|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunity, Inflammation, and Cancer显示文摘 | Sergei I. Grivennikov Florian R. Greten Michael Karin | 2010 | Cell2010，，6： | 16 |
| 2 | The IκB kinase- a bridge between inflammation and cancer显示文摘 | Michael Karin | 2008 | Cell Research2008，18，3： | 10 |
| 3 | Regulation and Function of NF-κB Transcription Factors in the Immune System显示文摘 | Sivakumar Vallabhapurapu Michael Karin | 2009 | Annual Review of Immunology2009，，： | 5 |
| 4 | Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer显示文摘 | Ilya Gukovsky Ning Li Jelena Todoric Anna Gukovskaya Michael Karin | 2013 | Gastroenterology2013，，6： | 5 |
| 5 | IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer显示文摘 | Florian R. Greten Lars Eckmann Tim F. Greten Jin Mo Park Zhi-Wei Li Laurence J. Egan Martin F. Kagnoff Michael Karin | 2004 | Cell2004，，3： | 4 |
| 6 | The two NF-κB activation pathways and their role in innate and adaptive immunity显示文摘 | Giuseppina Bonizzi Michael Karin | 2004 | Trends in Immunology2004，，6： | 3 |
| 7 | Missing Pieces in the NF-κB Puzzle显示文摘 | Sankar Ghosh Michael Karin | 2002 | Cell2002，，2： | 3 |
| 8 | IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer显示文摘 | Sergei Grivennikov Eliad Karin Janos Terzic Daniel Mucida Guann-Yi Yu Sivakumar Vallabhapurapu Jürgen Scheller Stefan Rose-John Hilde Cheroutre Lars Eckmann Michael Karin | 2009 | Cancer Cell2009，，2： | 3 |
| 9 | Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma显示文摘 | Patrizia Paterlini Karine Poussin Michael Kew Dominique Franco Christian Brechot | 1995 | Hepatology1995，，2： | 2 |
| 10 | J-Point Elevation in Survivors of Primary Ventricular Fibrillation and Matched Control Subjects显示文摘 | Raphael Rosso Evgeni Kogan Bernard Belhassen Uri Rozovski Melvin M. Scheinman David Zeltser Amir Halkin Arie Steinvil Karin Heller Michael Glikson Amos Katz Sami Viskin | 2008 | Journal of the American College of Cardiology2008，，15： | 2 |
| 11 | Physiological and Molecular Biological Characterization of Ammonia Oxidation of the Heterotrophic Nitrifier Pseudomonas putida显示文摘 | Michael Daum Wolfgang Zimmer Hans Papen Karin Kloos Kerstin Nawrath Hermann Bothe | 1998 | Current Microbiology1998，，4： | 2 |
| 12 | Inflammation and Colon Cancer显示文摘 | Jano? Terzi? Sergei Grivennikov Eliad Karin Michael Karin | 2010 | Gastroenterology2010，，6： | 2 |
| 13 | Phosphorylation Meets Ubiquitination: The Control of NF-&kgr;B Activity显示文摘 | Michael Karin Yinon Ben-Neriah | 2000 | Annual Review of Immunology2000，，： | 2 |
| 14 | IL-6 and related cytokines as the critical lynchpins between inflammation and cancer显示文摘 | Koji Taniguchi Michael Karin | 2014 | Seminars in Immunology2014，，： | 2 |
| 15 | Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation显示文摘 | Guobin He Guann-Yi Yu Vladislav Temkin Hisanobu Ogata Christian Kuntzen Toshiharu Sakurai Wolfgang Sieghart Markus Peck-Radosavljevic Hyam L. Leffert Michael Karin | 2010 | Cancer Cell2010，，3： | 2 |
| 16 | Inflammation and liver tumorigenesis显示文摘Inflammation has been considered as one of the hallmarks of cancer,and chronic hepatitis is a major cause of liver cancer.This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research,including cellular interaction,cytokines,microRNA and stem cells.All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma. | Beicheng Sun Michael Karin | 2013 | Frontiers of Medicine2013，7，2： | 2 |
| 17 | Regulation of antitumor immunity by inflammation-induced epigenetic alterations显示文摘Chronic inflammation promotes tumor development,progression,and metastatic dissemination and causes treatment resistance.The accumulation of genetic alterations and loss of normal cellular regulatory processes are not only associated with cancer growth and progression but also result in the expression of tumor-specific and tumor-associated antigens that may activate antitumor immunity.This antagonism between inflammation and immunity and the ability of cancer cells to avoid immune detection affect the course of cancer development and treatment outcomes.While inflammation,particularly acute inflammation,supports T-cell priming,activation,and infiltration into infected tissues,chronic inflammation is mostly immunosuppressive.However,the main mechanisms that dictate the outcome of the inflammation-immunity interplay are not well understood.Recent data suggest that inflammation triggers epigenetic alterations in cancer cells and components of the tumor microenvironment.These alterations can affect and modulate numerous aspects of cancer development,including tumor growth,the metabolic state,metastatic spread,immune escape,and immunosuppressive or immunosupportive leukocyte generation.In this review,we discuss the role of inflammation in initiating epigenetic alterations in immune cells,cancer-associated fibroblasts,and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes. | Michael Karin Shabnam Shalapour | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 18 | Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer显示文摘 | Sergei I. Grivennikov Michael Karin | 2009 | Cytokine and Growth Factor Reviews2009，，1： | 2 |
| 19 | New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma:a balancing act between immunosuppression and immunosurveillance显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths worldwide.HCC initiates as a consequence of chronic liver damage and inflammation caused by hepatitis B and C virus infections,excessive alcohol con sumption,or non-alcoholic fatty liver disease(NAFLD).Until recently,no effective treat-ments for advanced HCC were available and the 5-year survival rate had remained below 8%for many years.New insights into the mechanisms that drive the development of NAFLD-related HCC indicate that loss of T-cell-mediated immunosurveillance plays a cardinal role in tumor growth and malignant progression,in addition to previously identifhed inflammation-driven compensatory proliferation.Recently completed groundbreaking clinical studies have shown that treatments that restore antitumor immunity represent a highly effective therapeutic option for approximately 20%of advanced HCC patients.Understanding the causes of inflammation-driven immunosuppression and immune system dysfunction in the 80%of patients who fail to reignite antitumor immunity despite treatment with checkpoint inhibitors should lead to further and even more dramatic improvements in HCC immunotherapy. | Michael Karin | 2018 | Precision Clinical Medicine2018，1，1： | 2 |
| 20 | Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca 2+ signaling显示文摘 | Michael Kühl Karin Geis Laird C Sheldahl Tobias Pukrop Randall T Moon Doris Wedlich | 2001 | Mechanisms of Development2001，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员