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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | A pectate lyase from Zinnia elegans is auxin inducible显示文摘 | Domingo C Roberts K Stacey N J Connerton I RuoAz-TeraAn F McCann M C | 1998 | Plant J1998，13，： | 1 |
| 3 | A Review of Thin-film Crystalline Silicon for Solar Cell Applications Part 2∶Foreign Substrate显示文摘 | McCann M J Catchpole K R Weber K J | 2001 | Solar Energy Materials and Solar Cells2001，，68： | 1 |
| 4 | Osteoprotegerin and osteopontin are expressed at high concentrations within symptomatic carotid atherosclerosis显示文摘 | Golledge J Mccann M Mangan S | 2004 | Stroke2004，35，7： | 1 |
| 5 | Laparoscopic common bite duct exploration 显示文摘 | Stoker M E Leveillee R J McCann J C | 1991 | J Laparoendosc Surg1991，1，5： | 1 |
| 6 | Melt coaxial electrospinning:a versatile method for the encapsulation of solid materials and fabrication of phase change nanofibers显示文摘 | MCCANN J T MARQUEZ M XIA Y | | 0，，12： | 1 |
| 7 | Predictors of cardiac rehabilitation participation in older coronary patients显示文摘 | Ades P A Waldmann M L McCann W J | | 0，，05： | 1 |
| 8 | Osteoprotegerin and ostoopontin are expressed at high concentrations within symptomatic carotid atherosclerosis显示文摘 | Goolledge J McCann M Mangan S | 2004 | Stroke2004，35，7： | 1 |
| 9 | Demographic andtem po- ral trends in out of hospital sudden cardiac death in Belfast 显示文摘 | Moore M J Glover BM McCann C J | 2006 | Heart2006，92，3： | 1 |
| 10 | Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain显示文摘 | MCCANN C J GLOVER B M MENOWN I B | 2009 | Am J Cardiol2009，103，1： | 1 |
| 11 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 12 | Osteoprotegerin and os-teopontin are expressed at high concentrations within symptomatic carotid athemsclerosis 显示文摘 | GooUedge J McCann M Mangan S | 2004 | Stroke2004，35，7： | 1 |
| 13 | The bispectral index and expllcit recall during the intraoperative wake-up test for scoliosis surgery 显示文摘 | McCann M E Brustowicz R M Bacsik J | 2002 | Anesth Analg2002，94，6： | 1 |
| 14 | Experimental verifications of numerical predictions for the hydrodynamic performance of horizontal axis marine current turbines显示文摘 | BAHAJ A S BATTEN W M J MCCANN G | 2007 | Renewable Energy2007，32，15： | 1 |
| 15 | The nitric oxide hypothesis of aging显示文摘 | MCCANN S M UCINIO J WONG M L | 1998 | Exp Gerontol1998，33，78： | 1 |
| 16 | Lapa- roscopic common bile duct exploration 显示文摘 | STOKER M E LEVEILLEE R J MCCANN Jr J C | 1991 | J Laparoendosc Surg1991，1，5： | 1 |
| 17 | Melt coaxial electrospin- ning: a versatile method for the encapsulation of solid ma- terials and fabrication of phase change nanofibers 显示文摘 | Mccann J T Marquez M Xia Y | 2006 | Nano Letters2006，6，12： | 1 |
| 18 | Assessment of zygomatico-orbital complex fractures using ultrasonography显示文摘 | McCANN P J BROCKLEBANK L M AYOUB A F | 2000 | Br J Oral Maxillofac Surg2000，38，5： | 1 |
| 19 | Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T显示文摘 | McCann C J Glover B M Menown I B | 2008 | Eur Heart J2008，29，23： | 1 |
| 20 | Melt coaxial electrospinning: a versatile method for the encapsulation of solid materials and fabrication of phase change nanofibers 显示文摘 | MCCANN J T MARQUEZ M XIA Y | 2006 | Nano Lett2006，，6： | 1 |
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