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您的检索式：作者名="Meifang Pu"
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| 1 | On-demand assembly of polymeric nanoparticles for longer-blood-circulation and disassembly in tumor for boosting sonodynamic therapy显示文摘Sonodynamic therapy (SDT) is one of the promising strategies for tumor therapy, but its application is usually hindered by fast clearance in blood-circulation, abnormal tumor microenvironment, and inefficient generation of reactive oxygen species. To solve these problems, we proposed an on-demand assembly-disassembly strategy, where the assembly is favorable for longer-blood-circulation and then the disassembly in tumor is favorable for boosting SDT. Hematoporphyrin monomethyl ether (HMME) as the model of organic sonosensitizers were conjugated with hyaluronic acid (HA). Then HA-HMME was mixed with catalase (CAT) and assembled into polymeric nanoparticles (CAT@HA-HMME NPs) with size of ~80 nm. CAT@HA-HMME NPs exhibit good biocompatibility and a longer blood half-time (t1/2 = 4.17 h) which is obviously longer than that (~0.82 h) of HMME molecules. After HA receptor-mediated endocytosis of cancer cells, CAT@HA-HMME NPs can be cleaved by endogenous hyaluronidase, resulting in the on-demand disassembly in tumor to release HA-HMME molecules and CAT. The CAT catalyzes the endogenous H_(2)O_(2) into O_(2) to relieve the hypoxic microenvironment, and the released HA-HMME exhibits a higher ROS generation ability, greatly boosting SDT for the inhibition of tumor growth. Therefore, the on-demand assembly-disassembly strategy may provide some insight in the design and development of nanoagents for tumor therapy. | Mei Wen Nuo Yu Shiwen Wu Mengmeng Huang Pu Qiu Qian Ren Meifang Zhu Zhigang Chen | 2022 | Bioactive Materials2022，7，12： | 2 |
| 2 | Pressure-induced disordering of site occupation in iron–nickel nitrides显示文摘Controlled disordering of substitutional and interstitial site occupation at high pressure can lead to important changes in the structural and physical properties of iron–nickel nitrides.Despite important progress that has been achieved,structural characterization of ternary Fe–Ni–N compounds remains an open problem owing to the considerable technical challenges faced by current synthetic and structural approaches for fabrication of bulk ternary nitrides.Here,iron–nickel nitride samples are synthesized as spherical-like bulk materials through a novel highpressure solid-state metathesis reaction.By employing a wide array of techniques,namely,neutron powder diffraction,Rietveld refinement methods combined with synchrotron radiation angle-dispersive x-ray diffraction,scanning electron microscopy/energy dispersive x-ray spectroscopy,and transmission electron microscopy,we demonstrate that high-temperature and high-pressure confinement conditions favor substitutional and interstitial site disordering in ternary iron–nickel nitrides.In addition,the effects of interstitial nitrogen atoms and disorderly substituted nickel atoms on the elastic properties of the materials are discussed. | Binbin Wu Li Lei Feng Zhang Qiqi Tang Shan Liu Meifang Pu Duanwei He Yuanhua Xia Leiming Fang Hiroaki Ohfuji Tetsuo Irifune | 2021 | Matter and Radiation at Extremes2021，6，3： | 0 |
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