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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Enzymatic Degradability of Poly(lactide) :Effects of chain stereochemistry and material crystallinity 显示文摘 | REEVE M MCCARTHY S P GROSS R A | 1996 | Macromolecules1996，29，23： | 1 |
| 3 | A cost, profit, and efficiency analysis of performing carpal tunnel surgery in the operating room versus the clinic setting in the United States显示文摘 | Chatterjee A McCarthy J E Montagne S A | 2011 | Ann Plast Surg2011，66，3： | 1 |
| 4 | 显示文摘 | MARSHALL D J RUDNICK K A MCCARTHY S G | 2006 | Vaccine2006，24，3： | 1 |
| 5 | Inter-leukin-18 enhances Th1 immunity and tumor protec-tion of a DNA vaccine显示文摘 | Rudnick K A McCarthy S G | 2006 | Vaccine2006，24，： | 1 |
| 6 | The effect of nanoclays on the properties of PLLA-modified polymers part 1 : Mechanical and thermal properties 显示文摘 | LEWITUS D MCCARTHY S OPHIR A | 2006 | J Polym Envi- ron2006，14，2： | 1 |
| 7 | Phylogenetic community structure in Minnesota oak savanna is influenced by spatial extent and environmental variation 显示文摘 | Willis C G Halina M Lehman C Rcich P B Keen A McCarthy S Cavender-Bares J | 2010 | Ecography2010，33，： | 1 |
| 8 | A simple method for determining the effect of bolt hole clear ance on load distribution in single column multi-bolt compos ite joints显示文摘 | MCCARTHY M A MCCARTHY C T PADHI G S | 2006 | Composite Structures2006，73，1： | 1 |
| 9 | An antibody- and synthetic peptide-defined rubella virus E1 glycoprotein neutraliza- tiondomain显示文摘 | Wolinsky J S Sukholutsky E Moore W T Lovett A McCarthy M Adame B | 1993 | J Virol1993，67，2： | 1 |
| 10 | Effect of chain extender structure on the properties and morphology of polyurethanes based on H12MDI and mixed macrodiols (PDMS-PHMO)显示文摘 | Adhikari R Gunatillake P A Mccarthy S J | 1999 | Journal of Applied Polymer Science1999，74，12： | 1 |
| 11 | Perceived occupa- tional stress in nurses working in Ireland显示文摘 | McCarthy V J Power S Greiner B A | 2010 | Occup Med (Lond)2010，60，8： | 1 |
| 12 | Cy- clooxygenase - 2 ( COX - 2 ) mRNA expression and hormone receptor status in breast cancer显示文摘 | MCCARTHY K BUSTIN S A OGUNKOLADE B | 2006 | Eur J Soil Biol2006，32，7： | 1 |
| 13 | Stable isotopic composition of nitrate in Lake Taihu,China, and major inflow rivers显示文摘 | TOWNSEND S A MCCARTHY M J BRANDES J A | 2007 | Hydrobiologia2007，581，1： | 1 |
| 14 | AT2 receptors:functional relevance in cardiovascular disease显示文摘 | Jones E S Vinh A McCarthy C A | 2008 | Pharmacol Ther2008，120，3： | 1 |
| 15 | Visual analog scales for assessing surgical pain 显示文摘 | McCarthy M Jr Chang C H Pickard A S | 2005 | J Am Coll Surg2005，201，2： | 1 |
| 16 | Pathogen evolution and disease emergence in carnivores显示文摘 | McCarthy A J Shaw M A Goodman S J | | 0，，1629： | 1 |
| 17 | A strategy and methodology for defensibly correlating spilled oil to source candidates显示文摘 | Stout S A Uhler A D Mccarthy K J | 2001 | Environment Forensics2001，2，1： | 1 |
| 18 | Effect of chain extender structure on the properties and morphology of polyurethanes based on H12MDI and mixed macrodiols(PDMSPHMO) 显示文摘 | Adhikari R Gunatillake P A McCarthy S J | 1999 | J Appl Polym Sci1999，74，： | 1 |
| 19 | Perceived occupational stress in nurses working in Ireland 显示文摘 | McCarthy V J Power S Greiner B A | 2010 | Occup Med (Lond)2010，60，8： | 1 |
| 20 | Chemerin,a novel adipokine that regu lates adipogenesis and adipocyte metabolism显示文摘 | Goralski K B McCarthy T C Hanniman E A Zabel B A Butcher g C Parlee S D | 2007 | J Biol Chem2007，282，28： | 1 |
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