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| 1 | Intratidal and neap-spring variations of suspended sediment concentrations and sediment transport processes in the North Branch of the Changjiang Estuary显示文摘Profiles of tidal current and suspended sediment concentration(SSC) were measured in the North Branch of the Changjiang Estuary from neap tide to spring tide in April 2010. The measurement data were analyzed to determine the characteristics of intratidal and neap-spring variations of SSC and suspended sediment transport. Modulated by tidal range and current speed, the tidal mean SSC increased from 0.5 kg/m3 in neap tide to 3.5 kg/m3 in spring tide. The intratidal variation of the depth-mean SSC can be summarized into three types: V-shape variation in neap tide, M-shape and mixed M-V shape variation in medium and spring tides. The occurrence of these variation types is controlled by the relative intensity and interaction of resuspension, settling and impact of water exchange from the rise and fall of tide. In neap tide the V-shape variation is mainly due to the dominant effect of the water exchange from the rise and fall of tide. During medium and spring tides, resuspension and settling processes become dominant. The interactions of these processes, together with the sustained high ebb current and shorter duration of low-tide slack, are responsible for the M-shape and M-V shape SSC variation. Weakly consolidated mud and high current speed cause significant resuspension and remarkable flood and ebb SSC peaks. Settling occurs at the slack water periods to cause SSC troughs and formation of a thin fluff layer on the bed. Fluxes of water and suspended sediment averaged over the neap-spring cycle are all seawards, but the magnitude and direction of tidal net sediment flux is highly variable. | LI Zhanhai LI Michael Z DAI Zhijun ZHAO Fangfang LI Jiufa | 2015 | Acta Oceanologica Sinica2015，34，1： | 9 |
| 2 | Molecularly Imprinted Polymeric Nanospheres by Diblock Copolymer Self-Assembly显示文摘 | Li Z Ding J F Michael D | 2006 | Macromolecules2006，，39： | 1 |
| 3 | Risk-sensitive dynamic pricing for a single perishable product 显示文摘 | Li Michael Z F Zhuang W F | 2009 | Operations Research Letters2009，37，5： | 1 |
| 4 | Boundary layer dynamics and drag reduction in flows of high cohesive sediment suspensions显示文摘 | Li Michael Z Gust G | 2000 | Sedimentology2000，47，： | 1 |
| 5 | Multibeam bathymetric in vestigations of the morphology of sand ridges and associated hedforms and their relation to storm process, Sable Island Bank, Scotian Shelf 显示文摘 | Michael Z Li Edward L King | 2007 | Marine Geology2007，243，14： | 1 |
| 6 | Pricing non-storable perishable goods by using a purchase restriction: general optimality results显示文摘 | Michael Z Li F | 2005 | European Journal of Operational Research2005，161，： | 1 |
| 7 | The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q Y DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L JONES M R SKELTON R L MURRAY J E CHEN C X QIAN W B SHEN J G DU P EUSTICE M TONG E TANG H B LYONS E PAULL R E MICHAEL T P WALL K RICE D W AL- BERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N A- COB R A GUAN P Z BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J K SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X Y BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRI- PATHI S NEUPANE K WEI H R IRIKURA B PAIDI M JIANG N ZHANG W L PRESTING G WINDSOR A NAVAJAS-P?REZ R TORRES M J FELTUS F A PORTER B LI Y J BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J M SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E DEPAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，7190： | 1 |
| 8 | Boundary layer dynamics and drag reduction in flows of high cohesive sediment suspensions显示文摘 | Michael Z Li Gust G | 2000 | Sedimentology2000，47，： | 1 |
| 9 | Review: The role of microRNAs in kidney disease显示文摘 | Li J Y Yong T Y Michael M Z | 2010 | Nephrology2010，15，6： | 1 |
| 10 | Cultivable bacterial diversity and amylase production in three typical Daqus of Chinese spirits 显示文摘 | Li ZM Bai ZH Wang DL Zhang WJ Michael Z Francis L Gao LP Hui BD Zhang HX | 2014 | Int J Food SciTechnol2014，49，： | 1 |
| 11 | A Generic Characterization of Equilibrium Speed-flow Curves显示文摘 | Michael Z F Li Nanyang | 2008 | Journal of Transportation Science2008，42，2： | 1 |
| 12 | Heinrich event imprints in the Okinawa Trough:evidence from oxygen isotope and planktonic foraminifera显示文摘 | Li T G Liu Z X Michael A H Berne S Saito Y Cheng S X | 2001 | Palaeogeography Palaeoclimatology Palaeoecology2001，176，1： | 1 |
| 13 | AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development显示文摘 | Sellitto Caterina Li Leping Gao Junyuan Robinson Michael L Lin Richard Z Mathias Richard T White Thomas W | 2013 | Journal of Clinical Investigation2013，，12： | 1 |
| 14 | Influence of varying degrees of malnutrition on IGF-1 expression in the rat diaphragm显示文摘 | Michael I Lewis Li H Y Huang Z S | 2003 | J Appli Physiol2003，95，： | 1 |
| 15 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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