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| 1 | Synthesis of Needle-like Aragonite from Limestone in the Presence of Mag- nesium Chloride显示文摘 | Hu Zeshan Shao Minghao Cai Qiang | 2009 | Journal of Materials Processing Techonlogy2009，209，： | 1 |
| 2 | Smart epidermal electrophysiological electrodes:Materials,structures,and algorithms显示文摘Epidermal electrophysiological monitoring has garnered significant attention for its potential in medical diagnosis and healthcare,particularly in continuous signal recording.However,simultaneously satisfying skin compliance,mechanical properties,environmental adaptation,and biocompatibility to avoid signal attenuation and motion artifacts is challenging,and accurate physiological feature extraction necessitates effective signal-processing algorithms.This review presents the latest advancements in smart electrodes for epidermal electrophysiological monitoring,focusing on materials,structures,and algorithms.First,smart materials incorporating self-adhesion,self-healing,and self-sensing functions offer promising solutions for long-term monitoring.Second,smart meso-structures,together with micro/nanostructures endowed the electrodes with self-adaption and multifunctionality.Third,intelligent algorithms give smart electrodes a“soul,”facilitating faster and more-accurate identification of required information via automatic processing of collected electrical signals.Finally,the existing challenges and future opportunities for developing smart electrodes are discussed.Recognized as a crucial direction for next-generation epidermal electrodes,intelligence holds the potential for extensive,effective,and transformative applications in the future. | Yuanming Ye Haochao Wang Yanqiu Tian Kunpeng Gao Minghao Wang Xuanqi Wang Zekai Liang Xiaoli You Shan Gao Dian Shao Bowen Ji | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
| 3 | Recent Progress and Applications of HfO_(2)-Based Ferroelectric Memory显示文摘The discovery of ferroelectricity in hafnium oxide (HfO_(2)) based thin films in 2011 renewed the interest inferroelectrics. These new ferroelectrics possess completely different crystal morphology with conventional perovskiteferroelectrics, and present more robust ferroelectric properties upon aggressive scaling and compatibility withstandard integrated circuit fabrication processes. In this article, we give a brief introduction to the conventionalferroelectric memories, then review the basic properties, recent progress, and memory applications of theseHfO_(2)-based ferroelectrics. | Xiao Liu Xiangshun Geng Houfang Liu Minghao Shao Ruiting Zhao Yi Yang Tian-Ling Ren | 2023 | Tsinghua Science and Technology2023，28，2： | 0 |
| 4 | SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway显示文摘Lenvatinib has become the first-line therapy in advanced hepatocellular carcinoma(HCC),but its efficacy is still limited because of the inevitable development of resistance.It has been reported that cellular cholesterol levels are associated with tyrosine kinase inhibitor(TKI)efficacy.Here,we show that betulin,a sterol regulatory elementbinding protein 2(SREBP2)inhibitor,markedly enhances the anti-tumor effect of lenvatinib in HCC both in vitro and in vivo.Our results also show that the combination treatment of lenvatinib and betulin synergistically inhibits the proliferation and clonogenicity of HCC cells.The mRNA and protein expressions of IL-1βare markedly decreased in HCC cells treated with betulin,while the sensitivity of HCC cells to lenvatinib is enhanced.Moreover,we find that the knockdown of IL-1βalso enhances the efficacy of lenvatinib,and recombinant IL-1βprotein rescues cell viability,which is reduced by lenvatinib in HCC cells.Further mechanistic studies indicate that betulin decreases the level of IL-1βin HCC cells by inhibiting the mTOR signaling pathway.Finally,the growth of the tumors in xenograft mouse models subjected to combination treatment is significantly suppressed.In summary,our study reveals that the SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway,which may be a promising therapeutic strategy for patients with HCC. | Minghao Fan Zhenmei Chen Weiqing Shao Yiran Chen Zhifei Lin Chenhe Yi Yitong Li Lu Lu Yu Zhou Jing Lin | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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