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| 1 | Prediction of blasting mean fragment size using support vector regression combined with five optimization algorithms显示文摘The main purpose of blasting operation is to produce desired and optimum mean size rock fragments.Smaller or fine fragments cause the loss of ore during loading and transportation,whereas large or coarser fragments need to be further processed,which enhances production cost.Therefore,accurate prediction of rock fragmentation is crucial in blasting operations.Mean fragment size(MFS) is a crucial index that measures the goodness of blasting designs.Over the past decades,various models have been proposed to evaluate and predict blasting fragmentation.Among these models,artificial intelligence(AI)-based models are becoming more popular due to their outstanding prediction results for multiinfluential factors.In this study,support vector regression(SVR) techniques are adopted as the basic prediction tools,and five types of optimization algorithms,i.e.grid search(GS),grey wolf optimization(GWO),particle swarm optimization(PSO),genetic algorithm(GA) and salp swarm algorithm(SSA),are implemented to improve the prediction performance and optimize the hyper-parameters.The prediction model involves 19 influential factors that constitute a comprehensive blasting MFS evaluation system based on AI techniques.Among all the models,the GWO-v-SVR-based model shows the best comprehensive performance in predicting MFS in blasting operation.Three types of mathematical indices,i.e.mean square error(MSE),coefficient of determination(R^(2)) and variance accounted for(VAF),are utilized for evaluating the performance of different prediction models.The R^(2),MSE and VAF values for the training set are 0.8355,0.00138 and 80.98,respectively,whereas 0.8353,0.00348 and 82.41,respectively for the testing set.Finally,sensitivity analysis is performed to understand the influence of input parameters on MFS.It shows that the most sensitive factor in blasting MFS is the uniaxial compressive strength. | Enming Li Fenghao Yang Meiheng Ren Xiliang Zhang Jian Zhou Manoj Khandelwal | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 3 |
| 2 | Rational design of a visible-light photochromic diarylethene:a simple strategy by extending conjugation with electron donating groups显示文摘Photochromic diarylethenes have been widely used in many fields. However, their cyclization process must be induced by UV light. In this article, a simple strategy is developed by extending π-conjugation with electron donating groups. The modified dirylethene derivative can photocyclolize under 405-nm light with a good photochromic efficiency. Meanwhile, its absorption and moderate fluorescence can be switched effectively in both directions by visible lights(405 and 520 nm, respectively) in different solutions and in living cells. We believe that this simple method will become a versatile strategy for developing various dirylethylenes with visible-light photochromism. | Shanliang Tang Fengling Song Meiheng Lu Keli Han Xiaojun Peng | 2019 | Science China Chemistry2019，62，4： | 2 |
| 3 | Sol-gel derived hydroxyapatite/titania biocoatings on titanium substrate 显示文摘 | Xu Wei Hu Wangyu Li Meiheng | 2006 | Materials Letters2006，60，1314： | 1 |
| 4 | Enhancement of the bioactivity of titanium oxide nanotubes by precalcification显示文摘 | Ma Qiqi Li Meiheng Hu Ziying | | 0，，09： | 1 |
| 5 | Thermal shock behavior of EB-PVD thermal barrier coatings 显示文摘 | Li Meiheng Sun Xiaofeng Hu Wangyu | 2007 | Surfaee and Coatings Technol- ogy2007，201，1617： | 1 |
| 6 | Thermocyclic behavior of sputtered NiCrA1Y/EB - PVD 7wt% Y2 O3 - ZrO2 thermal barrier coatings显示文摘 | Meiheng Li Xiaofeng Sun Wangyu Hua | 2006 | Surface and Coatings Technology2006，200，： | 1 |
| 7 | Expression of and role for ovarian cancer G-protein-coupled receptor 1 ( OGR1 ) during osteoclastogenesis 显示文摘 | Meiheng Y Genevieve M Mark JB | 2006 | J Biol Chem2006，281，23： | 1 |
| 8 | 查看详情显示文摘 | Li Meiheng Sun Xiaofeng Hu Wangyu | | 0，，1： | 1 |
| 9 | Micmstructural Changes and Elemental Diffusion of Sputtered NiCrA1Y Coat- ing on a Ni-Base SC Superalloy Subjected to High Tempera- ture 显示文摘 | Li Meiheng Sun Xiaofeng Hu Wangyu | 2007 | Materials Letters2007，61，29： | 1 |
| 10 | Microstructral changes and elemental diffusion of sputtered NiCrAlY coating on a Ni-base SC Superalloy subjected to high temperature显示文摘 | Li Meiheng Sun Xiaofeng Hu Wangyu | 2007 | Materials Letters2007，61，： | 1 |
| 11 | Sol-gel derived hydroxyapatite/titania biocoatings on titanium substrate 显示文摘 | Wei Xu Wangyu Hu Meiheng Li | 2006 | Materials Letters2006，60，1314： | 1 |
| 12 | Drug discovery of sclerostin inhibitors显示文摘Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy. | Sifan Yu Dijie Li Ning Zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 13 | Micro- structral changes and elemental diffusion of sputtered NiCrA1Y coating on a Ni-base SC superalloy subjected to high temperature 显示文摘 | Li Meiheng Sun Xiaofeng Hu Wangyu | 2007 | Materials Letters2007，61，： | 1 |
| 14 | Structural determinants specific for retromer protein sorting nexin 5 in regulating subcellular retrograde membrane trafficking显示文摘The endosomal trafficking of signaling membrane proteins, such as receptors, transporters and channels, is mediated by the retromer-mediated sorting machinery, composed of a cargo-selective vacuolar protein sorting trimer and a membrane-deforming subunit of sorting nexin proteins. Recent studies have shown that the isoforms, sorting nexin 5 (SNX5) and SNX6, have played distinctive regulatory roles in retrograde membrane trafficking. However, the molecular insight determined functional differences within the proteins remains unclear. We reported that SNX5 and SNX6 had distinct binding affinity to the cargo protein vesicular monoamine transporter 2 (VMAT2). SNX5, but not SNX6, specifically interacted with VMAT2 through the Phox domain, which contains an alpha-helix binding motif. Using chimeric mutagenesis, we identified that several key residues within this domain were unique in SNX5, but not SNX6, and played an auxiliary role in its binding to VMAT2. Importantly, we generated a set of mutant SNX6, in which the corresponding key residues were mutated to those in SNX5. In addition to the gain in binding affinity to VMAT2, their overexpression functionally rescued the altered retrograde trafficking of VMAT2 induced by siRNA-mediated depletion of SNX5. These data strongly suggest that SNX5 and SNX6 have different functions in retrograde membrane trafficking, which is determined by the different structural elements within the Phox domain of two proteins. Our work provides a new information on the role of SNX5 and SNX6 in the molecular regulation of retrograde membrane trafficking and vesicular membrane targeting in monoamine neurotransmission and neurological diseases. | Qing Chen Meiheng Sun Xu Han Hongfei Xu Yongjian Liu | 2023 | The Journal of Biomedical Research2023，37，6： | 0 |
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