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| 1 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 2 | Effect of Mischmetal Addition on Catalytic Performance of PtSnNa/ZSM-5 for Propane Dehydrogenation显示文摘The influence of mischmetal addition on physicochemical properties of PtSnNa/ZSM-5 catalyst was studied by means of XRF,H 2 chemisorption,XRD,TPR,NH 3-TPD and TPO techniques.The results showed that the presence of mischmetal had an obvious impact on the catalytic performance of the PtSnNa/ZSM-5 catalyst.A suitable content of mischmetal not only could enhance the interactions between Pt species and the support,but also inhibit the formation of coke during the reaction,thus improving the catalytic activity and stability.In our experiments,when the content of mischmetal was 3m%,the catalyst exhibited best catalytic performance.However,the continuous addition of mischmetal could promote the reduction of Sn species to metallic tin,which was disadvantageous to the reaction. | Xue Mengwei Zhou Yuming Huang Li Zhang Yiwei Duan Yongzheng Sheng Xiaoli | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，3： | 4 |
| 3 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 4 | Spatial variation in grain-size population of surface sediments from northern Bering Sea and western Arctic Ocean: Implications for provenance and depositional mechanisms显示文摘In general,sediments in nature comprise populations of various diameters.Accurate information regarding the sources and depositional mechanisms of the populations can be obtained through their temporal and spatial comparisons.In this study,the grain size distribution of surface sediments from the Bering Sea and western Arctic Ocean were fitted and partitioned into populations using a log-normal distribution function.The spatial variations in the populations indicate differences in their sources and deposition mechanisms.The sediments on most of the Bering Sea Shelf originated from the Yukon River,and were transported westward by waves and currents.However,the presence of a coarser population outside Anadyr Bay was the result of Anadyr River transport.Additionally,a northward transport trend of fine suspended particles was observed on the west side of the Bering Sea Shelf.The sediments in Hope Valley in the south Chukchi Sea also originated from the Yukon River.The coarser population on the central Chukchi Sea Shelf originated from coast of Alaska to the east,not the Yukon River,and was transported by sea ice and bottom brine water.The populations of sediments from the Chukchi Basin and the base of the Chukchi Sea Slope are the result of sea ice and eddy action.Surface sediments from the western high Arctic Ocean predominantly comprised five populations,and two unique populations with mode diameters of 50–90μm and 200–400μm,respectively,were ubiquitous in the glacial and interglacial sediments.It was difficult to distinguish whether these two populations originated from sea ice or icebergs.Therefore,caution should be exercised when using either the>63μm or>250μm fractions in sediments as a proxy index for iceberg and ice sheet variation in the high Arctic Ocean. | WANG Weiguo YANG Jichao ZHAO Mengwei DONG Linsen JIANG Min HUANG Erhui | 2020 | Advances in Polar Science2020，31，3： | 2 |
| 5 | Ultralong cycle life enabled by in situ growth of CoMo_(1-x)P/Mo heterostructure for lithium-sulfur batteries显示文摘Lithium-sulfur batteries(Li-S batteries) are considered as promising new-generation electrochemical energy storage devices due to their extremely high theoretical energy density(2600 Wh kg-1) and theoretical specific capacity(1675 m Ah g^(-1)). However, numerous problems such as poor conductivity and the shuttle effect during discharge-charge process limit the practical application of lithium-sulfur batteries. In this work, porous tubular Co Mo_(1-x)P/Mo constructed by in situ growth of metal Mo was designed as the sulfur host for lithium-sulfur batteries. The introduction of Mo modulated the electronic structure of Co Mo P to improve the conductivity of cathode and facilitate the redox kinetics, as well as the Co Mo_(1-x)P/Mo heterostructure was beneficial to inhibit the shuttle effect through the interaction with lithium polysulfides, which improved cycling stability. As a result, Co Mo_(1-x)P/Mo/S cathode had a low-capacity decay rate of only 0.029% per cycle after 2000 cycles at 0.5 C. This work provided a new perspective for the further design of high-performance lithium-sulfur battery cathode materials. | Donghua Guo Mengwei Yuan Xingzi Zheng Miaomiao Li Caiyun Nan Genban Sun Xianqiang Huang Huifeng Li | 2022 | Journal of Energy Chemistry2022，31，10： | 2 |
| 6 | Experimental design and theoretical evaluation of nitrogen and phosphorus dual-doped hierarchical porous carbon for high-performance sodium-ion storage显示文摘Starch has a wide range of sources and can be used as a high-quality precursor for sodium-ion battery anode materials.However,the carbonization yield and specific capacity of carbon materials obtained by directly pyrolyzing starch are low.Herein,starch is used as the carbon source,and ammonium polyphosphate(APP)is used as the cross-linking agent and dopant to prepare a nitrogen and phosphorus co-doped porous carbon(NPPC).As the anode for sodium-ion batteries,NPPC-2 exhibits a high reversible capacity of 385.8 mAhg^(-1)at 50 mAg^(-1).Even after 1000 cycles at a large current density of 5 Ag^(-1),the reversible capacity can still be maintained at 126.9 mAhg^(-1).Based on detailed data and first-principles calculations,the excellent performance of NPPC is due to the effective doping of nitrogen and phosphorus elements,which distorts the graphite sheet,introduces defects,and increases the graphite layer spacing,thereby enhancing the adsorption capacity of the carbon material for sodium ions,reducing the diffusion barrier of sodium ions.This work provides a new idea for heteroatom doping and carbon material modification. | Chen Chen Ying Huang Zhuoyue Meng Mengwei Lu Zhipeng Xu Panbo Liu Tiehu Li | 2021 | Journal of Materials Science & Technology2021，，17： | 2 |
| 7 | In situ decoration of CoP/Ti_(3)C_(2)Tx composite as efficient electrocatalyst for Li-oxygen battery显示文摘Application of Li-oxygen(Li-O_(2)) battery is in urgent need of bifunctional ORR/OER electrocatalyst. A surface-functionalization CoP/Ti_(3)C_(2)Txcomposite was fabricated theoretically, with the optimized electronic structure and more active electron, which is beneficial to the electrochemical reaction. The accordion shaped Ti_(3)C_(2)Txis featured with large specific surface area and outstanding electronic conductivity, which is beneficial for the adequate exposure of active sites and the deposition of Li2O2. Transition metal phosphides provide more electrocatalytic active sites and present good electrocatalytic effect. The CoP/Ti_(3)C_(2)Txcomposite served as the electrocatalyst of Li-O_(2)battery reaches a high specific discharge capacity of 17,413 m Ah/g at 100 m A/g and the lower overpotential of 1.25 V, superior to those of the CoP and Ti_(3)C_(2)Txindividually. The composite of transition metal phosphides and MXene are applied in Li-O_(2)battery, not only demonstrating higher cycling stability of the prepared CoP/Ti_(3)C_(2)Txcomposite, but pointing out the direction for their electrochemical performance improvement. | Xingzi Zheng Mengwei Yuan Xianqiang Huang Huifeng Li Genban Sun | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 8 | Optimization of COVID-19 prevention and control measures during the Beijing 2022 Winter Olympics:a model-based study显示文摘Background:The continuous mutation of severe acute respiratory syndrome coronavirus 2 has made the coronavirus disease 2019(COVID-19)pandemic complicated to predict and posed a severe challenge to the Beijing 2022Winter Olympics and Winter Paralympics held in February and March 2022.Methods:During the preparations for the Beijing 2022 Winter Olympics,we established a dynamic model with pulsedetection and isolation efect to evaluate the efect of epidemic prevention and control measures such as entry policies,contact reduction,nucleic acid testing,tracking,isolation,and health monitoring in a closed-loop managementenvironment,by simulating the transmission dynamics in assumed scenarios.We also compared the importance ofeach parameter in the combination of intervention measures through sensitivity analysis.Results:At the assumed baseline levels,the peak of the epidemic reached on the 57th day.During the simulationperiod(100 days),13,382 people infected COVID-19.The mean and peak values of hospitalized cases were 2650and 6746,respectively.The simulation and sensitivity analysis showed that:(1)the most important measures to stopCOVID-19 transmission during the event were daily nucleic acid testing,reducing contact among people,and dailyhealth monitoring,with cumulative infections at 0.04%,0.14%,and 14.92%of baseline levels,respectively(2)strictlyimplementing the entry policy and reducing the number of cases entering the closed-loop system could delay thepeak of the epidemic by 9 days and provide time for medical resources to be mobilized;(3)the risk of environmentaltransmission was low.Conclusions:Comprehensive measures under certain scenarios such as reducing contact,nucleic acid testing,health monitoring,and timely tracking and isolation could efectively prevent virus transmission.Our research resultsprovided an important reference for formulating prevention and control measures during the Winter Olympics,andno epidemic spread in the closed-loop during the games indirectly proved the rationality of our research results. | Lingcai Kong Mengwei Duan Jin Shi Jie Hong Xuan Zhou Xinyi Yang Zheng Zhao Jiaqi Huang Xi Chen Yun Yin Ke Li Yuanhua Liu Jinggang Liu Xiaozhe Wang Po Zhang Xiyang Xie Fei Li Zhaorui Chang Zhijie Zhang | 2022 | Infectious Diseases of Poverty2022，11，5： | 0 |
| 9 | High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice显示文摘Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles.Previous studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein adducts.The lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with autophagosomes.In the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse livers.Genetic loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,respectively.Mechanistically,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against AILI.We also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB agonists.Among these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in mice.In conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI. | Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio Hartmut Jaeschke Hong-Min Ni Wen-Xing Ding | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 10 | Development of an Agrobacterium-mediated CRISPR/Cas9 system in pea(Pisum sativum L.)显示文摘Pea(Pisum sativum L.)is an annual cool-season legume crop.Owing to its role in sustainable agriculture as both a rotation and a cash crop,its global market is expanding and increased production is urgently needed.For both technical and regulatory reasons,neither conventional nor transgenic breeding techniques can keep pace with the demand for increased production.In answer to this challenge,CRISPR/Cas9 genome editing technology has been gaining traction in plant biology and crop breeding in recent years.However,there are currently no reports of the successful application of the CRISPR/Cas9 genome editing technology in pea.We developed a transient transformation system of hairy roots,mediated by Agrobacterium rhizogenes strain K599,to validate the efficiency of a CRISPR/Cas9 system.Further optimization resulted in an efficient vector,PsU6.3-tRNA-PsPDS3-en35S-PsCas9.We used this optimized CRISPR/Cas9 system to edit the pea phytoene desaturase(PsPDS)gene,causing albinism,by Agrobacterium-mediated genetic transformation.This is the first report of successful generation of gene-edited pea plants by this route. | Guan Li Rong Liu Rongfang Xu Rajeev KVarshney Hanfeng Ding Mengwei Li Xin Yan Shuxian Huang Juan Li Dong Wang Yishan Ji Chenyu Wang Junguang He Yingfeng Luo Shenghan Gao Pengcheng Wei Xuxiao Zong Tao Yang | 2023 | The Crop Journal2023，11，1： | 0 |
| 11 | Freeze-drying assisted liquid exfoliation of BiFeO_(3) for pressure sensing显示文摘Breaking up bulk crystals of functional materials into nanoscale thinner layers can lead to interesting properties and enhanced functionalities due to the size and interface effects.However,unlike the van der Waals layered crystals,many materials cannot be exfoliated into thin layers by liquid exfoliation.BiFeO_(3) is a piezoelectric ceramic material,which is commonly synthesized as bulk crystals,limiting its wider applications.In this contribution,a freeze-drying assisted liquid exfoliation method was adopted to fabricate thin-layered BiFeO_(3) nanoplates with lateral sizes of up to 500 nm and thicknesses of 10−20 nm.The freeze-drying process showed a vital role in the preparation process by imposing stress on the dispersed BiFeO_(3) crystals during the liquid-to-solid-to-gas transition of the solvent.Such stress resulted in lattice strains in the freeze-dried BiFeO_(3) crystals,which enabled their further exfoliation under subsequent ultrasonication.Considering the intrinsic piezoelectric effect of BiFeO_(3),pressure sensors based on bulk and thin-layer BiFeO_(3) were also fabricated.The pressure sensor based on BiFeO_(3) nanoplates exhibited a largely enhanced sensitivity with a wider working range than the bulk counterpart,because of the stronger piezoelectric effect induced and the extra electrical charges at abundant interlayer interfaces.We suggest that the freeze-drying assisted liquid exfoliation method can be applied to other non-van der Waals crystals to bring about more functional material systems. | Yuping Li Mengwei Dong Xuejie Zou Jinhao Zhang Jian Zhang Xiao Huang | 2023 | Frontiers of physics2023，18，6： | 0 |
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