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| 1 | DFOS Applications to Geo-Engineering Monitoring显示文摘Optical fiber sensing technology has developed rapidly since the 1980s with the development of the optical fiber and fiber optical communication technology.It is a new type of sensing technology that uses light as a carrier and optical fiber as a medium to sense and transmit external signals(measurands).Distributed fiber optical sensors(DFOS)can continuously measure the external physical parameters distributed along the geometric path of the optical fiber.Meanwhile,the spatial distribution and change information of the measured physical parameters over time can be obtained.This technology has unmatched advantages over traditional point-wise and electrical measurement monitoring technologies.This paper summarizes the state-of-the-art research of the application of the distributed optical fiber sensing tech no logy in geo-engineering in the past 10 years,mainly including the advantages of DFOS,the challenges in geo-engineering monitoring,related fundamental theoretical issues,sensing performance of the optical sensing cables,distributed optical fiber monitoring system for geo-engineering,and applications of optical fiber sensing technology in geo-engineering. | Bin SHI Dan ZHANG Honghu ZHU Chengcheng ZHANG Kai GU Hongwei SANG Heming HAN Mengya SUN Jie LIU | 2021 | Photonic Sensors2021，11，2： | 3 |
| 2 | TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway显示文摘Dear Editor,Colorectal cancer(CRC)is the third most common malignant tumor in human,ranking third in cancer-related mortality.1 Most colon cancer patients die of metastasis.2 Intriguingly,the deregulation of tumor necrosis factorα‑induced protein 8(TIPE)has been shown to play a vital regulatory role in tumor cell growth,proliferation,invasion,and metastasis.3 TIPE is a kind of cytoplasmic protein of 23 kDa.A large number of studies have shown that TIPE is closely related to the development of colon cancer.4 In addition,decreased expression of TIPE was linked to down-regulation of matrix metallopeptidase-1(MMP-1),MMP-9,and vascular endothelial growth factor receptor-2 in breast cancer. | Huiyu Chen Yuhan Ye Yan Yang Mengya Zhong Lei Gu Zhaopu Han Jinhua Qiu Zhongchen Liu Xingfeng Qiu Guohong Zhuang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 3 | Region-adaptive Concept Aggregation for Few-shot Visual Recognition显示文摘Few-shot learning (FSL) aims to learn novel concepts from very limited examples. However, most FSL methods suffer from the issue of lacking robustness in concept learning. Specifically, existing FSL methods usually ignore the diversity of region contents that may contain concept-irrelevant information such as the background, which would introduce bias/noise and degrade the performance of conceptual representation learning. To address the above-mentioned issue, we propose a novel metric-based FSL method termed region-adaptive concept aggregation network or RCA-Net. Specifically, we devise a region-adaptive concept aggregator (RCA) to model the relationships of different regions and capture the conceptual information in different regions, which are then integrated in a weighted average manner to obtain the conceptual representation. Consequently, robust concept learning can be achieved by focusing more on the concept-relevant information and less on the conceptual-irrelevant information. We perform extensive experiments on three popular visual recognition benchmarks to demonstrate the superiority of RCA-Net for robust few-shot learning. In particular, on the Caltech-UCSD Birds-200-2011 (CUB200) dataset, the proposed RCA-Net significantly improves 1-shot accuracy from 74.76% to 78.03% and 5-shot accuracy from 86.84% to 89.83% compared with the most competitive counterpart. | Mengya Han Yibing Zhan Baosheng Yu Yong Luo Han Hu Bo Du Yonggang Wen Dacheng Tao | 2023 | Machine Intelligence Research2023，20，4： | 0 |
| 4 | Spatiotemporal Dynamics of the Molecular Expression Pattern显示文摘Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits or promotes regeneration.Recent technological advances in spatial transcriptomics(ST)provide a unique opportunity to decipher most genes systematically throughout scar formation,which remains poorly understood.Here,we frst constructed the tissue-wide gene expression patterns of mouse spinal cords over the course of scar formation using ST after spinal cord injury from 32 samples.Locally,we profled gene expression gradients from the leading edge to the core of the scar areas to further understand the scar microenvironment,such as neurotransmitter disorders,activation of the pro-infammatory response,neurotoxic saturated lipids,angiogenesis,obstructed axon extension,and extracellular structure re-organization.In addition,we described 21 cell transcriptional states during scar formation and delineated the origins,functional diversity,and possible trajectories of subpopulations of fbroblasts,glia,and immune cells.Specifcally,we found some regulators in special cell types,such as Thbs1 and Col1a2 in macrophages,CD36 and Postn in fbroblasts,Plxnb2 and Nxpe3 in microglia,Clu in astrocytes,and CD74 in oligodendrocytes.Furthermore,salvianolic acid B,a blood–brain barrier permeation and CD36 inhibitor,was administered after surgery and found to remedy fbrosis.Subsequently,we described the extent of the scar boundary and profled the bidirectional ligand-receptor interactions at the neighboring cluster boundary,contributing to maintain scar architecture during gliosis and fbrosis,and found that GPR37L1_PSAP,and GPR37_PSAP were the most signifcant gene-pairs among microglia,fbroblasts,and astrocytes.Last,we quantifed the fraction of scar-resident cells and proposed four possible phases of scar formation:macrophage infltration,proliferation and diferentiation of scar-resident cells,scar emergence,and scar stationary.Together,these profles delineated the spatial heterogeneity of the scar,confrmed the previous concepts about scar architecture,provided some new clues for scar formation,and served as a valuable resource for the treatment of central nervous system injury. | Leilei Gong Yun Gu Xiaoxiao Han Chengcheng Luan Chang Liu Xinghui Wang Yufeng Sun Mengru Zheng Mengya Fang Shuhai Yang Lai Xu Hualin Sun Bin Yu Xiaosong Gu Songlin Zhou | 2023 | Neuroscience Bulletin2023，39，2： | 0 |
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