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| 1 | p63基因在肺癌组织中的表达显示文摘目的 研究肺鳞状细胞癌、腺癌、大细胞肺癌、小细胞肺癌以及淋巴结或肺内转移性肿瘤标本组织中p63基因的mRNA转录因子和蛋白表达水平,探讨p63基因表达与其定位在3q 27-q29区域改变的关系。方法 采用cDNA微阵列技术同时检测72例不同病理组织学类型的原发性肺癌(包括鳞状细胞癌、腺癌、大细胞癌、小细胞癌)和肺癌肺内转移及淋巴结转移灶内的p63基因mRNA水平。另外,利用组织芯片技术构建150例原发性肺癌石蜡包埋标本组织芯片,采用免疫组织化学LSAB法检测p63基因蛋白表达情况。同时应用比较基因组杂交(CGH)技术对70例原发性肺癌标本进行了3号染色体长臂改变的分析。结果 p63mRNA转录因子在肺鳞状细胞癌标本表达明显增强,与腺癌、大细胞癌、小细胞癌相比增多10倍以上。肺癌转移灶内p63基因mRNA表达水平明显高于其相对应的原发性灶,差异有统计学意义(P<0.001)。免疫组织化学染色结果显示:肺鳞状细胞癌阳性表达率为94.64%;腺癌是1.79%;4例大细胞肺癌中2例为阳性染色;但所有小细胞肺癌标本免疫组织化学染色均为阴性。pT1分期肺癌的p63基因蛋白表达阳性率与pT2分期肺癌相比有统计学差异(P<0.05)。比较基因组杂交结果发现:肺鳞状细胞癌3号染色体长臂27-29区域有显著的扩增,腺癌表现为缺失。鳞状细胞癌p63基因的? | 余永伟 Mitchell E Garber KarstenSchlüns ManuelaPacyna-Gengelbach IverPetersen | 2004 | 中华病理学杂志2004，33，4： | 7 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 4 | The influence of three endomycorrhizal fungi on the development of black shank of tobacco显示文摘 | Kannwicher M E Kellam M K Mitchell D J | 1978 | Phytophthora Newsletter1978，，6： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Community integration显示文摘 | Ross E Mitchell Donald G Reid | 2000 | Annals of Tourism Research2000，，1： | 2 |
| 7 | Medications as a Potential Source of Exposure to Phthalates in the U.S. Population显示文摘 | Hernández-Díaz Sonia Mitchell Allen A Kelley Katherine E Calafat Antonia M Hauser Russ | 2009 | Environmental Health Perspectives2009，，2： | 2 |
| 8 | Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population显示文摘Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field. | Frances M Mitchell Sanjay K Prasad Gerald F Greil Peter Drivas Vassilios S Vassiliou Claire E Raphael | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 9 | Loss expression of active fragile sites genes associated with the severity of breast epithelial abnormalities显示文摘背景 WWOX 和 FHIT 是位于活跃易碎的地点,其损坏与乳癌的发展被联系了的二候选人肿瘤 suppressor 基因。这些基因的表达式和乳癌的开发的协会充分没被探索。我们与正常组织学的外观在胸织物评估了 mRNA 和 WWOX 和 FHIT 的蛋白质表示,不正常的 ductal 增生,在 situ 的 ductal 癌,并且看在表示的进步衰落是否是 present.Methods 颠倒抄写聚合酶链反应并且西方的弄污的侵略癌症被用来为 mRNA 和蛋白质表示评估标本包括有正常织物的 28 个标本,有不正常的 ductal 增生的 28 个标本,有 ductal 的 33 个标本汽车结果与相比在 situ 和侵略癌症标本,正常、不正常的增生标本有可检测的 mRNA 的更大的率(WWOX 率 ratio=2.95, 95% CI 1.24-7.08;FHIT 率 ratio=4.58, 95% Cl 1.82-11.81 ) 并且西方的弄污的可检测的蛋白质(WWOX 率 ratio=4.12, 95% Cl 1.63-10.73;FHIT 率 ratio=3.76, 95% Cl 1.44-10.06 ) 。为两蛋白质,正常、不正常的增生标本之间并且在之间的差别在 situ 和侵略的癌,标本碰巧是可解说的(P > 0.05 为每分析) 。在每个组织学的范畴以内,在标本的部分之中的差别显示出那 FHIT 和 WWOX mRNA。并且蛋白质表示碰巧是可解说的(P > 0.05 为每分析) FHIT 和 WWOX 的 .Conclusion 表示从正常组织学的外观与胸织物进步一起减少到不正常的 ductal 增生在 situ 癌症,并且最后的侵略癌症。 | WANG Tian-tian Eldo E Frezza MA Rong HU San-yuan LIU Chong-zhong ZHANG Guang-yong Mitchell S. Wachtel LU Xiao-mei FENG Jin-bo LU Cui-xia | 2008 | Chinese Medical Journal2008，，20： | 2 |
| 10 | The national severe storms laboratory mesocyclone detection algorithm for the WSR-88D 显示文摘 | Stumpf G J Witt A Mitchell E D | 1998 | Wea Forecasting1998，13，2： | 1 |
| 11 | HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity显示文摘 | ADAMSON G E LAZARUS S A MITCHELL A E | 1999 | J Agric Food Chem1999，47，： | 1 |
| 12 | A retrospective study of the safety of BCNU wafers with concurrent temozolomide and radiotherapy and adjuvant temozolomide for newly diagnosed glioblastoma patients 显示文摘 | Pan E Mitchell SB Tsai JS | 2008 | J Neurooncol2008，88，3： | 1 |
| 13 | Prefrontal cortex activity associated with source monitoring in a working memory Task显示文摘 | JOHNSON M K RAYE C L GREENE E J | 2004 | Journal of Cognitive Neuroscience2004，16，6： | 1 |
| 14 | Viscosity of galactomannans during high temperature processing: influence of degradation and solubilisafion 显示文摘 | KOK M S Hill S E Mitchell J R | 1999 | Food Hydrocolloids1999，13，： | 1 |
| 15 | Evidence that physiLologic levels of circulating estrogens and neonatal sex-imprinting modify postpubertal hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase acivity显示文摘 | Carlson S E Mitchell A D Carter M L | 1980 | Biochem Biophys Acta1980，633，： | 1 |
| 16 | Cardiac Hypertrophy Alters Myocardial Response to 1/R in Vivo显示文摘 | JI L FU R MITCHELL E M | 1994 | Acta Physiol Scand1994，151，： | 1 |
| 17 | The phylogenetically con served histidines of Escherichia coli porphyhilinogen synthase are not require for catalysis 显示文摘 | Mitchell L W Volin M Jaffe E K | 1995 | J Bio Chem1995，270，24： | 1 |
| 18 | Underwater repair by friction stitch welding显示文摘 | Andrews R E Mitchell J S | 1990 | Metals & Materials( Institute of Metals)1990，6，12： | 1 |
| 19 | Coalition forma- tion in standard - setting alliances显示文摘 | Axelrod R Mitchell W Thomas R E | 1995 | Management science1995，41，9： | 1 |
| 20 | Neonatal enteropathies: de- fining the causes of protracted diarrhea of infancy 显示文摘 | Sherman PM Mitchell DJ Cutz E | 2004 | J Pediatr Gastroenterol Nutr2004，38，1： | 1 |
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