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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Long and fast Up/Down counters 显示文摘 | Mircea R Stan Alexandre F Tenca Milos D Ercegovac | 1998 | IEEE Trans on Computers1998，47，7： | 1 |
| 3 | Noninvasivelaser therapy for outpatients with chronic inflammatory disorders of cervix显示文摘 | Botez M Anton C Mircea R | 2012 | Rev Med Chir Soc Med Nat Iasi2012，116，4： | 1 |
| 4 | Hydrogen storage in metal organic frameworks 显示文摘 | Murray Leslie J Dinca Mircea Long Jeffrey R | 2009 | Chemical Socie- ty Reviews2009，38，5： | 1 |
| 5 | Synthesis and characterization of nanocrystalline Zn ferrites substituted with Ni显示文摘 | TAMARA S ALEXANDRA R I MIRCEA N P | | 0，，： | 1 |
| 6 | Noninvasive laser therapy for outpatients with chronic inflammatory disorders of cervix 显示文摘 | Botez M Anton C Mircea R | 2012 | Rev Med Chir Soc Med Nat Iasi2012，116，4： | 1 |
| 7 | Neural correlates of somatosensory processing in patients with neglect显示文摘 | Thomas Hassa Mircea Ariel Schoenfeld Christian Dettmers Christian Michael Stoppel Cornelius Weiller Rüdiger Lange | 2011 | Restorative Neurology and Neuroscience2011，，4： | 1 |
| 8 | Unified design space for regular parallel prefix adders显示文摘 | Matthew M Ziegler Mircea R StanA | 2004 | Design Au- tomation and Test in Europe Conference and Exhibi- tion2004，，2： | 1 |
| 9 | Dynamic Modelling and Nonlinear Model Predictive Control of a Fluid Catalytic Cracking Unit 显示文摘 | RALUCA R ZOLTAN K N MIRCEA V C | 2009 | Computers and Chemical Engineering2009，33，： | 1 |
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