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您的检索式：作者名="Michael Nimmo"
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| 1 | Intestinal lymphangiectasia in adults显示文摘Intestinal lymphangiectasia in the adult may be characterized as a disorder with dilated intestinal lacteals causing loss of lymph into the lumen of the small intestine and resultant hypoproteinemia, hypogamma-globulinemia, hypoalbuminemia and reduced number of circulating lymphocytes or lymphopenia. Most often, intestinal lymphangiectasia has been recorded in children, often in neonates, usually with other congenital abnormalities but initial def inition in adults including the elderly has become increasingly more common. Shared clinical features with the pediatric population such as bilateral lower limb edema, sometimes with lymphedema, pleural effusion and chylous ascites may occur but these reflect the severe end of the clinical spectrum. In some, diarrhea occurs with steatorrhea along with increased fecal loss of protein, reflected in increased fe- cal alpha-1-antitrypsin levels, while others may present with iron def iciency anemia, sometimes associated with occult small intestinal bleeding. Most lymphangiectasia in adults detected in recent years, however, appears to have few or no clinical features of malabsorption. Diagnosis remains dependent on endoscopic changes confirmed by small bowel biopsy showing histological evidence of intestinal lymphangiectasia. In some, video capsule endoscopy and enteroscopy have revealed moreextensive changes along the length of the small intes- tine. A critical diagnostic element in adults with lym- phangiectasia is the exclusion of entities (e.g. malignancies including lymphoma) that might lead to obstruction of the lymphatic system and 'secondary' changes in the small bowel biopsy. In addition, occult infectious (e.g. Whipple's disease from Tropheryma whipplei) or in? am- matory disorders (e.g. Crohn's disease) may also present with profound changes in intestinal permeability and protein-losing enteropathy that also require exclusion. Conversely, rare B-cell type lymphomas have also been described even decades following initial diagnosis of intestinal lymphangiectasia. Treatment has been historically def ined to include a low fat diet with medium-chain triglyceride supplementation that leads to portal venous rather than lacteal uptake. A number of other pharma- cological measures have been reported or proposed but these are largely anecdotal. Finally, rare reports of localized surgical resection of involved areas of small intestine have been described but follow-up in these cases is often limited. 2011 Baishideng. All rights reserved. | Hugh James Freeman Michael Nimmo | 2011 | World Journal of Gastrointestinal Oncology2011，3，2： | 13 |
| 2 | Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease显示文摘 | Johan Van Limbergen Richard K. Russell Hazel E. Drummond Marian C. Aldhous Nicola K. Round Elaine R. Nimmo Linda Smith Peter M. Gillett Paraic McGrogan Lawrence T. Weaver W. Michael Bisset Gamal Mahdi Ian D. Arnott Jack Satsangi David C. Wilson | 2008 | Gastroenterology2008，，4： | 1 |
| 3 | Detection of novel influenza A(H1N1) virus by real-time RT-PCR显示文摘 | David M. Whiley Seweryn Bialasiewicz Cheryl Bletchly Cassandra E. Faux Bruce Harrower Allan R. Gould Stephen B. Lambert Graeme R. Nimmo Michael D. Nissen Theo P. Sloots | 2009 | Journal of Clinical Virology2009，，3： | 1 |
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