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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Rheologic reflection in hypertriglyceridemia-induced pancreatitis 显示文摘 | Martin D McCann E G|ynn P | 2009 | South Med J2009，102，10： | 1 |
| 3 | Ni- trogen-linked diphosphine ligands with ethers attached to nitrogen for chromium-catalyzed ethylene tri- and tet- ramerizations 显示文摘 | ELOWE P R MCCANN C PRINGLE P G | 2006 | Organometallics2006，25，22： | 1 |
| 4 | NT-proBNP reflects fight ventricular structure and function in pulmonary hypertension 显示文摘 | Gan C T McCann G P Marcus J T | 2006 | Eur Respir J2006，28，6： | 1 |
| 5 | Association of a polymorphism in the dopamine-transporter gene with Parkinson' s disease 显示文摘 | Le Couteur D G Leighton P W McCann S J | 1997 | Mcrv Disord1997，12，5： | 1 |
| 6 | Nephrotoxi city from Contrast Media:Attenuationwith Theo phylline显示文摘 | Katholi R E Taylor G J McCann W P | 1995 | Radiology1995，195，1： | 1 |
| 7 | The discovery of indoxacarb:oxadiazines as a new class of pyrazoline-type insecticides显示文摘 | MCCANN S F ANNIS G D SHAPIRO R PIOTROWSKI D W LAHM G P LONG J K LEE K C HUGHES M M MYERS B J GRISWOLD S M REEVES B M MARCH R W SHARPE P LOWDER P BARNETTE W E WING K D | 2001 | Pest Manag Sci2001，57，2： | 1 |
| 8 | Gasdynamics of vented explosions-Part I:Experimental studies显示文摘 | Mccann D P J Thomas G O Edwards D H | 1985 | Combustion and Flame1985，59，3： | 1 |
| 9 | A Panel of 4 microRNAs facilitates the prediction of left ventrieular contractility after acute myocardial in- farction显示文摘 | DEVAUX Y VAUSORT M McCANN G P | 2013 | PLoS One2013，8，70： | 1 |
| 10 | The Sorghum bicolor genome and the diversification of grasses显示文摘 | PATERSON A H BOWERS J E BRUGGMANN R DUBCHAK I GRIMWOOD J GUNDLACH H HABERER G HELLSTEN U MITROS T POLIAKOV A SCHMUTZ J SPANNAGL M TANG H WANG X WICKER T BHARTI A K CHAPMAN J FELTUSF A GOWIK U GRIGORIEV I V LYONS E MAHER C A MARTIS M NARECHANIA A OTILLAR R P PENNING B W SALAMOV A A WANG Y ZHANG L CARPITA N C FREELING M GINGLE AR HASH CT KELLER B KLEIN P KRESOVICH S MCCANN M C MING R PETERSON D G MEHBOOBUR-RAHMAN WARE D WESTHOFF P MAYER K F MESSING J ROKHSAR D S | 2009 | Nature2009，457，： | 1 |
| 11 | S-adenosyl- mehionine and methylation 显示文摘 | Chiang P K Gordon R K Tal J Zeng G C Doctor B P Pardhasaradhi K McCann P P | 1996 | FASEB J1996，10，： | 1 |
| 12 | Gasdynamics of vented explosions part I: Experimental studies显示文摘 | McCann D P J Thomas G O Edwards D H | 1985 | Combustion and Flame1985，59，： | 1 |
| 13 | Gasdynamies of vented explosions Part I : Experimen- tal Studies显示文摘 | MCCANN D P J THOMAS G O EDWARDS D H | 1985 | Combustion and Flame1985，，59： | 1 |
| 14 | Non-invasive imaging in coronary artery disease including anatomical and functional evaluation of ischaemia and viability assessment显示文摘 | M Pakkal V Raj G P Mccann | 2011 | 2011 (Spec)2011，，： | 1 |
| 15 | Selective tumor necrosis factor receipt I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor Ⅱ in collagen-induced arthritis 显示文摘 | McCann F E Penrodau D P Ruspi G | 2014 | Arthritis Rheumatol2014，66，10： | 1 |
| 16 | Nephrotoxicity from contrast media: attenuation with theophyline 显示文摘 | KATHOLI R E TAYLOR G J MCCANN W P | 1995 | Radiology1995，195，： | 1 |
| 17 | Use of restriction frag-ment length polymorphism to fingerprint beets at the genotype and specieslevels显示文摘 | NAGAMINE T TODD G A MCCANN K P | 1989 | Tag Theoretical and Applied Genetics1989，78，6： | 1 |
| 18 | Nitrogen-linked diphosphine ligands with ethers attached to nitrogen for chromimn-catalyzed ethylene triand tetramerizations 显示文摘 | ELOWE P R MCCANN C PRINGLE P G | 2006 | Organometallics2006，25，22： | 1 |
| 19 | Extent of MRI de- layed enhancement of myocardial mass is related to right ventric ular dysfunction in pulmonary artery hypertension 显示文摘 | McCann G P Gan C T Beck A M | 2007 | A JR2007，188，2： | 1 |
| 20 | Gasdynamics of vented explosions:experimental studies显示文摘 | Mccann D P J Thomas G O Edwards D H | 1985 | Combustion and Flame1985，59，： | 1 |
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