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| 1 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 2 | 接受纳武单抗治疗的晚期肝细胞癌患者炎症生物标志物与临床转归的相关性显示文摘【据Journal of Hepatology 2020年7月报道】题:接受纳武单抗治疗的晚期肝细胞癌患者炎症生物标志物与临床转归的相关性(作者Sangro B等)程序性死亡因子-1(PD-1)抑制剂纳武单抗治疗晚期肝细胞癌患者具有持久的疗效,较高的安全性,且能够显著提高患者的生存期。该研究回顾性分析了接受纳武单抗治疗的肝细胞癌患者的免疫生物学特征以及生物标志物和临床转归之间可能的相关性。 | 周豪 牛俊奇 SANGRO B MELERO I WADHAWAN S | 2020 | 临床肝胆病杂志2020，36，9： | 4 |
| 3 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 4 | Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway 显示文摘 | Melero 1 Bach N Hellstrom K E | 1998 | Eur J Immunol1998，28，3： | 1 |
| 5 | Oxygen lattice instability as a capacity fading mechanism for 5 V cathode materials显示文摘 | Caballero A Hernan L Melero M | 2005 | J Electrochem Soc2005，152，1： | 1 |
| 6 | Monoclonal antibodies against the 4-1BB T-cell activation molecule eradiate established tumors显示文摘 | Melero I Shuford WW Newby SA | 1997 | Nat Med1997，3，6： | 1 |
| 7 | Nanocrystalline ZSM-5:A catalyst with high activity and selectivity for epoxide rearrangement reactions显示文摘 | SERRANO D P VAN GRIEKEN R MELERO J A | 2010 | Journal of Molecular Catalysis A:Chemical2010，318，12： | 1 |
| 8 | Conservation tillage: Short- and long-term effects on soil carbon fractions and enzymatic activities under Mediterranean conditions显示文摘 | MELERO S LOPEZ--GARRIDO R MURILLO J M | 2009 | Soil & Tillage Research2009，104，： | 1 |
| 9 | Direct syntheses of ordered SBA-15 mesoporous silica containing sulfonic acid groups 显示文摘 | Margolese D Melero J A Christiansen S C | 2000 | Chemistry of Materials2000，12，8： | 1 |
| 10 | Mineralization of phenol by a heterogeneous uhrasound/Fe-SBA-15/H2O2 process: Multivariate study by factorial design of experiments显示文摘 | Molina R Martinez F Melero J A | 2006 | Appl Catal B: Environ2006，，66： | 1 |
| 11 | Costimulation, tolerance and ignorance of cytolytic T lymphocytes in immune responses 显示文摘 | Melero I Bach N Chen LP | 1997 | Life Science1997，60，23： | 1 |
| 12 | Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand:synergy with the CD28 co-stimulatory pathway显示文摘 | Melero I Bach N Hellstrom KE | 1998 | Eur J Immunol1998，28，3： | 1 |
| 13 | 查看详情显示文摘 | Grieken R V Sotelo J L Menéndez J M Melero J A | | 0，，： | 1 |
| 14 | Protein O-mannosyltransferases partici- pate in ER protein quality control 显示文摘 | Goder V Melero A | 2011 | J Cell Sei2011，124，1： | 1 |
| 15 | Amplification of tumor immunity lay gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway显示文摘 | Melero I Bach N Hellsmm K E | 1998 | Eur J Immunol1998，28，： | 1 |
| 16 | Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years显示文摘 | Peter L. Collins José A. Melero | 2011 | Virus Research2011，，1： | 1 |
| 17 | Are Workplaces with Many Women in Management Run Differently? 显示文摘 | Eduardo Melero | 2011 | Journal of Business Research2011，64，4： | 1 |
| 18 | Gene therapy of cancer based on interleukin 12 显示文摘 | Sangro B Melero I Cheng Q | 2005 | Cur Gene Ther2005，5，6： | 1 |
| 19 | Crystallization mechanism of Fe-MFI from wetness impregnated Fe2O3-SiO2 amorphous xerogels: Role of iron species in Fenton-like processes 显示文摘 | Melero J A Calleja G Martinez F | 2004 | Microporous Meso- porous Mater2004，，74： | 1 |
| 20 | Environmental strategies and organizational competitiveness in the hotel industry: The role of learning and innovation as determinants of environmental success显示文摘 | Elena Fraj Jorge Matute Iguácel Melero | 2015 | Tourism Management2015，，： | 1 |
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