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| 1 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 2 | Effect of Cadmium and Herbicides on the Growth, Chlorophyll and Soluble Sugar Content in Rice Seedlings显示文摘调查联合效果Cd~(2+)( 0,10,100,500 亩 mol/L ), acetochlor (交流)( 0,1.6,4.0,8.0 亩 mol/L ),和生物资源上的bensulfuron甲基( BSM )( 0,0.16,0.40,0.80 亩 mol/L ),长叶可溶的糖,全部的叶绿素( chl )内容, chl a/b 比率,并且 Cd 在米饭幼苗在根和射击满足,壶文化实验与米饭( Oryzasaliva L.)被进行栽培变种 Jinyou 402 。结果证明 Cd 和交流显著地联合了处理(Cd + ACtreatment ) 禁止了根和射击的生长。根干燥重量/射击干燥重量( RDW/SDW )比率,全部的叶绿素内容和 chl a/b 比率在41%减少了,50%,56%分别地,与控制,以及叶比较,可溶的糖满足,新鲜重量( PDW/PFW )比率分别地增加了284%和44%的 plantdryweight /plant 。在根和射击的 Cd 内容在 theCd+AC 处理下面与交流的增加的集中有一个减少的趋势。Cd 和 BSM 联合了有的处理(Cd+BSM 处理) 类似的结果到 theCd+AC 处理。结果建议到米饭幼苗的 Cd 的毒性与除草剂由于它的联合被提高了。 | HUANG He XIONG Zhiting LI Minjing XIONG Shuanglian LI Shenglan Felicite Obono Mba | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 6 |
| 3 | Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage显示文摘The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange, respectively. However, the regulation of proximal–distal patterning at the embryonic stage of human lung development is largely unknown. Here we investigated the early lung development of human embryos at weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, and obtained a transcriptomic atlas of 169,686 cells. We observed discernible gene expression patterns of proximal and distal epithelia at week 4, upon the initiation of lung organogenesis. Moreover, we identified novel transcriptional regulators of the patterning of proximal (e.g., THRB and EGR3) and distal (e.g., ETV1 and SOX6) epithelia. Further dissection revealed various stromal cell populations, including an early-embryonic BDNF+ population, providing a proximal–distal patterning niche with spatial specificity. In addition, we elucidated the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development. Together, our study expands the scope of human lung developmental biology at early embryonic stages. The discovery of intrinsic transcriptional regulators and novel niche providers deepens the understanding of epithelial proximal–distal patterning in human lung development, opening up new avenues for regenerative medicine. | Shangtao Cao Huijian Feng Hongyan Yi Mengjie Pan Lihui Lin Yao Santo Zhang Ziyu Feng Weifang Liang Baomei Cai Qi Li Zhi Xiong Qingmei Shen Minjing Ke Xing Zhao Huilin Chen Qina He Mingwei Min Quanyou Cai He Liu Jie Wang Duanqing Pei Jiekai Chen Yanlin Ma | 2023 | Cell Research2023，33，6： | 0 |
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