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| 1 | Ginsenoside Rg1 protects against transient focal cerebral ischemic injury and suppresses its systemic metabolic changes in cerabral injury rats显示文摘Ginsenoside Rg1(GR),a major bioactive compound of traditional Chinese medicine,such as Panax ginseng or Radix Notoginseng,has been shown to exert neuroprotective effects against ischemic stroke.However,pharmacokinetic studies have suggested that GR could not be efficiently transported through the blood–brain barrier.The mechanism by which GR attenuates cerebral ischemic injury in vivo remains largely unknown.Therefore,this study explored potential neuro-protective effects of GR through its systemic metabolic regulating mechanism by using mass spectrometry–based metabolomic profiling.Rats with middle cerebral artery occlusion(MCAO) were treated with GR intravenously.Their metabolic profiles in serum were measured by gas chromatography coupled with mass spectrometry on 1 and 3 days after MCAO.GR exhibited a potent neuro-protective effect by significantly decreasing the neurological scores and infarct volume in the MCAO rats.Moreover,18 differential metabolites were tentatively identified,all of which appeared to correlate well with these disease indices.Our findings suggested that GR carries a therapeutic potential in stroke possibly through a feed-back mechanism by regulating systematic metabolic mediation. | Mingbao Lin Wei Sun Wan Gong Yasi Ding Yuanyan Zhuang Qi Hou | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 7 |
| 2 | Quasi-convex Functions in Carnot Groups显示文摘在这篇论文,作者在 Carnot 组 G 上介绍 h-quasiconvex 功能的概念。h-quasiconvex 功能和 h 凸的集合的观点是相等的, L~ ∞第一估计 h-quasiconvex 功能的衍生物被给,这被显示出。为步二的 aCarnot 组 G, h-quasiconvex 功能局部地从上面被围住,这被证明。而且,作者获得那 h 凸的功能是局部地连续的 Lipschitz 和那 h 凸的功能到处几乎是两次可辨的。 | Mingbao SUN Xiaoping YANG | 2007 | Chinese Annals of Mathematics,Series B2007，28，2： | 3 |
| 3 | Global analysis of smooth solutions to a hyperbolic-parabolic coupled system显示文摘 | Yinghui ZHANG Haiying DENG Mingbao SUN | 2013 | Frontiers of Mathematics in China2013，8，6： | 2 |
| 4 | Flow shop scheduling problems with deteriorating jobs on no-idle dominant machines显示文摘 | Sun ShiJie He LongMin | 2007 | European Journal of Operational Research2007，183，： | 1 |
| 5 | Some inequalities for two simplexes显示文摘 | Sun Mingbao | 2001 | Geom Dedicata2001，85，： | 1 |
| 6 | Flow shop scheduling problem with deteriorating jobs on no-idle dominant machines显示文摘 | Cheng Mingbao Sun Shijie He Longmin | 2007 | European Journal of Operational Research2007，183，： | 1 |
| 7 | Schur Convexity for Two Classes of Symmetric Functions and Their Applications显示文摘For x =(x1, x2, ···, xn) ∈ Rn+∪ Rn-, the symmetric functions Fn(x, r) and Gn(x, r) are defined by r1 + xFij n(x, r) = Fn(x1, x2, ···, xn; r) =x1≤iij1 | Mingbao SUN Nanbo CHEN Songhua LI Yinghui ZHANG | 2014 | Chinese Annals of Mathematics,Series B2014，35，6： | 1 |
| 8 | Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water显示文摘Accompanying an annual increase in cancer incidence,the global use of anticancer drugs has remarkably increased with their worldwide environmental prevalence and ecological risks.In this study,the oxidation of methotrexate(MTX),a typical anticancer drug with ubiquitous occurrence and multi-endpoint toxicity,by ferrate(VI)(Fe(VI))and permanganate(Mn(VII)))was investigated in water.Fe(VI)exhibited a higher reactivity with MTX(93.34 M^(−1) s^(−1))than Mn(VII)(3.01 M^(−1) s^(−1)) at pH 8.0.The introduction of Cu(II)and Fe(III)at 1.0 mM improved the removal efficiency of 5.0μM MTX by 100.0μM Fe(VI)from 80%to 95%and 100%after 4 min,respectively.Seven oxidized products(OPs)were identified during oxidative treatments,while OP-191 and OP-205 were characterized as specific products for Fe(VI)oxidation.Initial ketonization of the L-glutamic acid moiety and cleavage of the peptide bond of MTX were proposed.Additionally,a multi-endpoint toxicity evaluation indicated no genotoxicity,neurotoxicity,or endocrine-disrupting effects of MTX and its OPs.Particularly,serious developmental toxicity in zebrafish larvae was observed in the treated MTX solutions.Based on the acute and chronic aquatic toxicity prediction,OP-190,OP-192,OP-206,and OP-208 were deemed toxic or very toxic compared to harmful MTX.Furthermore,the reduced biodegradability index from 0.15(MTX)to−0.5 to−0.2(OP-192,OP-206,and OP-468)indicated the formation of lower biodegradable OPs.Overall,this study suggests that Fe(VI)and Mn(VII)oxidation are promising treatments for remediating anticancer drug-contaminated water.However,the environmental risks associated with these treatments should be considered in the evaluation of water safety. | Shengqi Zhang Chengsong Ye Wenjun Zhao Lili An Xin Yu Lei Zhang Hongjie Sun Mingbao Feng | 2022 | Frontiers of Environmental Science & Engineering2022，16，7： | 0 |
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