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| 1 | 应用PCR检测人工感染鸡体内鸡传染性贫血病毒的动态分布显示文摘应用聚合酶链反应(PCR)技术检测人工感染12周龄SPF鸡体内鸡传染性贫血病毒(CAV)的动态分布结果,感染后第2周可从外周血液白细胞中检出CAVDNA,在第3周时达到最高峰,然后逐渐下降,第6周时检出率仅为6.3%(3/48),第7周以后均未能从血液白细胞中检测到CAVDNA;人工感染后第2~12周均能从骨髓、胸腺、脾、肾、肝和腔上囊等组织检出CAVDNA,其中以骨髓和胸腺的检出率最高(85.0%),其次是脾(80.0%)、肾和肝(60.0%),腔上囊最低(25.0%),从12周以后上述几种组织中再未检测到CAVDNA。并从PCR检测结果为阳性的组织中也分离到CAV。 | 谢芝勋 Mazhar I.Khan Theodore Girshick | 1999 | 中国兽医科技1999，29，2： | 15 |
| 2 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 3 | Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia显示文摘Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences,including the weakened immune system.Quercetin is widely distributed bioflavonoid;it has been debated for its dual roles in iron regulation.Quercetin-iron interaction in the body is a complex mechanism which has not been completely understood.The present study aimed to investigate the effect of quercetin on iron supplementation in iron deficiency anemia and on i NOS expression in splenic macrophages.The rat model of iron deficiency anemia was induced by feeding low iron diet to weanling rats for 20 days.The animals were then administered with ferrous sulfate,quercetin,and their combination for 30 days.Blood parameters,histopathological analysis,iron storage,CD68,i NOS and SLC40 expression in rat spleen were investigated.Our results showed that quercetin regulated iron absorption,despite SLC40 down-expression,indicating possible alternate route of iron transport,and that quercetin modulated i NOS production in splenic macrophages.. | Maryam Mazhar Nurul Kabir Shabana U Simjee | 2018 | Chinese Journal of Natural Medicines2018，16，8： | 4 |
| 4 | 心脏细胞衰老与Uvrag基因的缺失显示文摘背景:前期工作发现自噬相关基因Uvrag缺失导致年龄相关心肌病,但细胞衰老在此过程中的作用尚不清楚。目的:研究Uvrag基因缺失对心脏细胞衰老的影响。方法:从Uvrag基因缺失纯合子小鼠和野生型小鼠中各取14只雄性小鼠分两批分别饲养到3月龄和8月龄。采用real time RT-PCR检测小鼠心脏组织衰老相关分泌表型相关因子mRNA表达变化,苏木精-伊红染色、天狼猩红染色、衰老相关β-半乳糖苷酶染色进行心肌组织学观察,透射电镜观察小鼠心肌细胞超微结构的变化,蛋白免疫印迹检测小鼠心脏组织p53蛋白表达量。实验方案经上海交通大学动物实验伦理委员会批准。结果与结论:①苏木精-伊红染色和天狼猩红染色结果显示,Uvrag基因缺失导致单个心肌细胞显著增大及心脏纤维化;②透射电镜显示,Uvrag基因缺失小鼠心肌细胞线粒体形态异常、排列紊乱,肌浆网肿胀;③衰老相关β-半乳糖苷酶染色发现,Uvrag基因缺失小鼠心脏衰老细胞显著增多;④real time RT-PCR结果表明,Uvrag基因缺失小鼠心脏衰老相关分泌表型因子表达显著上调;⑤Western blot结果显示Uvrag基因缺失导致心脏组织衰老调控关键蛋白p53表达显著升高;⑥结果说明,自噬相关基因Uvrag缺失促进小鼠心脏细胞衰老;Uvrag基因是潜在的延缓心脏衰老及抗衰老相关心脏疾病的靶分子。 | 来帅威 张沙沙 刘晓芸 Haniya Mazhar Amber Naz 贺林 朱洪新 | 2021 | 中国组织工程研究2021，25，14： | 3 |
| 5 | Comments on “Distillability sudden death in qutrit qutrit systems under thermal reservoirs”显示文摘In a recent paper(2012 Chin.Phys.B 21 084205),the authors studied the problem of distillability sudden death.We find that their equation of motion is incorrect and consequently the rest of the paper is wrong.Even apart from starting with a wrong equation of motion,their description of the phenomenon of distillability sudden death is totally misleading and needs to be rectified.To this aim,we show that certain initially prepared free-entangled states become bound-entangled in a finite time under thermal reservoirs.Moreover,in contrast with zero-temperature reservoirs,simple local unitary transformations cannot completely avoid distillability sudden death. | Mazhar Ali | 2014 | Chinese Physics B2014，23，9： | 3 |
| 6 | Determination of Trace Amounts of Nickel (Ⅱ) by Graphite Furnace Atomic Absorption Spectrometry Coupled with Cloud Point Extraction显示文摘A new method based on the cloud point extraction(CPE) for separation and preconcentration of nickel(Ⅱ) and its subsequent determination by graphite furnace atomic absorption spectrometry(GFAAS) was proposed, 8-hydroxyquinoline and Triton X-100 were used as the ligand and surfactant respectively. Nickel(Ⅱ) can form a hy-drophobic complex with 8-hydroxyquinoline, the complex can be extracted into the small volume surfactant rich phase at the cloud point temperature(CPT) for GFAAS determination. The factors affecting the cloud point extraction, such as pH, ligand concentration, surfactant concentration, and the incubation time were optimized. Under the optimal conditions, a detection limit of 12 ng/L and a relative standard deviation(RSD) of 2.9% were obtained for Ni(Ⅱ) determination. The enrichment factor was found to be 25. The proposed method was successfully applied to the determination of nickel(Ⅱ) in certified reference material and different types of water samples and the recovery was in a range of 95%―103%. | SHAH Syed Mazhar WANG Hao-nan SU Xing-guang | 2011 | Chemical Research in Chinese Universities2011，27，3： | 3 |
| 7 | Provocative Mesenteric Angiography for Lower Gastrointestinal Hemorrhage: Results from a Single-institution Study显示文摘 | Charles Y. Kim Paul V. Suhocki Michael J. Miller Mazhar Khan Gemini Janus Tony P. Smith | 2010 | Journal of Vascular and Interventional Radiology2010，，4： | 2 |
| 8 | Effect of gravistimulation on amino acid profile of pea,rice,corn,wheat during early growth stages显示文摘The amino acids are one of the major cellular components of plants,which are involved in different metabolic pathways.In present study,effect of artificial gravistimulation on amino acid profiles of pea,rice,corn,wheat during early growth stages was investigated.One-axis clinostat was used for gravistimulation application,which was applied at embryonic stage.Amino acid profile was measured in 10-days old seedlings of pea,rice,corn and wheat cultivars.The effect of clinostat rotation was also evaluated under salt stress and MS medium supplement.Germinated pea,rice,corn and wheat seedlings were grown under the gravity condition for specific time interval.Corn and wheat seeds showed slowgermination as compared to pea and rice cultivars.The rate of amino acid formation under gravity condition was significantly higher than control(un-treated seedling).The variation in amino acid profile of pea,rice,corn and wheat cultivars vary deferentially.Results revealed that gravistimulation applied through clinostat has positive effect on amino acid profile in plant tissue and future studies should be focused on growth,biochemical,physiological at lateral stages of growth. | Raghad S.Mouhamad Munawar Iqbal MAfzal Qamar Lamiaa A.Mutlag Ibrahim B.Razaq Mazhar Abbas Fida Hussain | 2016 | Information Processing in Agriculture2016，3，4： | 2 |
| 9 | In vitro larvicidal potential against Anopheles stephensi and antioxidative enzyme activities of Ginkgo biloba,Stevia rebaudiana and Parthenium hysterophorous显示文摘Objective:To investigate in vitro larvicidal and antioxidant enzymes potential of the medicinal plants Ginkgo biloba(G.biloba),Stevia rebaudiana(S.rebaudiana) and Parthenium hysterophorous(P.hysterophorous) against Anopheles stephensi(An.stephensi) 4th instars larvae. Methods:For evaluation of larvicidal potential,the ethanolic,methanolic and dichloromethane leaves extracts of three different plants were used in dose-dependent experiments in two media, while the antioxidant enzymes activities were investigated using four different methods viz., superoxide dismutase,peroxidase,ascorbate and catalase.Results:An.stephensi has developed resistance to various synthetic insecticides,making its control increasingly difficult.The comparative performance of ethanolic extracts(65%-90%) was found better than the methanolic extract(70%-87%) and dichloromethane extract(60%-70%).Among the three plants extracts tested in two media,S.rebaudiana exhibited higher larvicidal activity with LC50(24 h) in methanolic extract than P.hysterophorous and G.biloba.G.biloba and P.hysterophorous exhibited the strongest antioxidative enzymes activity and S.rebaudiana were less active and no significant difference was observed.Conclusions:These three plants exhibit larvicidal potential and can be further used for vector control alternative to synthetic insecticide due to eco-friendly and diseases control,furthermore these plant species have potent antioxidative enzyme activities, therefore,making them strong natural candidate particularly for diseases which are caused due to free radicals. | Nisar Ahmad Hina Fazal Bilal H Abbasi Mazhar Iqbal | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 2 |
| 10 | Effects of different irrigation frequencies and incorporation of rice straw on yield and water productivity of wheat crop显示文摘The current rapid increase in irrigation water consumption is considered unsustainable and threatens the world food production.Therefore,it is mandatory to promote modern techniques and to manage existing conventional irrigation methods.The present study was attempted to determine the effects of different irrigation frequencies and rice straw incorporation rates on yield and water productivity of the wheat crop.The experiment was arranged with randomize complete block design involving nine treatments(RS 0 I 7,RS 0 I 15,RS 0 I 22,RS 1 I 7,RS 1 I 15,RS 1 I 22,RS 2 I 7,RS 2 I 15 and RS 2 I 22)under three replications.Results exposed that the incorporation of rice straw with different irrigation frequencies significantly improved physico-chemical properties of soil.Moreover,soil bulk density,infiltration rate,pH,electrical conductivity significantly decreased and soil porosity significantly increased under all treatments.Furthermore,maximum crop yield and crop water productivity of 7706.4 kg/hm 2 and 1.92 kg/m 3 respectively were found under RS 1 I 15 treatment.Based on experimental results it can be concluded that irrigation frequency and incorporation of rice straw had significant effects on the physico-chemical properties of soil,total grain yield and water productivity of the wheat crop.However,this study suggested that the wheat crop yield and water productivity could be increased by incorporating 1 t/hm 2 rice straw with 15 d of irrigation frequency. | Mazhar Hussain Tunio Jianmin Gao Mashooque Ali Talpur Imran Ali Lakhiar Farman Ali Chandio Sher Ali Shaikh Kashif Ali Solangi | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 2 |
| 11 | Hepatitis C virus prevalence and genotype distribution inPakistan:Comprehensive review of recent data显示文摘Hepatitis C virus(HCV) is endemic in Pakistan and its burden is expected to increase in coming decades owing mainly to widespread use of unsafe medical procedures. The prevalence of HCV in Pakistan has previously been reviewed. However, the literature search conducted here revealed that at least 86 relevant studies have been produced since the publication of these systematic reviews. A revised updated analysis was therefore needed in order to integrate the fresh data. A systematic review of data published between 2010 and 2015 showed that HCV seroprevalence among the general adult Pakistani population is 6.8%, while active HCV infection was found in approximately 6% of the population. Studies included in this review have also shown extremely high HCV prevalence in rural and underdeveloped peri-urban areas(up to 25%), highlighting the need for an increased focus on this previously neglected socioeconomic stratum of the population. While a 2.45% seroprevalence among blood donors demands immediate measures to curtail the risk of transfusion transmitted HCV, a very high prevalence in patients attending hospitals with various non-liver disease related complaints(up to 30%) suggests a rise in the incidence of nosocomial HCV spread. HCV genotype 3a continues to be the most prevalent subtype infecting people in Pakistan(61.3%). However, recent years have witnessed an increase in the frequency of subtype 2a in certain geographical sub-regions within Pakistan. In Khyber Pakhtunkhwa and Sindh provinces, 2a was the second most prevalent genotype(17.3% and 11.3% respectively). While the changing frequency distribution of various genotypes demands an increased emphasis on research for novel therapeutic regimens, evidence of high nosocomial transmission calls for immediate measures aimed at ensuring safe medical practices. | muhammad umer mazhar iqbal | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 12 | Total phenolic,chromium contents and antioxidant activity of raw and processed sugars显示文摘Processing improves the visual quality of food;however,the ingredient and nutritional values may alter.In present study,the sugar samples(refined,raw,gur(Jaggery/jaggeree)and molasses)were collected from 20 different agro-climatic regions of Pakistan and analyzed for the chromium concentration,total phenolic and antioxidant activity,in order to evaluate the processing effect.The concentration of Cr was determined by digestion method using atomic absorption spectrophotometer,while antioxidant activity was determined by DPPH(1,1-diphenyl-2-picrylhydrazyl)and reducing power.It was observed that chromium content in Jaggery was 74%higher than raw sugar,while molasses showed 21.27%higher concentration versus jaggery.The total phenolic contents were found considerably higher in molasses(3751 lg GAE/g)followed by Jaggery(3285 lg GAE/g),raw sugar(27.75 lg GAE/g)and refined sugar(23.81 lg GAE/g).The DPPH scavenging activity and reducing power was also found dependent to sugar type.Form results,it can be concluded that processing significantly affected the chromium contents,total phenolics and antioxidant activity. | Munawar Iqbal MAfzal Qamar Tanveer H.Bokhari Mazhar Abbas Fida Hussain Nasir Masood Ali Keshavarzi Naseem Qureshih Arif Nazir | 2017 | Information Processing in Agriculture2017，4，1： | 2 |
| 13 | Distillability Sudden Birth of Entanglement for Qutrit-Qutrit Systems显示文摘我们报导在二座统计上独立的水库之间的 distillability 的突然的出现作为 qutrit-qutrit 系统当模特儿。由两部组成的量系统的这个特征与纠纷的以前观察的现象不同突然的出生。水库的状态首先变得界限纠缠,这被发现,因此展出纠纷突然的出生,因而由 distillability 的突然的出生列在后面,并且每当 distillability 从主要系统突然地被失去时,它必然也在水库自由的学位之中突然地出现,这被显示出。这令人吃惊的观察反映量纠纷的动态方面的另一个怪癖。 | Mazhar Alit 黄江 | 2014 | Chinese Physics Letters2014，31，11： | 2 |
| 14 | Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2显示文摘Background:Coronavirus disease 2019(COVID-19)linked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cause severe illness and life-threatening pneumonia in humans.The current COVID-19 pandemic demands an effective vaccine to acquire protection against the infection.Therefore,the present study was aimed to design a multiepitope-based subunit vaccine(MESV)against COVID-19.Methods:Structural proteins(Surface glycoprotein,Envelope protein,and Membrane glycoprotein)of SARS-CoV-2 are responsible for its prime functions.Sequences of proteins were downloaded from GenBank and several immunoinformatics coupled with computational approaches were employed to forecast B-and T-cell epitopes from the SARS-CoV-2 highly antigenic structural proteins to design an effective MESV.Results:Predicted epitopes suggested high antigenicity,conserveness,substantial interactions with the human leukocyte antigen(HLA)binding alleles,and collective global population coverage of 88.40%.Taken together,276 amino acids long MESV was designed by connecting 3 cytotoxic T lymphocytes(CTL),6 helper T lymphocyte(HTL)and 4 B-cell epitopes with suitable adjuvant and linkers.The MESV construct was non-allergenic,stable,and highly antigenic.Molecular docking showed a stable and high binding affinity of MESV with human pathogenic toll-like receptors-3(TLR3).Furthermore,in silico immune simulation revealed significant immunogenic response of MESV.Finally,MEV codons were optimized for its in silico cloning into the Escherichia coli K-12 system,to ensure its increased expression.Conclusion:The MESV developed in this study is capable of generating immune response against COVID-19.Therefore,if designed MESV further investigated experimentally,it would be an effective vaccine candidate against SARS-CoV-2 to control and prevent COVID-19. | Muhammad Tahir ul Qamar Farah Shahid Sadia Aslam Usman Ali Ashfaq Sidra Aslam Israr Fatima Muhammad Mazhar Fareed Ali Zohaib Ling-Ling Chen | 2020 | Infectious Diseases of Poverty2020，9，5： | 2 |
| 15 | Endoscopic ultrasound-fine needle injection for oncological therapy显示文摘The minimal invasiveness and precision of endoscopicultrasound(EUS) has lead to both its widespread use as a diagnostic and staging modality for gastrointestinal and pancreaticobiliary malignancies, and to its expand-ing role as a therapeutic modality. EUS-guided celiac plexus neurolysis is now a well-accepted modality for palliation of pain in patients with pancreatic cancer. EUS-guided ablation, brachytherapy, fiducial marker placement, and antitumor agent injection have been described as methods of performing minimally invasive oncological therapy. EUS-fine needle injection may be performed as adjunctive, alternative, or palliative treatment. This review summarizes the studies to date that have described these methods. A literature search using the Pub Med/MEDLINE databases was performed. While most published studies to date are limited with disappointing outcomes, the concept of a role of EUS in oncological therapy seems promising. | Jeremy Kaplan Amaara Khalid Natalie Cosgrove Ayesha Soomro Syed Mohsin Mazhar Ali A Siddiqui | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 16 | Lobar transplantation, split lung transplantation and peripheral segmental resection-reliable procedures for downsizing donor lungs显示文摘 | Clemens Aigner Samy Mazhar Peter Jaksch | 2004 | Eur J Cardiothorac Surg2004，，25： | 1 |
| 17 | Plant extract-loaded bacterial cellulose composite membrane for potential biomedical applications显示文摘Bacterial cellulose(BC)has been extensively explored as biomaterial for various biomedical applications owing to its non-toxic nature and unique structural morphology and impressive physicochemical and mechanical properties.However,its high production cost and lack of antimicrobial activity have restricted its large-scale production and therapeutic applications.Therefore,the current study is aimed to devise a strategy for low-cost BC production and develop its composite with bioactive materials to bless it with antimicrobial activity.Herein,5 mm thick reticulated fibrous and highly porous BC was produced by utilizing the wasted rotten tomatoes as the production medium.The produced bacterial cellulose waste(BCW)(i.e.,produced from wastes)was ex-situ modified with bioactive plant extract(PE)obtained from Euclea schimperi,and the bactericidal activity of the developed BCW/PE was evaluated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli through disc diffusion and colony forming unit(CFU)count methods.The BCW/PE composite showed high bactericidal activities against S.aureus and produced clear inhibition zone whereas negligible activity was observed against E.coli,indicating its bactericidal activity mainly against the Gram-positive bacterium.Overall,this study illustrates that there is a huge potential for developing valuable biomaterials from food wastes and utilizing their liquid holding capabilities for value-added applications in medical and pharmaceutical fields. | Atiya Fatima Sumayia Yasir MohdShariq Khan Sehrish Manan Muhammad Wajid Ullah Mazhar Ul-Islam | 2021 | Journal of Bioresources and Bioproducts2021，6，1： | 1 |
| 18 | Risk factors and mortality associated with calciphylaxis in end-stage renal disease显示文摘 | Mazhar AR Johnson RJ Gillen D | 2001 | Kidney Int2001，60，： | 1 |
| 19 | Papaya Ring Spot Virus:An Understanding of a Severe Positive-Sense Single Stranded RNA Viral Disease and Its Management显示文摘Viral diseases have been studied in-depth for reducing quality,yield,health and longevity of the fruit,to highlight the economic losses.Positive-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit trees.One of the best examples is papaya ringspot virus(PRSV).It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae,Cucurbitaceae and Caricaceae.This virus has a serious threat to the production of papaya,which is famous for its high nutritional and pharmaceutical values.The plant parts such as leaves,latex,seeds,fruits,bark,peel and roots may contain the biological compound that can be isolated and used in pharmaceutical industries as a disease control.Viral disease symptoms consist of vein clearing and yellowing of young leaves.Distinctive ring spot patterns with concentric rings and spots on fruit reduce its quality and taste.The virus has two major strains P and W.The former cause disease in papaya and cucurbits while the later one in papaya.Virion comprises 94.4%protein,including a 36 kDa coat protein which is a component responsible for a non-persistent transmission through aphids,and 5.5%nucleic acid.Cross protection,development of transgenic crops,exploring the resistant sources and induction of pathogen derived resistance have been recorded as effective management of PRSV.Along with these practices reduced aphid population through insecticides and plant extracts have been found ecofriendly approaches to minimize the disease incidence.Adoption of transgenic crops is a big challenge for the success of disease resistant papaya crops.The aim of this review is to understand the genomic nature of PRSV,detection methods and the different advanced control methods.This review article will be helpful in developing the best management strategies for controlling PRSV. | Muhammad Umer Mustansar Mubeen Yasir Iftikhar Haider Ali Muhammad Zafar-ul-Hye Rafia Asghar Mazhar Abbas Malik Abdul Rehman Ernesto A.Moya-Elizondo Yuejun He | 2022 | Phyton-International Journal of Experimental Botany2022，91，10： | 1 |
| 20 | Approximation by modified Szasz operators显示文摘 | S M Mazhar V Totik | 1985 | Acta Sci Math1985，49，： | 1 |
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