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| 1 | Treatment of active steroid-refractory inflammatory bowel diseases with granulocytapheresis: Our experience with a prospective study显示文摘瞄准:与活跃的类固醇倔强的煽动性的肠疾病(IBD ) 在 14 个病人与 granulocytapheresis (GCAP ) 的使用报导我们的经验以便在完成宽恕并且维持一个长持续没有症状的时期评估它的功效。方法:疾病的活动被临床的活动索引(蔡) 和内视镜的索引(EI ) 在 ulcerative (UC ) 评估,当时由 Crohn 在 Crohn 的疾病(CD ) 的疾病活动索引(CDAI ) 。病人用 Adacolumn 系统被对待,有选择地绑在 granulocytes 和单核白血球的吸附列。GCAP 的一个会议 / 星期为 5 wk 被执行。类固醇在词首字母的脱落期间被停止。结果:所有病人完成了不显示出复杂并发症的五星期的功课。在最后会议的结束, 93% 病人显示出为 6 瞬间坚持了的疾病的临床的宽恕。在治疗的结束以后的九个月, 60% 案例维持了宽恕,当 23% 病人仍然在在 12 瞬间以后的临床的宽恕时。结论:就算我们有类固醇倔强的 IBD 的病人的数字不大,我们能断言 GCAP 很好被容忍并且有效特别在在治疗以后的开始的六个月内,在盒子的一个重要百分比。持续反应的率在 12 瞬间以后在 6 瞬间以后并且显著地稍微落下,然而,严重副作用的缺席能是为进一步评估治疗的新时间表的刺激。 | Bresci Giampaolo Parisi Giuseppe Bertoni Michele Mazzoni Alessandro Scatena Fabrizio Capria Alfonso | 2006 | World Journal of Gastroenterology2006，12，14： | 5 |
| 2 | Restorative Proctocolectomy or Rectum-Preserving Surgery in Patients with Familial Adenomatous Polyposis: Results of a Prospective Study显示文摘 | Francesco Tonelli Rosa Valanzano Iacopo Monaci Paolo Mazzoni Alessandro Anastasi Ferdinando Ficari | 1997 | World Journal of Surgery1997，，6： | 1 |
| 3 | Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience显示文摘AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin. | Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone | 2016 | World Journal of Hepatology2016，8，22： | 1 |
| 4 | Testing aspheric surfaces using mulitiple annular interferograms显示文摘 | Mauro Melozzi Luca Pezzati Alessandro Mazzoni | 1993 | Optical Engineering1993，32，5： | 1 |
| 5 | Wafer技术:一种骨重建的新方法显示文摘本研究介绍了基于引导骨组织再生技术与三维骨增量onlay植骨技术的一种新技术。这个技术分为两阶段:首先用自体皮质骨板与胶原膜形成屏障,再用该屏障将包括脱蛋白牛骨基质、自体血液与口内移植骨在内的混合物加以包裹。五位患者接受了该技术的治疗。术后6个月,可观察到平均骨体积增大值为1062mm'。平均最大线性增量为3.65mm。对再生区域进行组织学检查,可见有新生密质骨的形成,并不伴有炎症征象。共计13颗种植体被植入.所有患者均对效果表示满意,且未观察到并发症出现。 | Mauro Merli Marco Moscatelli Giorgia Mariotti Alessandro Motroni Annalisa Mazzoni Simona Mazzoni Lorenzo Breschi Michele Nier 李嫣斐(译) 张新春(审) | 2020 | 中国口腔医学继续教育杂志2020，23，2： | 0 |
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