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| 1 | 基于问题链的中学数学有效教学研究——一项课例研究的启示显示文摘以问题解决数学观为依据,提出基于问题链的数学教学理念.课例研究中,新手教师与专家教师整体上体现了该理念,通过问题链为学生提供逐渐深入的数学理解和一定的探索空间.在数学主题联结上分别表现出知识关联与方法关联两种类型,并对整个教学产生影响.问题链教学受到课时的限制较为明显,这需要单元设计等方式加以进一步解决. | 唐恒钧 HAZEL TAN 徐元根 张维忠 | 2018 | 数学教育学报2018，27，3： | 51 |
| 2 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 3 | A Host KH RNA-Binding Protein Is a Susceptibility Factor Targeted by an RXLR Effector to Promote Late Blight Disease显示文摘植物病原体交付改变主人过程创造对殖民导致的环境的受动器蛋白质。注意集中了于识别受动器的目标并且他们的操作怎么便于疾病。从土豆老家病原体 Phytophthora infestans 的 RXLR 受动器 Pi04089 在主人原子核积累并且当短暂地在 planta 表示了时,提高殖民。它的原子本地化为提高的 P.infestans 殖民被要求。Pi04089 与通常认为的土豆 K 相同(KH ) 在酵母并且在 planta 交往 RNA 有约束力的蛋白质, StKRBP1。Pi04089 和 StKRBP1 的合作本地化,和在他们之间的双分子的荧光互补,显示他们在原子点缀联系。当它与 Pi04089 被共同表示时, StKRBP1 蛋白质层次增加了。确实, StKRBP1 的如此的累积被病原体在叶殖民的第一天也观察。显著地, StKRBP1 的 overexpression 显著地提高 P.infestans 感染。当与受动器共同表示时,到在 StKRBP1 的所有三个 KH 领域的 GDDG 的核苷酸绑定主题 GxxG 的变化与 Pi04089,它到原子点缀的本地化,和它的增加的累积废除它的相互作用。而且,变异的 StKRBP1 蛋白质不再由 P.infestans 提高叶殖民,暗示那核苷酸绑定多半为这项活动被要求。我们因此主张 StKRBP1 能被认为是一个危险性因素,因为它的活动对病原体有益。 | Xiaodan Wang Petra Boevink Hazel McLellan Miles Armstrong Tatyana Bukh-arova Zhiwei Qin Paul R.J. Birch | 2015 | Molecular Plant2015，8，9： | 15 |
| 4 | Cochrane脑卒中组简介显示文摘 | Hazel Fraser Brenda Thomas Peter Sandercock 曾亚莉 | 2005 | 中国循证医学杂志2005，5，2： | 6 |
| 5 | Water softening by induced crystallization in fluidized bed显示文摘Fluidized bed and induced crystallization technology were combined to design a new type of induced crystallization fluidized bed reactor. The added particulate matter served as crystal nucleus to induce crystallization so that the insoluble material, which was in a saturated state, could precipitate on its surface. In this study, by filling the fluidized bed with quartz sand and by adjusting water p H, precipitation of calcium carbonate was induced on the surface of quartz sand, and the removal of water hardness was achieved.With a reactor influent flow of 60 L/hr, a fixed-bed height of 0.5 m, pH value of 9.5, quartz sand nuclear diameter of 0.2–0.4 mm, and a reflux ratio of 60%, the effluent concentration of calcium hardness was reduced to 60 mg/L and 86.6% removal efficiency was achieved. The resulting effluent reached the quality standard set for circulating cooling water. Majority of the material on the surface of quartz sand was calculated to be calcium carbonate based on energy spectrum analysis and moisture content was around 15.994%. With the low moisture content, dewatering treatment is no longer required and this results to cost savings on total water treatment process. | Yuefang Che Rong Fan Danfeng An Yujie Cheng Hazel Tan | 2016 | Journal of Environmental Sciences2016，28，12： | 6 |
| 6 | Connecting scales: Achieving in-field pest control from areawide and landscape ecology studies显示文摘Areawide 管理有完成然而,在那里指向害虫的答案的长历史是节肢动物天赋敌人的 areawide 管理的小焦点。显示出在生来的敌人丰富和产地差异之间的一种积极关系的风景生态学研究表明风景依赖者害虫抑制,但是还没有清楚地连接了他们的调查结果到害虫管理或到与要求控制的庄稼联系的害虫的套房。相反焦点经常在单个害虫种类和他们的生来的敌人的模型系统上。我们建议从生来的敌人捕获害虫控制的管理行动可能向前正在来如果:(i) 害虫建筑群和特定的管理行动上的反应和预言者变量焦点的套房;(ii )“the landscape” 的贡献被估计预定和生来的敌人移民并且移民到并且从目标庄稼,以及害虫的数字识别;并且(iii ) 与庄稼发展阶段排列的害虫控制阀值是基准在害虫上测量生来的敌人的影响,接着允许在学习区域之间的比较,和归纳。为了完成害虫控制,我们将需要合并什么从模型害虫和生来的敌人系统的生态的理解被学习了并且与内场害虫管理集成 areawide 风景管理。 | Nancy A. Schellhorn Hazel R. Parry Sarina Macfadyen Yongmo Wang Myron P. Zalucki | 2015 | Insect Science2015，22，1： | 6 |
| 7 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 8 | Effects of mindfulness-based intervention programs on sleep among people with common mental disorders:A systematic review and meta-analysis显示文摘BACKGROUND Sleep problems are particularly prevalent in people with depression or anxiety disorder.Although mindfulness has been suggested as an important component in alleviating insomnia,no comprehensive review and meta-analysis has been conducted to evaluate the effects of different mindfulness-based intervention(MBI)programs on sleep among people with depression or anxiety disorder.AIM To compare the effects of different MBI programs on sleep among people with depression or anxiety disorder.METHODS Related publications in Embase,Medline,PubMed and PsycINFO databases were systematically searched from January 2010 to June 2020 for randomised controlled trials.Data were synthesized using a random-effects or a fixed-effects model to analyse the effects of various MBI programs on sleep problems among people with depression or anxiety disorder.The fixed-effects model was used when heterogeneity was negligible,and the random-effects model was used when heterogeneity was significant to calculate the standardised mean differences(SMDs)and 95%confidence intervals(CIs).RESULTS We identified 397 articles,of which 10 randomised controlled trials,involving a total of 541 participants,were included in the meta-analysis.Studies of internet mindfulness meditation intervention(IMMI),mindfulness meditation(MM),mindfulness-based cognitive therapy(MBCT),mindfulness-based stress reduction(MBSR)and mindfulness-based touch therapy(MBTT)met the inclusion criteria.The greatest effect sizes are reported in favour of MBTT,with SMDs of-1.138(95%CI:-1.937 to-0.340;P=0.005),followed by-1.003(95%CI:-1.645 to-0.360;P=0.002)for MBCT.SMDs of-0.618(95%CI:-0.980 to-0.257;P=0.001)and-0.551(95%CI:-0.842 to-0.260;P<0.0001)were reported for IMMI and MBSR in the pooling trials,respectively.Significant effects on sleep problem improvement are shown in all reviewed MBI programs,except MM,for which the effect size was shown to be nonsignificant.CONCLUSION All MBI programs(MBTT,MBCT,IMMI and MBSR),except MM,are effective options to improve sleep problems among people with depression or anxiety disorder. | Sunny Ho-Wan Chan Danielle Lui Hazel Chan Kelly Sum Ava Cheung Hayley Yip Chong Ho Yu | 2022 | World Journal of Psychiatry2022，12，4： | 5 |
| 9 | Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?显示文摘AIM To study the relationship between overhydration(OH) in peritoneal dialysis(PD) patients and cardiac mortality.METHODS OH, as measured by body composition monitor(BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T(cT n T) levels. Finally, we wished to determine if improving OH values would lead to a decrement in cT n T. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCM and cT nT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH(> +2L).The Fresenius Body Composition Monitor was used to obtain hydration parameters. cT nT levels were done as part of routine clinical care. Data was analysed using SPSS version 20.0.RESULTS There were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage(10.3 mo vs 37.0 mo, P < 0.0001) and were significantly more overhydrated by BCM measurement(2.95 L vs 1.35 L, P < 0.05). The mean(standard error of the means) hydration status of the 336 patients was +1.15(0.12) L and the median [interquartile range(IQR)] cT nT level was 43.5(20-90) ng/L. The cT nT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log(cT nT) with the OH value(Spearman r value 0.425, P < 0.0001). We identified a sub-group of patients that were severely overhydrated; median(IQR) hydration at baseline was +2.7(2.3 to 3.7) L. They were followed up for a minimum of 6 mo. Reduction in OH values in these patients over 6 mo correlated with lowering of cT nT levels(Spearman r value 0.29, P < 0.02). CONCLUSION Patients that were overhydrated had higher cT nT, and had deaths that were more likely to be cardiac related. Reduction in OH correlated with lowering of cT nT. | Elizabeth Oei Klara Paudel Annemarie Visser Hazel Finney Stanley L Fan | 2016 | World Journal of Nephrology2016，5，5： | 4 |
| 10 | Chronic pancreatitis:A diagnostic dilemma显示文摘Typical clinical symptoms of chronic pancreatitis are vague and non-specific and therefore diagnostic tests are required, none of which provide absolute diagnostic certainly, especially in the early stages of disease. Recently-published guidelines bring much needed structure to the diagnostic work-up of patients with suspected chronic pancreatitis. In addition, novel diagnostic modalities bring promise for the future. The assessment and diagnosis of pancreatic exocrine insufficiency remains challenging and this review contests the accepted perspective that steatorrhea only occurs with > 90% destruction of the gland. | Sinead N Duggan Hazel M NíChonchubhair Oladapo Lawal Donal B O’Connor Kevin C Conlon | 2016 | World Journal of Gastroenterology2016，22，7： | 4 |
| 11 | Seasonal Forecasts of the Summer 2016 Yangtze River Basin Rainfall显示文摘The Yangtze River has been subject to heavy flooding throughout history,and in recent times severe floods such as those in 1998 have resulted in heavy loss of life and livelihoods.Dams along the river help to manage flood waters,and are important sources of electricity for the region.Being able to forecast high-impact events at long lead times therefore has enormous potential benefit.Recent improvements in seasonal forecasting mean that dynamical climate models can start to be used directly for operational services.The teleconnection from El Ni ?no to Yangtze River basin rainfall meant that the strong El Ni ?no in winter 2015/16 provided a valuable opportunity to test the application of a dynamical forecast system.This paper therefore presents a case study of a real-time seasonal forecast for the Yangtze River basin,building on previous work demonstrating the retrospective skill of such a forecast.A simple forecasting methodology is presented,in which the forecast probabilities are derived from the historical relationship between hindcast and observations.Its performance for2016 is discussed.The heavy rainfall in the May–June–July period was correctly forecast well in advance.August saw anomalously low rainfall,and the forecasts for the June–July–August period correctly showed closer to average levels.The forecasts contributed to the confidence of decision-makers across the Yangtze River basin.Trials of climate services such as this help to promote appropriate use of seasonal forecasts,and highlight areas for future improvements. | Philip E. BETT Adam A. SCAIFE Chaofan LI Chris HEWITT Nicola GOLDING Peiqun ZHANG Nick DUNSTONE Doug M. SMITH Hazel E. THORNTON Riyu LU Hong-Li REN | 2018 | Advances in Atmospheric Sciences2018，35，8： | 3 |
| 12 | STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation显示文摘 | Hazel Tye Catherine L. Kennedy Meri Najdovska Louise McLeod William McCormack Norman Hughes Anouk Dev William Sievert Chia Huey Ooi Tomo-o Ishikawa Hiroko Oshima Prithi S. Bhathal Andrew E. Parker Masanobu Oshima Patrick Tan Brendan J. Jenkins | 2012 | Cancer Cell2012，，4： | 3 |
| 13 | All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors显示文摘The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant pathogen.Here,we review intracellular effectors from filamentous(fungal and oomycete)phytopathogens and the host proteins and processes that are targeted to promote disease.We cover contrasting virulence strategies and effector modes of action.Filamentous pathogen effectors alter the fates of host proteins that they target,changing their stability,their activity,their location,and the protein partners with which they interact.Some effectors inhibit target activity,whereas others enhance or utilize it,and some target multiple host proteins.We discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support susceptibility.We also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens,including those representing different kingdoms of life. | Qin He Hazel McLellan Petra C.Boevink Paul R.J.Birch | 2020 | Plant Communications2020，1，4： | 3 |
| 14 | 新西兰无过失伤害的预防、康复和赔偿体制介绍显示文摘新西兰意外赔偿局(ACC),是管理新西兰意外事件赔偿的政府机构。ACC计划是对在新西兰境内的公民、居民或临时来访的人提供受伤赔偿的服务。每年在复原、治疗和酬劳补偿等方面要花费十几亿元,为了保证这些服务,ACC从劳动者的薪金、燃油税、政府赞助和投资收入等方面来支付赔偿金,不同行业的工伤赔偿申请比率也不同。另外,ACC建立了培训基金,代替雇主负责对员工的安全与健康培训。虽然这一体制正面临一些私有化和费用不断增加的挑战和困难,但总体来说,ACC体制是适合新西兰的一个优良的方案,比其他国家的体制在管理效率和雇主利益等方面明显显示出优势。 | Hazel Armstrong | 2007 | 中国安全生产科学技术2007，3，1： | 3 |
| 15 | Oomycetes Seek Help from the Plant:Phytophthora infestans Effectors Target Host Susceptibility Factors显示文摘 | Petra C. Boevink Hazel McLellan Eleanor M. Gilroy Shaista Naqvi Qin He Lina Yang Xiaodan Wang Dionne Turnbull Miles R. Armstrong Zhendong Tian Paul R.J. Birch | 2016 | Molecular Plant2016，9，5： | 2 |
| 16 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 17 | Genome‐wide methylation profiling in Crohn’s disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway显示文摘 | Elaine R.Nimmo James G.Prendergast Marian C.Aldhous Nicholas A.Kennedy PaulHenderson Hazel E.Drummond Bernard H.Ramsahoye David C.Wilson Colin A.Semple JackSatsangi | 2012 | Inflamm Bowel Dis2012，，： | 2 |
| 18 | ^(14)C-尿素呼吸试验检测胃幽门弯曲菌显示文摘本文建立改良^(14)C-尿素呼吸试验。试验以5μCi^(14)C-尿素与50mg非标记尿素加入高浓度奶粉溶液中同服。呼气分别在0、7、15、30、45、60、90分钟直接收集于1mmol氢氧化海胺中。呼出的^(14)C量直接以dpm/mmolCO_2表示。实验显示,在试餐后7至90分钟内,确诊为幽门弯曲菌阴性18例其dpm值均在200以下,而阳性17例则均在200以上;两者比较,在试餐后测定之任何时相,差异均有高度显著性(P<0.05)。^(14)C呼出高峰期在试餐后30分钟,因此可以第30分钟呼气的dpm值大于200作为判断^(14)-尿素呼吸试验之阳性标准。本文进而对46例呼吸试验结果与胃窦及胃体活检标本的培养及组织学检查结果进行比较,计算出呼吸试验的敏感性为100%、特异性为95.5%,阳性预测值为96.0%,阴性预测值为100%。 该试验具有简易、可行、准确的优点,适于作为胃幽门弯曲菌感染流行病学调查之用。 | 胡品津 李瑜元 杜国光 陈旻湖 Stuart Hazell 章天予 | 1990 | 中山医科大学学报1990，11，3： | 2 |
| 19 | Randomised phase 2 trial of SIR‐Spheres? plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer显示文摘 | GuyVan Hazel AnthonyBlackwell JamesAnderson DavidPrice PaulMoroz GeoffBower GiuseppeCardaci BruceGray | 2004 | J. Surg. Oncol2004，，2： | 2 |
| 20 | Randomised trial of SIR-Spheres? plus chemotherapy vs.chemotherapy alone for treating patients with liver metastases fromprimary large bowel cancer显示文摘 | B. Gray G. Van Hazel M. Hope M. Burton P. Moroz J. Anderson V. Gebski | 2001 | Annals of Oncology2001，，12： | 2 |
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