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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Design and test of the VLT M1 mirror passive and active supporting system显示文摘 | HOVSEPIAN T MICHELIN J M STANGHELLINI S | | 0，，3352： | 1 |
| 3 | Distribution ofcanthaxanthin andlycopene in rats and monkeys显示文摘 | Micheline M M Sudha W Prabahat K S | 1990 | J Nutr1990，120，： | 1 |
| 4 | 2-Amino-2-oxazoline and trialkylisourea Pt(ll) complexes derived from organocyanamides 显示文摘 | FERREIRA C M P SILVA DA M F C G MICHELIN R A | 2003 | Dalton Trans2003，，19： | 1 |
| 5 | Industrial Application of an H-Infinity Design Method for Flexible Structures显示文摘 | COUSTAL P MICHELIN J M | 1994 | IEEE Control System1994，14，4： | 1 |
| 6 | Local cytokine profiles of patients with cervical intraepithelial and invasive neoplasia显示文摘 | Bethanea Crema Peghini Douglas Reis Abdalla Ana Cristina Macedo Barcelos Lívia das Gra?as Vieito Lombardi Teodoro Eddie Fernando Candido Murta Márcia Antoniazi Michelin | 2012 | Human Immunology2012，，9： | 1 |
| 7 | Cloning,sequencing and expression of human TSH receptor显示文摘 | Micheline M Hugues L Michel A | 1990 | Biochem Biophys Res Commun1990，166，1： | 1 |
| 8 | Purification and biochemical characterization of a thermostable extracellular glucoamylase produced by the thermotolerant fungus Paecilomyces variotii显示文摘 | MICHELIN M RULLER R WARD R J | 2008 | J Ind Microbiol Biotechnol2008，35，1： | 1 |
| 9 | Synergism between flame retardant and modified layered silicate on thermal stability and fire behaviour of polyurethane nanocomposite foams 显示文摘 | Modesti M Lorenzetti A Besco S Hrelja D Semenzato S Bertani R Michelin R A | 2008 | Polym Degrad Stab2008，93，： | 1 |
| 10 | Purification and Biochemical Characterization of a Thermostable Extracellular Glucoamylase Produced by the Thermotolerant Fungus Paecilomyces Variotii 显示文摘 | Michelin M Ruller R Ward R J | 2008 | Ind Mierobiol Biotechnol2008，35，： | 1 |
| 11 | High-grade cervical intraepithelial neoplasia,human papillomavirus and factors connected with recurrence following surgical treatment显示文摘 | RAMOS M C PIZARRO DE LORENZOB H MICHELIN M A | 2008 | Clin Exp Obstet Gynecol2008，35，4： | 1 |
| 12 | Physicochemical equilibria of cement-based mate- rials in aggressive environments-experiment and modeling显示文摘 | MICHELINE M SIHAM K EMMANUEL G | 2004 | Cement Concrete Research2004，34，9： | 1 |
| 13 | Purification and bio-chemical characterization ofa thermostable extracellular glucoamy- lase produced by the thermotolerant fungus Paecilomyces variotii显示文摘 | MICHELIN M RULLER R WARD R J | 2008 | J Ind Mierobiol Blot2008，，1： | 1 |
| 14 | Kinetics of ultrasound-assisted enzymatic biodiesel production from Macaubacoconut oil显示文摘 | MICHELIN S PENHA F M SYCHOSKI M M | 2015 | Renewable Energy2015，，76： | 1 |
| 15 | The effects of GSTMI and GSTTI polymorphisms on micronucleus frequencies in hu- man lymphocytes in vivo 显示文摘 | Micheline K V Raluca A M Franqoise M R | 2006 | Cancer Epidemiol Biomarkers Prey2006，15，5： | 1 |
| 16 | Influence and optimization of the electrodes position in a piezoelectric energy harvesting flag显示文摘 | PIEIRUA M DOARO MICHELIN S | 2015 | Journal of Sound and Vibration2015，346，： | 1 |
| 17 | The rhoptry neck protein RON4 re-localizes at the moving junction during Toxoplasma gondii invasion显示文摘 | Lebrun M Michelin A El Hajj H | 2005 | Cell Microbiol2005，7，12： | 1 |
| 18 | Increased activity and involvement of caspase-3 in radiation-induced apoptosis in neural cells precursors from developing rat brain显示文摘 | Michelin S del Rosario Perez M Dubner D et a1 | 2004 | Neurotoxicology2004，25，3： | 1 |
| 19 | Use of adherence monitors as part of a team approach to control clonal spread of multidrug-resistant Acinetobacter baumannii in a research hospital显示文摘 | Palmore T N Michelin A V Bordner M Odom R T Stock F Sinaii N | 2011 | Infect Control Hosp Epidemiol2011，32，： | 1 |
| 20 | Immunotherapy with dendriticcells as a cancer treatment: perspectives and therapeutic poten-tial显示文摘 | Aleixo A A Michelin M A Murta E F | 2013 | Recent Pat Endocr Metab Immune Drug Discov2013，7，3： | 1 |
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