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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Engineering optimization approach of nonaqueous electrolyte for sodium ion battery with long cycle life and safety显示文摘Electrolyte design strategies are closely related to the capacities, cycle life and safety of sodium–ion batteries. In this study, we aimed to optimize electrolyte with the focus on engineering aspects. The basic physicochemical properties including ionic conductivity, viscosity,wettability and thermochemical stability of the electrolytes using Na PF6 as the solute and the mixed solvent with different components of EMC,DMC or DEC in PC or EC were systematically measured. Ah pouch cell with NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon electrodes was used to evaluate the performance of the prepared electrolytes. By using the Inductive Coupled Plasma Emission Spectrometer(ICP), X-ray photoelectron spectroscopy(XPS), Thermogravimetric-differential scanning calorimetry(TG-DSC) and Accelerating Rate Calorimeter(ARC), we show that an optimized electrolyte can effectively promote the formation of a protective interfacial layer on two electrodes, which not only retards parasitic reactions between the electrodes and electrolyte but also suppresses dissolution of metal ions from the cathode. With an optimized electrolyte, a NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon cell can attain 56.16% capacity retention under the low temperature of -40℃, and can be able to retain 80%capacity retention after more than 2500 cycles while presenting excellent thermal safety. | Haiying Che Xinrong Yang Yan Yu Chaoliang Pan Hong Wang Yonghong Deng Linsen Li Zi-Feng Ma | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 3 | Overview of the Solar Polar Orbit Telescope Project for Space Weather Mission显示文摘The Solar Polar ORbit Telescope(SPORT) project for space weather mission has been under intensive scientific and engineering background studies since it was incorporated into the Chinese Space Science Strategic Pioneer Project in 2011.SPORT is designed to carry a suite of remote-sensing and in-situ instruments to observe Coronal Mass Ejections(CMEs),energetic particles,solar high-latitude magnetism,and the fast solar wind from a polar orbit around the Sun.The first extended view of the polar regions of the Sun and the ecliptic enabled by SPORT will provide a unique opportunity to study CME propagation through the inner heliosphere,and the solar high-latitude magnetism giving rise to eruptions and the fast solar wind.Coordinated observations between SPORT and other spaceborne/ground-based facilities within the International Living With a Star(ILWS) framework can significantly enhance scientific output.SPORT is now competing for official selection and implementation during China's 13 th Five-Year Plan period of 2016-2020. | XIONG Ming LIU Ying LIU Hao LI Baoquan ZHENG Jianhua ZHANG Cheng XIA Lidong ZHANG Hongxin RAO Wei CHEN Changya SUN Weiying WU Xia DENG Yuanyong HE Han JIANG Bo WANG Yuming WANG Chuanbing SHEN Chenglong ZHANG Haiying ZHANG Shenyi YANG Xuan SANG Peng WU Ji | 2016 | 空间科学学报2016，36，3： | 3 |
| 4 | Global analysis of smooth solutions to a hyperbolic-parabolic coupled system显示文摘 | Yinghui ZHANG Haiying DENG Mingbao SUN | 2013 | Frontiers of Mathematics in China2013，8，6： | 2 |
| 5 | Separation and Anti-Hantaan Virus Activity of Extracts from Alternanthera philoxcroides in vitro and in vivo显示文摘A water-soluble substance was extracted from the Chi-nese herb, Alternanthera philoxcroides with hot water and alcohol. Aliquots of this initial extract were further fractionated by treat-ment with ether, ethyl acetate and alcohol respectively. The four extracts were assayed for anti-viral activity against three serum, Hantaan virus 114 (HV114),HV435 and A9 strains. Results show that the four extracts are capable of inhibiting Hantaan virus propagation, of which extract No.1 has the best efficiency. The three dosage of extract No.1, which are used upon three Hantaan virus serum IC50, are 153, 157, 154 μ?/mL. New-born mice were made to be infected with HV114 and then fed in vivo with extract No.1 on the 3rd, 10th and 14th days after being infected by the virus. The treatment continued for 8 days with a dosage of 2.5 g/kg. Result shows that survival rates of mice were 75%, 50% and 0, respectively. The median time to death (MTDs) of the three groups were 37, 30, 23 days. | LIU Yingjuan YANG Zhanqiu DENG Haiying XIAO Hong QU Chunfeng | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 2 |
| 6 | The calibration and initial results of the HeI D3 line flash spectrum obtained during the 2008 total solar eclipse显示文摘The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The average integrated intensity is Eave = 8.13×1013 erg·cm-1· s-1·ster-1 at h = 1100 km, which confirms that the HeI D3 emission is negatively correlated with the solar activity. The surface brightness reaches a maximum of F ave = 8.25×105 erg·cm-2·s-1·ster-1 at about h ≈ (1290 ± 75) km and then decreases exponentially with height when h >1800 km with an exponential index β = 1.63×10-8 cm-1. | LI Hui JI HaiSheng NI HouKun ZHANG HaiYing ZHANG YaNan LIU HongRui DENG YuanYong WANG DongGuang DU QiuSheng ZHOU TuanHui LI JingWei SHEN JinHua | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 7 | A new process for preparing dialdehydes bycatalytic oxidation of cyclic olefines with aqueous hydrogen peroxide显示文摘 | Deng Jinfa Xu Xinhua Chen Haiying | 1992 | Tetrahedron1992，48，17： | 1 |
| 8 | A new process for preparing dialdehydes by catalytic oxidation of cyclic olefins with aqueous hydrogen peroxide显示文摘 | DENG Jinfa XU Xinhua CHEN Haiying | 1992 | Tetrahedron1992，48，17： | 1 |
| 9 | Radio-frequency system of the high energy photon source显示文摘Purpose High energy photon source is a 6 GeV diffraction-limited storage ring light source currently under construction in Beijing.A low-frequency fundamental radio-frequency(rf)system of 166.6 MHz was proposed to accommodate the accelerator physics design.Superconducting rf(srf)technologies were chosen for the storage ring rf accompanied by solid-state power amplifiers and digital low-level rf controls.The design of the rf system was completed,and the parameters are frozen.Elucidation of the rf design with key parameters is desired.Methods The requirements from the accelerator physics design will be presented followed by the detailed rf design.The logic behind the choice of key rf parameters is elaborated.The configuration of the entire rf system is presented.Results and conclusions The fundamental srf cavity of 166.6 MHz was designed to accelerate the ultrarelativistic electron beam.Heavy damping of higher-order modes in these cavities is required to avoid the coupled bunch instabilities.An active third harmonic srf of 499.8 MHz was adopted to realize the required rf gymnastics.Normal-conducting 5-cell cavities will be used for the booster rf.Solid-state amplifiers of 2.4 MW in total will be installed at HEPS to drive these cavities in the booster and the storage ring.A digital low-level rf system will be used to regulate rf field inside each cavity with high stabilities.The rf configuration during the commissioning and the operation scenarios are also presented. | Pei Zhang Jin Dai Ziwei Deng Lin Guo Tongming Huang Dongbing Li Jian Li Zhongquan Li Haiying Lin Yuanli Luo Qiang Ma Fanbo Meng Zhenghui Mi Qunyao Wang Haisheng Xu Xinying Zhang Facheng Zhao Hongjuan Zheng | 2023 | Radiation Detection Technology and Methods2023，7，1： | 1 |
| 10 | A new process for preparing dialdehydes by catalytic oxidation of cyclic olefins with aqueous hydrogen peroxide显示文摘 | Deng Jingfa Xu Xinhua Chen Haiying | 1992 | Tetrahedron1992，48，17： | 1 |
| 11 | An amperometric lactate sensor employing tetrathiafulvalene in nation film as electron shuttle显示文摘 | LIU Haiying DENG Jiaqi | 1995 | Eiectrochim Acta1995，40，： | 1 |
| 12 | Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells 显示文摘 | Liu Haiying Deng Suo Zhao Zihan | 2011 | Mol Biol Rep2011，38，3： | 1 |
| 13 | A Novel Amorphous Nickel- Tungsten-Phosphorus Alloy Powder and Its Hydrogenation Activity显示文摘 | Deng Jingfa Chen Haiying | 1993 | J Mater Sci Lett1993，12，19： | 1 |
| 14 | Development of a 500-MHz waveguide directional coupler with high directivity for HEPS显示文摘Purpose In order to achieve a high-precision measurement of the incident and the reflected power,a WR1800 rectangular waveguide directional coupler with high directivity and high power level has been in-house developed.Multiple couplers will be installed in the 500-MHz high-power radio-frequency transmission lines delivering 200-kW continuous-wave power for the High Energy Photon Source(HEPS).Methods The directional coupler adopts the design scheme of primary and secondary transmission lines and coaxial coupling-head structure.The shape and dimensional parameters of the coupling head were carefully optimized by using microwave simulation codes.An optimum directivity of 64 dB was achieved in simulations.Results and conclusions A prototype coupler was subsequently manufactured,and its directivity was measured to be 48.2 dB following a rigorous calibration procedure,largely exceeding the design goal and the commercial product.The coupler was then connected to an existing 500-MHz klystron system,and a high-power test with short-circuit termination was conducted.The high directivity of the coupler was confirmed up to 200 kW.During the 6 hours of power aging with continuous-wave 200 kW in a standing-wave setup,no performance degradation was observed on the coupler.The coupler temperature was measured to be 20◦C above the ambient environment.The design requirements were comfortably fulfilled.These constitute thefirst in-house development of a large-size waveguide directional coupler with high directivity and high power level for HEPS.The design,fabrication,and performance tests of the directional coupler are presented. | Yuanli Luo Jian Li Pei Zhang Qiang Ma Haiying Lin Tongming Huang Fanbo Meng Facheng Zhao Ziwei Deng | 2022 | Radiation Detection Technology and Methods2022，6，3： | 1 |
| 15 | Different therapeutic proportion of patients undergone coronary angiography in the era of development in MSCT显示文摘Objective To study the different therapeutic proportion of the patient populations undergone coronary angiography (CAG) in the era of development in multislice spiral computed tomography(MSCT). Methods Two hundred and fifty four consecutive patients(mean age 59.24±10.65) , who underwent CAG at Daxing Hospital from February 2007 through October 2007, were enrolled, 160 patients were male and 94 were female. By evaluating from the coronary angiogram, the patients were not diagnosed to have coronary heart disease(CHD) with less than 50% diameter stenosis of coronary artery; the patients to have CHD with more than or equal to 50% stenosis of coronary artery; the patients were performed the procedure of percutaneous coronary intervention(PCI) with more than or equal to 70% stenosis; the patients were proposed to have coronary aortic bypass graft(CABG) surgery with left main coronary artery lesions or diffuse triple coronary artery lesions. Results In the 254 consecutive patients, 59 patients(23.2%) had not been diagnosed to have CHD; 195(76.8%)to have CHD, of these patients with CHD, 49 patients(19.3%)were not indicated for PCI (including the patients receiving follow-up coronary angiography after stenting), 81(31.9%)had been performed the procedure of stent implantation, 57(22.4%)proposed to have CABG, 8(3.1%)the procedure of PCI had not been successful, or had not been performed because of patients opposing to this therapy. Conclusion Multislice spiral computed tomography can be applied as a non-invasive screening tool to exclude the presence of CHD, to increase the positive proportion of the populations with CHD in all patients receiving coronary angiograhpy, to avoid the use of CAG in a subset of | Juan Deng Wenbin Wang Shuoqing Hu Yue Xiao Feng Liang Xuewei Guo Haiying Wang Pengchuan Zhang Dayi Hu Tianchang Li Chuzhong Tang Jiyun Wang Changlin Lu | 2008 | Journal of Geriatric Cardiology2008，5，2： | 0 |
| 16 | BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models显示文摘t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine production.Therefore,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great interest.However,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy.Here,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell function.In addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity.In the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook effect.Furthermore,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.Taken together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation. | Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wangl Ye Liu | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 17 | Whole‑genome transcriptome and DNA methylation dynamics of pre‑implantation embryos reveal progression of embryonic genome activation in buffaloes显示文摘Background During mammalian pre-implantation embryonic development(PED),the process of maternal-to-zygote transition(MZT)is well orchestrated by epigenetic modification and gene sequential expression,and it is related to the embryonic genome activation(EGA).During MZT,the embryos are sensitive to the environment and easy to arrest at this stage in vitro.However,the timing and regulation mechanism of EGA in buffaloes remain obscure.Results Buffalo pre-implantation embryos were subjected to trace cell based RNA-seq and whole-genome bisulfite sequencing(WGBS)to draw landscapes of transcription and DNA-methylation.Four typical developmental steps were classified during buffalo PED.Buffalo major EGA was identified at the 16-cell stage by the comprehensive analy-sis of gene expression and DNA methylation dynamics.By weighted gene co-expression network analysis,stage-spe-cific modules were identified during buffalo maternal-to-zygotic transition,and key signaling pathways and biological process events were further revealed.Programmed and continuous activation of these pathways was necessary for success of buffalo EGA.In addition,the hub gene,CDK1,was identified to play a critical role in buffalo EGA.Conclusions Our study provides a landscape of transcription and DNA methylation in buffalo PED and reveals deeply the molecular mechanism of the buffalo EGA and genetic programming during buffalo MZT.It will lay a foundation for improving the in vitro development of buffalo embryos. | Penghui Fu Du Zhang Chunyan Yang Xiang Yuan Xier Luo Haiying Zheng Yanfei Deng Qingyou Liu Kuiqing Cui Fei Gao Deshun Shi | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
| 18 | Control on Gradient Adhesive Loading of Porous Laminate:Effects on Multiple Performance of Composites with Bamboo Bundle and Sliver显示文摘Elementary units“bamboo bundle”and“bamboo sliver”were processed and cross-linked as“bamboo-bundle veneer(BBV)”and“bamboo-sliver veneer(BSV)”for preparation of laminated composites.The concept of“high-content-adhesive surface treatment”was raised to improve boards’performance,rather than increasing adhesive absorption of every layer’s porous unit.That is,some BBVs experienced an extra“dipping&drying”to absorb more resin(named“HBBV”).The effect of the amount of knitting threads was also discussed for influencing BBV’s quality.Results indicated that light transmittance of BBVs decreased as the amount of threads added from 3 to 8,while mechanical stiffness increased.Adding two skin layers of HBBVs symmetrically was helpful to enhance 24-hour underwater and 28-hour“boil-dry-boil”dimensional stability for boards with BSVs as core,while more than two pairs of HBBVs were needed to improve 28-hour“boil-dry-boil”dimensional stability of boards with BBVs as core.Two symmetrical surface layers of BBVs/HBBVs provided BSV-boards/BBV-boards with greater bending resistance,while such“surface treatment”would not raise shearing strength of BSV-boards upon 28-hour“boil-dry-boil”treatment.Besides,the data obtained from drop-hammer impact test indicated that more than two pair of surface BBVs or HBBVs were required for significant improvement in anti-impact property. | Jianchao Deng Haiying Zhou Fuming Chen Shuangbao Zhang Ge Wang | 2021 | Journal of Renewable Materials2021，9，9： | 0 |
| 19 | Tet酶调控端粒和基因组稳定性的作用和机制显示文摘Tets家族催化5-甲基胞嘧啶转变为5-羟甲基胞嘧啶。在小鼠胚胎干细胞中单独干扰Tet1或/和Tet2,伴随着端粒重组下降,导致端粒长度缩短和基因组稳定性异常。 | Jiao Yang Renpeng Guo Hua Wang Xiaoying Ye Zhongcheng Zhou Jiameng Dan Haiying Wang Peng Gong Wei Deng Yu Yin Shi Qing Mao Lingbo Wang Junjun Ding Jinsong Li David L.Keefe Meelad M.Dawlaty Jianlong Wang Guo Liang Xu 刘林 | 2017 | 科学新闻2017，19，4： | 0 |
| 20 | Chemical looping conversion of methane via Fe_(2)O_(3)-LaFeO_(3)calcined from LaFe-MOF precursor显示文摘The effective utilization of natural gas resources is a promising option for the implementation of the'dual carbon'strategy.However,the capture of carbon dioxide with relatively lower concentration after the combustion of natural gas is the crucial step.Fortunately,the lattice oxygen is used for chemical cycle conversion of methane to overcome the shortcomings mentioned above.A method was proposed to synthesize perovskite for methane cycle conversion using metal organic framework as a precursor.Morphology and pore structure of Fe_(2)O_(3)-LaFeO_(3)composite oxides were regulated by precursor synthesis conditions and calcination process.Moreover,the chemical looping conversion performance of methane was evaluated.The results showed that the pure phase precursor of La[Fe(CN)_(6)]·5H_(2)O was synthesized with the specific surface area of 23.91 m^(2)·g^(-1)under the crystallization of 10 h and the pH value of10.5.Fe_(2)O_(3)-LaFeO_(3)was obtained by controlled calcination of La[Fe(CN)_(6)]·5H_(2)O and Fe_(2)O_(3)with variable mass ratio.The selectivity of CO_(2)can reach more than 99%under the optimal parameters of methane chemical looping conversion:m(Fe_(2)O_(3)):m(LaFeO_(3))=2:1,the reaction temperature is 900℃,the lattice oxygen conversion is less than 40%.Fe_(2)O_(3)-LaFeO_(3)still has good phase and structure stability after five redox reaction and regeneration cycles. | Jitong Deng Yongjun Zhang Xiaopeng Wang Wei Zhang Hongjing Han Haiying Wang Huimin Yuan Yanan Zhang Yanguang Chen | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
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