|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Warming moxibustion attenuates inflammation and cartilage degradation in experimental rabbit knee osteoarthritis显示文摘OBJECTIVE:To explore the molecular mechanism of warming moxibustion(WM)in knee osteoarthritis(KOA).METHODS:The knee joints of 40 New Zealand rabbits were placed in a plaster cast in an extended position to establish a KOA model.The animals were randomly divided into four groups:the control group,model group,WM group,and diclofenac(DF)group.Hematoxylin-eosin staining and the modified Mankin score were applied to evaluate the histopathological changes.Chondrocyte apoptosis was determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay.Western blotting and real-time quantitative polymerase chain reaction were performed to measure the expression of interleukin-1β(IL-1β),prostaglandin E receptor 3(PTGER3),a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-5(ADAMTS-5),matrix metalloproteinase-13(MMP-13),and C-terminal telopeptides of collagen typeⅡ(CTX-Ⅱ)in cartilage tissues of the different groups.The concentrations of IL-1β,PTGER3,and CTX-Ⅱin serum were detected by the enzyme-linked immunosorbent assay.RESULTS:Rabbits with KOA in the WM and DF groups showed significantly reduced cartilage erosion and Mankin scores,compared with the untreated rabbits.The number of TUNEL-positive cells observed in the WM group was much fewer than that in the model group.The expression of PTGER3,MMP-13,CTX-Ⅱ,IL-1β,and ADAMTS-5 in cartilage tissues was remarkably downregulated following therapy with WM and DF.Moreover,a marked reduction was observed in the serum levels of IL-1β,PTGER3,and CTX-Ⅱin the WM and DF groups.CONCLUSION:WM exerts favorable therapeutic effects on articular injuries of KOA by regulating the expression of inflammatory and cartilage degradation-related cytokines. | LIU Di WU Yongli LI Chun WANG Minglei MA Xiaoxiu LIU Junwei ZHANG Yanling YANG Lei | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 9 |
| 2 | Classified real-time flood forecasting by coupling fuzzy clustering and neural network显示文摘This paper presented a new classified real-time flood forecasting framework by integrating a fuzzy clustering model and neural network with a conceptual hydrological model. A fuzzy clustering model was used to classify historical floods in terms of flood peak and runoff depth, and the conceptual hydrological model was calibrated for each class of floods. A back-propagation (BP) neural network was trained by using real-time rainfall data and outputs from the fuzzy clustering model. BP neural network provided a rapid on-line classification for real-time flood events. Based on the on-line classification, an appropriate parameter set of hydrological model was automatically chosen to produce real-time flood forecasting. Different parameter sets was continuously used in the flood forecasting process because of the changes of real-time rainfall data and on-line classification results. The proposed methodology was applied to a large catchment in Liaoning province, China. Results show that the classified framework provided a more accurate prediction than the traditional non-classified method. Furthermore, the effects of different index weights in fuzzy clustering were also discussed. | Minglei REN Bende WANG Qiuhua LIANG Guangtao FU | 2010 | International Journal of Sediment Research2010，25，2： | 8 |
| 3 | In situ construction of porous hierarchical(Ni3-xFex)FeN/Ni heterojunctions toward efficient electrocatalytic oxygen evolution显示文摘As a choke point in water electrolysis,the oxygen evolution reaction(OER)suffers from the severe electrode polarization and large overpotential.Herein,the porous hierarchical hetero-(Nis Fe)FeN/Ni catalysts are in situ constructed for the eficient electrocatalytic OER.X-ray absorption fine structure characterizations reveal the strong Ni-Fe bimetallic interaction in(Niz Fex)FeN/Ni.Theoretical study indicates the heterojunction and bimetallic interaction decrease the free-energy change for the rate-limiting step of the OER and the overpotential thereof.In addition,the high conductivity and porous hierarchical morphology favor the electron transfer,electrolyte access and O2 release.Consequently,the optimized catalyst achieves a low overpotential of 223 mV at 10 mA.cm^-2,a small Tafel slope of 68 mV:dec^-1,and a high stability.The excellent performance of the optimized catalyst is also demonstrated by the overall water electrolysis with a low working voltage and high Faradaic efficiency.Moreover,the correlation between the structure and performance is well established by the experimental characterizations and theoretical calculations,which confirms the origin of the OER activity from the surface metal oxyhydroxide in situ generated upon applying the current.This study suggests a promising approach to the advanced OER electrocatalysts for practical applications by constructing the porous hierarchical metal-compound/metal heterojunctions. | Minglei Yan Kun Mao Peixin Cui Chi Chen Jie Zhao Xizhang Wang Lijun Yang Hui Yang Qiang Wu Zheng Hu | 2020 | Nano Research2020，13，2： | 8 |
| 4 | Extractive Distillation of Methyl Acetate-Methanol Azeotrope Using [DMIM]DMP as Solvent显示文摘In order to separate methyl acetate and methanol azeotrope, the ionic liquid(IL) 1,3-dimethylimidazolium dimethylphosphate([DMIM]DMP) was used as the solvent. The Aspen Plus software was used to design and optimize the extractive distillation process. Under the optimized conditions, the mass fractions of methyl acetate and methanol were both above 99.5%. Compared with the dimethyl sulfoxide(DMSO) process, the [DMIM]DMP process has the advantages of saving energy and lower equipment investment cost. The result shows that using [DMIM]DMP as the solvent to separate a methyl acetate and methanol azeotrope has better prospect in industrial application. | Li Jing Wang Keliang Lian Minglei Li Zhi Du Tingzhao | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，4： | 6 |
| 5 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 6 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 7 | A phase I study of nimotuzumab plus docetaxel in chemotherapy- refractory/resistant patients with advanced non-small-cell lung cancer显示文摘Background: To determine the safety and therapeutic efficacy of nimotuzumab(h-R3) combined with docetaxel in advanced non-small-cell lung cancer(NSCLC) patients who have failed to respond to prior first-line chemotherapy.Methods: In this single-center, open-label, dose-escalating phase I trial, patients with epidermal growth factor receptor(EGFR)-expressing stage IV NSCLC were treated with nimotuzumab plus docetaxel according to a dose escalation schedule. The safety and efficacy of the combination treatment were observed and analyzed.Results: There were 12 patients with EGFR-expressing stage IV NSCLC enrolled. The dose of nimotuzumab was escalated from 200 to 600 mg/week. The longest administration of study drug was 40 weeks at the 600 mg/week dose level. Grade III–IV toxicities included neutropenia and fatigue, and other toxicities included rash. Dose-limiting toxicity occurred with Grade 3 fatigue at the 200 mg dose level of nimotuzumab and Grade 4 neutropenia with pneumonia at the 600 mg dose level of nimotuzumab. No objective responses were observed, and stable disease was observed in eight patients(66.7%). The median progression-free survival(PFS) was 4.4 months in all patients, 1.3 months in patients with the EGFR mutation, and 4.4 months in those with wild type EGFR(EGFR WT). The median survival time(MST) was 21.1 months in all patients, 21.1 months in patients with EGFR mutation, and 26.4 months in patients with EGFR WT.Conclusions: Nimotuzumab and docetaxel combination therapy was found to be well tolerated and efficacious. Further study of nimotuzumab is warranted in advanced NSCLC patients. | Jun Zhao Minglei Zhuo Zhijie Wang Jianchun Duan Yuyan Wang Shuhang Wang Tongtong An Meina Wu Jie Wang | 2016 | Chinese Journal of Cancer Research2016，28，1： | 3 |
| 8 | Lead-bismuth-free piezoceramics (Na_(0.5)K_(0.44)Li_(0.06))Nb_(0.95)Sb_(0.05)O_3-Na_(5.6)Cu_(1.2)Sb_(10)O_(29)显示文摘Newly developed sintering aid Na5.6Cu1.2Sb10O29 (NCS) and lead-bismuth-free piezoceramics (Na0.5K0.44Li0.06) Nb0.95Sb0.05O3 (NKLNS) were prepared by the conventional solid state reaction. The effects of sintering aid NCS on the electrical properties of NKLNS were investigated. It was found that the addition of a proper amount of sintering aid NCS to NKLNS is effective not only on improving the density and the piezoelectric activity, but also on reducing the dielectric loss of NKLNS. The NKLNS doped with 0.4 mol% NCS has a piezoelectric constant d33 as high as 261pC/N and an electromechanical coupling factor k33 above 60%. These results show that NCS-doped NKLNS is a promising and practicable candidate for lead-bismuth-free piezoceramics. | ZHENG LiMei WANG JinFeng ZANG GuoZhong ZHAO MingLei QI Peng DU Juan SU WenBin MING BaoQuan | 2007 | Chinese Science Bulletin2007，52，4： | 2 |
| 9 | Progress in the beam commissioning of separated function RFQ accelerator显示文摘Separated Function RFQ (SFRFQ) was proposed as a post accelerator of RFQ to accelerate heavy ions at low frequency. It introduces gap accelerating in the quadrupole electrodes, and therefore it has higher accelerating efficiency than the conventional RFQ accelerator. The first SFRFQ prototype cavity has been specially designed and constructed as a post accelerator to accelerate O+ beam from 1.03 MeV to 1.64 MeV. Based on accomplishment of low power measurement and high power test, the beam commissioning was carried out to verify its feasibility. The measured energy gain per cell of SFRFQ is 45 keV, which is about 60% higher than that of Peking University Integral Split Ring (ISR) RFQ. | MingLei Kang (1) YuanRong Lu (1) Zhi Wang (1) Kun Zhu (1) XueQing Yan (1) ZhiYu Guo (1) ShuLi Gao (1) ShiXiang Peng (1) Ao Liu (2) JiaXun Fang (1) JiaEr Chen (1) | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 2 |
| 10 | A reviewon engineering application of FRP material: case studyand practice 显示文摘 | Ma Minglei Wang Guiling Miao Dongmei | 2013 | Applied Mechanics and Materials?2013，，： | 1 |
| 11 | FRPStructure Design Method Based On Equality Of Stiff-ness :Case Study And Practice 显示文摘 | Ma Minglei Wang Guiling Lian bayou | 2012 | Engineering Re-view2012，32，3： | 1 |
| 12 | Promoting surface reconstruction of NiFe layered double hydroxides via intercalating[Cr(C_(2)O_(4))_(3)]^(3-)for enhanced oxygen evolution显示文摘Rationally manipulating surface reconstruction of catalysts for water oxidation,inducing formation and dynamic accumulation of catalytically active centers still face numerous challenges.Herein,the introduction of[Cr(C_(2)O_(4))_(3)]^(3-)into NiFe LDHs by intercalation engineering to promote surface reconstruction achieves an advanced oxygen evolution reaction(OER)activity.In view of the weak electronegativity of Cr^(3+) in[Cr(C_(2)O_(4))_(3)]^(3-),the intercalation of[Cr(C_(2)O_(4))_(3)]^(3-)is expected to result in an electron-rich structure of Fe sites in NiFe LDHs,and higher valence state of Ni can be formed with the charge transfer between Fe and Ni.The optimized electronic structure of NiFe-[Cr(C_(2)O_(4))_(3)]^(3-)-LDHs with more active Ni^(3+) species and the expedited dynamic generation of Ni^(3+) (Fe)OOH phase during the OER process contributed to its excellent catalytic property,revealed by in situ X-ray absorption spectroscopy,Raman spectroscopy,and quasi-in situ X-ray photoelectron spectroscopy.With the modulated electronic structure of metal sites,NiFe-[Cr(C_(2)O_(4))_(3)]^(3-)-LDHs exhibited promoted OER property with a lower overpotential of 236 mV at the current density of 10 mA cm^(-2).This work illustrates the intercalation of conjugated anion to dynamically construct desired Ni^(3+) sites with the optimal electronic environment for improved OER electrocatalysis. | Yujie Wu Minglei Song Yu-Cheng Huang Chung-Li Dong Yingying Li Yuxuan Lu Bo Zhou Dongdong Wang Jianfeng Jia Shuangyin Wang Yanyong Wang | 2022 | Journal of Energy Chemistry2022，31，11： | 1 |
| 13 | A review on engineering application of FRP material z case study and practice 显示文摘 | Ma Minglei Wang Guiling Miao Dongmei | 2013 | Applied Mechanics and Materials2013，，： | 1 |
| 14 | FRP Structure Design Method Based On Equality Of Stiff- ness: Case Study And Practice 显示文摘 | Ma Minglei Wang Guiling Lian Bayou | 2012 | Engineering Re- view2012，32，3： | 1 |
| 15 | Preparation and characterization of multiresponsive polymer composite microspheres with core–shell structure显示文摘 | Jie Cai Jia Guo Minglei Ji Wuli Yang Changchun Wang Shoukuan Fu | 2007 | Colloid and Polymer Science2007，，14： | 1 |
| 16 | A rhodamine-based chromogenic and fluorescent chemosensor for copper ion in aqueous media显示文摘 | Minglei Zhao Xiao-Feng Yang Shenfeng He Liping Wang | 2008 | Sensors & Actuators: B Chemical2008，，2： | 1 |
| 17 | Clinical outcomes of atezolizumab in combination with etoposide/platinum for treatment of extensive-stage small-cell lung cancer:A real-world,multicenter,retrospective,controlled study in China显示文摘Objective:Atezolizumab along with chemotherapy has prolonged the survival of patients with extensive-stage small-cell lung cancer(ES-SCLC)worldwide,although real-world(RW)data are lacking in China.This study was designed to evaluate the efficacy and clinical outcomes of atezolizumab plus etoposide/platinum(EP).Methods:Data obtained in this retrospective study were captured from six oncology units of five medical facilities from January 2019 to April 2022.For first-line treatments,atezolizumab combined with EP vs.EP alone,we primarily evaluated progression-free survival(PFS);other efficacy indicators,including overall survival(OS),objective response rate(ORR),and patterns of SCLC progression and adverse events(AEs)were assessed.Results:The primary analysis included data from 225 patients,of whom 133 received EP along with atezolizumab(atezolizumab group)and 92 received EP alone(EP group).The PFS duration of the atezolizumab group[7.10 months;95%confidence interval(95%CI),6.53-9.00]exceeded that of the EP group(6.50 months;95%CI,4.83-7.53).Overall,the hazard ratio(HR)was 0.69(95%CI,0.49-0.97)(P=0.029);particularly,the HR was 0.54(95%CI,0.36-0.80)among patients undergoing≥4 chemotherapy cycles and 0.33(95%CI,0.20-0.56)among individuals with atezolizumab maintenance.The ORR and disease-control rate(DCR)were similar between the two groups.Because of incomplete OS data,the median OS was not determined for either group.Bone marrow suppression was the most common AE detected(58.6%)in the atezolizumab group.Immune-related AEs occurred in 19 patients in the atezolizumab group(14.3%),with only one case of grade 3 encephalitis.Conclusions:This RW study in China demonstrated improved clinical outcomes of atezolizumab along with EP for ES-SCLC,particularly in the chemosensitive population.These results align with the results of the IMpower133 study,although the impact of this treatment modality on OS warrants additional follow-up studies. | Hanxiao Chen Xiangjuan Ma Jie Liu Yu Yang Yong Fang Liping Wang Jian Fang Jun Zhao Minglei Zhuo | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
| 18 | Influence of Chemotherapy on EGFR Mutation Status Among Patients With Non–Small-Cell Lung Cancer显示文摘 | Hua Bai Zhijie Wang Keneng Chen Jun Zhao J. Jack Lee Shuhang Wang Qinghua Zhou Minglei Zhuo Li Mao Tongtong An Jianchun Duan Lu Yang Meina Wu Zhen Liang Yuyan Wang Xiaozheng Kang Jie Wang | 2012 | Journal of Clinical Oncology2012，，25： | 1 |
| 19 | Synthesis of transition-metal phosphides from oxidic precurors by re- duction in hydrogen plasma 显示文摘 | GUAN Jie WANG Yao QIN Minglei | 2009 | Journal of Solid State Chemistry2009，182，6： | 1 |
| 20 | Ferroelectric relaxor as a critical state显示文摘After revisiting models for the ferroelectric relaxors, we notice that the models can be classified into two categories. One group models are directly based upon the compositional fluctuations, such as Smolenskii's theory and SRBRF model. The other models are experimental phenomenon oriented, such as macro-micro domain crossover and superparaelectric state. The later explanations imply that the ferroelectric relaxor is in a critical state. The unusual field induced phase transition in ferroelectric relaxor also suggests that this is a critical phenomenon with first order phase transition feature. Therefore within the framework of effective field approach and with introducing the concept of quantum temperature scale, we reproduce the diffused phase transition of the dielectric constant and the field induced phase transition. It seems that the larger quantum fluctuation at low temperature depresses the ferroelectricity in ferroelectric relaxors, and results in their unusual physical properties. | WANG ChunLei LI JiChao ZHAO MingLei LIU Jian ZHANG JiaLiang | 2009 | Science China(Technological Sciences)2009，52，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员