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| 1 | Involvement of aquaporins in a mouse model of rotavirus diarrhea显示文摘Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems to occur because of aquaporins(AQPs). Accumulating evidence indicates that alterations in AQPs may play an important role in pathogenesis. Here, we focus on changes in AQPs in a mouse model of rotavirus diarrhea. In the present study, 32 of 35 mice developed diarrhea and mild dehydration within 24 hours after infection with rotavirus strain SA11. Intestinal epithelial cells demonstrated cytoplasmic vacuolation, malaligned villi, and atrophy. AQP1 expression was significantly attenuated in the ileum and colon in comparison with controls; likewise, AQP4 and-8 protein expression were significantly decreased in the colon of rotavirus diarrhea-infected mice. In contrast, AQP3 protein expression was significantly increased in the colon of rotavirus-infected mice in comparison with controls. These results indicate that rotavirus diarrhea is associated with the downregulation of AQP1,-4, and-8 expression. Therefore, AQPs play an important role in rotavirus diarrhea. | Meiwan Cao Min Yang Zhiying Ou Dingyou Li Lanlan Geng Peiyu Chen Huan Chen Sitang Gong | 2014 | Virologica Sinica2014，29，4： | 13 |
| 2 | Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel显示文摘结合的指向的药交货在细胞质的快速的药版本是强大的策略提高反癌症药的功效和还原剂离开目标效果。此处,我们描述由 pH 应答的共聚物 D 组成的一个双功能的混合 micellar 系统 -- tocopheryl 聚乙烯乙二醇 1000-blockpoly-( 氨基的酉旨)(TPGS-b-PBAE, TP ) 并且 AS1411 aptamer (恰当) 装饰了 TPGS 聚合物(Apt-TPGS ) ,它在癌症房间的血浆膜上认出过去表示的 nucleolin。反癌症药 paclitaxel (PTX ) 在恰当混合的微粒被包含,并且这些装载药的微粒有一种合适的粒子尺寸和 116.3 nm eir single-crystalline-like 的希腊语的第六个字母潜力远程的电子连接, VN MCNS 交付 1.44 的电的传导性 ??? 汰獵瀭畬 ?? ￣吗? | Jinming Zhang Rule Chen Xiefan Fang Fengqian Chen Yitao Wang Meiwan Chen | 2015 | Nano Research2015，0，1： | 6 |
| 3 | Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures显示文摘为肿瘤的高度精确的治疗的激活刺激的指向的交货系统在最近的年里收到了可观的注意。此处,我们揭示使用一个互补 DNA 序列到 hybridize 和结合到象金 nanorods 或围单人赛的碳 nanotubes (SWNT ) 那样的 photothermal 代理人上的面具 sgc8 aptamers 的光能被活化的指向癌症的策略。在暴露到之上在红外线附近(NIR ) 激光,局部性的 photothermal 在双 stranded DNA 的 dehybridization 加热那些 nano 代理人结果的表面并且 aptamer 顺序放允许指向的特定的癌症房间。作为一个模型系统利用装载 doxorubicin 的 SWNT,到 NIR 光激活的癌症房间的指向的药交货被完成。这个工作与有约束力的可控制的癌症房间表明 NIR 能被活化的指向肿瘤的交货系统的概念潜在地启用高度特定、有效的癌症治疗。 | Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen | 2016 | Nano Research2016，0，1： | 4 |
| 4 | A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy显示文摘The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment. | Yihan Wu Jingjing Li Xuemei Zhong Jinfeng Shi Yanfen Cheng Chenglin He Jiaxin Li Liang Zou Chaomei Fu Meiwan Chen Jinming Zhang Huile Gao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 4 |
| 5 | Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review显示文摘Dihydroartemisinin(DHA),a first-line antimalarial drug,has demonstrated great anticancer effects in many types of tumors,including liver cancer,glioblastoma,and pancreatic cancer.Due to its abilities to induce programmed cell death(PCD;apoptosis,autophagy and ferroptosis),inhibit tumor metastasis and angiogenesis,and modulate the tumor microenvironment,DHA could become an antineoplastic agent in the foreseeable future.However,the therapeutic efficacy of DHA is compromised owing to its inherent disadvantages,including poor stability,low aqueous solubility,and short plasma halflife.To overcome these drawbacks,nanoscale drug delivery systems(NDDSs),such as polymeric nanoparticles(NPs),liposomes,and metal-organic frameworks(MOFs),have been introduced to maximize the therapeutic efficacy of DHA in either single-drug or multidrug therapy.Based on the beneficial properties of NDDSs,including enhanced stability and solubility of the drug,prolonged circulation time and selective accumulation in tumors,the outcomes of DHA-loaded NDDSs for cancer therapy are significantly improved compared to those of free DHA.This reviewfirst summarizes the current understanding of the anticancer mechanisms of DHA and then provides an overview of DHA-including nanomedicines,aiming to provide inspiration for further application of DHA as an anticancer drug. | Ka Hong Wong Donglin Yang Shanshan Chen Chengwei He Meiwan Chen | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 3 |
| 6 | Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection显示文摘The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of drugs.Therefore,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in AD.RAGE is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal brain.Meanwhile,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of ROS.As a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was decreased.Neurotoxicity was also alleviated with structural regeneration and functional recovery of neurons.Besides,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the brain.Overall,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD lesion.Thus it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection. | Xueqin He Xiaorong Wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 7 | Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery显示文摘尽管有高 echogenicity 的充满气体的 microbubbles 是广泛地应用的 inclinical ultrasonography,微米规模粒子尺寸在稳固的肿瘤的处理阻碍他们的使用,它对目标可存取不到几百纳米。我们此处建议包含导致 apH 的核心壳 micelle-to-vesicle 转变准备拥有多重特征的超声敏感的聚合 nanospheres (在结构的 polymersomes ) 的一条不平常的途径,包括进水的腔的一个阶段过渡的成像代理人的 nanosize, monodispersity,和加入。这些特征不经由为 polymersome 准备的常规双乳剂方法是可完成的。nanospheres 与双 pH 敏感基于新奇 triblock 共聚物被构造。外部低频率的超声导致的成像代理人的 liquid-to-gas 阶段转变可以为一个快速的药版本破坏 nanospheres,与在一个肿瘤内的同时的渗透织物的药交货。这些效果可以为有效癌症治疗的发展向新机会提供很少不利效果。 | Yiru Wang Tinghui Yin Zhenwei Su Chen Qiu Yong Wang Rongqin Zheng Meiwan Chen Xintao Shuai | 2018 | Nano Research2018，11，7： | 3 |
| 8 | Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β -Elemene显示文摘 | Meiwan Chen Jinming Zhang Siqin Yu Shengpeng Wang Zaijun Zhang Jianqiang Chen Jian Xiao Yitao Wang Yoshiyuki Kimura | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 9 | Non-apoptotic cell death-based cancer therapy:Molecular mechanism,pharmacological modulators,and nanomedicine显示文摘As an emerging cancer therapeutic target,non-apoptotic cell death such as ferroptosis,necroptosis and pyroptosis,etc.,has revealed significant potential in cancer treatment for bypassing apoptosis to enhance the undermined therapeutic efficacy triggered by apoptosis resistance.A variety of anticancer drugs,synthesized compounds and natural products have been proven recently to induce non-apoptotic cell death and exhibit excellent anti-tumor effects.Moreover,the convergence of nanotechnology with functional materials and biomedicine science has provided tremendous opportunities to construct non-apoptotic cell death-based nanomedicine for innovative cancer therapy.Nanocarriers are not only employed in targeted delivery of non-apoptotic inducers,but also used as therapeutic components to induce non-apoptotic cell death to achieve efficient tumor treatment.This review first introduces the main characteristics,the mechanism and various pharmacological modulators of different non-apoptotic cell death forms,including ferroptosis,necroptosis,pyroptosis,autophagy,paraptosis,lysosomal-dependent cell death,and oncosis.Second,we comprehensively review the latest progresses of nanomedicine that induces various forms of non-apoptotic cell death and focus on the nanomedicine targeting different pathways and components.Furthermore,the combination therapies of non-apoptotic cell death with photothermal therapy,photodynamic therapy,immunotherapy and other modalities are summarized.Finally,the challenges and future perspectives in this regard are also discussed. | Xuan Wang Peng Hua Chengwei He Meiwan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 10 | Polymeric micelles drug delivery system in oncology显示文摘 | Jian Gong Meiwan Chen Ying Zheng Shengpeng Wang Yitao Wang | 2012 | Journal of Controlled Release2012，，3： | 1 |
| 11 | Emodin loaded solid lipid nanoparticles: Preparation, characterization and antitumor activity studies显示文摘 | Shengpeng Wang Tongkai Chen Ruie Chen Yangyang Hu Meiwan Chen Yitao Wang | 2012 | International Journal of Pharmaceutics (-)2012，，1： | 1 |
| 12 | Polymeric micelles drug delivery system in oncology显示文摘 | GONG J MEIWAN C YING Z | 2012 | J Control Release2012，159，3： | 1 |
| 13 | Berberine hydrochloride: anticancer activity and nanoparticulate delivery system显示文摘 | Wen Tan Yitao Wang Meiwan Chen Li | 2011 | International Journal of Nanomedicine (default)2011，，： | 1 |
| 14 | A series of simple curcumin-derived colorimetric and fluorescent probes for ratiometric-pH sensing and cell imaging显示文摘Colorimetric and fluorescent probes have emerged as a potent tool for pH sensing due to easy operation and high sensitivity.However,most of the existing bimodal probes require complicated synthesis,which greatly limits their wide applications.Herein,a simple fluorescent dye(called BFCUR)featuring a D-π-A-π-D conjugated system was developed from the natural polyphenol curcumin(CUR).BFCUR exhibited significant red-shift in UV absorption and fluorescence emission as pH increased because of the deprotonation of the phenolic hydroxyl groups,which resulted in the enhanced intramolecular charge transfer(ICT).The ratiometric pH detection of BFCUR was achieved with remarkable accuracy by monitoring both the absorbance ratio A;/A;and the fluorescence intensity ratio I;/I;under various pH values.In addition,the clear color changes of BFCUR under different pH conditions were visible,which enabled BFCUR to be used in test strips for rapid,visual pH detection.Moreover,BFCUR exhibited low cytotoxicity,and was successfully applied for intracellular pH detection,where the fluorescence intensity was linearly related to pH value.This study highlighted the great potential of CUR-derived BFCUR as colorimetric and fluorescent probes for ratiometric-pH sensing and cell imaging. | Guangjie Song Di Jiang Lei Wang Xiangzhong Sun Hongtian Liu Yanqing Tian Meiwan Chen | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 15 | Linear-like polypeptide-based micelle with pH-sensitive detachable PEG to deliver dimeric camptothecin for cancer therapy显示文摘Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).However,many challenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,and poor cellular internalization.Herein,we report a novel dual-sensitive polypeptide-based micelle with remarkably high drug loading of CPT for cancer therapy.This self-assembled micelle possesses the following essential components for CPT:(1)pH-sensitive PEG(OHC-PEG-CHO)for prolonging blood circulation and allowing biocompatibility by shielding the cationic micelles,which can be detached under the tumor acidic microenvironment and facilitates the cellular uptake;(2)polypeptide polylysine-polyphenylalanine(PKF)synthesized via ring-opening polymerization for micelle formation and CPT analogue loading;(3)dimeric CPT(DCPT)with redox-sensitive linker for increasing CPT loading and ensuring drug release at tumor sites.Interestingly,the linear-like morphology of PEG-PKF/DCPT micelles was able to enhance their cellular internalization when compared with the spherical blank PKF micelles.Also,the anticancer efficacy of DCPT against lung cancer cells was significantly improved by the micelle formation.In conclusion,this work provides a promising strategy facilitating the safety and effective application of CPT in cancer therapy. | Ka Hong Wong Zhaopei Guo Di Jiang Xingzhi Zhou Lizhu Lin Denggao Zhao Meiwan Chen | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，1： | 0 |
| 16 | Decorating ketjen black with ultra-small Mo_(2)C nanoparticles to enhance polysulfides chemisorption and redox kinetics for lithium-sulfur batteries显示文摘The low sulfur utilization and fast capacity fading resulting from the sluggish redox reaction and abominable polysulfides shuttle greatly hinder the practical applications of lithium-sulfur(Li-S) batteries.Herein, we develop a facile 'in-situ growth' method to decorate ultra-small Mo2 C nanoparticles(USMo2 C) on the surface of Ketjen Black(KB) to functionalize the commercial polypropylene(PP) separators,which can accelerate the redox kinetics of lithium polysulfides conversion and effectively increase the utilization of sulfur for Li-S batteries. Importantly, the US-Mo2 C nanoparticles have abundant sites for chemical adsorption towards polysulfides and the conductive carbon networks of KB have cross-linked pore channels, which can promote electron transport and provide physical barrier and volume expansion space for polysulfides. Due to the combined effects of the US-Mo2 C and KB, Li-S cells employing the multifunctional PP separators modified with KB/US-Mo2 C composite(KB/US-Mo2 C@PP) exhibit a high specific capacity(1212.8 mAh g^(-1) at 0.2 C), and maintain a reversible capacity of 1053.3 m Ah g^(-1) after 100 cycles.More importantly, the KB/US-Mo2 C@PP cells with higher sulfur mass loading of 4.9 mg cm^(-2) have superb areal capacity of 2.3 mAh cm^(-2). This work offers a novel and promising perspective for high-performance Li-S batteries from both the shuttle effect and the complex polysulfides conversion. | Nan Jiang Guangyu Jiang Dechao Niu Jiayi Mao Meiwan Chen Kaiyuan Li Yongsheng Li | 2020 | Journal of Energy Chemistry2020，29，12： | 0 |
| 17 | Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation显示文摘Intelligent drug delivery system based on “stimulus-response”mode emerging a promising perspective in next generation lipidbased nanoparticle.Here,we classify signal sources into physical and physiological stimulation according to their origin. | Fuxue Zhang Bozhang Xia Jiabei Sun Yufei Wang Jinjin Wang Fengfei Xu Junge Chen Mei Lu Xin Yao Peter Timashev Yuanyuan Zhang Meiwan Chen Jing Che Fangzhou Li Xing-Jie Liang | 2023 | Research2023，，2： | 0 |
| 18 | GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer显示文摘Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer. | Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 19 | Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils显示文摘Normalizing inflamed soils including reactive oxygen species(ROS),nitric oxide(NO),cellfree DNA,and regulating infammation-related seeds such as macrophages,neutrophils,fibroblasts,represent a promising strategy to maintain synovial tissue homeostasis for rheumatoid arthritis(RA)treatment.Herein,ROS scavenging amphiphilic block copolymer PEGylated bilirubin and NO-scavenging PEGylated o-phenylenediamine were fabricated to self-assemble into a dually responsive nanoparticle loaded with JAK inhibitor notopterol(Not@BR/oPDA-PEG,NBOP NPs).The simultaneous ROS and NO depletion combined with JAK-STAT pathway inhibition could not only promote M2 polarization to reduce further ROS and NO generation,but also decrease cytokines and chemokines to prevent immune cell recruitment.Specifically,NBOP NPs responded to high level ROS and NO,and disintegrated to release notopterol in inflamed joints as the hydrophobic heads BR and oPDA were transformed into hydrophilic ones.The released notopterol could inhibit the JAK-STAT pathway of infammatory cells to reduce the secretion of pro-inflammatory cytokines and chemokines.This strategy represented an effective way to regulate RA soils and seeds through breaking the positive feedback loop of inflammation aggravation,achieving an excellent anti-RA efficacy in a collagen-induced arthritis rat model.Taken together,our work offered a reference to adjust RA soils and seeds for enhanced RA treatment. | Peng Hua Ruifeng Liang Yanbei Tu Yuying Yin Man-Kay Law Meiwan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 20 | Changes in target ability of nanoparticles due to protein corona composition and disease state显示文摘Many studies have shown the influence of protein corona(PC)on the active targeting capability of ligand-modified nanoparticles;however,the influence of clinical status on PC composition and targeting capacity is rarely discussed.In this study,when transferrinmodified PEGylated polystyrene nanoparticles(Tf-PNs)is intravenously injected into mice with non-small cell lung cancer(NSCLC)comorbid with type 2 diabetes mellitus(T2DM),more Tf-PNs accumulated in the tumor tissue than in those of NSCLC model mice.This indicated that PC derived fromdifferent states of disease changed the active targeting ability of Tf-PNs.To explain the occurrence of this phenomenon,our analysis of PC from different disease states revealed that Tf(transferrin)modification had no significant effect on the formation of PC,and that the PC from the NSCLC comorbid with T2DM model contained more proteins like fibrin and clusterin.This work demonstrates the impacts of comorbidity,such as with T2DM,on the active targeting capability of ligand-modified nanoparticles,and the results promote the application of nanoparticles for precision medicine. | Wenwen Xu Mingyu Xu Yumeng Xiao Lu Yu Huiru Xie Xuehua Jiang Meiwan Chen Huile Gao Ling Wang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，3： | 0 |
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