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| 1 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 2 | Effects of T-S wave amplitude on the control of boundary layer transition by streaks显示文摘The effects of streaks on boundary layer transition depend on the initial amplitude of T-S waves introduced to excite the transition. This problem was studied in a flat-plate boundary layer in water tunnel by using hydrogen bubble method. Three T-S wave initial amplitudes were tested. The results show that both narrow and wide-spacing streaks depress the transition excited by T-S waves with lower initial amplitude. However, when transition is excited by T-S waves of higher initial amplitude, the narrow-spacing streaks depress the transition, while the wide-spacing streaks promote the transition. Further the underlying mechanisms were also analyzed. | Hui Guo Yulong Feng Haiwen Wang Ziteng Liu | 2013 | Theoretical & Applied Mechanics Letters2013，3，4： | 2 |
| 3 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 4 | Role of mito- ehondrial reactive oxygen species in hypoxia-dependent in- crease in intracellular calcium in pulmonary artery myocytes 显示文摘 | WANG Q S ZItENG Y hi DONG L | 2007 | Free Radie Biol Med2007，42，5： | 1 |
| 5 | Quantita- tive measurement of pass-by noise radiated by vehicles running at high speeds 显示文摘 | Yang Diange Wang Ziteng Li Bing | 2011 | Journal of Sound and Vi- bration2011，330，： | 1 |
| 6 | A hybridacoustic holography technique for moving sound sourceidentification based on wave superposition algorithm 显示文摘 | YANG Diange WANG Ziteng LI Bing | 2012 | Noise Control Eng J2012，60，1： | 1 |
| 7 | Developmentand calibration of acoustic video camera system for movingvehicles 显示文摘 | YANG Diange WANG Ziteng LI Bing et ai | 2011 | J Sound Vibr2011，330，： | 1 |
| 8 | Quantitativemeasurement of pass-by noise radiated by vehicles running alhigh speeds 显示文摘 | YANG Diange WANG Ziteng LI Bing | 2011 | J Sound Vibr2011，330，： | 1 |
| 9 | Manipulation of clusteroluminescence in carbonyl-based aliphatic polymers显示文摘Clusteroluminogens(CLgens),nonconjugated structures with visible luminescence at the clustering state,have recently received remarkable attention due to their great theoretical significance and practical values.In carbonyl-based aliphatic polymers,(n,π*)transition of carbonyl groups and the through-space interactions have been demonstrated to play an important role in their clusteroluminescence(CL)properties,but it is still a big challenge to manipulate their CL at the molecular level.In this work,six nonconjugated carbonyl-based polymers with different heteroatoms and steric hindrances were synthesized,and their photophysical properties were systematically studied.These polymers all showed CL but with different emission efficiency and wavelength.Experimental and theoretical studies indicated that the CL properties could be manipulated by changing the electronic structures of carbonyl groups and the rigidity of polymer chains.This work not only gains further insights into the CL mechanism but also provides reliable strategies to design and manipulate non-conjugated luminescent materials. | Ziteng Zhang Zuping Xiong Bo Chu Zhiming Zhang Yuan Xie Lei Wang Jing Zhi Sun Haoke Zhang Xing-Hong Zhang Ben Zhong Tang | 2022 | Aggregate2022，3，6： | 1 |
| 10 | Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses显示文摘A steep rise in Omicron reinfection cases suggests that this variant has increased immune evasion ability.To evaluate its antigenicity relationship with other variants,antisera from guinea pigs immunized with spike protein of SARS-CoV-2 variants of concern(VOCs)and variants of interest(VOIs)were cross-tested against pseudotyped variants.The neutralization activity against Omicron was markedly reduced when other VOCs or VOIs were used as immunogens,and Omicron(BA.1)-elicited sera did not efficiently neutralize the other variants.However,a Beta or Omicron booster,when administered as the 4th dose 3-months after the 3rd dose of any of the variants,could elicit broad neutralizing antibodies against all of the current variants including Omicron BA.1.Further analysis with 280 available antigen–antibody structures and quantification of immune escape from 715 reported neutralizing antibodies provide explanations for the observed differential immunogenicity.Three distinct clades predicted using an in silico algorithm for clustering of sarbecoviruses based on immune escape provide key information for rational design of vaccines. | Qianqian Li Li Zhang Ziteng Liang Nan Wang Shuo Liu Tao Li Yuanling Yu Qianqian Cui Xi Wu Jianhui Nie Jiajing Wu Zhimin Cui Qiong Lu Xiangxi Wang Weijin Huang Youchun Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 11 | Geochemical Characteristics and Prospecting Direction of the Hongwei-Xiongguan-Songheyi Dongshan Area in the Greater Xing’an Mountains, Heilongjiang Province显示文摘The Daxinganling area collided during the Late Paleozoic.The study area Hongwei-Xiongguan-Songheyi Dongshan area is located at the superimposed transition site of the Paleozoic paleo-Asian tectonic-metallogenic domain and the Mesozoic-Cenozoic Pacific Ocean tectonic-mineralization area.It is a good ore-forming fluid channel and has very good ore metallogenic geological conditions.The comprehensive research and metallogenic prediction of the geological background and geochemical characteristics of this area are carried out.It is believed that this area has good prospecting potential,and the prospecting area is circled.Suggestions for further prospecting work in this area are put forward. | Wang Ziteng Shi Yajing Shi Jiayuan Du Bangyu Du Chunsheng | 2019 | Meteorological and Environmental Research2019，10，5： | 0 |
| 12 | Lactobacillus casei protects intestinal mucosa from damage in chicks caused by Salmonella pullorum via regulating immunity and the Wnt signaling pathway显示文摘This study is to explore the mechanisms underlying the protective effects of Lactobacillus casei(L.casei)on the intestinal mucosal barrier of chicks infected with Salmonella pullorum(S.pullorum)through histological,immunological,and molecular biology methods.The results showed that L.casei significantly reduced the diarrhea rate,increased the daily weight gain,and maintained normal levels of IgA,IgM,and IgG in the serum of chicks infected with S.pullorum.Furthermore,we found that L.casei markedly improved the immunity of gut mucosa by regulating cytokine and chemokine receptor balance,elevating the number of intraepithelial lymphocytes. | Deng Ziteng Han Deping Wang Yuying Wang Qiuzhen Ma Yunfei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | Toward batch synthesis of high-quality graphene by cold-wall chemical vapor deposition approach显示文摘Chemical vapor deposition(CVD)has emerged as a promising approach for the controlled growth of graphene films with appealing scalability,controllability,and uniformity.However,the synthesis of high-quality graphene films still suffers from low production capacity and high energy consumption in the conventional hot-wall CVD system.In contrast,owing to the different heating mode,cold-wall CVD(CW-CVD)system exhibits promising potential for the industrial-scale production,but the quality of as-received graphene remains inferior with limited domain size and high defect density.Herein,we demonstrated an efficient method for the batch synthesis of high-quality graphene films with millimeter-sized domains based on CW-CVD system.With reduced defect density and improved properties,the as-received graphene was proven to be promising candidate material for electronics and anti-corrosion application.This study provides a new insight into the quality improvement of graphene derived from CW-CVD system,and paves a new avenue for the industrial production of high-quality graphene films for potential commercial applications. | Kaicheng Jia Ziteng Ma Wendong Wang Yongliang Wen Huanxin Li Yeshu Zhu Jiawei Yang Yuqing Song Jiaxin Shao Xiaoting Liu Qi Lu Yixuan Zhao Jianbo Yin Luzhao Sun Hailin Peng Jincan Zhang Li Lin Zhongfan Liu | 2022 | Nano Research2022，15，11： | 0 |
| 14 | Ore-controlling Regularities of Thrust-fold structures and features of Tectono-geochemical Anomalies at the Xiaozhuqing Exploration Area in the Huize Zn-Pb District显示文摘1 Introduction The huize Zn-Pb ore district in Yunnan province is locatedinthecentralsouthernofthe Sichuan—Yunnan—GuizhouPb-ZnPoly-metallic Mineralization Area in the southwestern margin of the Yangtze Block,and is strictly controlled by fault structures.It has developed to one of the famous production bases of lead&zinc and germanium in China. | Gong Hongsheng Han Runsheng Li Ziteng Ren Tao Wang Jiasheng | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
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