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| 1 | Clinical significance of lymphadenectomy in patients with gastric cancer显示文摘Approximately thirty percent of patients with gastric cancer undergo an avoidable lymph node dissection with a higher rate of postoperative complication. Comparing the D1 and D2 dissections,it was found that there is a significant difference in morbidity,favoured D1 dissection without any difference in overall survival. Subgroup analysis of patients with T3 tumor shows a survival difference favoring D2 lymphadenectomy,and there is a better gastric cancer-related death and non-statistically significant improvement of survival for node-positive disease in patients with D2 dissection. However,the extended lymphadenectomy could improve stage-specific survival owing to the stage migration phenomenon. The deployment of centralization and application of national guidelines could improve the surgical outcomes. The Japanese and European guidelines enclose the D2 lymphadenectomy as the gold standard in R0 resection. In the individualized,stageadapted gastric cancer surgery the Maruyama computer program(MCP) can estimate lymph node involvement preoperatively with high accuracy and in addition the Maruyama Index less than 5 has a better impact on survival,than D-level guided surgery. For these reasons,the preoperative application of MCP is recommended routinely,with an aim to perform 'low Maruyama Index surgery'. The sentinel lymph node biopsy(SNB) may decrease the number of redundant lymphadenectomy intraoperatively with a high detection rate(93.7%) and an accuracy of 92%. More accurate stage-adapted surgery could be performed using the MCP and SNB in parallel fashion in gastric cancer. | dezso tóth jános plósz miklós torok | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 8 |
| 2 | Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary显示文摘Objective: The Union for International Cancer Control(UICC) Node(N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes(LNs) to be dissected; therefore different staging systems were invented.Methods: Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio(MLR) and the log odds of positive LNs(LODDS) were determined to measure their 5-year survival rates and to compare them to each other.Results: The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. N0 and N3 vs. N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate(more than or equal to 16) lymphadenectomy was performed.Conclusions: We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy. | dezso tóth adrienn bíró zsolt varga miklós torok péterárkosy | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 3 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 4 | Gain-of-Function Mutations Associated with Hereditary Pancreatitis Enhance Autoactivation of Human Cationic Trypsinogen显示文摘 | Miklós Sahin-Tóth Miklós Tóth | 2000 | Biochemical and Biophysical Research Communications2000，，2： | 2 |
| 5 | Calpain-1-sensitive myofibrillar proteins of the human myocardium显示文摘 | Judit Barta Attila Tóth István édes Miklós Vaszily Julius Gy. Papp András Varró Zoltán Papp | 2005 | Molecular and Cellular Biochemistry (-)2005，，1： | 1 |
| 6 | Stem cell characteristics of amniotie epithelial ceils显示文摘 | Mikl T Lebanann T Cai H | 2005 | Stem Cells2005，23，： | 1 |
| 7 | Brentuximab vedotin (SGN-35) in a 3-year-old child with relapsed systemicanaplastic large cell lymphoma 显示文摘 | Mikles B Levine J Gindin T | 2014 | J Pediatr Hematol Oncol2014，36，2： | 1 |
| 8 | Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning显示文摘 | Mikl T hob T Sunaga D | 2012 | Cardlovasc Diabetol2012，11，： | 1 |
| 9 | Varicella zoster virus myelitis in two elderly patients:Diagnostic value of nested polymerase chain reaction assay and antibody index for cerebrospinal fluid specimens显示文摘 | TAKAHASHI T TAMURA M MIKl K | 2013 | Case Rep Neurol2013，5，1： | 1 |
| 10 | Brentuximab vedotin (SGN- 35) in a 3-ye~-old child with relapsed systemic anaplastic large cell lymphoma显示文摘 | Mikles B Levine J Gindin T | 2014 | J Pediatr Hematol Oncol2014，36，2： | 1 |
| 11 | Trypsinogen Stabilization by Mutation Arg117→His: A Unifying Pathomechanism for Hereditary Pancreatitis?显示文摘 | Miklós Sahin-Tóth László Gráf Miklós Tóth | 1999 | Biochemical and Biophysical Research Communications1999，，2： | 1 |
| 12 | Correlation between the levels of potassium and polyamines in the leaves of grapevine显示文摘 | Mikl ós E Sarjala T | 2002 | Plant Physiology2002，46，34： | 1 |
| 13 | Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility显示文摘 | István Szokodi Pasi Tavi Gábor F?ldes Sari Voutilainen-Myllyl? Mika Ilves Heikki Tokola Sampsa Pikkarainen Jarkko Piuhola Jaana Rys? Miklós Tóth Heikki Ruskoaho | 2002 | Circulation Research: Journal of the American Heart Association2002，，5： | 1 |
| 14 | Correlation between the levels of potassium and polyamines in the leaves of grapevine显示文摘 | Miklós E Sarjala T | 2002 | Plant Physiology2002，46，34： | 1 |
| 15 | Determinants of chymotrypsin C cleavage specificity in the calcium‐binding loop of human cationic trypsinogen显示文摘 | András Szabó Miklós Sahin‐Tóth | 2012 | FEBS J2012，，23： | 1 |
| 16 | Gain-of-Function Mutations Associated with Hereditary Pancreatitis Enhance Autoactivation of Human Cationic Trypsinogen显示文摘 | Miklós Sahin-Tóth Miklós Tóth | 2000 | Biochemical and Biophysical Research Communications2000，，2： | 1 |
| 17 | Enhancement of chalcopyrite leaching by ferrous ions in acidic ferric sulfate solutions 显示文摘 | Hiroyoshi N Mikl it Hirajima T | 2001 | Hydrometallurgy2001，60，3： | 1 |
| 18 | Pheromone variation among eastern European and a western Asian population of the turnip mothAgrotis segetum显示文摘 | Bill S. Hansson Miklós Tóth Christer L?fstedt Gábor Sz?cs Mitko Subchev Jan L?fqvist | 1990 | Journal of Chemical Ecology1990，，5： | 1 |
| 19 | Improving ecosystem services in farmlands:beginning of a long-term ecological study with restored flower-rich grasslands显示文摘Biodiversity declines in an unprecedented way,mostly due to land use change.Restoration interventions proved to be one of the most effective tools to halt the decline,especially in ecosystems such as agricultural fields.Evidence-based,locally adapted recommendations on grassland restoration,however,are often missing,so we present a novel approach for such interventions that can be implemented anywhere and that are based on scientific rigor.In a recently started long-term field ecological study,we established 0.5 ha wildflower parcels,using a diverse local seed mixture of 32 insect-visited plant species in Central European agricultural landscapes in 2020.Our focus is on the landscape-scale effects of this ecological intensification on ecosystem services such as crop yield,pollination and pest control,and the long-term monitoring of the successional processes.The aim is to showcase an effective restoration protocol that could serve as a model for future farm management,and provide much-needed evidence for policy on landscape ecological restoration of international relevance. | András Báldi Raoul Pellaton Áron Domonkos Bihaly Viktor Szigeti Eszter Lellei-Kovács András Máté Miklós Sárospataki Zoltán Soltész LászlóSomay AnikóKovács-Hostyánszki | 2022 | Ecosystem Health and Sustainability2022，8，1： | 0 |
| 20 | Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer显示文摘瞄准:屏蔽一个怀疑的匈牙利 HNPCC 家庭发现特定的变化并且在疾病的演讲上评估他们的效果。方法:家庭被使用阿姆斯特丹和 Bethesda 标准识别。Immunohistochemistry 被执行,并且从肿瘤织物孤立的 DNA 样品为微卫星不稳定性被评估。可能的变化的鉴定被定序 hMLH1 和 hMSH2 基因执行。结果:二个不同变化在索引病人并且在他的家庭成员被观察。第一个变化在 7 上位于前, 422 hMSH2 上的鳕鱼,并且上从 Glu 引起了一个变化到站鳕鱼。没有其它这报导一个变化被出版了,根据我们能在国际数据库发现。第二个变化在 127 hMSH2 基因上在 3 鳕鱼上在前被发现,导致毒蛇 -->Ser 替换。第二个变化已经被出版,作为一个非病原的突变而产生之遗传的变化。结论:家谱分析建议在 7 hMSH2 基因上的前的最新检测的胡说八道变化可能为结肠癌的发展负责。没在 7 变化上的前的家庭成员结合这个错误感觉变化,结肠癌出现在 40 岁以后。这二个变化的协会似乎是疾病的表明的年龄到减少进早三十。 | Miklós Tanyi Judith Olasz Géza Lukács Orsolya Csuka László Tóth Zoltán Szentirmay Zsuzsa Ress Zsolt Barta János L Tanyi László Damjanovich | 2006 | World Journal of Gastroenterology2006，12，8： | 0 |
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