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| 1 | Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities显示文摘Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma(PRP) therapy is a promising treatment for musculoskeletal injuries.Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field.Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms.This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and(pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed. | Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde Jacobs | 2017 | International Journal of Oral Science2017，9，1： | 10 |
| 2 | Hemodynamics and vasopressor support in therapeutic hypothermia after cardiac arrest: Prognostic implications显示文摘 | John Bro-Jeppesen Jesper Kjaergaard Helle S?holm Michael Wanscher Freddy K. Lippert Jacob E. M?ller Lars K?ber Christian Hassager | 2013 | Resuscitation2013，，： | 1 |
| 3 | Combining pressure and inertial measurement for submarine depth determination显示文摘 | Michael Glass Jacob A M Ter Horst | 1986 | Naval Engineers1986，6268，： | 1 |
| 4 | Enhanced lithium ion transport in PEO-based solid polymer electrolytes employing a novel class of plasticizers显示文摘 | Michael M S Jacob M M E Prabahara S R S | 1997 | Solid State Ionics1997，98，34： | 1 |
| 5 | Enhanced lithium ion transport in PEO-based solid polymer electrolytes employing a novel class of plasticizers显示文摘 | Michael M S Jacob M M E | 1997 | Solid State Ionics1997，98，： | 1 |
| 6 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 7 | Incidence of intraoperative flap complications in laser in situ keratomileusis显示文摘 | Jason M Jacobs Michael J Taravella | 2002 | Journal of Cataract & Refractive Surgery2002，，1： | 1 |
| 8 | Incidence of intraoperative flap complications in laser in situ keratomileusis显示文摘 | Jason M Jacobs MD Michael J | 2002 | J Cataract Refract Surg2002，28，1： | 1 |
| 9 | Computed relation- ships between the inherent and apparent optical properties of a flat homogeneous ocean显示文摘 | Gordon H R Brown O B Michael M Jacobs | 1975 | Applied Optics1975，14，2： | 1 |
| 10 | Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction显示文摘 | Bo Lagerqvist Ole Fr?bert G?ran K. Olivecrona Thórarinn Gudnason Michael Maeng Patrik Alstr?m Jonas Andersson Fredrik Calais J?rg Carlsson Olov Collste Matthias G?tberg Peter H?rdhammar Dan Ioanes Anders Kallryd Rickard Linder Anders Lundin Jacob Odensted | 2014 | The New England Journal of Medicine2014，，： | 1 |
| 11 | Enhanced lithium ion transport in PEO-based solid polymer electrolytes employing a novel class of plasticizers显示文摘 | Michael M S Jacob M M E Prahaharan S R S | 1997 | Solid State Ionics1997，98，34： | 1 |
| 12 | Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study显示文摘 | Atsushi Hozawa David R Jacobs Michael W Steffes Myron D Gross Lyn M Steffen Duk-Hee Lee | 2009 | Journal of Hypertension2009，，2： | 1 |
| 13 | Enhanced lithium ion transport in PEO-based solid polymer electrolytes employing a novel class of plasticizers 显示文摘 | Michael M S Jacob M M E Prabaharan S R S | 1997 | Solid State Ionics1997，98，34： | 1 |
| 14 | The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss显示文摘 | Secher Anna Jelsing Jacob Baquero Arian F Hecksher-S?rensen Jacob Cowley Michael A Dalb?ge Louise S Hansen Gitte Grove Kevin L Pyke Charles Raun Kirsten Sch?ffer Lauge Tang-Christensen Mads Verma Saurabh Witgen Brent M Vrang Niels Knudsen | 2014 | Journal of Clinical Investigation2014，，10： | 1 |
| 15 | Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell injury显示文摘AIM:To study the effect of circulating cell-free oxy-hemoglobin(FHb) on intestinal microcirculation and intestinal epithelial injury in a rat model. METHODS:To induce elevated intravascular circulating FHb,male Sprague-Dawley rats received water or FHb infusion.Microcirculatory changes in jejunum,ileum and colon were evaluated using fluorescent microspheres.Intestinal injury was quantified as plasmatic release of ileal lipid binding protein(iLBP) and verified by histological analysis of the ileum. RESULTS:Water and FHb infusions resulted,when compared with saline infusion,in reduced intestinal microcirculation(after 30 min P<0.05,or better;after 60 min FHb infusion P<0.05 for jejunum and colon) .Circulating FHb levels correlated significantly with release of iLBP(Spearman r=0.72,P=0.0011) .Epithelial cell injury of the villi was histologically observed after water and FHb infusions. CONCLUSION:This study shows that circulating FHb leads to a reduction in intestinal microcirculatory blood flow with marked injury to intestinal epithelial cells. These data support the hypothesis that circulating FHb contributes to the development of intestinal injury. | Sebastiaan J Hanssen Tim Lubbers Caroline M Hodin Frits W Prinzen Wim A Buurman Michael J Jacobs | 2011 | World Journal of Gastroenterology2011，17，2： | 0 |
| 16 | 奥拉帕利维持治疗BRCA 1/2突变铂敏感复发性卵巢癌患者(SOLO2/ENGOT-Ov21):一项双盲随机对照Ⅲ期试验的最终分析显示文摘背景既往发表的SOLO2/ENGOT-Ov21试验的第一部分研究结果表明,作为BRCA1或BRCA2(BRCA1/2)突变铂敏感型的高级别浆液性或子宫内膜样卵巢癌复发患者使用奥拉帕利可延长无进展生存期。因此,本研究的最终分析目的是研究奥拉帕利对这类患者总生存期的影响。方法本研究是一项在16个国家123个医疗中心进行的双盲、随机、安慰剂对照、Ⅲ期临床试验。纳入标准包括:年龄≥18岁;ECOG体能状态评分基线水平为0~1分;组织学检查确诊为复发性、高级别浆液性或高级别子宫内膜样卵巢癌,包括原发性腹膜癌或输卵管癌;以及既往接受过2种或2种以上铂类药物的治疗方案。入选患者按2∶1分配到奥拉帕利组(150 mg片剂,每日2次口服,共300 mg)或安慰剂组;根据既往化疗后是否缓解以及无铂治疗间隔时长进行分层;受试者、治疗提供者和数据分析人员在治疗分配时均设盲。主要终点是既往已报道过的无进展生存期;总生存期作为重要的次要终点之一,在所有随机分配的患者中进行分析;安全性评估在至少接受过1次给药的所有患者中进行。结果2013年9月3日—2014年11月21日,共295例患者参与了试验并被随机分到奥拉帕利组(196例,66%)或安慰剂组(99例,34%)治疗。奥拉帕利组患者中位随访时间为65.7个月(IQR:63.6~69.3),安慰剂组为64.5个月(IQR:63.4~68.7)。奥拉帕利组中位总生存期为51.7个月(95%CI:41.5~59.1),安慰剂组为38.8个月(95%CI:31.4~48.6)(HR=0.74,95%CI:0.54~1.00,P=0.054)。安慰剂组38%接受PARP抑制剂治疗的患者未作调整。治疗引发的最常见的Ⅲ级以上不良事件为贫血,奥拉帕利组发生率为21%(41/195),安慰剂组为2%(2/99)。 | Andrés Poveda Anne Floquet Jonathan A Ledermann Rebecca Asher Richard T Penson Amit M Oza Jacob Korach Tomasz Huzarski Sandro Pignata Michael Friedlander Alessandra Baldoni Tjoung-Won Park-Simon Kenji Tamura Gabe S Sonke Alla Lisyanskaya Jae-Hoon Kim Elias Abdo Filho Tsveta Milenkova Elizabeth S Lowe Phil Rowe Ignace Vergote Eric Pujade-Lauraine the SOLO/ENGOT-Ovinvestigators 王娟(校) 李征(校) | 2021 | 肿瘤药学2021，11，3： | 0 |
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