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| 1 | Hybridization of metal–organic framework and monodisperse spherical silica for chromatographic separation of xylene isomers显示文摘Metal–organic frameworks(MOFs) packed in the column have been a promising candidate as the stationary phase for high performance liquid chromatography(HPLC). However, the direct packing of irregular MOF powder could raise some problems like high back pressure and low column efficiency in the HPLC separation. In this work, UiO-66 capable of separating xylenes was supported effectively on the surface of the monodisperse spherical silica microspheres by one-pot method. The hybridization of Ui O-66 and silica microspheres(termed UiO-66@SiO2 shell–core composite) was prepared by stirring the suspension of the precursors of Ui O-66 and\\COOH terminated silica in the N,N-dimethylformamide with heating. The shell–core composite material UiO66@SiO2 was characterized by SEM, TEM, PXRD and FTIR. Then, it was used as a packing material for the chromatographic separation of xylene isomers. Xylene isomers including o-xylene, m-xylene and p-xylene were efficiently separated on the column with high resolution and good reproducibility. Moreover, the Ui O-66@SiO2 shell–core composites packed column still remained reverse shape selectivity as Ui O-66 possessed, and the retention of xylenes was probably ascribed to the hydrophobic effect between analytes and the aromatic rings of the Ui O-66 shell. The Ui O-66@SiO2 shell–core composites obtained in this study have some potential for the separation of structural isomers in HPLC. | Bixuan Gao Minhui Huang Zhiguo Zhang Qiwei Yang Baogen Su Yiwen Yang Qilong Ren Zongbi Bao | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 4 |
| 2 | Risk factors for tissue expander infection in scar reconstruction:a retrospective cohort study of 2374 consecutive cases显示文摘Background:Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes;however,the complications that emerge from tissue expansion hinder repair.Infection is considered a major complication of tissue expansion.This study aimed to analyze the perioperative risk factors for expander infection.Methods:A large,retrospective,single-institution observational study was carried out over a 10-year period.The study enrolled consecutive patients who had undergone tissue expansion for scar reconstruction.Demographics,etiological data,expander-related characteristics and postoperative infection were assessed.Univariate and multivariate logistic regression analysis were performed to identify risk factors for expander infection.In addition,we conducted a sensitivity analysis for treatment failure caused by infection as an outcome.Results:A total of 2374 expanders and 148 cases of expander infection were assessed.Treatment failure caused by infection occurred in 14 expanders.Multivariate logistic regression analysis identified that disease duration of≤1 year(odds ratio(OR),2.07;p<0.001),larger volume of expander(200–400ml vs<200 ml;OR,1.74;p=0.032;>400ml vs<200 ml;OR,1.76;p=0.049),limb location(OR,2.22;p=0.023)and hematoma evacuation(OR,2.17;p=0.049)were associated with a high likelihood of expander infection.Disease duration of≤1 year(OR,3.88;p=0.015)and hematoma evacuation(OR,10.35;p=0.001)were so related to high risk of treatment failure.Conclusions:The rate of expander infection in patients undergoing scar reconstruction was 6.2%.Disease duration of<1 year,expander volume of>200 ml,limb location and postoperative hematoma evacuation were independent risk factors for expander infection. | Chen Dong Minhui Zhu Luguang Huang Wei Liu Hengxin Liu Kun Jiang Zhou Yu Xianjie Ma | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | An ethnopharmacological investigation of medicinal Salvia plants (Lamiaceae) in China显示文摘In China,over 40 species of the genus Salvia have been used as medicinal plants for various diseases,some for thousands of years.Recently,research has focused on the biological activities of Salvia medicinal plants used in traditional chinese medicine(TCM).However,to date a scientific survey of the genus Salvia in China has not been carried out.In this paper,we report the results of 10 field surveys of Salvia medicinal plants collected in 17 provinces including detailed information on their local names,growing environment,distribution and therapeutic effects.We also summarize the results of research on the materia medica,phytochemistry and pharmacology of some of the important Salvia medicinal plants.Our study reveals that 35 Salvia plants have been used in TCM in different regions of China,including 20 species used as Danshen to treat heart diseases,and 15 species used to treat a range of other conditions including gynecological diseases,muscular or skeletal problems,hepatitis,urological diseases,and mouth and eye conditions.It is clear that some species of Salvia L.possess significant pharmacological activity in the context of ethnopharmacological knowledge,especially in the treatment of heart disease.Further studies of the phytochemistry and pharmacology of Salvia species will no doubt improve their medical utilization and contribute to the development of new natural drugs. | Minhui Li Qianquan Li Chunhong Zhang Na Zhang Zhanhu Cui Luqi Huang Peigen Xiao | 2013 | Acta Pharmaceutica Sinica B2013，3，4： | 2 |
| 4 | CONSIDERING NEIGHBORHOOD INFORMATION IN IMAGE FUZZY CLUSTERING显示文摘Fuzzy C-means clustering algorithm is a classical non-supervised classification method.For image classification, fuzzy C-means clustering algorithm makes decisions on a pixel-by-pixel basis and does not take advantage of spatial information, regardless of the pixels' correlation. In this letter, a novel fuzzy C-means clustering algorithm is introduced, which is based on image's neighborhood system. During classification procedure, the novel algorithm regards all pixels'fuzzy membership as a random field. The neighboring pixels' fuzzy membership information is used for the algorithm's iteration procedure. As a result, the algorithm gives a more smooth classification result and cuts down the computation time. | Huang Ning Zhu Minhui Zhang Shourong(The Nat. Key Lab of Microwave Imaging Tech, Inst. of Electronics, CAS, Beijing 100080) | 2002 | Journal of Electronics(China)2002，19，3： | 2 |
| 5 | Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings显示文摘 | Zheng Xuebin Huang Minhui Ding Chuanxian | 2000 | Biomaterials2000，21，： | 1 |
| 6 | Bond strength of plasma-sprayed hydroxyapatite composite coatings显示文摘 | Minhui Huang Chuanxian Ding | 2000 | Biomaterials2000，21，8： | 1 |
| 7 | Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges显示文摘In recent years,significant breakthroughs have been made in the field of gene ther-apy.Adeno-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest.Among the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific tissues.Currently,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases. | Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang | 2024 | Genes & Diseases2024，11，1： | 1 |
| 8 | Biomaterials 显示文摘 | Zheng Xuebin Huang Minhui Ding Chuanxian | 2000 | 21(8): 8412000，21，8： | 1 |
| 9 | Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings显示文摘 | Zheng Xuebin Huang Minhui Ding Chuanxian | 2000 | Biomaterials2000，21，8： | 1 |
| 10 | Construction of a One-Vector Multiplex CRISPR/Cas9 Editing System to Inhibit Nucleopolyhedrovirus Replication in Silkworms显示文摘Recently the developed single guide(sg)RNA-guided clustered regularly interspaced short palindromic repeats/associated protein 9 nuclease(CRISPR/Cas9) technology has opened a new avenue for antiviral therapy. The CRISPR/Cas9 system uniquely allows targeting of multiple genome sites simultaneously. However, there are relatively few applications of CRISPR/Cas9 multigene editing to target insect viruses. To address the need for sustained delivery of a multiplex CRISPR/Cas9-based genome-editing vehicle against insect viruses, we developed a one-vector(pSL1180-Cas9-U6-sgRNA) system that expresses multiple sgRNA and Cas9 protein to excise Bombyx mori nucleopolyhedrovirus(BmNPV) in insect cells.We screened the immediate-early-1 gene(ie-1), the major envelope glycoprotein gene(gp64), and the late expression factor gene(lef-11), and identified multiple sgRNA editing sites through flow cytometry and viral DNA replication analysis. In addition, we constructed a multiplex editing vector(PSL1180-Cas9-sgIE1-sgLEF11-sgGP64, sgMultiple) to efficiently regulate multiplex gene-editing and inhibit BmNPV replication after viral infection. This is the first report of the application of a multiplex CRISPR/Cas9 system to inhibit insect virus replication. This multiplex system can significantly enhance the potential of CRISPR/Cas9-based multiplex genome engineering in insect virus. | Zhanqi Dong Qi Qin Zhigang Hu Peng Chen Liang Huang Xinling Zhang Ting Tian Cheng Lu Minhui Pan | 2019 | Virologica Sinica2019，34，4： | 1 |
| 11 | Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings 显示文摘 | Zheng Xuebin Huang Minhui Ding Chuanxian | 2000 | Biomaterials2000，21，： | 1 |
| 12 | Bond strength of plasma-sprayed hydrox yapatite/Ti composite coat-ings显示文摘 | Zheng Xuebin Huang Minhui Ding Chuanxian | 2000 | Biomaterials2000，21，8： | 1 |
| 13 | Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery显示文摘Submucosal injection material has shown protective effect against gastrointestinal injury during endoscopic surgery in clinic.However,the protective ability of existing submucosal injection material is strictly limited by their difficult injectability and short barrier time.Herein,we report a shear-thinning gellan gum hydrogel that simultaneously has easy injectability and long-lasting barrier function,together with good hemostatic property and biocompatibility.Shear-thinning property endows our gellan gum hydrogel with excellent endoscopic injection performance,and the injection pressure of our gellan gum hydrogel is much lower than that of the small molecule solution(50 wt%dextrose)when injected through the endoscopic needle.More importantly,our gellan gum hydrogel shows much stronger barrier retention ability than normal saline and sodium hyaluronate solution in the ex vivo and in vivo models.Furthermore,our epinephrine-containing gellan gum hydrogel has a satisfactory hemostatic effect in the mucosal lesion resection model of pig.These results indicate an appealing application prospect for gellan gum hydrogel utilizing as a submucosal injection material in endoscopic surgery. | Yinxiang Tang Minhui Hu Fuxin Tang Rongkang Huang Hui Wang Dingcai Wu Ping Lan | 2022 | Bioactive Materials2022，7，9： | 0 |
| 14 | Leaky Gut Plays a Critical Role in the Pathophysiology of Autism in Mice by Activating the Lipopolysaccharide‑Mediated Toll‑Like Receptor 4-Myeloid Differentiation Factor 88-Nuclear Factor Kappa B Signaling Pathway显示文摘Increased intestinal barrier permeability,leaky gut,has been reported in patients with autism.However,its contribution to the development of autism has not been determined.We selected dextran sulfate sodium(DSS)to disrupt and metformin to repair the intestinal barrier in BTBR T+tf/J autistic mice to test this hypothesis.DSS treatment resulted in a decreased affinity for social proximity;however,autistic behaviors in mice were improved after the administration of metformin.We found an increased affinity for social proximity/social memory and decreased repetitive and anxiety-related behaviors.The concentration of lipopolysaccharides in blood decreased after the administration of metformin.The expression levels of the key molecules in the toll-like receptor 4(TLR4)–myeloid differentiation factor 88(MyD88)–nuclear factor kappa B(NF-κB)pathway and their downstream inflammatory cytokines in the cerebral cortex were both repressed.Thus,“leaky gut”could be a trigger for the development of autism via activation of the lipopolysaccharide-mediated TLR4–MyD88–NF-κB pathway. | Fang Li Haoran Ke Siqi Wang Wei Mao Cexiong Fu Xi Chen Qingqing Fu Xiaori Qin Yonghua Huang Bidan Li Shibing Li Jingying Xing Minhui Wang Wenlin Deng | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 15 | Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement显示文摘Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 gene.The patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial features.Familial whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein family.The p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in vivo.Additionally,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index patient.The human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by E13.5.RNA-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development. | Yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng Huang Jinglan Zhang Chenming Xu | 2024 | Protein & Cell2024，15，1： | 0 |
| 16 | Gut microbiota axis:potential target of phytochemicals from plant-based foods显示文摘Food-microbiota-host interactions provide an overarching framework for understanding the function of the gut microbiota axis.Diet is a major modulator of gut microbiota.Plant-based foods are rich in phytochemicals;therefore,it is essential to assess such foods and elucidate the mechanisms underlying their action.In this review,we summarize the role of gut microbiota in the communication between the gut and the brain,liver,lung,kidney,and joints,as well as the role of the gut microbiota axis in diseases involving these organs.In addition,we assess the effects of phytochemicals from plant-based foods on the gut microbiota axis via different pathways. | Ruyu Shi Congying Huang Yuan Gao Xing Li Chunhong Zhang Minhui Li | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
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