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| 1 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 2 | Effects of HMG on revascularization and follicular survival in heterotopic autotransplants of mouse ovarian tissue显示文摘 | Yanrong Wang Qing Chang Jing Sun Ling Dang Wenzhi Ma Changchun Hei Xinsheng Shen Chengjun Zhao Yufang Cai Xiuying Pei Xiaoguang Zhang Yin Wang Xiaohua Jiang | 2012 | Reproductive BioMedicine Online2012，，6： | 4 |
| 3 | Application of Real-time Fluorescent Quantitative PCR in Studies on Plants显示文摘Real-time fluorescent quantitative PCR is a method for quantitative analysis of gene expression developed in recent years, which has been widely used in various fields such as basic scientific research, clinical diagnosis, disease study, drug research and development since its appearance. It starts relatively late in study on plants, but has already been used for analysis of gene expression in plants and gene identification of exogenous genes. The principles or advantages and disadvantages of real-time fluorescent quantitative PCR, or its potential problems and condition optimizations in tests were introduced in this study, and then the application and prospect of real-time fluorescent quantitative PCR in study on plants were also been discussed. | Yueping MA Silan DAI Yanrong MA | 2012 | Agricultural Biotechnology2012，1，1： | 3 |
| 4 | Comparison of aerosol characteristics during haze periods over two urban agglomerations in China using CALIPSO observations显示文摘 | Qiong Liu Xiaojun Ma Yanrong Yu Yan Qin Yonghang Chen Yanming Kang Hua Zhang Tiantao Cheng Yan Ling Yujie Tang | 2017 | Particuology2017，15，4： | 2 |
| 5 | High-performance Li-ion capacitor based on black-TiO2-x/graphene aerogel anode and biomass-derived microporous carbon cathode显示文摘Lithium-ion capacitor (LIC) has been regarded as a promising energy storage system with high powder density and high energy density.However,the kinetic mismatch between the anode and the cathode is a major issue to be solved.Here we report a high-performance asymmetric LIC based on oxygen-deficient black-TiO2-x/graphene (B-TiO2-x/G) aerogel anode and biomass derived microporous carbon cathode.Through a facile one-pot hydrothermal process,graphene nanosheets and oxygen-vacancy-rich porous B-TiO2-x/G nanosheets were self-assembled into three-dimensional (3D) interconnected B-TiO2-x/G aerogel.Owing to the rich active sites,high conductivity and fast kinetics,the B-TiO2-x/G aerogel exhibits remarkable reversible capacity,high rate capability and long cycle life when used as anode material for lithium ion storage.Moreover,density functional theory (DFT) calculation reveals that the incorporation of graphene nanosheets can reduce the energy barrier of Li^+ diffusion in B-TiO2-x.The asymmetric LIC based on B-TiO2-x/G aerogel anode and naturally-abundant pine-needles derived microporous carbon (MPC) cathode work well within a large voltage window (1.0-4.0 V),and can deliver high energy density (166.4 Wh·kg^-1 at 200 mA·g^-1),and high power density (7.9 kW·kg^-1 at 17.1 Wh·kg^-1).Moreover,the LIC shows a high capacitance retention of 87% after 3,000cycles at 2,000 mA·g^-1.The outstanding electrochemical performances indicate that the rationally-designed LICs have promising prospect to serve as advanced fast-charging energy storage devices. | Guoyin Zhu Lianbo Ma Huinan Lin Peiyang Zhao Lei Wang Yi Hu Renpeng Chen Tao Chen Yanrong Wang Zuoxiu Tie Zhong Jin | 2019 | Nano Research2019，12，7： | 2 |
| 6 | Three-dimensional spongy framework as superlyophilic, strongly absorbing,and electrocatalytic polysulfide reservoir layer for high-rate and long-cycling lithiumsulfur batteries显示文摘In the development of lithium-sulfur (Li-S)batteries,various approaches have been adopted to enhance the electronic conductivity of the sulfur cathode and alleviate the shuttle effect of polysulfides;however,the strategies providing efficient solutions are still limited.To further improve the electrochemical performance of Li-S batteries,in this work we propose a new strategy involving the incorporation of a three-dimensional functional spongy framework as polysulfide reservoir layer,with strong absorbability and electrocatalytic activity towards sulfur species.The spongy framework has a hierarchical architecture composed of highly conductive Ni foam/graphene/carbon nanotubes/MnO2nanoflakes (NGCM).The strongly interconnected Ni foam,graphene,and carbon nanotubes of the NGCM sponge facilitate electron transfer during discharge/charge processes;moreover,the superlyophilic properties of the NGCM sponge ensure good wettability and interface contact with the Li-S electrolyte,and the porous MnO2nanoflakes provide strong chemisorptive and electrocatalytic effects on polysulfides (as confirmed theoretically and experimentally).The NGCM sponge, serving as a polysulfide reservoir layer attached on a conventional sulfur-mixed carbon nanotubes (S/CNTs)cathode,can provide improved reversible capacity, rate capability (593mAh·g^-1at 3.0C),and cycling stability.In addition,the self-discharge rate is greatly reduced,owing to the efficient conservation of polysulfides in the NGCM spongy framework. | Lianbo Ma Guoyin Zhu Wenjun Zhang Peiyang Zhao Yi Hu Yanrong Wang Lei Wang Renpeng Chen Tao Chen Zuoxiu Tie Jie Liu Zhong Jin | 2018 | Nano Research2018，11，12： | 2 |
| 7 | Models and related mechanisms of NBTI degradation of 90 nm pMOS- FETs 显示文摘 | Cao Yanrong Ma Xiaohua Hao Yue | 2007 | Chinese Journal of Semiconductors2007，28，5： | 1 |
| 8 | Designed preparation of CoS/Co/MoC nanoparticles incorporated in N and S dual-doped porous carbon nanofibers for high-performance Zn-air batteries显示文摘The development of low-cost and highly efficient bifunctional electrocatalysts toward oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is of critical importance for clean energy devices such as fuel cells and metal-air batteries.Herein,a sophisticated na nostructure composed of CoS,Co and MoC nanoparticles incorporated in N and S dual-doped porous carbon nanofibers(CoS/Co/MoC-N,SPCNFs)as a high-efficiency bifunctional electrocatalyst is designed and synthesized via an efficient multistep strategy.The as-prepared CoS/Co/MoC-N,S-PCNFs exhibit a positive half-wave potential(E1/2)of0.871 V for ORR and a low overpotential of 289 mV at 10 mA/cm^(2) for OER,outperforming the non-noble metal-based catalysts reported.Furthermore,the assembled Zn-air battery based on CoS/Co/MoC-N,SPCNFs delivers an excellent power density(169.1 mW/cm^(2)),a large specific capacity(819.3 mAh/g)and robust durability,demonstrating the great potential of the as-developed bifunctional electrocatalyst in practical applications.This work is expected to inspire the design of advanced bifunctional nonprecious metal-based electrocatalysts for energy storage. | Yanrong Ren Haiyan Wang Tianyu Zhang Luankexin Ma Pengcheng Ye Yijun Zhong Yong Hu | 2021 | Chinese Chemical Letters2021，32，7： | 1 |
| 9 | Analysis of 35 cases显示文摘 | Liu Yuxiang Liu Jingui Ma Yanrong | 1999 | ChineseJournal of Contemporary Pediatrics hemorrhage of upper digestive tractendoscopy in children1999，，02： | 1 |
| 10 | A general strategy to the synthesis of carbon-supported PdM(M=Co,Fe and Ni)nanodendrites as high-performance electrocatalysts for formic acid oxidation显示文摘Rational synthesis of a new class of electrocatalysts with high-performance and low-cost is of great significance for future fuel cell devices. Herein, we demonstrate a general one-step simultaneous reduction method to prepare carbon-supported Pd M(M = Co, Fe, Ni) alloyed nanodendrites with the assistance of oleylamine and octadecylene. The morphology, structure and composition of the obtained Pd M nanodendrites/C catalysts have been fully characterized. The combination of the dendritic structural feature and alloyed synergy offer higher atomic utilization efficiency, excellent catalytic activity and enhanced stability for the formic acid oxidation reaction(FAOR). Strikingly, the as-synthesized Pd Co nanodendrites/C catalyst could afford a mass current density of 2467.7 A g^(-1), which is almost 3.53 and 10.4 times higher than those of lab-made Pd/C sample(698.3 A g^(-1)) and commercial Pd/C catalyst(237.6 A g^(-1)), respectively. Furthermore, the PdC o nanodendrites/C catalyst also exhibit superior stability relative to the Pd/C catalysts, make it a promising anodic electrocatalyst in practical fuel cells in the future. Additionally, the present feasible synthetic approach is anticipated to provide a versatile strategy toward the preparation of other metal alloy nanodendrites/carbon nanohybrids. | Yanrong Ma Tongfei Li Hao Chen Xiaojie Chen Sihui Deng Lin Xu Dongmei Sun Yawen Tang | 2017 | Journal of Energy Chemistry2017，26，6： | 1 |
| 11 | An asynchronous and synchronous coupling approach in networked rapid product development显示文摘 | Yanrong Ni Feiya Fan Juanqi Yan Dengzhe Ma Ye Jin | 2003 | The International Journal of Advanced Manufacturing Technology2003，，1： | 1 |
| 12 | Preparation of Core/Shell Electrically Conductive Fibers by Efficient Coating Carbon Nanotubes on Polyester显示文摘Conducting fibers with improved properties and functionalities are needed for diverse applications.Here we report the fabrica-tion of core/shell conductive Dacron fibers by dip-coating method through originating from multi-walled carbon nanotubes(MWCNTs)coated on polyester fibers.The annealing process was conducted to enhance interaction between the conductive shell and polyester core as well as within the MWCNTs network.The properties of two kinds of MWCNTs dispersions and the electrical properties of conductive fibers were studied,respectively.The results show that both MWCNTs-polyurethane resin(MWCNTs-WPU)dispersion and MWCNTs-acrylic resin(MWCNTs-PAA)dispersion present a typical characteristic of pseudo-plastic fluid and an excellent wetting ability to polyester fibers.The ultimate tensile stress and elongation at break for the MWCNTs-PAA coated fiber are 261 MPa and 25.43%.The ultimate tensile stress and the elongation at break are both increasing with the increasing of MWCNTs contents,due to the strong interface bonding ability between the conduc-tive shell and polyester core and strengthen the MWCNTs network.The electrical resistance of the obtained fibers can be controlled in the range from 732 to 30Ω/cm by changing MWCNTs content,dipping times and annealing temperature.It was found that it is able to light a LED.All results suggest that the conductive fibers embody a good synergy effect of carbon nanotubes and polymers.Therefore,the fabricated conductive fibers have a widely prospect for being applied in the field of flexible electronics. | Liangyu Ma Yi Nie Yanrong Liu Feng Huo Lu Bai Qian Li Suojiang Zhang | 2021 | Advanced Fiber Materials2021，3，3： | 1 |
| 13 | The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats显示文摘The liver is an important organ for drugs disposition,and thus how to accurately evaluate hepatic clearance is essential for proper drug dosing.However,there are many limitations in drug dosage adjustment based on liver function and pharmacogenomic testing.In this study,we evaluated the ability of endogenous glycochenodeoxycholate-3-sulfate(GCDCA-S)and 4β-hydroxycholesterol(4β-HC)plasma levels to evaluate organic anion-transporting polypeptide(Oatps)-mediated hepatic uptake and Cyp3 a-meidated metabolism of atorvastatin(ATV)in rats.The concentration of ATV and its metabolites,2-OH ATV and 4-OH ATV,was markedly increased after a single injection of rifampicin(RIF),an inhibitor of Oatps.Concurrently,plasma GCDCA-S levels were also elevated.After a single injection of the Cyp3 a inhibitor ketoconazole(KTZ),plasma ATV concentrations were significantly increased and 2-OH ATV concentrations were decreased,consistent with the metabolism of ATV by Cyp3 a.However,plasma 4β-HC was not affected by KTZ treatment despite it being a Cyp3 a metabolite of cholesterol.After repeated oral administration of RIF,plasma concentrations of ATV,2-OH ATV and 4-OH ATV were markedly increased and the hepatic uptake ratio of ATV and GCDCA-S was decreased.KTZ did not affect plasma concentrations of ATV,2-OH ATV and 4-OH ATV,but significantly decreased the metabolic ratio of total and 4-OH ATV.However,the plasma level and hepatic metabolism of 4β-HC were not changed by KTZ.The inhibition of hepatic uptake of GCDCA-S by RIF was fully reversed after a 7-d washout of RIF.Plasma concentration and hepatic uptake ratio of GCDCA-S were correlated with the plasma level and hepatic uptake of ATV in rats with ANIT-induced liver injury,respectively.These results demonstrate that plasma GCDCA-S is a sensitive probe for the assessment of Oatps-mediated hepatic uptake of ATV.However,Cyp3 a-mediated metabolism of ATV was not predicted by plasma 4β-HC levels in rats. | Yanrong Ma Mingyan Xin Yuanjie Wen Huan Wang Guoqiang Zhang Jianye Dai Xin-An Wu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，4： | 0 |
| 14 | Advances in magnetic resonance imaging contrast agents for glioblastoma-targeting theranostics显示文摘Glioblastoma(GBM)is the most aggressive malignant brain tumour,with a median survival of 3 months without treatment and 15 months with treatment.Early GBM diagnosis can significantly improve patient survival due to early treatment and management procedures.Magnetic resonance imaging(MRI)using contrast agents is the preferred method for the preoperative detection of GBM tumours.However,commercially available clinical contrast agents do not accurately distinguish between GBM,surrounding normal tissue and other cancer types due to their limited ability to cross the blood-brain barrier,their low relaxivity and their potential toxicity.New GBM-specific contrast agents are urgently needed to overcome the limitations of current contrast agents.Recent advances in nanotechnology have produced alternative GBM-targeting contrast agents.The surfaces of nanoparticles(NPs)can be modified with multimodal contrast imaging agents and ligands that can specifically enhance the accumulation of NPs at GBM sites.Using advanced imaging technology,multimodal NP-based contrast agents have been used to obtain accurate GBM diagnoses in addition to an increased amount of clinical diagnostic information.NPs can also serve as drug delivery systems for GBM treatments.This review focuses on the research progress for GBMtargeting MRI contrast agents as well as MRI-guided GBM therapy. | Zijun Wu Lixiong Dai Ke Tang Yiqi Ma Bin Song Yanrong Zhang Jinxing Li Su Lui Qiyong Gong Min Wu | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 15 | Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel显示文摘Renal tubular secretion mediated by organic anion transporters(OATs)and the multidrug resistanceassociated protein 4(MRP4)is an important means of drug and toxin excretion.Unfortunately,there are no biomarkers to evaluate their function.The aim of this study was to identify and characterize an endogenous biomarker of the renal tubular OATs-MRP4 channel.Twenty-six uremic toxins were selected as candidate compounds,of which kynurenic acid was identified as a potential biomarker by assessing the protein-binding ratio and the uptake in OAT1-,OAT3-,and MRP4-overexpressing cell lines.OAT1/3 and MRP4 mediated the transcellular vectorial transport of kynurenic acid in vitro.Serum kynurenic acid concentration was dramatically increased in rats treated with a rat OAT1/3(rOAT1/3)inhibitor and in rOAT1/3 double knockout(rOAT1/3^(-/-))rats,and the renal concentrations were markedly elevated by the rat MRP4(rMRP4)inhibitor.Kynurenic acid was not filtered at the glomerulus(99%of albumin binding),and was specifically secreted in renal tubules through the OAT1/3-MRP4 channel with an appropriate affinity(Km)(496.7 mM and 382.2 mM for OAT1 and OAT3,respectively)and renal clearance half-life(t1/2)in vivo(3.7±0.7 h).There is a strong correlation in area under the plasma drug concentration-time curve(AUC0et)between cefmetazole and kynurenic acid,but not with creatinine,after inhibition of rOATs.In addition,the phase of increased kynurenic acid level is earlier than that of creatinine in acute kidney injury process.These results suggest that albumin-bound kynurenic acid is an appropriate endogenous biomarker for adjusting the dosage of drugs secreted by this channel or predicting kidney injury. | Yanrong Ma Fenglin Ran Mingyan Xin Xueyan Gou Xinyi Wang Xinan Wu | 2023 | Journal of Pharmaceutical Analysis2023，13，10： | 0 |
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