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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | Thermosensitive Particles with Unusual Morphology Prepared by Dispersion Copolymerization显示文摘The monodispersed polymeric particles with an unusual structure were prepared by the dispersion copolymerization of acrylonitrile/styrene(AN/St) in mixed solvents of ethanol/water by using the poly(N-isopropylacrylamide) (PNIPAAm) macromonomer as a reaction stabilizer. It was found that the AN monomer plays a key role in the formation of the particles with special morphology analyzed via scanning electron microscopy(SEM). The reaction parameters have remarkable influences on the particle size and morphology. The particles possess a thermosensitive property according to the result of laser light scattering(LLS). | CHEN Ming-qing YUAN Yan-hua LIU Xiao-ya YANG Cheng KANEKO Tatsuo AKASHI Mitsuru | 2005 | Chemical Research in Chinese Universities2005，21，6： | 3 |
| 3 | Use of an opened umbilical vein patch for the reconstruction of the injured biliary tract显示文摘 | Masashi Watanabe Kunihiro Yamazaki Masaru Tsuchiya Yuichiro Otsuka Akira Tamura Kontoku Shimokawa Hironori Kaneko Tatsuo Teramoto | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，3： | 1 |
| 4 | Tough,thinhydrogel membranes with giant crystalline domains composed of precisely synthesized macromolecules显示文摘 | Tatsuo Kaneko Shinji Tanaka Atsuhiko Ogura | 2005 | Macromolecules2005，38，： | 1 |
| 5 | One-step formation of morphologically controlled nanospheres with projection coronas显示文摘 | Tatsuo Kaneko Kazuhiro Hamada Ming-Qing Chen | 2004 | Macromolecules2004，37，： | 1 |
| 6 | Tolerance of loop-mediated isothermal amplification to a culture medium and biological substances显示文摘 | Hisatoshi Kaneko Takashi Kawana Eiko Fukushima Tatsuo Suzutani | 2006 | Journal of Biochemical and Biophysical Methods2006，，3： | 1 |
| 7 | Analysis of 109 Japanese children's lip and nose shapes using 3-dimensional digitizer显示文摘 | Ayako Mori Tatsuo Nakajima Tsuyoshi Kaneko | 2005 | Bri J Plast Surg2005，58，： | 1 |
| 8 | Use of an opened umbilical vein patch for the reconstruction of the injured biliary tract显示文摘 | Masashi Watanabe Kunihiro Yamazaki Masaru Tsuchiya Yuichiro Otsuka Akira Tamura Kontoku Shimokawa Hironori Kaneko Tatsuo Teramoto | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，3： | 1 |
| 9 | Use of an opened umbilical vein patch for the reconstruction of the injured biliary tract显示文摘 | Masashi Watanabe Kunihiro Yamazaki Masaru Tsuchiya Yuichiro Otsuka Akira Tamura Kontoku Shimokawa Hironori Kaneko Tatsuo Teramoto | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，3： | 1 |
| 10 | Syntheses of rigid-rod but degradable biopolyamides from itaconic acid with aromatic diamines显示文摘 | Mohammad Asif Ali Seiji Tateyama Tatsuo Kaneko | 2014 | Polymer Degradation and Stability2014，109，： | 1 |
| 11 | Vascular Endothelial Growth Factor-C and Vascular Endothelial Growth Factor-D mRNA Expression in Breast Cancer: Association with Lymph Node Metastasis显示文摘 | Yu Koyama Kouji Kaneko Kohei Akazawa Chizuko Kanbayashi Tatsuo Kanda Katsuyoshi Hatakeyama | 2003 | Clinical Breast Cancer2003，，5： | 1 |
| 12 | Effects of gasoline properties on cold start emission characteristic显示文摘 | Oyama Koji Kaneko Takashi Hamatani Kazumasa Omata Tatsuo | 1997 | Abstract/JSAE Review1997，18，： | 1 |
| 13 | 显示文摘 | Taka-aki Asoh Tatsuo Kaneko Michiya Matsusak | 2006 | Journal of Controlled Release2006，110，2： | 1 |
| 14 | Reversible crystal deformation observed in the main-chain type of liquid crystalline polyimide 显示文摘 | Kaneko Tatsuo I Imamura Ken Watanabe Junji | 1997 | Macromolecules1997，30，14： | 1 |
| 15 | Template preparation of twisted nanoparticles of mesoporous silica显示文摘Optical isomers of N-lauroyl-l-(or-d-) alanine sodium salt {C 12 -l-(or-d-)AlaS} surfactants were used for the preparation of mesoporous silica nanoparticles with a twisted hexagonal rod-like morphology. Ther- mogravimetric analysis (TGA) was used to determine the temperature for template removal. Circular dichroism (CD) spectra of the surfactant solution with various compositions illustrated the formation and supramolecular assembly of protein-like molecular architecture leading to formation of twisted nanoparticles. Scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM) and X-ray powder diffraction (XRD) patterns of these as-synthesized mesoporous silica confirmed that the twisted morphology of these nanoparticles was closely related to the supramolecular-assembled complex of amino acid surfactants. | Kui Niu Zhongbin Ni Chengwu Fu Tatsuo Kaneko Mingqing Chen | 2011 | Particuology2011，9，1： | 0 |
| 16 | Syntheses of Soluble Biopolyimides Using 4-Aminophenylalanine显示文摘4-Aminophenylalanine(4APhe),an exotic amino acid which is obtained as a microorganism metabolite of glucose,is polycondensed with various tetracarboxylic dianhydrides as a diamine monomer to obtain poly(amic acid)s.Subsequent thermal imidization of poly(amic acid)s is made at 220°C with stepwise heating from 100°C.Some of the obtained polyimides(PIs)exhibited good solubility in organic solvents such as N,N-dimethylformamide,N.N dimethylacetamide,and more.The progress of imidization was observed by proton nuclear magnetic resonance and infrared spectroscopy to confrm that the imidization ratio was up to 98%.Carboxylate group of the side-chains of PIs affected their solubilities despite the high imidization ratio,and the solubility was lost for any organic solvents by decarboxylation at 280。C,confirmed from mass-loss of thermogravimetric analysis.Thus,a new series of PIs were obtained with abilities of solvent-molding in PI state and thermal resistivityt enhancement by further heating after molding. | Kenji Takad Hiromasa Shinagaw Yuki Morita Manjit SGrewal Kazuya Taya Amit Kumar Tatsuo Kaneko | 2020 | Chinese Journal of Polymer Science2020，38，10： | 0 |
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