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| 1 | GSH-induced chemotaxis nanomotors for cancer treatment by ferroptosis strategy显示文摘Overexpression of glutathione(GSH) in tumor cells greatly inhibits the therapy effect of traditional ferroptosis inducers;thus,control of the GSH level is an important way to improve the efficacy of ferroptosis.Herein,a kind of nanomotor based on metal organic framework material NH_(2)-MIL-101 is constructed,in which polyethylene glycol(PEG) and glutathione hydrolase γ-glutamyltransferase(GGT) are asymmetrically modified to obtain mPEG@MIL-101@GGT nanomotors(PMG NMs).The nanomotor proposed in this article can be induced by overexpressing GSH in tumors to form chemotactic effects through the specific affinity between enzymes and substrates.Results indicate that the tail structure provided by PEG and the affinity between GGT and GSH can enable the stable chemotaxis behavior of nanomotors in a complex environment,thus enriching and penetrating deeply at the tumor site.In addition,after loading the ferroptosis inducer Erastin,the system shows a highly effective induction effect of tumor ferroptosis.Erastin in the system can effectively inhibit the synthesis of GSH,and PMG NMS can react with GSH through Fe^(3+)and GGT to promote GSH depletion.The produced Fe^(2+)can generate excessive reactive oxygen species through Fenton reaction,which further promotes the death of tumor cells.Meantime,the chemotaxis behavior of the nanomotors based on the endogenous biochemical reaction of GGT-catalyzed GSH hydrolysis can endow nanomotors with the enhanced delivery and penetration ability in tumors,thus collaboratively enhancing the ferroptosis effect.This strategy designed according to the physiological characteristics of tumors has good biosafety and treatment effect,providing new perspectives for micro/nanomotor and tumor treatment. | Zhiyong Liu Ting Li Nan Li Yujing Wang Lin Chen Xueting Tang Mimi Wan Chun Mao | 2022 | Science China Chemistry2022，65，5： | 1 |
| 2 | Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots显示文摘 | Mimi Wan Stephen SJ Zhang XY | 1999 | Am J Hum Genet1999，65，6： | 1 |
| 3 | Novel CO2-capture derived from the basic ionic liquids orientated on mesoporous materials显示文摘 | WAN Mimi ZHU Haoyue LI Yanyan | 2014 | ACS Applied Materials and Interfaces2014，6，12： | 1 |
| 4 | Automated methods in clustered microcalcifications detection module of a CAD system显示文摘 | Wan Mimi Diyana Rosli Besar | 2003 | Journal of Mechanics in Medicine and Biology2003，3，3： | 1 |
| 5 | Nanomotor-based adsorbent for blood Lead(II)removal in vitro and in pig models显示文摘Blood lead(Pb(II))removal is very important but challenging.The main difficulty of blood Pb(II)removal currently lies in the fact that blood Pb(II)is mainly complexed with hemoglobin(Hb)inside the red blood cells(RBCs).Traditional blood Pb(II)removers are mostly passive particles that do not have the motion ability,thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively low.Herein,a kind of magnetic nanomotor adsorbent with movement ability under alternating magnetic field based on Fe3O4 nanoparticle modified with meso-2,3-dimercaptosuccinic acid(DMSA)was prepared and a blood Pb(II)removal strategy was further proposed.During the removal process,the nanomotor adsorbent can enter the RBCs,then the contact probability between the nanomotor adsorbent and the Pb(II)-contaminated Hb can be increased by the active movement of nanomotor.Through the strong coordination of functional groups in DMSA,the nanomotor adsorbent can adsorb Pb(II),and finally be separated from blood by permanent magnetic field.The in vivo extracorporeal blood circulation experiment verifies the ability of the adsorbent to remove blood Pb(II)in pig models,which may provide innovative ideas for blood heavy metal removal in the future. | Meng Wang Tianyi Bao Wenqiang Yan Dan Fang Yueqi Yu Zhiyong Liu Guoyong Yin Mimi Wan Chun Mao Dongquan Shi | 2021 | Bioactive Materials2021，6，4： | 0 |
| 6 | Chemotactic nanomotor for multimodal combined therapy of glioblastoma显示文摘Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment. | Ting Li Lin Chen Yunxin Xue Xiangyu Xiao Wenjun Dai Kaiyuan Tan Tiantian Chen Yingfang Tao Chun Mao Jian Shen Mimi Wan | 2024 | Science China Chemistry2024，67，4： | 0 |
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