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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | 蛋白质糖基化修饰研究进展显示文摘蛋白质翻译后修饰是蛋白质组学的一个组成部分,而蛋白质糖基化是生命体中最重要的一种蛋白质翻译后修饰之一。糖基化在细胞免疫、信号传导、蛋白翻译调控、蛋白降解等诸多生物过程中起着重要作用。随着蛋白质组学技术的不断发展,糖基化研究也越来越受到广泛的关注。本文综述了糖基化的分类、在生命体中的作用、最新的研究技术及进展。 | 李军 杜鑫 Hosseini Moghaddam S.H. 陈玉银 | 2009 | 科技通报2009，25，6： | 26 |
| 3 | NUMERICAL SIMULATION OF FLOW OVER TWO CIRCULAR CYLINDERS IN TANDEM ARRANGEMENT显示文摘In this article,the 2-D unsteady viscous flow around two circular cylinders in a tandem arrangement is numerically simulated in order to study the characteristics of the flow in both laminar and turbulent regimes.The method applied alternatively is based on the finite volume method on a Cartesian-staggered grid.The great source term technique is employed to identify the cylinders placed in the flow field.To apply the boundary conditions,the ghost-cell technique is used.The implemented computational method is firstly validated through simulation of laminar and turbulent flows around a fixed circular cylinder.Finally,the flow around two circular cylinders in a tandem arrangement is simulated and analyzed.The flow visualization parameters,the Strouhal numbers,and drag and lift coefficients are comprehensively presented and compared for different cases in order to reveal the effect of the Reynolds number and gap spacing on the behavior of the flow.The obtained results have shown two completely distinct flow characteristics in laminar and turbulent regimes. | DEHKORDI Behzad Ghadiri MOGHADDAM Hesam Sarvghad JAFARI Hamed Houri | 2011 | Journal of Hydrodynamics2011，23，1： | 11 |
| 4 | Additive manufacturing of high entropy alloys:A practical review显示文摘The novel idea of alloying,which is based on the utilization of multiple principal elements in high concentrations,has created a novel class of promising materials called high entropy alloys(HEAs).So far,several HEAs with outstanding properties beyond those of conventional alloys have been discovered,and new superior high-entropy alloys are still expected to be developed in the future.However,the fabrication process of HEAs through conventional manufacturing techniques suffers from significant limitations due to the intrinsic requirements of HEAs.Additive manufacturing(AM),on the other hand,has provided new opportunities for fabricating geometrically complex HEAs with the possibility of in situ tailoring of their microstructure features.Considering the growing interest in AM of HEAs during most recent years,this review article aims at providing the state of the art in AM of HEAs.It describes the feedstock requirements for laser based AM techniques.Thereafter,a comprehensive picture of the current state of nearly all HEAs processed by laser metal deposition(LMD),selective laser melting(SLM)and selective electron beam melting(SEBM)is presented.Special attention is paid to the features of AM derived microstructures along with their outstanding properties and underlying mechanisms for various material processing combinations.The AM of interstitial solute hardening HEAs,HEA matrix composites as well as non-beam based AM of HEAs will also be addressed.The post-AM treatments and the strategies to fabricate defect-free HEAs are summarized.Finally,a conclusion of current state and future prospects of additive manufacturing of HEAs will be presented. | Ahmad Ostovari Moghaddam Nataliya A.Shaburova Marina N.Samodurova Amin Abdollahzadeh Evgeny A.Trofimov | 2021 | Journal of Materials Science & Technology2021，，18： | 11 |
| 5 | Study of effective parameters for enhancement of methane gas production from natural gas hydrate reservoirs显示文摘Natural gas hydrate resources have become the major source of energy in the second half of 21st century.Gas production and fluid behavior in natural gas hydrate reservoirs are different from conventional ones.There are three major methods for methane decomposition such as depressurization,thermal stimulation and inhibitor injection.However,CO2 substitution can also be introduced as an alternative method to inject in sediments containing gas hydrate.All these methods tend to imbalance equilibrium condition via temperature and pressure variation in order to fulfill hydrate decomposition process.This study aims to simulate depressurization method for gas production from a hydrate gas bearing layer.Hence,a sensitivity analysis of reservoir parameters includes porosity,permeability,hydrate saturation,hydrate thickness layer;pressure and temperature of single well hydrate model were investigated to determine how these parameters impact on gas production.Results show that depressurization is an efficient method for gas production from hydrate bearing sediments.Through sensitivity analysis,it has been concluded that if properties of a hydrate layer such as porosity and permeability become greater,methane production will be increased significantly.Moreover,results investigate that the rate of hydrate dissociate is strongly dependent on pressure reduction,and it has a reverse relationship with bottomhole pressure and reservoir temperature. | Hamid Aghajari Moien Habibi Moghaddam Mehdi Zallaghi | 2019 | Green Energy & Environment2019，4，4： | 5 |
| 6 | 若干家蚕品种的复壮及比较试验显示文摘对浙江省夏秋蚕品种薪杭,白云,丰1和54A等进行了充血复壮改良,基本稳定后的复壮系与现行生产系进行了生产性能的比较试验。结果表明复壮系在各项性状都有一定的提高,其中龄期经过,各品种的复壮系与生产系之间差别不大,只有薪杭丙和白云丙稍有延长。全茧量和茧层量基本上复壮系都比生产系有所提高。生命率差异比较大,其中薪杭的复壮系低于生产系,差异达到显著水平,白云复壮系略微低于白云甲,但高于白云乙,丰1的复壮系与生产系无明显差异,54A则是复壮系高于生产系。良卵数除薪杭丙比薪杭甲略低外,其他品种的复壮系都比生产系显著提高,有的甚至达到极显著水平。说明复壮系在生产性能上有较大的改良,有一定的推广应用价值。 | 刘光锋 李军 杜鑫 淘涛 傅春红 Hosseini Moghaddam S.H. 陈玉银 | 2007 | 蚕桑通报2007，38，4： | 4 |
| 7 | Methane hydrate stability in the presence of water-soluble hydroxyalkyl cellulose显示文摘The effect of low-dosage water-soluble hydroxyethyl cellulose (approximate MW~90,000 and 250,000) as a member of hydroxyalkyl cellulosic polymer group on methane hydrate stability was investigated by monitoring hydrate dissociation at pressures greater than atmospheric pressure in a closed vessel. In particular, the influence of molecular weight and mass concentration of hydroxyethyl cellulose (HEC) was studied with respect to hydrate formation and dissociation. Methane hydrate formation was performed at 2℃ and at a pressure greater than 100 bar. Afterwards, hydrate dissociation was initiated by step heating from -10℃ at a mild pressure of 13 bar to 3℃, 0℃ and 2℃. With respect to the results obtained for methane hydrate formation/dissociation and the amount of gas uptake, we concluded that HEC 90,000 at 5000 ppm is suitable for long-term gas storage and transportation under a mild pressure of 13 bar and at temperatures below the freezing point. | M. Mohammad-Taheri A. Zarringhalam Moghaddam K. Nazari N. Gholipour Zanjani | 2012 | Journal of Natural Gas Chemistry2012，21，2： | 4 |
| 8 | 硫化锌精矿直接浸出动力学及其半经验模型(英文)显示文摘在中试规模管式反应器中直接浸出贫铁硫化锌精矿,研究其浸出动力学。为满足静压浸出条件,将含硫酸亚铁和硫酸的矿浆注入到垂直放置的直径8 m的管式反应器中,空气从反应器的底部吹入。考察了初始硫酸浓度、反应温度、矿粒直径、初始硫酸锌浓度、矿浆浓度和铁含量对反应动力学的影响。结果表明,硫化锌精矿的直接浸出遵循收缩核模型,过程受化学反应控制,其表观活化能为49.7 k J/mol。采用半经验模型描述该过程,得到铁含量、硫酸浓度、硫化锌精矿浓度和矿粒直径的反应级数分别为0.982、0.189、-0.097和-0.992。采用SEM-EDS对硫化锌精矿浸出反应前后的矿粒进行分析,发现当锌的浸出率低于60%时,由于反应器搅拌的问题,颗粒表面硫产物层脱落,会影响浸出溶液与颗粒表面的接触。 | Nima SADEGHI Javad MOGHADDAM Mehdi OJAGHI ILKHCHI | 2017 | Transactions of Nonferrous Metals Society of China2017，27，10： | 4 |
| 9 | Power Maximization of A Point Absorber Wave Energy Converter Using Improved Model Predictive Control显示文摘This paper considers controlling and maximizing the absorbed power of wave energy converters for irregular waves.With respect to physical constraints of the system, a model predictive control is applied. Irregular waves' behavior is predicted by Kalman filter method. Owing to the great influence of controller parameters on the absorbed power,these parameters are optimized by imperialist competitive algorithm. The results illustrate the method's efficiency in maximizing the extracted power in the presence of unknown excitation force which should be predicted by Kalman filter. | Farideh MILANI Reihaneh Kardehi MOGHADDAM | 2017 | China Ocean Engineering2017，31，4： | 3 |
| 10 | Green synthesis,characterization and physiological stability of gold nanoparticles from Stachys lavandulifolia Vahl extract显示文摘The synthesis of nontoxic stable gold nanoparticles is important for medical applications.An aqueous extract of the plant Stachys lavandulifolia Vahl was used to synthesize gold nanoparticles.This green method involved the S.lavandulifolia Vahl extract acting as a reducing and stabilizing agent.The nanoparticles were characterized by transmission electron microscopy,dynamic light scattering analysis and UV-vis absorption and Fourier transform-infrared spectroscopies.Stability under physiological conditions is important for medical applications.The stability of the nanoparticles was compared with that of conventional citrate-capped nanoparticles,under both synthetic and physiological conditions.The nanoparticles synthesized from the S.lavandulifolia Vahl extract were stable under physiological conditions,in contrast with conventional citrate-capped nanoparticles. | Pooriya Khademi-Azandehi Javad Moghaddam | 2015 | Particuology2015，13，2： | 3 |
| 11 | Genetic and Genotype × Environment Interaction Effects for Appearance Quality of Rice显示文摘This study was conducted to generate genetic information in rice varieties based on a complete diallel crosses over two years. The results indicated that genotype effect was significant for all traits. Genotype × environment interaction effects were significant only for cooked grain length (CGL) and cooked grain shape (CGSH). General combining ability (GCA) and specific combining ability (SCA) effects were significant for entire traits, which indicated the important roles of both additive and non-additive gene actions. GCA × environment interaction effects were significant for CGL, CGSH and grain elongation index (GEI). In the controlling of the inheritance of milled grain shape (GSH), milled grain width (MGW), GEI, milled grain length (MGL), CGSH and cooked grain width (CGW), the additive gene effects were more important than non-additive one. The average degree of dominance was within the range of partial dominance for all of the traits. The narrow-sense heritability was ranged from 0.65 (GSH) to 0.36 (CGL). GCA effects were significant for all of the parents in milled grain length and it was significant for some of the parents in other traits. The crosses of Deilmani × IRFAON-215 exhibited significant SCA for GEI. The positive mean of heterosis was observed for CGW. The highest maximum values of heterosis were revealed in GEI, flowed by GSH, MGW and CGW. GCA and MPV were significantly and positively correlated together for all traits. | Sharifi Peyman Dehghani Hamid Mumeni Ali Moghaddam Mohammad | 2009 | Agricultural Sciences in China2009，8，8： | 3 |
| 12 | An analytical model for pyrolysis of a single biomass particle显示文摘Decreasing in emissions of greenhouse gases to confront the global warming needs to replace fossil fuels as the main doer of the world climate changes by renewable and clean fuels produced from biomass like wood waste which is neutral on the amount of CO2. An analytical and engineering model for pyrolysis process of a single biomass particle has been presented. Using a two-stage semi global kinetic model which includes both primary and secondary reactions, the effects of parameters like shape and size of particle as well as porosity on the particle temperature profile and product yields have been investigated. Comparison of the obtained results with experimental data shows that our results are in a reasonable agreement with previous researchers' works. Finally, a sensitivity analysis is done to determine the importance of each parameter on pyrolysis of a single biomass particle which is affected by many constant parameters. | Mehdi Bidabadi Mohammad Rastegar Moghaddam Seyed Alireza Mostafavi Farzad Faraji Dizaji Hossein Beidaghy Dizaji | 2015 | Journal of Central South University2015，22，1： | 3 |
| 13 | One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe_2O_3 supported sulfonic acid nanocatalyst under solvent-free conditions显示文摘Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe_2O_3[γ-Fe_2O_3@HAp-SO_3H]catalyzed condensation of 6-arnino-2-(methylthio or ethylthio)pyrimidin-4(3H)-one,Meldrum's acid and aryl aldehydes at 60 ℃ and under solvent-free conditions.In this protocol the use of nanocatalyst provided a green,useful and rapid method to generate the products in short reaction times and excellent yields(88%-94%). | Moona Mohsenimehr Manouchehr Mamaghani Farhad Shirini Mehdi Sheykhan Fatemeh Azimian Moghaddam | 2014 | Chinese Chemical Letters2014，25，10： | 2 |
| 14 | Statistical evaluation and optimization of zinc electrolyte hot purification process by Taguchi method显示文摘The neutral zinc sulfate solution obtained from hydrometallurgical process of Angouran zinc concentrate has cadmium, nickel and cobalt impurities, that must be purified before electrowinning. Therefore, cadmium and nickel are usually cemented out by addition of zinc dust and remained nickel and cobalt cemented out at second stage with zinc powder and arsenic trioxide. In this research, a new approach is described for determination of effective parameters and optimization of zinc electrolyte hot purification process using statistical design of experiments. The Taguchi method based on orthogonal array design(OAD) has been used to arrange the experimental runs. The experimental conditions involved in the work are as follows: the temperature range of 70-90 ℃ for reaction temperature(T), 30-90 min for reaction time(t), 2-4 g/L for zinc powder mass concentration(M), one to five series for zinc dust particle size distributions(S1-S5), and 0.1-0.5 g/L(C) for arsenic trioxide mass concentration. Optimum conditions for hot purification obtained in this work are T4(85 °C), t4=75 min, M4=3.5 g/L, S4(Serie 4), and C2=0.2 g/L. | Bahram Behnajady Javad Moghaddam | 2015 | Journal of Central South University2015，22，6： | 2 |
| 15 | The effect of gas mixture of post-oxidation on structure and corrosion behavior of plasma nitrided AISI 316 stainless steel显示文摘 | N. Karimzadeh E.G. Moghaddam M. Mirjani K. Raeissi | 2013 | Applied Surface Science2013，，： | 2 |
| 16 | Gamma-ray shielding study of light to heavyweight concretes using MCNP-4C code显示文摘In this work, linear and mass attenuation coefficients, half and tenth-value layers, effective atomic number and electron density of different types of concretes were determined at 316.51, 468.07, 511, 662, 1173 and 1332 keV using MCNP-4C code and Win XCom programs. The MCNP-4C and Win XCom results agreed well with each other, with differences of \±1.9%. The results agreed with available experimental data, too, with differences of \±6%.The MCNP-4C results showed better agreement with the experimental data than the Win XCom results. Also, it was found that the effective electron density of studied concretes varies in the range of(2.83–3.2) 9 10^(23)electron/g. | Reza Bagheri Alireza Khorrami Moghaddam Ali Yousefi | 2017 | Nuclear Science and Techniques2017，28，2： | 2 |
| 17 | Predicting the yield of pomegranate oil from supercritical extraction using artificial neural networks and an adaptive-network-based fuzzy inference system显示文摘 | J. Sargolzaei A. Hedayati Moghaddam | 2013 | Frontiers of Chemical Science and Engineering2013，7，3： | 2 |
| 18 | 从低品位铜矿石中生物浸出铜的基于响应面方法的经验模型(英文)显示文摘使用响应面方法对在摇动的生物反应器里浸出铜进行模拟和优化。采用中温细菌生物浸出低品位铜矿石,研究浸矿过程参数的影响,包括p H值、矿浆浓度、亚铁离子起始浓度。检测了浸出1、4、9、14和24天后的铜浸出率,对浸出时间对浸出率的影响进行建模。采用中心组合设计法(CCD)建立模型,以预测最佳参数值。采用二次方程建模对实验范围内浸出22天的参数进行优化,以达到最大铜浸出率。在最佳条件下(初始p H值2.0,矿浆浓度1.59%,亚铁离子浓度为0)模型预测的铜浸出率为85.98%,这非常接近实验结果(84.57%)。对p H值和矿浆浓度之间以及p H值和亚铁离子浓度之间的相互作用的影响进行研究。结果显示,亚铁离子起始浓度和矿浆浓度之间没有明显的相互作用,而且发现在最佳p H值和矿浆浓度下,铜的浸出率与亚铁离子起始浓度值没有关系。 | M.YAGHOBI MOGHADDAM S.Z.SHAFAEI M.NOAPARAST F.DOULATI ARDEJANI H.ABDOLLAHI M.RANJBAR M.SCHAFFIE Z.MANAFI | 2015 | Transactions of Nonferrous Metals Society of China2015，25，12： | 2 |
| 19 | Effect of Sinter Hardening on Microstructure and Mechanical Properties of Astaloy 85Mo显示文摘Effect of sinter hardening on the microstructure, density, hardness and tensile properties of Astaloy 85Mo+0.7% graphite was investigated. For this purpose, Astaloy 85Mo, a pre-alloyed powder, was mixed with 0.7% UF4 graphite and then pressed in single action die and sintered at 1 120 ℃ for 30 min in N2-10%H2 atmosphere. Then samples were cooled from 0.5 to 3 ℃/s sintering temperature in accordance with different cooling rates. The difference in microstructure, hardness, density and tensile properties of the samples associated with different cooling rates from sintering temperature has been investigated. The results show that the microstructure remains bainitic by changing cooling rate, but it becomes finer and then the hardness and tensile strength of the samples will increase by increasing the cooling rate from sintering temperature. | K Sheikhi Moghaddam M Ghambari H Farhangi N Solimanjad | 2012 | Journal of Iron and Steel Research(International)2012，19，10： | 2 |
| 20 | Enlarging the guaranteed region of attraction in nonlinear systems with bounded parametric uncertainty显示文摘A novel approach to enlarge the guaranteed region of attraction in nonlinear systems with bounded parametric uncertainties based on the design of a nonlinear controller is proposed.The robust domain of attraction(RDA) is estimated using the parameter-dependent quadratic Lyapunov function and enlarged by the optimal controlling parameters.The problem of extending the RDA is indicated in a form of three-layer optimization problem.Some examples illustrate the efficiency of the proposed strategy in enlarging RDA. | Sara HAGHIGHATNIA Reihaneh Kardehi MOGHADDAM | 2013 | Journal of Zhejiang University-Science C(Computers and Electronics)2013，14，3： | 2 |
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