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| 1 | Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis显示文摘AIM: To investigate the clinicopathological factors underlying the ethnic differences of Helicobacter pylori gastritis and cancer.METHODS: We analyzed clinicopathological parameters of gastric biopsies having H pylori infection that were randomly selected from different ethnic populations including 147 Americans, 149 Japanese, and 181 Koreans.RESULTS: Males were predominant in Japanese and Korean populations (77.9 and 67.4% respectively) in comparison with Americans (48.3%) (P<0.001). H pylori gastritis in Koreans and Japanese was characterized by the predominant antral involvement. In the antrum,neutrophilic infiltration into the proliferative zone of pit, i,e.acute foveolitis, was more frequent in Koreans (82%) than in Japanese (71%) (P<0.05) and Americans (61%) (P<0.001).Interstitial neutrophilic infiltration, intestinal metaplasia and atrophy were also frequent in Koreans and Japanese. In the body, the prevalence of acute foveolitis was not significantly different among the populations while chronic interstitial inflammation and lymphoid follicles were more pronounced in the body of Americans than in the body of others (P<0.01).CONCLUSION: The male-, and antrum-predominant Hpylori gastritis in Koreans and Japanese is compatible with the pattern of sex and topographical distribution of gastric cancer incidence. Our data suggest that persistent acute foveolitis at the proliferative zone is a crucial step in the gastric carcinogenesis. | Inchul Lee Hojung Lee Mijung Kim Manabu Fukumoto Shinji Sawada Shriram Jakate Victor E.Gould | 2005 | World Journal of Gastroenterology2005，11，1： | 5 |
| 2 | Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients显示文摘Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases.Overexpressed miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still unclear.Methods:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or miRNAs.We identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT cells.Results:SOD1 mutations decreased the level of miR-18b-5p.Induced Hif1a which is the target for miR-18b increased Mef2c expression as a transcription factor.Mef2c upregulated miR-206 as a transcription factor.Inhibition of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,respectively.The miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)patient.Conclusions:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 mutation.These results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS. | Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-Young Shin Jin Young Kim Yoon Ho Hong Manho Kim Jong-ll Kim Jung-Joon Sung | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 3 | XML-Based Network Management for IP Networks 显示文摘 | CHOI Mijung JAMES W H JU H T | 2003 | ETRI Journal2003，25，6： | 1 |
| 4 | XML-Based Configuration Management for IP Network Devices显示文摘 | CHOI Mijung CHOI Hyounmi JAMES W H | 2004 | IEEE Communications Magazine2004，42，7： | 1 |
| 5 | A Study on the Determination of Adulteration of Sesame Oil by Near Infrared Spectroscopy 显示文摘 | Mijung Noh Jin-Il Jeong Seung-Sik Min | 2004 | Korean journal of food science and technology2004，36，4： | 1 |
| 6 | Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear显示文摘 | Mijung Yeom Sung-Hun Kim Bombi Lee Jeong-Jun Han Guk Hoon Chung Hee-Don Choi Hyejung Lee Dae-Hyun Hahm | 2012 | Journal of Dermatological Science2012，，2： | 1 |
| 7 | Comparison of sonog- raphy with sonographically guided fine-needle aspiration biopsy and core-needle biopsy for initial axillary stsag- ing of breast cancer显示文摘 | Hye SA Sun MK Mijung J | 2013 | J Ultra Med2013，32，12： | 1 |
| 8 | Water adsorption and storage characteristics of optimized LiCoO2 and LiNi1/3Co1/3Mn1/3O2 composite cathode material for Li-ion cells 显示文摘 | MIJUNG N LEE Y CHO J | 2006 | J Electrochem Soc2006，153，5： | 1 |
| 9 | Low pH increases the yield of exosome isolation显示文摘 | Jae-Jun Ban Mijung Lee Wooseok Im Manho Kim | 2015 | Biochemical and Biophysical Research Communicatio2015，，： | 1 |
| 10 | A Study on the determination of adulteration of sesame oil by near infrared spectroscopy显示文摘 | MIJUNG N JIN-II J SEUNG-SIK M | 2004 | Korean Journal of Food Science and Technology2004，36，4： | 1 |
| 11 | Synthesis of Hydrophobic Ionic Liquids for Electrochemical Applications 显示文摘 | Mijung N Lee Y Cho J | 2006 | J Electrochem Soc2006，153，： | 1 |
| 12 | Critical size of a nano SnO2 electrode for Li-secondary battery 显示文摘 | Kim Chunjoong Noh Mijung Choi Myungsuk | 2005 | Chem Mater2005，17，： | 1 |
| 13 | Depression among older adults with diabetes mellitus显示文摘 | Mijung Park Charles F Reynold S | 2015 | Clinics in Geriatric Medicine2015，31，1： | 1 |
| 14 | Hydrogen and methane production from untreated rice straw and raw sewage sludge under thermophilic anaerobic conditions显示文摘 | Mijung Kim Chunguang Liu Jin-Won Noh Yingnan Yang Sechang Oh Kazuya Shimizu Dong-Yeol Lee Zhenya Zhang | 2013 | International Journal of Hydrogen Energy2013，，： | 1 |
| 15 | Hydrogen production by anaerobic co-digestion of rice straw and sewage sludge显示文摘 | Mijung Kim Yingnan Yang | 2012 | International journal of hydrogen energy2012，37，： | 1 |
| 16 | Oxygen permeability of soft contact lenses in different pH, osmolality and buffering solution显示文摘AIM: To determine the effect of p H, osmolality, and buffering system on the oxygen permeability(Dk) of soft contact lenses.·METHODS: Two hydrogel lenses(nelfilcon A and etafilcon A) and 2 silicone hydrogel lenses(lotrafilcon A and balafilcon A) were used in the study. These lenses were incubated in phosphate-buffered saline(PBS) and borate-buffered saline(BBS) solutions adjusted by 0.8p H increments to a p H in the range of 5.8-9.0 or in hypotonic(280 m Osmol/kg), isotonic(310 m Osmol/kg)and hypertonic(380 m Osmol/kg) PBS solutions.Polarographic method was used for measuring the Dk and lenses were stacked as 4 layers to correct the boundary effect.·RESULTS: Dk values of all contact lenses measured in BBS solutions were more stable than those in PBS solutions. Especially the etafilcon A lens showed a relative big change compared with other types of contact lenses at the same conditions. When the osmolality of PBS solution increased from hypotonic to hypertonic, Dk of all contact lenses decreased. Variations in Dk existed depending on lens materials, etafilcon A lens was the most affected and nelfilcon A was the least affected by osmolality.·CONCLUSION: From the result obtained, it is revealed that Dk of contact lenses is changed by the p H,osmolality, and buffering condition of tear. Thus, Dk of contact lens can be varied by the lens wearers' physiological and/or pathological conditions. | Se Eun Lee So Ra Kim Mijung Park | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 0 |
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