2.3(ZGW-L)and 4.6(ZGW-H)g/kg/day lyophilized powder daily for 3 months,respectively.The serum biochemical parameters of 17β-estrogen(17β-E2),tartrate-resistant acid phosphatase(TRACP-5 b)and bone alkaline phosphatase(BALP)were measured by enzyme-linked immunosorbent assay.Hematoxylin-eosin staining was used to detect the changes in the morphological structure in bones.Microcomputed tomography was used to evaluate the bone mineral density and microarchitecture of the distal femur.The gene or protein expression of orexin-A,orexin receptor 1(OX1R),orexin receptor 2(OX2R),osteoprotegerin(OPG)and receptor activator of nuclear factor-κB ligand(RANKL)were assayed by either quantitative polymerase chain reaction or Western blot analysis.RESULTS:Compared with the OVX group,ZGW could reduce the serum level of TRACP-5b and increased the serum levels of BALP and 17β-E2(P<0.01).Meanwhile,ZGW could prevent bone loss and improved bone trabecular microarchitecture by increasing the trabeculae structure thickness and trabecular number,and arranging the trabeculae structure properly.Compared with the OVX group,it was upregulated for the orexin-A and OX2R mRNA or protein expression from the hypothalamus and tibiae,and OPG in the tibiae of ZGW groups(P<0.01,<0.05),while downregulated for the OX1R mRNA and protein expression in the tibiae and hypothalamus and RANKL from the tibiae(P<0.01).CONCLUSION:ZGW exhibited a protective effect for PMOP that may be mediated via orexin-A and orexin receptors regulation. | LIU Feixiang TAN Feng FAN Qiaoling TONG Weiwei TENG Zhanli YE Sumin LI Xing ZHANG Mingyue CHAI Yi MAI Chongying | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员