|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical characteristics of 310 SARS-CoV-2 Omicron variant patients and comparison with Delta and Beta variant patients in China显示文摘Although the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant has spread,data on the clinical characteristics of infected patients are limited.In this study,the demographic,clinical characteristics,and laboratory data of 310 SARS-CoV-2 Omicron variant patients treated at Haihe Hospital of Tianjin were collected and analyzed.Information on these patients was compared to 96 patients with the Delta variant of concern(VOC)and 326 patients with the Beta VOC during the previous coronavirus disease 2019(COVID-19)outbreak in Harbin.Of the 310 patients infected with the Omicron variant,the median age was 35 years.Most patients were clinically classified as mild(57.74%),and the most common symptoms were cough(48.71%),fever(39.35%),and sore throat(38.26%).The results for different vaccination groups in the Omicron group showed that the median of“SARS-CoV-2 specific IgG”after 2 or 3 doses of vaccination was higher than the unvaccinated group(all Ps<0.05).Older age was associated with a higher proportion of moderate cases and lower asymptomatic and mild cases based on clinical classifications.Compared to the Delta and Beta groups,the median age of the Omicron group was younger.The total number of asymptomatic patients and mild patients in the Omicron virus group was higher than the Delta and Beta groups(60.97%vs.54.17%vs.47.55%).This study presented the clinical characteristics of the first group of patients infected with the Omicron variant in Tianjin,China,and compared their clinical features with patients infected by the Delta and Beta variants,which would increase our understanding of the characteristics of SARS-CoV-2 Omicron variant. | Wei Yang Songliu Yang Lei Wang Yuxin Zhou Yu Xin Hongxu Li Wenjing Mu Qi Wu Lei Xu Mingyan Zhao Changsong Wang Kaijiang Yu | 2022 | Virologica Sinica2022，37，5： | 4 |
| 2 | Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay显示文摘 | Jin-zi JI Ke-jing LAO Jie HU Tao PANG Zhen-zhou JIANG Hao-liang YUAN Jing-shan MIAO Xin CHEN Shan-shan NING Hua XIANG Yu-meng GUO MingYAN Jie HU | 2014 | Acta Pharmacologica Sinica2014，35，8： | 2 |
| 3 | Activity study of a hydroxynaphthoquinone fraction from Arnebia euchroma in experimental arthritis显示文摘 | Huaying Fan Mingyan Yang Xin Che Ziliang Zhang Hui Xu Ke Liu Qinggang Meng | 2012 | Fitoterapia2012，，7： | 1 |
| 4 | Facile Synthesis of Bi2MoO6 Nanosheets@Nitrogen and Sulfur Codoped Graphene Composites for Sodium-ion Batteries显示文摘Recently,sodium-ion batteries gradually become the promising alternative to lithium-ion batteries because of cost considerations.In this work,a kind of Bi2MoO6 nanosheets@N,S codoped graphene composite is designed and fabricated for sodium storage applications.Detailed characterizations are employed to investigate its morphology,structure and chemical compositions.When evaluated as an anode material for sodium-ion batteries,the as-prepared composite is able to display a specific capacity of 254 mA·h/g after 50 cycles at a current density of 0.2 A/g,and 186 mA·h/g at 1.6 A/g during the rate capability test.As a result,the further morphology and structure optimization is still required for high performance sodium-ion batteries. | XU Xin LI Mingyan YU Ting | 2020 | Chemical Research in Chinese Universities2020，36，1： | 1 |
| 5 | Downlink System Performance of Cooperative Multiple Points Transmission with Realistic RRM Structure 显示文摘 | Wang Xiaoyi Kou Mingyan Qi Xin | 2010 | Computer Modeling and Simulation2010，，4： | 1 |
| 6 | Downlink system per-formance of cooperative multiple points transmissionwith realistic RRM structure显示文摘 | Xiaoyi W Mingyan K Xin Q | 2010 | ICCMS2010，，： | 1 |
| 7 | Malondialdehyde treatment reduced immunoreactivity of amandin and delayed its digestion显示文摘Objectives:The secondary products of lipid oxidation are one of the main factors inducing protein oxidation.The effects of oxidation treatment with malondialdehyde(MDA)on the immunoreactivity of amandin and its digestion were studied.Materials and Methods:The rabbit IgG binding ability of amandin was analyzed by western blotting,and the changes in amandin oxidation and immunoreactivity during digestion of amandin with different degrees of oxidation were investigated in combination with an almond allergen enzyme-linked immunosorbent assay kit.Alteration of linear epitopes of amandin by oxidation was investigated by liquid chromatography-tandemmass spectrometry(LC-MS/MS).Results:The results showed that the immunoreactivity of amandin was significantly reduced after 1 mmol/L MDA and 100 mmol/L MDA treat-ment.However,the 1 mmol/L MDA treatment was owing to cleavage of linear epitope peptide in amandin and oxidation of the active amino acid.The 100 mmol/L MDA treatment was due to aggregation of amandin and significant decrease in its solubility.Oxidation also reduced di-gestibility of amandin and significantly affected immunoreactivity during digestion.LC-MS/MS also identified four oxidation-prone methionine sites(aa 264-274,298-308,220-240,and 275-297)in gamma conglutinin 1.Conclusions:MDA treatment reduced the immunoreactivity of amandin.MDA treatment also led to protein aggregation,which slowed down the digestion of amandin and altered the immunoreactivity of amandin during digestion. | Xin Luo Mingyan Ai Yongyan Wu Qia Wang Hongbo Song Qun Huang Jiankang Lu | 2023 | Food Quality and Safety2023，7，2： | 0 |
| 8 | The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats显示文摘The liver is an important organ for drugs disposition,and thus how to accurately evaluate hepatic clearance is essential for proper drug dosing.However,there are many limitations in drug dosage adjustment based on liver function and pharmacogenomic testing.In this study,we evaluated the ability of endogenous glycochenodeoxycholate-3-sulfate(GCDCA-S)and 4β-hydroxycholesterol(4β-HC)plasma levels to evaluate organic anion-transporting polypeptide(Oatps)-mediated hepatic uptake and Cyp3 a-meidated metabolism of atorvastatin(ATV)in rats.The concentration of ATV and its metabolites,2-OH ATV and 4-OH ATV,was markedly increased after a single injection of rifampicin(RIF),an inhibitor of Oatps.Concurrently,plasma GCDCA-S levels were also elevated.After a single injection of the Cyp3 a inhibitor ketoconazole(KTZ),plasma ATV concentrations were significantly increased and 2-OH ATV concentrations were decreased,consistent with the metabolism of ATV by Cyp3 a.However,plasma 4β-HC was not affected by KTZ treatment despite it being a Cyp3 a metabolite of cholesterol.After repeated oral administration of RIF,plasma concentrations of ATV,2-OH ATV and 4-OH ATV were markedly increased and the hepatic uptake ratio of ATV and GCDCA-S was decreased.KTZ did not affect plasma concentrations of ATV,2-OH ATV and 4-OH ATV,but significantly decreased the metabolic ratio of total and 4-OH ATV.However,the plasma level and hepatic metabolism of 4β-HC were not changed by KTZ.The inhibition of hepatic uptake of GCDCA-S by RIF was fully reversed after a 7-d washout of RIF.Plasma concentration and hepatic uptake ratio of GCDCA-S were correlated with the plasma level and hepatic uptake of ATV in rats with ANIT-induced liver injury,respectively.These results demonstrate that plasma GCDCA-S is a sensitive probe for the assessment of Oatps-mediated hepatic uptake of ATV.However,Cyp3 a-mediated metabolism of ATV was not predicted by plasma 4β-HC levels in rats. | Yanrong Ma Mingyan Xin Yuanjie Wen Huan Wang Guoqiang Zhang Jianye Dai Xin-An Wu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，4： | 0 |
| 9 | Simultaneous regulation on coordination environment and interfacial chemistry via taurine for stabilized Zn metal anode显示文摘Aqueous Zn-ion batteries(AZIBs)are the potential options for the next-generation energy storage scenarios due to the cost effectiveness and intrinsic safety.Nevertheless,the industrial application of AZIBs is still impeded by a series of parasitic reactions and dendrites at zinc anodes.In this study,taurine(TAU)is used in electrolyte to simultaneously optimize the coordination condition of the ZnSO4electrolyte and interfacial chemistry at the anode.TAU can preferentially adsorb with the zinc metal and induce an in situ stable and protective interface on the anode,which would avoid the connection between H_(2)O and the zinc metal and promote the even deposition of Zn^(2+).The resulting Zn//Zn batteries achieve more than 3000 hours long cyclic lifespan under 1 mA cm^(-2)and an impressive cumulative capacity at 5 mA cm^(-2).Moreover,Zn//Cu batteries can realize a reversible plating/stripping process over 2,400cycles,with a desirable coulombic efficiency of 99.75%(1 mA cm^(-2)).Additionally,the additive endows Zn//NH_(4)V_(4)O_(10)batteries with more stable cyclic performance and ultrafast rate capability.These capabilities can promote the industrial application of AZIBs. | Xin Xu Junyi Yin Ruimin Qin Haoliang Liu Xiang Feng Minghui Wang Mingyan Li Weiyu Sun Weichen Shi Bing Xiao Yaqiong Su Yonghong Cheng | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 10 | Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel显示文摘Renal tubular secretion mediated by organic anion transporters(OATs)and the multidrug resistanceassociated protein 4(MRP4)is an important means of drug and toxin excretion.Unfortunately,there are no biomarkers to evaluate their function.The aim of this study was to identify and characterize an endogenous biomarker of the renal tubular OATs-MRP4 channel.Twenty-six uremic toxins were selected as candidate compounds,of which kynurenic acid was identified as a potential biomarker by assessing the protein-binding ratio and the uptake in OAT1-,OAT3-,and MRP4-overexpressing cell lines.OAT1/3 and MRP4 mediated the transcellular vectorial transport of kynurenic acid in vitro.Serum kynurenic acid concentration was dramatically increased in rats treated with a rat OAT1/3(rOAT1/3)inhibitor and in rOAT1/3 double knockout(rOAT1/3^(-/-))rats,and the renal concentrations were markedly elevated by the rat MRP4(rMRP4)inhibitor.Kynurenic acid was not filtered at the glomerulus(99%of albumin binding),and was specifically secreted in renal tubules through the OAT1/3-MRP4 channel with an appropriate affinity(Km)(496.7 mM and 382.2 mM for OAT1 and OAT3,respectively)and renal clearance half-life(t1/2)in vivo(3.7±0.7 h).There is a strong correlation in area under the plasma drug concentration-time curve(AUC0et)between cefmetazole and kynurenic acid,but not with creatinine,after inhibition of rOATs.In addition,the phase of increased kynurenic acid level is earlier than that of creatinine in acute kidney injury process.These results suggest that albumin-bound kynurenic acid is an appropriate endogenous biomarker for adjusting the dosage of drugs secreted by this channel or predicting kidney injury. | Yanrong Ma Fenglin Ran Mingyan Xin Xueyan Gou Xinyi Wang Xinan Wu | 2023 | Journal of Pharmaceutical Analysis2023，13，10： | 0 |
| 11 | Driving mechanism and boundary control of urban sprawl显示文摘自从改革和洞起来,瓷器经济完成了显著开发那么做都市化。然而,在之间有一个不可避免的矛盾城市散漫并且可耕地和环境的保护。由重新定义城市散漫边界,这份报纸是在瓷器都市化上下文上为上面的冲突提供一个答案。理想的边界,中等边界和限制边界被定义为城市在空间散漫。作为一个盒子拿南京城市,三城市散漫边界基于农业陆地资源的计算在这份报纸被估计在南京的价值。结果显示出那 1 ) 综合价值农业(栽培) 在南京的陆地资源是 1. | Dongmei JIANG Xiaoshun LI Futian QU Mingyan LI Shaoliang ZHANG Yunlong GONG Xiaoping SHI Xin CHEN | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员