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| 1 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 4 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 5 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 6 | A contactless biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representation2012，23，7： | 1 |
| 7 | Comment on ' Green Space, health inequality, and pregnancy'显示文摘 | Donovan G H Michael Y L Butry D T | 2012 | Environ Int2012，39，1： | 1 |
| 8 | Acute cholangitis and pancreatitis secondary to common duct stones: management update显示文摘 | MICHAEL G T RARATY M B MARGARET F | 1998 | World J Surg1998，22，： | 1 |
| 9 | Determination of moxifloxacin in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry 显示文摘 | Veshwanathan Karthik Bartlett Michael G Stewart James T | 2002 | J Pham Biomed Anal2002，30，4： | 1 |
| 10 | Evaluation of the marine traffic congestion of north harbor in Busan port显示文摘 | YEO G T MICHAEL R SOAK S M | 2007 | J Waterway Port Coastal & Ocean Eng2007，133，2： | 1 |
| 11 | A contactless biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representation2012，23，7： | 1 |
| 12 | Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope gly- coprotein E显示文摘 | MICHAEL K KLUPP B G METTENLEITER T C | 2006 | J Virol2006，80，3： | 1 |
| 13 | Synthesis and ring-opening polymerization of new monoalkylsubstituted lactides 显示文摘 | THOMAS T MICHAEL M ROBERT G | 2004 | J Poly Sci Part A: Poly Chem2004，42，17： | 1 |
| 14 | Protein control of porphyrin conformation,comparison of resonance raman spectra of heme proteins with mesoporphyrin Ⅸ analogs显示文摘 | SPIRO T G MICHAEL B J | | 0，，18： | 1 |
| 15 | A novel,semi-dominant allele of MONOPTEROS provides in- sight into leaf initiation and vein pattern formation显示文摘 | JASMINE J T G MIRANDA J M MICHAEL T B | 2012 | Plan- ta2012，236，1： | 1 |
| 16 | Application of power unltrasound forazo dye degradation显示文摘 | ASTRID R MICHAEL T GEORG G | 2004 | Ultrasonics Sonochemistry2004，11，34： | 1 |
| 17 | Touch-less palm print biometrics: Novel design and implementation 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2008 | Image and Vision Computing2008，26，12： | 1 |
| 18 | An automated palmprint recognition system显示文摘 | Tee C Andrew T B J Michael G K O | 2005 | Image and vision computing2005，23，5： | 1 |
| 19 | Composition of pseudorabies virus particles lacking tegu- ment protein US3, UL47, or UL49 or envelope glycoprotein E 显示文摘 | Michael K Klupp B G Mettenleiter T C | 2006 | J Virol2006，80，3： | 1 |
| 20 | Contour Interpolation by Straight Skeletons显示文摘 | Barequet G Michael T G Aya Levi-Steiner | 2004 | Graphical Models2004，4，66： | 1 |
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