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| 1 | The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats显示文摘The liver is an important organ for drugs disposition,and thus how to accurately evaluate hepatic clearance is essential for proper drug dosing.However,there are many limitations in drug dosage adjustment based on liver function and pharmacogenomic testing.In this study,we evaluated the ability of endogenous glycochenodeoxycholate-3-sulfate(GCDCA-S)and 4β-hydroxycholesterol(4β-HC)plasma levels to evaluate organic anion-transporting polypeptide(Oatps)-mediated hepatic uptake and Cyp3 a-meidated metabolism of atorvastatin(ATV)in rats.The concentration of ATV and its metabolites,2-OH ATV and 4-OH ATV,was markedly increased after a single injection of rifampicin(RIF),an inhibitor of Oatps.Concurrently,plasma GCDCA-S levels were also elevated.After a single injection of the Cyp3 a inhibitor ketoconazole(KTZ),plasma ATV concentrations were significantly increased and 2-OH ATV concentrations were decreased,consistent with the metabolism of ATV by Cyp3 a.However,plasma 4β-HC was not affected by KTZ treatment despite it being a Cyp3 a metabolite of cholesterol.After repeated oral administration of RIF,plasma concentrations of ATV,2-OH ATV and 4-OH ATV were markedly increased and the hepatic uptake ratio of ATV and GCDCA-S was decreased.KTZ did not affect plasma concentrations of ATV,2-OH ATV and 4-OH ATV,but significantly decreased the metabolic ratio of total and 4-OH ATV.However,the plasma level and hepatic metabolism of 4β-HC were not changed by KTZ.The inhibition of hepatic uptake of GCDCA-S by RIF was fully reversed after a 7-d washout of RIF.Plasma concentration and hepatic uptake ratio of GCDCA-S were correlated with the plasma level and hepatic uptake of ATV in rats with ANIT-induced liver injury,respectively.These results demonstrate that plasma GCDCA-S is a sensitive probe for the assessment of Oatps-mediated hepatic uptake of ATV.However,Cyp3 a-mediated metabolism of ATV was not predicted by plasma 4β-HC levels in rats. | Yanrong Ma Mingyan Xin Yuanjie Wen Huan Wang Guoqiang Zhang Jianye Dai Xin-An Wu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，4： | 0 |
| 2 | Research on motor rotation anomaly detection based on improved VMD algorithm显示文摘Purpose–The electromechanical brake system is leading the latest development trend in railway braking technology.The tolerance stack-up generated during the assembly and production process catalyzes the slight geometric dimensioning and tolerancing between the motor stator and rotor inside the electromechanical cylinder.The tolerance leads to imprecise brake control,so it is necessary to diagnose the fault of the motor in the fully assembled electromechanical brake system.This paper aims to present improved variational mode decomposition(VMD)algorithm,which endeavors to elucidate and push the boundaries of mechanical synchronicity problems within the realm of the electromechanical brake system.Design/methodology/approach–The VMD algorithm plays a pivotal role in the preliminary phase,employing mode decomposition techniques to decompose the motor speed signals.Afterward,the error energy algorithm precision is utilized to extract abnormal features,leveraging the practical intrinsic mode functions,eliminating extraneous noise and enhancing the signal’s fidelity.This refined signal then becomes the basis for fault analysis.In the analytical step,the cepstrum is employed to calculate the formant and envelope of the reconstructed signal.By scrutinizing the formant and envelope,the fault point within the electromechanical brake system is precisely identified,contributing to a sophisticated and accurate fault diagnosis.Findings–This paper innovatively uses the VMD algorithm for the modal decomposition of electromechanical brake(EMB)motor speed signals and combines it with the error energy algorithm to achieve abnormal feature extraction.The signal is reconstructed according to the effective intrinsic mode functions(IMFS)component of removing noise,and the formant and envelope are calculated by cepstrum to locate the fault point.Experiments show that the empirical mode decomposition(EMD)algorithm can effectively decompose the original speed signal.After feature extraction,signal enhancement and fault identification,the motor mechanical fault point can be accurately located.This fault diagnosis method is an effective fault diagnosis algorithm suitable for EMB systems.Originality/value–By using this improved VMD algorithm,the electromechanical brake system can precisely identify the rotational anomaly of the motor.This method can offer an online diagnosis analysis function during operation and contribute to an automated factory inspection strategy while parts are assembled.Compared with the conventional motor diagnosis method,this improved VMD algorithm can eliminate the need for additional acceleration sensors and save hardware costs.Moreover,the accumulation of online detection functions helps improve the reliability of train electromechanical braking systems. | Fuzhao Chen Zhilei Chen Qian Chen Tianyang Gao Mingyan Dai Xiang Zhang Lin Sun | 2024 | Railway Sciences2024，3，1： | 0 |
| 3 | DEARSENICATION FROM COBALT-ARSENIC CONCENTRATE BY VACUUM DISTILLATION显示文摘DEARSENICATIONFROMCOBALT-ARSENICCONCENTRATEBYVACUUMDISTILLATIONDEARSENICATIONFROMCOBALT-ARSENICCONCENTRATEBYVACUUMDISTILLATIO... | Cao, Mingyan Dai, Yongnian Sima, Zhongzhi | 1994 | 中国有色金属学会会刊:英文版1994，4，2： | 0 |
| 4 | 绿色新知显示文摘气候友好型膳食指南今年一月,丹麦推出了官方气候友好型的膳食指南,建议民众多吃豆类、水果、坚果等富含植物的食物,减少肉类食用量,选择低脂乳制品。推出这项指南,是因为通过调整丹麦人的饮食习惯,就可以大大减排. | MINGYAN LI RENAC DAI | 2021 | 世界时装之苑2021，，6： | 0 |
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