|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage显示文摘Background: Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results. The purpose of this study was to identify the most stable housekeeping genes in porcine articular cartilage subjected to a mechanical injury from a panel of 10 candidate genes. Results: Ten candidate housekeeping genes were evaluated in three different treatment groups of mechanically impacted porcine articular cartilage. The genes evaluated were: beta actin, beta-2-microglobulin, glyceraldehyde-3-phosphate dehydrogenase, hydroxymethylbilane synthase, hypoxanthine phosphoribosyl transferase, peptidylprolyl isomerase A (cyclophilin A), ribosomal protein L4, succinate dehydrogenase flavoprotein subunit A, TATA box binding protein, and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein-zeta polypeptide. The stability of the genes was measured using geNorm, BestKeeper, and NormFinder software. The four most stable genes measured via geNorm were (most to least stable) succinate dehydrogenase flavoprotein, subunit A, peptidylprolyl isomerase A, glyceraldehyde-3-phosphate dehydrogenase, beta actin; the four most stable genes measured via BestKeeper were glyceraldehyde-3-phosphate dehydrogenase, peptidylprolyl isomerase A, beta actin, succinate dehydrogenase flavoprotein, subunit A; and the four most stable genes measured via NormFinder were peptidylprolyl isomerase A, succinate dehydrogenase flavoprotein, subunit A, glyceraldehyde-3-phosphate dehydrogenase, beta actin. Conclusions: BestKeeper, geNorm, and NormFinder all generated similar results for the most stable genes in porcine articular cartilage. The use of these appropriate reference genes will facilitate accurate gene expression studies of porcine articular cartilage and suggest appropriate housekeeping genes for articular cartilage studies in other species. | Ryan S McCulloch Melissa S Ashwell Audrey T O'Nan Peter L Mente | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 2 |
| 3 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 4 | The structure and annealing properties of multilayer carbon films 显示文摘 | McCulloch D G Xiao X L Peng J L | 2005 | Surf Coating Techol2005，198，： | 1 |
| 5 | A simple method for the precise determination of ≥ 40 trace elements in geological samples by ICPMS using enriched isotope internal standardisafion显示文摘 | Eggins S M Woodhead J D Kinsley L P J Mortimer G E Sylvester P McCulloch M T Hergt J M Handler M R | 1997 | Chem Geol1997，134，4： | 1 |
| 6 | Evidence for ocean acidification in the Great Barrier Reef of Australia显示文摘 | Wei G J McCulloch M T Mortimer G Deng W F Xie L H | 2009 | Geochim Cosmochim Aeta2009，73，8： | 1 |
| 7 | Chirped Fiber Bragg Grating Detonation Velocity Sensing 显示文摘 | Rodriguez G Sandberg R L McCulloch Q | 2013 | Re- view of Scientific Instruments2013，84，01： | 1 |
| 8 | Mechanisms for the behavior of carbon films during annealing显示文摘 | Mcculloch D G Peng J L Mckenzie D R | 2004 | Phys Rev B2004，70，08： | 1 |
| 9 | Daytime cardiac autonomic activity during one week of continuous night shift显示文摘 | Holmes A L Burgess H J McCulloch K | 2001 | J Hum Ergol(Tokyo)2001，30，12： | 1 |
| 10 | The distribution of colony- forming cells among spleen colonies 显示文摘 | Siminovitch L McCulloch EA Till JE | 1963 | J Cell Physiol1963，62，3： | 1 |
| 11 | Identification and monitoring of Australian plague locust habitats from Landsat显示文摘 | MCCULLOCH L HINTER D M | 1983 | Remote Sensing of Environment1983，，： | 1 |
| 12 | Global emissions of hydrogen chloride and chloromethane from coal combustion,incineration and industrial activities:Reactive Chlorine Emissions Inventory显示文摘 | McCulloch A Aucott M L | 1999 | Journal of Geophysical Research-Atmospheres1999，104，7： | 1 |
| 13 | Tumor necrosis factor- c~ - 238G> A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arte- riovenous malformations显示文摘 | Achrol AS Pawlikowska L McCulloch CE | 2006 | Stroke2006，37，1： | 1 |
| 14 | Bi-directional processing of DNA loops by mismatch repair-dependent and independent pathways in human cells显示文摘 | McCulloch SD Gu L Li GM | 2003 | J Biol Chem2003，278，6： | 1 |
| 15 | Association between tumor angiogenesis and tumor cell shedding into effluent venous blood during breast cancer surgery显示文摘 | Mcculloch P Choy A Martin L | 1995 | Lancet1995，346，8986： | 1 |
| 16 | Geochemicaland isotopic variations in the calcalkaline rocks of Aeolian arc,southern Tyrrhenian Sea, Italy: Constraints on magma genesis 显示文摘 | Francalanci L Taylor S R McCulloch M T | 1993 | Contributions to Mineral and Petrology1993，113，： | 1 |
| 17 | Identification and Monitoring of Australian Plague Locust Habitats from Landsat显示文摘 | Mcculloch L Hinter D M | 1983 | Remote Sensing of Environment1983，13，1： | 1 |
| 18 | Neuropeptide Y: immunocytochemical localization to and effect upon feline pial arteries and veins invitro and insitu显示文摘 | Edvinsson L Emson P McCulloch J | 1984 | Acta Physiol Scand1984，122，2： | 1 |
| 19 | Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes显示文摘 | Sancerman J J Zhang J Martin J C Peng L X Stenbit A E Tsien R Y McCulloch A D | | 0，，： | 1 |
| 20 | 查看详情显示文摘 | McCulloch M T Normand E L Langford N Duxbury G | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员