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| 1 | miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines显示文摘化疗是为 colorectal 腺癌癌症的重要治疗;然而, colorectal 腺癌房间经常开发抵抗到化学疗法的药,导致恶化和差的耐心的预后。药抵抗的发展经常是一个 multifactor 过程,它包含了几基因和细胞的机制。microRNAs 是否定地在 post-transcriptional 水平调整基因表示的内长的小非编码的 RNA。在现在的学习,我们在调整 colorectal 腺癌房间 SW620 和 SW480 的药敏感调查了 microRNAs 的可能的角色。使用 microRNA 表达式数组和我们发现了房间展出了的那 SW620 的量的反向的 transcriptase (RT )-PCR, 与 SW480 房间相比提高了 miR-20a 表示。另外,这二房间行显示了不同敏感到化学疗法的药氟尿嘧啶, oxaliplatin,和 teniposide。miR-20a 的调整改变了 SW620 和 SW480 房间的敏感到这些药;miR-20a 击倒敏化的 SW620 房间到化学疗法的代理人,而在 SW480 房间的 miR-20a 的 overexpression 导致了 chemoresistance。内长的 BNIP2 mRNA 和 BNIP2 蛋白质层次是相反地由量的 RT-PCR 和西方的污点分析与是的 miR-20a 层次有关检测了。荧光记者试金显示出在 miR-20a 和 BNIP2 3UTR 之间的一个直接相互作用。一起拿,我们的调查结果建议 miR-20a 可以在 colorectal 腺癌癌症房间药抵抗起一个作用并且可以是对在 colorectal 腺癌的化疗药抵抗的一个治疗学的目标。 | Huijuan Chai Min Liu Ruiqing Tian Xin Li Hua Tang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 18 |
| 2 | Effect of processing on the alkaloids in Aconitum tubers by HPLC-TOF/MS显示文摘According to the Chinese Pharmacopoeia 2015, only processed Aconitum tubers can be clinically applied, and the effect of processing is unclear. This research aimed to explore the effect of processing on cardiac efficacy of alkaloids in Aconitum tubers. First, the chemical ingredients in unprocessed and processed Aconitum tubers were identified and compared by using high performance liquid chromatography time-of-flight mass spectrometry(HPLC-TOF/MS) and multivariate pattern recognition methods. Then the representative alkaloids in Aconitum tubers, aconitine, benzoylaconine, and aconine, which belong to diester-diterpenoid alkaloids,monoester-diterpenoid alkaloids, and amine-diterpenoid alkaloids, respectively, were selected for further validation of attenuated mechanism. Subsequent pharmacological experiments with aconitine, benzoylaconine,and aconine in SD rats were used to validate the effect of processing on cardiac functions. After processing the Aconitum tubers, it was found that the contents of diester-diterpenoid alkaloids were reduced, and those of monoester-diterpenoid alkaloids and amine-diterpenoid alkaloids were increased, suggesting that diesterditerpenoid alkaloids were transformed into monoester-diterpenoid alkaloids and amine-diterpenoid alkaloids.Through further decocting the aconitine in boiling water, it was confirmed that the three alkaloids could be progressively transformed. Pharmacological experiments with aconitine, benzoylaconine, and aconine in SD rats showed that aconitine at a dose of 0.01 mg/kg and aconine at a dose of 10 mg/kg enhanced the cardiac function, while benzoylaconine at a dose of 2 mg/kg weakened the cardiac function. The effect of processing is attributed to the transformation of the most toxic diester-diterpenoid alkaloids into less toxic monoesterditerpenoid alkaloids and amine-diterpenoid alkaloids. | Min Liu Yan Cao Diya Lv Wen Zhang Zhenyu Zhu Hai Zhang Yifeng Chai | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 10 |
| 3 | Study on the mechanism of copper-ammonia complex decomposition in struvite formation process and enhanced ammonia and copper removal显示文摘Heavy metals and ammonia are difficult to remove from wastewater,as they easily combine into refractory complexes.The struvite formation method(SFM) was applied for the complex decomposition and simultaneous removal of heavy metal and ammonia.The results indicated that ammonia deprivation by SFM was the key factor leading to the decomposition of the copper-ammonia complex ion.Ammonia was separated from solution as crystalline struvite,and the copper mainly co-precipitated as copper hydroxide together with struvite.Hydrogen bonding and electrostatic attraction were considered to be the main surface interactions between struvite and copper hydroxide.Hydrogen bonding was concluded to be the key factor leading to the co-precipitation.In addition,incorporation of copper ions into the struvite crystal also occurred during the treatment process. | Cong Peng Liyuan Chai Chongjian Tang Xiaobo Min Yuxia Song Chengshan Duan Cheng Yu | 2017 | Journal of Environmental Sciences2017，29，1： | 9 |
| 4 | Effect of vitamin B12 on cleft palate induced by 2,3.7.8-tetrachlorodibenzo-p-dioxin and dexamethasone in mice显示文摘 | Shu-fan ZHAO Mao-zhou CHAI Min WU Yong-hong HE Tian MENG Bing SHI | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，3： | 9 |
| 5 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 6 | Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury显示文摘我们评估了 LIM-kinase 2 禁止者(LIMK2i ) 是否能由通过联系 Rho 的卷卷蛋白质 kinase 的正规化压制肉体的纤维变性改进可勃起的功能 1 (ROCK1 ) 在多孔的神经压碎损害(CNCI ) 的一个老鼠模型的 /LIMK2/Cofilin 小径。六十只 11-week-old 男性 Sprague-Dawley 老鼠同等地被划分成五个组:与低剂量的(L) ,中等剂量的(M) ,和高剂量的(H) LIMK2i 对待的假冒的外科(S) , CNCI (I) ,和 CNCI。L, M,和 H 组与 LIMK2i 的每日的 intraperitoneal 注射被对待(2.5, 5.0,和 10.0 mg kg 1 身体重量,分别地) 为在外科以后的 1 个星期。可勃起的反应手术后地在 1 个星期用 electrostimulation 被估计。阴茎纸巾为 Massons 被处理三色的染色的、双 immunofluorescence,和西方的污点试金。在 H 组的可勃起的回答改善了与相比我组织,当 M 组出现了时仅仅偏爱的改进。显著地减少的光滑的肌肉 / 骨胶原比率和为 phospho-LIMK2 积极的成纤维细胞的一个增加的内容在 I 组被注意。M 和 H 组在组织学的改变和 dysregulated LIMK2/Cofilin 小径揭示了重要改进,除了在 M 组的 LIMK2 phosphorylation。LIMK2 的抑制没影响 ROCK1 蛋白质表示。为在 H 组的 phospho-LIMK2 积极的成纤维细胞的内容回到了在 S 组发现的水平,而它没在 M 组织。然而, L 组没展出如此的改进。我们的数据建议特别地与 10.0 mg kg 1 身体重量 LIMK2i 的管理, LIMK2 的抑制能由使 LIMK2/Cofilin 小径正常化改进肉体的纤维变性和可勃起的功能。 | Juhyun Park Sung Yong Cho Kwanjin Park Ji Sun Chai Hwancheol Son Soo Woong Kim Jae-Seung Paick Min Chul Cho | 2018 | Asian Journal of Andrology2018，20，4： | 4 |
| 7 | Expression pattern and tissue localization of the class B scavenger receptor BmSCRBQ4 in Bombyx moil显示文摘类 B scavenger 受体(SR-Bs ) 是在 vivo 涉及各种各样的生理的进程的房间表面 glycoproteins,包括 xenobiotics 的类脂化合物,绑定和吞噬作用的运输和新陈代谢,并且发信号。但是很少信息都不关于蚕 SR-Bs 是可得到的;为揭示他们的功能学习这些 SR-Bs 是必要的。在这研究,我们克隆 BmSCRBQ4 的全身的编码顺序,从蚕 Bombyx mori L 的 SR-B 基因。我们发现 BmSCRBQ4 基因由九 exons 和八 introns 组成,与编码 456 氨基酸的 1371bp 的一个开的读物框架。基因表示研究决定 BmSCRBQ4 送信人 RNA (mRNA ) 在未受精的鸡蛋被表示,在胚胎的开发期间并且在整个幼虫的时期的多数。mRNA 的表示在中间的内脏,中间的丝绸腺,以后的丝绸腺,头, integumentum,胖身体,睾丸和幼虫的 B 的卵巢被检测。mori Dazao 紧张,以及在蚕,房间衬里 BmN 和 BmE。蛋白质表示研究发现 BmSCRBQ4 蛋白质仅仅在睾丸,胖身体和幼虫的中间的丝绸腺,以及在蚕房间行 BmN 和 BmE 被表示。BmSCRBQ4 蛋白质在不同纸巾和房间在 banding 模式看了可变性什么时候由西方的弄污分析了。染色的 Immunohistochemical 证明 BmSCRBQ4 蛋白质本地化到组成的膜或这些纸巾的细胞的膜。这些结果显示那 BmSCRBQ4 基因可以在每纸巾在房间表面起一些生理地相关的作用。 | Zhan-Peng Dong Chun-Li Chai Fang-Yin Dai Min-Hui Pan Ping Huang Wei Wang Peng-Fei Liao Min Liu Cheng Lu | 2015 | Insect Science2015，22，6： | 4 |
| 8 | Three new sesquiterpene alkaloids from the root of Tripterygium wilfordii显示文摘三新 sesquiterpene 碱, 1-desacetylwilforgine (1 ) , 1-desacetylwilforine (2 ) ,和 9 鈥 ? hydroxy-2-nicotinoylwilforine (3 ) 从 Tripterygium wilfordii 钩 f. 的根被孤立,与六已知的碱一起。他们的结构被建立根据光谱分析。 | Chun Min Wu Lin Mei Zhou Yi Feng Chai Yu Tian Wu Guo Rong Fan | 2010 | Chinese Chemical Letters2010，21，7： | 4 |
| 9 | Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma显示文摘瞄准: 在调整树枝状的房间成熟并且在尖锐气喘的病理决定胸回归 protein-39 (BRP-39 ) 的角色。 | Qian XU Shou-jie CHAI Ying-ying QIAN Min ZHANG Kai WANG | 2012 | Acta Pharmacologica Sinica2012，33，12： | 3 |
| 10 | Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures显示文摘抗菌素编码 anti-CRISPR suppressors 抵抗他们的细菌的主人的 CRISPR/Cas 免疫,因此便于他们的幸存和复制。以前的研究显示出那二编码噬菌体的 anti-CRISPR 蛋白质, AcrF1 和 AcrF2,如果由由 Csy 监视建筑群阻止目标 DNA 识别的 Pseudomonas aeruginosa 的 CRISPR/Cas 系统,而是精确位于下面机制是未知的,压制类型。这里我们在场 Csy 建筑群一定的 AcrF1/2 的结构由 cryo 他们决定了单个粒子的重建。由结构的分析,我们发现 AcrF1 由防碍在 DNA 目标海滨和 crRNA 分隔符之间的基础配对禁止 Csy 建筑群的目标 DNA 识别。另外,当个别地工作或与 AcrF2 合作时, AcrF1 的多重拷贝与不同模式绑在 Csy 建筑群,它可能排除通过不同机制有约束力的目标 DNA。和以前的报告,我们为二 anti-CRISPR suppressors, AcrF1 和 AcrF2 提供一种全面工作情形,它由指向 Csy 监视建筑群的沉默 CRISPR/Cas 免疫。 | Ruchao Peng Ying Xu Tengfei Zhu Ningning Li Jianxun Qi Yan Chai Min Wu Xinzheng Zhang Yi Shi Peiyi Wang Jiawei Wang Ning Gao George Fu Gao | 2017 | Cell Research2017，27，7： | 3 |
| 11 | High-pressure microwave-assisted synthesis of WS_(x)/Ni_(9)S_(8)/NF hetero-catalyst for efficient oxygen evolution reaction显示文摘Designing the specific crystal phase with better intrinsic activity and more active sites is a very promising strategy for earth-abundant electrocatalysts for oxygen evolution reaction(OER).Herein,a facile two-step method including the high-pressure microwave and the hydrothermal sulfurization is adopted to prepare the WS_(x)/Ni_(9)S_(8) hetero-catalyst on nickel foam(WS_(x)/Ni_(9)S_(8)/NF).Firstly,WO3 polyhedrons homogeneously cover the surface of NF through the high-pressure microwave hydrothermal process.Secondly,WS_(x)/Ni_(9)S_(8) nanoparticles on the surface of NF can be synthesized after a hydrothermal sulfurization,which has been confirmed by scanning electron microscopy(SEM) elemental mapping and high-resolution transmission electron microscopy(HRTEM).The amorphous WSx and Ni9 S8 phase may provide the dual active sites for OER.The electrochemical measurements show that WS_(x)/Ni_(9)S_(8)/NF has superior OER activity with a low overpotential of 320 mV at the current density of 100 mA·cm^(-2),better than those of other samples.The enhanced OER performance may be due to the synergistic catalysis from Ni9 S8 phase and high valence of W.Owing to the stable structure of Ni9 S8,the long-term stability of WS_(x)/Ni_(9)S_(8)/NF for at least 10 h can be obtained.This work may provide a new approach for the doped nickel sulfides crystal phase through high-pressure microwave hydrothermal assistance for OER. | Xue Ma Xin-Yu Zhang Min Yang Jing-Yi Xie Ren-Qing Lv Yong-Ming Chai Bin Dong | 2021 | Rare Metals2021，40，5： | 3 |
| 12 | The Malaysian cataract surgery registry:incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period显示文摘AIM:To report the incidence,risk factors and visual outcomes for postoperative endophthalmitis(POE)based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry(MOH CSR).METHODS:Data was collected from the web-based MOH CSR.All consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were identified.Exclusion criteria were traumatic cataract or previous ocular surgery.Demographic data,ocular co-morbidities,intraoperative details and postoperative visual acuity(VA)at final ophthalmological follow-up were noted.All eyes were taken for analysis.Subjects with POE were compared against subjects with no POE for risk factor assessment using multiple logistic regressions.RESULTS:A total of 163 503 subjects were screened.The incidence of POE was 0.08%(131/163 503).Demographic POE risk factors included male gender(OR:2.121,95%CI:1.464-3.015)and renal disease(OR:2.867,95%CI:1.503-5.467).POE risk increased with secondary causes of cataract(OR:3.562,95%CI:1.740-7.288),uveitis(OR:11.663,95%CI:4.292-31.693)and diabetic retinopathy(OR:1.720,95%CI:1.078-2.744).Intraoperative factors reducing POE were shorter surgical time(OR:2.114,95%CI:1.473-3.032),topical or intracameral anaesthesia(OR:1.823,95%CI:1.278-2.602),posterior chamber intraocular lens(PCIOL;OR:4.992,95%CI:2.689-9.266)and foldable IOL(OR:2.276,95%CI:1.498-3.457).POE risk increased with posterior capsule rupture(OR:3.773,95%CI:1.915-7.432)and vitreous loss(OR:3.907,95%CI:1.720-8.873).Postoperative VA of 6/12 or better was achieved in 15.27%(20/131)subjects with POE.CONCLUSION:This study concurs with other studies regarding POE risk factors.Further strengthening of MOH CSR data collection process will enable deeper analysis and optimization of POE treatment. | Yong Zheng Wai Fiona Lee Min Chew Mohamad Aziz Salowi Chai Liang Ang Yong Yuin Chong Tassha Hilda Adnan Pik-Pin Goh | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 3 |
| 13 | Prospect of China's ambient air quality standards显示文摘Ambient air quality standards are the core strategic goal of ambient air quality management.Countries worldwide have given importance to research on the development of ambient air quality standards.To understand the history of the development of China’s ambient air quality standards,this study analyzed the background associated with all previous formulations and revisions of the standards,classification of functional areas,standard grading,pollutants,and evolution of the standard limits over the past 40 years.The results show that since the initial release of the“Ambient Air Quality Standard”by China in 1982,it has been supplemented once,revised twice,and modified twice.The first ambient air quality standard specified the standard limits of six pollutants commonly found in ambient air.With the development of ambient air quality management,the number of pollutants has increased to ten.Since the release of the“Ambient Air Quality Standards”in 2012,the ambient air quality in China has significantly improved.However,the proportion of cities meeting these standards is still low.At present,China is suitably positioned to make the standards associated with 24 hr SO2concentrations more stringent such that it meets the values defined in the World Health Organization(WHO)interim target-2 and the WHO air quality guideline(AQG).We further suggested that the SO2standard should be revised promptly.Simultaneously,regions with a relatively high proportion of cities meeting the standard are encouraged to introduce more stringent interim target limits in due course to manage the local ambient air quality. | Zongshuang Wang Yufei Tan Min Guo Miaomiao Cheng Yanyue Gu Siyu Chen Xuefang Wu Fahe Chai | 2023 | Journal of Environmental Sciences2023，，1： | 2 |
| 14 | Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud.显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xiaochen Song Zongyi Min Xin Xiao | 2007 | Environmental and Experimental Botany2007，，3： | 2 |
| 15 | Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer(version 2022)显示文摘Introduction Liver cancer remains a global health challenge,and its incidence is increasing worldwide.It is estimated that by 2025,more than one million individuals will be affected by liver cancer annually[1,2].In recent years,ablation has become a widely accepted treatment option for patients with primary and secondary liver malignancies[3].The commonly used ablation method for liver cancer is thermal ablation,including radiofrequency ablation. | Min Xu Li-Ting Xie Yue-Yong Xiao Ping Liang Qi-Yu Zhao Zhong-Min Wang Wei-Lu Chai Ying-Tian Wei Lin-Feng Xu Xiao-Kun Hu Ming Kuang Li-Zhi Niu Chen-Guo Yao Hai-Ying Kong Guo Tian Xiao-Yan Xie Xin-Wu Cui Dong Xu Jun Zhao Tian-An Jiang The Interventional Diagnosis and Treatment Group of the Ultrasonic Medicine Branch of Chinese Medical Association,The Nanoknife Tumor Ablation Society of the Interventional Minimally Invasive Therapy Special Committee of China Medicine Education Association | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 2 |
| 16 | DNS analysis of incipient drop impact dynamics using an accurate level set method显示文摘A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts.The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal and oblique impacts.A square-root correction for neck bases was modified in accuracy as well as scope of applications.In addition,process of jet formation and evolution was studied to reveal internal dynamics in drop impacts.It's found that pressure gradient and vortex are coexisting and completive reasons for jet topology while the inclined angle has a significant effect on them.Mechanisms of jet formation and evolution are different in the front and back necks.With the help of PDF distribution and correction calculation,a compromise in the competition is observed.This work lays a solid foundation for further studies of dynamics in gas-liquid flows. | Min Chai Kun Luo Changxiao Shao Song Chen Jianren Fan | 2017 | Chinese Journal of Chemical Engineering2017，25，1： | 2 |
| 17 | Metal-doped(Cu,Zn)Fe2O4 from integral utilization of toxic Zn-containing electric arc furnace dust: An environment-friendly heterogeneous Fenton-like catalyst显示文摘Pure metal-doped(Cu,Zn)Fe2O4 was synthesized from Zn-containing electric arc furnace dust(EAFD)by solid-state reaction using copper salt as additive.The effects of pretreated EAFD-to-Cu2(OH)2CO3·6H2O mass ratio,calcination time,and calcination temperature on the structure and catalytic ability were systematically studied.Under the optimum conditions,the decolorization efficiency and total organic carbon(TOC)removal efficiency of the as-prepared ferrite for treating a Rhodamine B solution were approximately 90.0%and 45.0%,respectively,and the decolorization efficiency remained 83.0%after five recycles,suggesting that the as-prepared(Cu,Zn)Fe2O4 was an efficient heterogeneous Fenton-like catalyst with high stability.The high catalytic activity mainly depended on the synergistic effect of iron and copper ions occupying octahedral positions.More importantly,the toxicity characteristic leaching procedure(TCLP)analysis illustrated that the toxic Zncontaining EAFD was transformed into harmless(Cu,Zn)Fe2O4 and that the concentrations of toxic ions in the degraded solution were all lower than the national emission standard(GB/31574-2015),further confirming that the as obtained sample is an environment-friendly heterogeneous Fenton-like catalyst. | Jun-wu Li Xing Han Rong-xia Chai Fang-qin Cheng Mei Zhang Min Guo | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，7： | 2 |
| 18 | Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death显示文摘AIM To describe the prevalence of posttransplant metabolic syndrome(PTMS) after donation after cardiac death(DCD) liver transplantation(LT) and the pre-and postoperative risk factors.METHODS One hundred and forty-seven subjects who underwent DCD LT from January 2012 to February 2016 were enrolled in this study. The demographics and the clinical characteristics of pre-and post-transplantation were collected for both recipients and donors. PTMS was defined according to the 2004 Adult Treatment Panel-Ⅲ criteria. All subjects were followed monthly for the initial 6 mo after discharge, and then, every 3 mo for 2 years. The subjects were followed every 6 mo or as required after 2 years post-LT.RESULTS The prevalence of PTMS after DCD donor orthotopic LT was 20/147(13.6%). Recipient's body mass index(P = 0.024), warm ischemia time(WIT)(P = 0.045), and posttransplant hyperuricemia(P = 0.001) were significantly associated with PTMS. The change in serum uric acid levels in PTMS patients was significantly higher than that in non-PTMS patients(P < 0.001). After the 1 s t mo, the level of serum uric acid of PTMS patients rose continually over a period, while it was unaltered in non-PTMS patients. After transplantation, the level of serum uric acid in PTMS patients was not associated with renal function.CONCLUSION PTMS could occur at early stage after DCD LT with growing morbidity with the passage of time. WIT and post-LT hyperuricemia are associated with the prevalence of PTMS. An increased serum uric acid level is highly associated with PTMS and could act as a serum marker in this disease. | Liang-Shuo Hu Yi-Chao Chai Jie Zheng Jian-Hua Shi Chun Zhang Min Tian Yi Lv Bo Wang Ai Jia | 2018 | World Journal of Gastroenterology2018，24，43： | 2 |
| 19 | Fe-doped CoP core–shell structure with open cages as efficient electrocatalyst for oxygen evolution显示文摘Developing a facile approach based on transition metal-based Prussian blue(PB)and its analogues(PBAs)with core-shell nanostructure is a very promising choice for constructing cost-effective electrocatalysts for oxygen evolution reaction(OER).Herein,a bimetallic core-shell structure with open cages of Fe-doped CoP(Fe-CoP cage)has been synthesized using CoFe-PBA cage-4 as precursor through a facile hydrothermal method and following phosphating process.Interestingly,there is an open hole in each face center of Fe-CoP cage,which suggests the more exposure of active sites for OER.Electrochemical measurements show that Fe-CoP cage can afford a current density of 10 mA cm-2 at a low overpotential(300 mV),which is better than that of RuO2.The excellent performance can be attributed to Fe doping composition and unique open-cage core-shell structure.The synergistic effect derived from bimetallic active for OER has been discussed.And its great catalytic stability has been evaluated via 1000 cycles of CV and chronoamperometry measurement.This work provides a potential method to design multiple transitional metal-doping electrocatalysts with complex framework derived from PBAs for water splitting. | Jing-Yi Xie Zi-Zhang Liu Jia Li Lei Feng Min Yang Yu Ma Da-Peng Liu Lei Wang Yong-Ming Chai Bin Dong | 2020 | Journal of Energy Chemistry2020，29，9： | 2 |
| 20 | 在结核病患者中通过评估解剖结构和视功能变化早期发现乙胺丁醇毒性(英文)显示文摘目的:通过评估比较治疗前后解剖结构和视功能的变化,包括视网膜神经纤维厚度、图形视觉诱发电位、传统视神经功能检查,早期检测乙胺丁醇毒性。方法:前瞻性研究,包括参加马来西亚理科大学医院的短期治疗观察项目的36例72眼结核病患者。视力和视神经功能检查由同一位研究者进行。同样,Humphrey自动视野检查、光学相干断层扫描(OCT)检查视网膜神经纤维厚度(RNFL)和图形视觉诱发电位(PVEP)均由同一位技术人员进行。在开始乙胺丁醇治疗前和治疗3mo后各进行检查一次。结果:乙胺丁醇治疗前后视力、彩色视觉、光亮度、红光反射和眼底检查无明显改变。然而,平均视野缺损在治疗后较前变差(P=0.010)。OCT和PVEP有显著变化,P100潜伏期延长、幅度降低,RNFL在各个象限均增厚(P<0.05)。结论:通过OCT检测RNFL厚度以及使用PVEP检测P100波峰潜伏期和幅度,可以在传统视神经功能检查异常之前,发现乙胺丁醇治疗后早期解剖结构和视功能的亚临床改变。 | Jessica Mani Penny Tevaraj Tan Chai Keong Evelyn Tai Li Min Muhammed Julieana Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam | 2017 | 国际眼科杂志2017，17，11： | 2 |
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