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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Electrospun silk material systems for wound healing显示文摘 | S E Wharram X Zhang D L Kaplan S P McCarthy | | 0，，： | 1 |
| 3 | Chemerin,a novel adipokine that regu lates adipogenesis and adipocyte metabolism显示文摘 | Goralski K B McCarthy T C Hanniman E A Zabel B A Butcher g C Parlee S D | 2007 | J Biol Chem2007，282，28： | 1 |
| 4 | Evaluation of alkaline phosphatase- and digoxigenin-labeled probes for detection of the thermolabile hemolysin (tlh) gene of Vibrio parahaemolyticus 显示文摘 | McCarthy S A DePaola A Cook D W Kaysner C A and Hill W E | 1999 | Letters in Applied Microbiology1999，28，： | 1 |
| 5 | Modification of the nitrogen solubility properties of soy protein isolate following proteoly- sis and transglutaminase cross linking显示文摘 | WALSH D J CLEARY D MCCARTHY E | 2003 | Food Res Int2003，36，8： | 1 |
| 6 | Allograft bone in spinal fusion for paralytic scoliosis显示文摘 | McCarthy R E Peek R D Morrissy R T el al | 1986 | J Bone Joint surg(Am)1986，68，： | 1 |
| 7 | Cloning,expres-sion,characterization and role of the leader sequenceofa lipase from Rhi-zopusoryzase显示文摘 | BEER H D MCCARTHY J E BOMSCHEUER U T | 1998 | BBA-Gene Structure and Expression1998，1399，23： | 1 |
| 8 | Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups显示文摘 | Scherag A Dina C Hinney A Vatin V Scherag S Vogel C I Muller T D Grallert H Wichmann H E Balkau B Heude B Jarvelin M R Hartikainen A L Levy-Marchal C Weill J Delplanque J Korner A Kiess W Kovacs P Rayner N W Prokopenko I McCarthy M I Schafer H Jarick I Bo | | 0，，04： | 1 |
| 9 | Effects of water temperature on protein synthesis and protein growth in juvenile Atlantic wolfish (Anarhichas iupus) 显示文摘 | McCarthy I D Moksness E Pavlov D A | 1999 | Can J Fish Sci1999，56，： | 1 |
| 10 | Spaceborne Laser-altimeter-pointing Bias Calibration from Range Residual Analysis显示文摘 | LUTHCKE S MCCARTHY J J PAVLIS D E | 2000 | Journal of Spacecraft and Rockets2000，37，3： | 1 |
| 11 | Modification of the nitrogan solubility properties of soy protein isolate following prote, olysis and transglutaminase cross-linking显示文摘 | WALSH D J CLEARY D MCCARTHY E ctal | 2003 | Food Research International2003，36，7： | 1 |
| 12 | Hydrogen atom transfer in mass spectrometric fragmentation patterns of saturated aliphatic hydrocarbons显示文摘 | McCarthy E D Han J Calvin M | 1968 | Analytical Chemistry1968，40，10： | 1 |
| 13 | Application of response surface methodology in the development of gluten-free bread显示文摘 | McCarthy D F Gallagher E | 2005 | Cereal Chem2005，82，5： | 1 |
| 14 | Investigation of foam stability in porous media at elevated temperatures显示文摘 | Isaacs E E McCarthy F C Maunder J D | 1988 | Preprints-Division of Petroleum Chemistry: American Chemical Society1988，，1： | 1 |
| 15 | Lipid responses in mildly hypertriglyceridemic men and women to con- sumption of docosahexaenoic acid-enriched eggs显示文摘 | Maki K C Van Elswyk M E McCarthy D | 2003 | Int J Vi- tam Nutr Res2003，73，： | 1 |
| 16 | Effects of the beta-amino acid antagonist TAG on thalamocortical inhibition 显示文摘 | Mathers D A McCarthy S M Cooke J E | 2009 | Neuropharmacology2009，56，8： | 1 |
| 17 | Rates of growth and protein synthesis correlated with nucleic acid content in fry of rainbow trout, Oncorhynchus mykiss :effects of age and temperature显示文摘 | Mathers E M Houlihan D F McCarthy I D | 1993 | Journal of Fish Biology1993，43，2： | 1 |
| 18 | The relation of connection,regulation,and support for autonomy to adolescents' functioning显示文摘 | Eccles J.S Early D Frasier K Belansky E & McCarthy K | | 0，，02： | 1 |
| 19 | Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy显示文摘 | McCarthy Douglas D Kujawa Julie Wilson Cheryl Papandile Adrian Poreci Urjana Porfilio Elisa A Ward Lesley Lawson Melissa A E Macpherson Andrew J McCoy Kathy D Pei York Novak Lea Lee Jeannette Y Julian Bruce A Novak Jan Ranger Ann Gommerman | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
| 20 | Incidence of Guillain Barre syndrome following infection with Campylobact erjejuni显示文摘 | McCarthy N Gieseeke J Weinberg E D | 2001 | Am J Epidemiol2001，153，6： | 1 |
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