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| 1 | PI3K signaling pathway targeting by using different molecular approaches to treat cancer显示文摘Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment. | Mohammad Rashid Shahid Karim Babar Ali Shamshir Khan Makhmur Ahmad Asif Husain Ravinesh Mishra | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，9： | 7 |
| 2 | Morphological and Genetical Variability among Rhizoctonia solani Isolates Causing Sheath Blight Disease of Rice显示文摘Eighteen isolates of Rhizoctonia solani collected from infected rice plants in four different locations of Bangladesh were studied by using morphological characters and molecular markers. Anastomosis study with a reference isolate confirmed that all the isolates belonged to R. solani. Significant variation was observed in sclerotial size, shape and distribution. Un-weighted pair group method with arithmetic mean dendrogram constructed based on the Gower's general similarity coefficient showed that these isolates were grouped into four clusters at the 0.68 similarity coefficent according to morphological characters. Cluster I was a major cluster consisting of 13 isolates, while clusters Ⅱ to Ⅳ consisted of 1 or 2 isolates. Analyses by variable number of tandem repeat and amplified fragment length polymorphism markers showed that the isolates were grouped into five and three clusters at a similarity coefficient of 0.64 and 0.69, respectively. Although most of the variability was found between isolates from different regions as expected, significant variation was observed within the isolates collected from similar agro-ecological regions. Our results suggest the presence of different races of R. solani within the same local geographic regions. | Zakiah Rahman MONI Md Ansar ALI Md Shahidul ALAM Md Asif RAHMAN Md Rejwan BHUIYAN Md Salim MIAN Khandakar Md IFTEKHARUDDAULA Md Abdul LATIF Mohammad Ashik Iqbal KHAN | 2016 | Rice science2016，23，1： | 2 |
| 3 | Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoria显示文摘 | Gurpreet Kaur Hinna Hamid Asif Ali M Sarwar Alam Mohammad Athar | 2003 | Journal of Ethnopharmacology2003，，2： | 1 |
| 4 | Syntheses of rigid-rod but degradable biopolyamides from itaconic acid with aromatic diamines显示文摘 | Mohammad Asif Ali Seiji Tateyama Tatsuo Kaneko | 2014 | Polymer Degradation and Stability2014，109，： | 1 |
| 5 | IoTFLiP: IoT-based flipped learning platform for medical education显示文摘 | Maqbool Ali Hafiz Syed Muhammad Bilal Muhammad Asif Razzaq Jawad Khan Sungyoung Lee Muhammad Idris Mohammad Aazam Taebong Choi Soyeon Caren Han Byeong Ho Kang | 2017 | Digital Communications and Networks2017，3，3： | 0 |
| 6 | Facile synthesis of ironenickelecobalt ternary oxide(FNCO)mesoporous nanowires as electrode material for supercapacitor application显示文摘Transition Metal Oxides have drawn significant attention due to their reversible chemical redox reaction and long-life stability.Inexorable agglomeration and shrinkage/expansion of transition metal oxides in the nanosize regime have a noticeable effect on their electrochemical properties.Here in this work,mesoporous nanowires(NWs)with a typical composition of iron-nickel-cobalt ternary oxide(FNCO)are synthesized using a simple,facile and cost-effective hydrothermal process followed by furnace annealing.These NWs are then extensively investigated as an electrode material for supercapacitor application.To compare the electrochemical properties,nanowires of nickel-cobalt oxide(NCO),iron-cobalt oxide(FCO)and cobalt oxide(CO)were also produced by following the same protocol.The FNCO NWs are found to overcome the shortcomings in the electrochemical energy storage devices by exhibiting higher values of specific capacitance(2197 Fg^(-1))and energy density(109 Whkg^(-1))at 1 Ag^(-1) current rate.Moreover,the FNCO NWs also showed a cyclic charge/discharge stability of 96%even up to 20,000 cycles.Furthermore,a FNCO//graphene asymmetric device,fabricated with FNCO NWs and graphene as positive and negative electrodes,respectively,which exhibit high energy density(47 Whkg^(-1)),power density(375 Wkg^(-1))and excellent capacitance retention(86%)after 15,000 cycles. | Muhammad Usman Muhammad Tayyab Ahsan Sofia Javed Zeeshan Ali Yiqiang Zhan Irfan Ahmed Sajid Butt Mohammad Islam Asif Mahmood M.Aftab Akram | 2022 | Journal of Materiomics2022，8，1： | 0 |
| 7 | Systematic Analysis of Safety and Security Risks in Smart Homes显示文摘The revolution in Internet of Things(IoT)-based devices and applications has provided smart applications for humans.These applications range from healthcare to traffic-flow management,to communication devices,to smart security devices,and many others.In particular,government and private organizations are showing significant interest in IoT-enabled applications for smart homes.Despite the perceived benefits and interest,human safety is also a key concern.This research is aimed at systematically analyzing the available literature on smart homes and identifying areas of concern or risk with a view to supporting the design of safe and secure smart homes.For this systematic review process,relevant work in the most highly regarded journals published in the period 2016–2020(a section of 2020 is included)was analyzed.A final set of 99 relevant articles(journal articles,book sections,conference papers,and survey papers)was analyzed in this study.This analysis is focused on three research questions and relevant keywords.The systematic analysis results and key insights will help researchers and practitioners to make more informed decisions when dealing with the safety and security risks of smart homes,especially in emergency situations. | Habib Ullah Khan Mohammad Kamel Alomari Sulaiman Khan Shah Nazir Asif Qumer Gill Alanoud Ali Al-Maadid Zaki Khalid Abu-Shawish Mostafa Kamal Hassan | 2021 | Computers, Materials & Continua2021，，7： | 0 |
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