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| 1 | The effect of nanohybrid materials on the pour-point and viscosity depressing of waxy crude oil显示文摘The pipeline transportation of waxy crude oil is a problem both at home and abroad.In this paper,a novel nanohybrid pour-point depressant (PPD) was used to decrease the pour point and viscosity of waxy crude oil.The pour point and apparent viscosity of waxy crude oil was decreased significantly upon addition of the nanohybrid PPD,and the long-term stability of the nanohybrid PPD was superior to that of a conventional ethylene-vinyl acetate copolymer PPD.Polarized optical microscopy and X-ray diffraction were used to study the effect of the nanohybrid PPD on the crystallization of crude oil.Addition of the nanohybrid PPD reduced the amount of wax crystals,prevented their aggregation,and reduced the temperature at which the crude oil started to crystallize.The significant effect of this nanohybrid PPD on the pour point and viscosity depressing of crude oil is of great importance for facilitating the safe,efficient and energy-minimized transportation of waxy crude oil. | WANG Feng ZHANG DongMin DING YanFen ZHANG LiXin YANG MingShu JIANG BaoLiang ZHANG ShiMin AI MuYang LIU GuangWen ZHI ShuJie HUO LianFeng OUYANG Xin LI Li | 2011 | Chinese Science Bulletin2011，56，1： | 9 |
| 2 | Non-iterative complex wave-field reconstructionbased on Kramers–Kronig relations显示文摘A non-iterative and non-interferometric computational imaging method to reconstruct a complex wave field called synthetic aperture imaging based on Kramers–Kronig relations(KKSAI)is reported.By collecting images through a modified microscope system with pupil modulation capability,we show that the phase and amplitude profile of the sample at pupil limited resolution can be extracted from as few as two intensity images by using Kramers–Kronig(KK)relations.It is established that as long as each subaperture’s edge crosses the pupil center,the collected raw images are mathematically analogous to off-axis holograms.This in turn allows us to adapt a recently reported KK-relations-based phase recovery framework in off-axis holography for use in KKSAI.KKSAI is non-iterative,free of parameter tuning,and applicable to a wider range of samples.Simulation and experiment results have proved that it has much lower computational burden and achieves the best reconstruction quality when compared with two existing phase imaging methods. | CHENG SHEN MINGSHU LIANG AN PAN CHANGHUEI YANG | 2021 | Photonics Research2021，9，6： | 6 |
| 3 | Camouflage Patterning in Maize Leaves Results from a Defect in Porphobilinogen Deaminase显示文摘玉米叶子从导致沿着叶的长轴穿的同种细胞的房间系的极化的房间部门被生产。我们利用了这个 stereotypical 部门模式识别形成违背同种细胞的房间系的叶绿体色素沉着部门的许多异种。这里,我们描述 camouflage1 (cf1 ) 异种,开发 nonclonal,在它的叶子的 yellowgreen 部门。我们由标注的 transposon 克隆 cf1 基因并且决定它编码 porphobilinogen 脱氨基酶(PBGD ) ,在叶绿素和 heme 早工作的酶生合成。当 PBGD 生物化学地被描绘了时,在这基因的可行变化都没在植物被报导。调查在里面 PBGD 的 vivo 功能,我们描绘了 cf1 异种。组织学的分析表明 cf1 黄扇区显示捆鞘的新奇显型房间特定的死亡。轻移动的实验决定经常的光压制了 cf1 部门形成,黑暗 / 轻的转变被要求仅仅在叶开发的一有限时间期间导致黄部门,和那种部门形式。生物化学的实验决定 cf1 异种叶子减少了 PBGD 活动和在绿、黄的区域的酶底层的增加的层次。而且, cf1 黄区域在过氧化氢酶活动显示了减小。一个阀值模型被假设向 cf1 解释上色并且合并光合的细胞区别,清除的反应的氧种,和 PBGD 功能。 | Mingshu Huanga Thomas L. Slewinski R. Frank Baker , Diane Janick-Buckner Brent Buckner Gurmukh S. Johal David M. Braun | 2009 | Molecular Plant2009，2，4： | 6 |
| 4 | Live cell single molecule-guided Bayesian localization super resolution microscopy显示文摘 | Xu, Fan Zhang, Mingshu He, Wenting Han, Renmin Xue, Fudong Liu, Zhiyong Zhang, Fa Lippincott-Schwartz, Jennifer Xu, Pingyong | 2017 | Cell Research2017，27，5： | 6 |
| 5 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 6 | Unifying the Software Process Spectrum显示文摘Software Process Workshop (SPW 2005) was held in Beijing on May 25-27, 2005. This paper introduces the motivation of organizing such a workshop, as well as its theme and paper gathering and review; and summarizes the main content and insights of 11 keynote speeches, 30 regular papers in five sessions of “Process Content”, “Process Tools and Metrics”, “Process Management”, “Process Representation and Analysis”, and “Experience Reports”, 8 software development support tools demonstration, and the ending panel “Where Are We Now? Where Should We Go Next?”. | Mingshu Li Barry W. Boehm Leon J. Osterweil | 2006 | 软件学报2006，17，4： | 5 |
| 7 | Catalysis under shell: Improved CO oxidation reaction confined in Pt@h-BN core-shell nanoreactors显示文摘Core-shell nanostructures consisting of active metal cores and protective shells often exhibit enhanced catalytic performance, in which reactants can access a small part of the core surfaces through the pores in the shells. In this study, we show that Pt nanoparticles (NPs) can be embedded into few-layer hexagonal boron nitride (h-BN) overlayers, forming Pt@h-BN core-shell nanocatalysts. The h-BN shells not only protect the Pt NPs under harsh conditions but also allow gaseous molecules such as CO and O2 to access a large part of the Pt surfaces through a facile intercalation process. As a result, the Pt@h-BN nanostructures act as nanoreactors, and CO oxidation reactions with improved activity, selectivity, and stability occur at the core-shell interfaces. The confinement effect exerted by the h-BN shells promotes the Pt-catalyzed reactions. Our work suggests that two-dimensional shells can function as robust but flexible covers on nanocatalyst surfaces and tune the surface reactivity. | Mengmeng Sun Qiang Fu Lijun Gao Yanping Zheng Yangyang Li Mingshu Chen Xinhe Bao | 2017 | Nano Research2017，10，4： | 5 |
| 8 | Characterization of codon usage bias in the dUTPase gene of duck enteritis virus显示文摘A comparative analysis of the codon usage bias in the newly discovered dUTPase gene (Assigned Accession No.:DQ486149) of the duck enteritis virus (DEV) and the dUTPase gene of 32 reference herpesviruses was performed.The results indicated that the DEV dUT-Pase gene encodes a protein of 477 amino acids, which includes five conserved motifs with a 3-1-2-4-5 arrangement.The codon adap-tation index (CAI), efiective number of codons (ENC), and GC3S values indicated synonymous codon usage bias in the dUTPase gene of herpesviruses, and this synonymous bias was correlated with host evolution.The codon usage patterns of the DEV dUTPase gene were phylogenetically conserved and similar to that of the dUTPase genes of the avian alphaherpesvirus.Although codon usage in each micro-organism was difierent, there were no strain-specific difierences among them.Sixty-one codons in the predicted polypeptide, with a strong bias towards A and T at the third codon position, were used.Comparison of the codon usage in the dUTPase gene of difierent organisms revealed that there were 19 codons showing distinct codon usage difierences between the DEV and Escherichia coli dUTPase genes;16 between the DEV and yeast dUTPase genes;and 15 between the DEV and human dUTPase genes.Analysis of variance (ANOVA) showed significant difierences between the DEV and yeast dUTPase genes (r = 0.536, P < 0.01).The extent of codon usage bias in the DEV dUTPase gene was highly correlated with the gene expression level, therefore the results may provide useful information for gene classification and functional studies. | Lichan Zhao Anchun Cheng Mingshu Wang Guiping Yuan Mingsheng Cai | 2008 | Progress in Natural Science:Materials International2008，18，9： | 4 |
| 9 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
| 10 | Host cell apoptosis induced by infection with duck swollen head hemorrhagic disease virus显示文摘This study aimed to examine the host cell apoptosis in the tissues of Peking ducks infected with duck swollen head hemorrhagic disease virus(DSHDV).The dynamic changes associated with apoptosis occurring in the internal tissues were evaluated at different time points postinoculation(PI) by performing hematoxylin and eosin(HE) staining,followed by light microscopy,terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL) assay,and transmission electron microscopy(TEM).The results showed that DSHDV infection could induce apoptosis in host cells,including those of the bursa of Fabricius(BF),thymus,spleen,liver,intestinal tract,kidney,and esophagus.The apoptotic index(AI) values increased with time from 2 to 72 h PI,and the highest values were recorded at 72 h PI.Further,cell death due to classic necrosis was observed in the dying or deceased ducks after 72 h PI.In conclusion,host cell apoptosis can be induced by DSHDV and may play an important role in the pathogenesis of duck viral swollen head hemorrhagic disease(DVSHD). | Chuanfeng Li Anchun Cheng Mingshu Wang Chanjuan Shen Na Zhang Yi Zhou Dekang Zhu Qihui Luo Renyong Jia Xiaoyue Chen | 2009 | Progress in Natural Science:Materials International2009，19，1： | 3 |
| 11 | Ultrafast,accurate,and robust localization of anisotropic dipoles显示文摘The resolution of single molecule localization imaging techniques largely depends on the precision of localization algorithms.However,the commonly used Gaussian function is not appropriate for anisotropic dipoles because it is not the true point spread function.We derived the theoretical point spread function of tilted dipoles with restricted mobility and developed an algorithm based on an artifi cial neural network for estimating the localization,orientation and mobility of individual dipoles.Compared with fi tting-based methods,our algorithm demonstrated ultrafast speed and higher accuracy,reduced sensitivity to defocusing,strong robustness and adaptability,making it an optimal choice for both two-dimensional and threedimensional super-resolution imaging analysis. | Yongdeng Zhang Lusheng Gu Hao Chang Wei Ji Yan Chen Mingshu Zhang Lu Yang Bei Liu Liangyi Chen Tao Xu | 2013 | Protein & Cell2013，4，8： | 2 |
| 12 | Size and support effects for CO oxidation on supported Pd catalysts显示文摘Supporting Pd catalysts characterized significant different size distribution were obtained using PdCl2,[Pd(NH3)4](NO3)2 and Pd(acac)2 as precursors.High-resolution transmission electron microscopy(TEM),X-ray diffraction(XRD),in-situ Fourier transform infrared spectroscopy(FTIR) and Raman spectroscopy were used to examine the dispersion of Pd.Catalytic performance measurements show that the activities for CO oxidation increase as the Pd particle size decreases and the O2/CO ratio increases.The activities under oxygen rich conditions are significantly higher than those at near the stoichiometric conditions.Pd on TiO2 prepared by the Pd(acac)2 precursor is highly dispersed,leading to a considerable activity for CO oxidation at near room temperature.CO oxidation on the 1 wt% Pd/TiO2 and under an O2/CO ratio of 1 characterized an apparent activation energy of 36.7 kJ/mol,which is closed to those reported for CO oxidation on the supported Au catalysts.The present work demonstrates a high catalytic activity of highly dispersed noble metals,and suggests a promising approach of using noble metals as catalysts with exceeding high efficiency. | WANG ZhaoWen,LI Bin,CHEN MingShu,WENG WeiZheng & WAN HuiLin State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China | 2010 | Science China Chemistry2010，53，9： | 2 |
| 13 | Hessian single-molecule localization microscopy using sCMOS camera显示文摘 | Fudong Xue Wenting He Fan Xu Mingshu Zhang Liangyi Chen Pingyong Xu | 2018 | Biophysics Reports2018，4，4： | 2 |
| 14 | Nerve growth factor and inducible nitric oxide synthase expression in the mesencephalon and diencephalon, as well as visual-and auditory-related nervous tissues, in a macaque model of type 2 diabetes显示文摘The present study detected distribution and expression of nerve growth factor and inducible nitric oxide synthase in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes using immunohistochemistry. Results showed that nerve growth factor expression decreased, but inducible nitric oxide synthase expression increased, in the mesencephalon and diencephalon, as well as visual- and auditory- related nervous tissues. These results suggested that nerve growth factor and inducible nitric oxide synthase play an important role in regulating the development of diabetic visual- and auditory-related diseases. | Qihui Luo Wentao Liu Jingyao Chen Mingshu Wang Wen Zeng Zhengli Chen Anchun Cheng | 2012 | Neural Regeneration Research2012，7，4： | 2 |
| 15 | Study on Potential and Countermeasures of Artificial Precipitation Enhancement in Fuxin Region显示文摘To exploit cloud water resources to increase precipitation on the ground effectively,according to the principles of artificial precipitation enhancement,based on historical data of weather and precipitation from Fuxin National Basic Meteorological Stations from 1981 to 2010,the distribution characteristics of cloud water resources,potential and countermeasures of artificial precipitation enhancement in Fuxin region of Liaoning Province were studied. The results show that the annual average quantity of cloud water resources in the air over Fuxin region over the past 30 years was 285. 6 × 10~8m^3,but the annual average precipitation was only 471.8 mm( amounting to 47.2 ×10~8m^3 of water resources),accounting for only16. 5% of total quantity of cloud water resources in the air; 12 times of artificial precipitation enhancement operation experiments were carried out by using the weather models and technical indicators suitable for artificial precipitation enhancement in Fuxin region,and the artificial precipitation efficiency was 18. 3% on average,5. 2% higher than before,and the annual average precipitation could increase by 2. 5 × 10~8m^3 approximately. All of these have great significance for implementing artificial precipitation enhancement operation scientifically and effectively,maximizing the exploitation of cloud water resources in the air,increasing total quantity of water resources,and mitigating drought in Fuxin region. | Sun Baoli Zhang Xu Sun Ke Cao Mingshu | 2016 | Meteorological and Environmental Research2016，7，6： | 2 |
| 16 | Solidification Behavior of in situ TiB_(2)/Cu Composite Powders during Reactive Gas Atomization显示文摘2wt%TiB_(2)/Cu composite powders were fabricated in situ by reactive gas atomization.The fabricated composite powder exhibits high sphericity,and the powder sizes range from 5μm to 150μm.The morphology of the Cu matrix and the distribution of the TiB2 particles in the composite powders vary with the powder size.The critical transitions of interface morphologies from dendritic-to-cellular and cellular-to-planar interfaces occurs when the composite powder sizes decrease to 34μm and 14μm,respectively.Compared with pure Cu droplets,the composite droplets undergo critical transition of the interface morphologies at a smaller droplet size corresponding to a higher cooling rate because the existence of TiB2 particles can cause instability in the advancing solidification front and heterogeneous nucleation.With decreasing powder size,the extent of the TiB_(2) particle interdendritic segregation decreases as the result of enhanced engulfment of TiB2 particles by the advancing solidification front. | 姜伊辉 ZHANG Mingshu LI Yufa HE Jiangtan CAO Fei 梁淑华 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，2： | 2 |
| 17 | Finite Groups with 2р^m Elements Having the Highest Order are Solvable显示文摘 | Jiang Youyi Tan Mingshu | 2004 | Southeast Asina Bulletin of Mathematics2004，28，1： | 1 |
| 18 | Efficacy and safety of single-bolus tenecteplase compared with front-loaded alteplase in Chinese patients with acute myocardial infarction显示文摘Background and Objective Previous study showed tenecteplase and alteplaxe were equovalent for 30-day mortality in the treatment of acute myocardial infarction. The purpose of this open-label,randomized,multi-center,angiographic trial was to assess the efficacy and safety of tenecteplase compared with alteplase in Chinese patients with acute myocardial infarction. Methods We recruited patients with acute ST-elevation myocardial infarction presenting within 6 hours of symptom onset from October,2002 to March,2004,in 5 hospitals in Beijing. After giving informed consent,patients were randomly assigned a single-bolus injection of tenecteplase(30-50 mg according to body weight) or front loaded alteplase(100 mg) ,and underwent coronary angiography at 90 min after starting the study drug. All patients received aspirin and heparin(target activated partial thromboplastin time 50-70 s) . The primary efficacy end point was the rate of TIMI grade 3 flow at 90 minutes. Other efficacy end points included TIMI grade 2/3 flow at 90 minutes. Safety end points included all stroke,intracranial hemorrhage(ICH) ,moderate/severe hemorrhage(except for ICH) ,all-cause mortality at 30-days,and major non-fatal cardiac events at 30 days. Results Overall 110 patients were eligible for statistical analysis,with 58 patients assigned to receive tenecteplase and 52 patients to alteplase. Tenecteplase produced a rate of TIMI grade 3 flow at 90 minutes after the start of thrombolysis(68.4%) similar to that of alteplase(66.7%,P=1.0) ;the rates of TIMI grade 2 or 3 were similar for patients treated with tenecteplase versus alteplase(89.5% versus 80.4%,respectively,P=0.278) . At 30 days,rates for all strokes were similar for the two groups(5.17% for tenecteplase and 1.92% for alteplase,P=0.62) ;rates of ICH were 3.45% and 1.92%(tenecteplase and rt-PA,P=1.00) respectively. The rate of moderate/severe hemorrhage was 8.62% with tenecteplase and 5.77% with alteplase(P=0.72) ;total mortality was almost identical in the two groups(13.8% versus 9.6%,respectively,P=0.565) while the rates of non-fatal cardiac complications were 10.35% and 11.54%(tenecteplase and alteplase,P=1.0) . Conclusions The efficacy of a single-bolus,weight-adjusted tenecteplase fibrinolytic regimen is equivalent to front-loaded alteplase in terms of the rates of TIMI grade 3 flow,and TIMI 2 or 3 flow,but the 30-day mortality and ICH in both groups was so high that the use of tenecteplase is not permitted in China. These negative safety results might be due to the high rate of percutaneous coronary intervention(PCI) and high dose of bolus heparin and suboptimal concomitant medical therapy during hospitalization,so further studies are needed to confirm the safety for tenecteplase in Chinese patients. | Feng Liang Dayi Hu Xubo Shi Mingshu Gao Jiaping Wei Hong Zhao Lei Wang Sanqing Jia Hongyu Wang Ruhuai Liu Yundai Chen Yanling Lu | 2007 | Journal of Geriatric Cardiology2007，4，3： | 1 |
| 19 | Evaluation of sound- ness of concrete containing MgO-based expansive agent 显示文摘 | MO Liwu DENG Min TANG Mingshu | 2007 | Journal of Central South University2007，，14： | 1 |
| 20 | Microwave Curing Technique in Concrete Manufacture显示文摘 | Wu Xuequan Dong Jianbgo Tang Mingshu | 1987 | Cement and Concrete Research1987，，2： | 1 |
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