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| 1 | Injectable hydrogels for cartilage and bone tissue engineering显示文摘Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix(ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed. | Mei Liu Xin Zeng Chao Ma Huan Yi Zeeshan Ali Xianbo Mou Song Li Yan Deng Nongyue He | 2017 | Bone Research2017，5，2： | 54 |
| 2 | Multidisciplinary Design and Optimization of Multistage Ground-launched Boost Phase Interceptor Using Hybrid Search Algorithm显示文摘This article proposes a multidisciplinary design and optimization (MDO) strategy for the conceptual design of a multistage ground-based interceptor (GBI) using hybrid optimization algorithm,which associates genetic algorithm (GA) as a global optimizer with sequential quadratic programming (SQP) as a local optimizer.The interceptor is comprised of a three-stage solid propulsion system for an exoatmospheric boost phase intercept (BPI).The interceptor's duty is to deliver a kinetic kill vehicle (KKV) to the optimal position in space to accomplish the mission of intercept.The modules for propulsion,aerodynamics,mass properties and flight dynamics are integrated to produce a high fidelity model of the entire vehicle.The propulsion module comprises of solid rocket motor (SRM) grain design,nozzle geometry design and performance prediction analysis.Internal ballistics and performance prediction parameters are calculated by using lumped parameter method.The design objective is to minimize the gross lift off mass (GLOM) of the interceptor under the mission constraints and performance objectives.The proposed design and optimization methodology provide designers with an efficient and powerful approach in computation during designing interceptor systems. | Qasim Zeeshan Khurram Nisar Ali Kamran Amer Rafique | 2010 | Chinese Journal of Aeronautics2010，23，2： | 8 |
| 3 | Simultaneous extraction of DNA and RNA from Escherichia coli BL 21 based on silica-coated magnetic nanoparticles显示文摘The extraction of nucleic acid is recognized as one of the most essential steps in molecular biology for initiating other downstream applications such as sequencing, amplification, hybridization, and cloning. Many commercial kits and methods are currently available that allow the extraction of only one type of nucleic acids-DNA or RNA. However, in parallel clinical detection of several diseases, a method for simultaneous extraction of both DNA and RNA from the same source is needed in such cases. In this study, a method for simultaneous extraction of DNA and RNA from bacteria based on magnetic nanoparticles(MNPs) was described. Lysis buffers were prepared to help the nucleic acid released and adsorbed to MNPs. Then, two washing buffers were used to remove the contamination of proteins and carbohydrates. The nucleic acids were finally eluted by Deoxyribonuclease(DNase) and Ribonucleases(RNase) free water. Different factors which might affect the purification of the nucleic acid were investigated, and the quantity and quality parameters of the nucleic acid were also recorded. The DNA and RNA extracted from bacteria were then respectively subjected to polymerase chain reaction(PCR) and reverse transcription PCR(RT-PCR) to further confirm its quality. The results indicated that our method can be successfully used to simultaneously extract DNA and RNA from bacteria. | Jiuhai Wang Zeeshan Ali Nianyue Wang Wenbiao Liang Hongna Liu Fu Li Haowen Yang Lei He Libo Nie Nongyue He Zhiyang Li | 2015 | Science China Chemistry2015，58，11： | 5 |
| 4 | Enhancing through-plane thermal conductivity of fluoropolymer composite by developing in situ nano-urethane linkage at graphene–graphene interface显示文摘Attributed to the intense development and complexity in electronic devices,energy dissipation is becoming more essential nowadays.The carbonaceous materials particularly graphene(Gr)-based thermal interface materials(TIMs)are exceptional in heat management.However,because of the anisotropic behavior of Gr in composites,the TIMs having outstanding through-plane thermal conductivity(┴TC)are needed to fulfill the upcoming innovation in numerous devices.In order to achieve this,herein,nano-urethane linkage-based modified Gr and carbon fibers architecture termed as nanourethane linkage(NUL)-Gr/carbon fibers(CFs)is fabricated.Wherein,toluene diisocyanate is utilized to develop a novel but simple NUL to shape a new interface between graphene sheets.Interestingly,the prepared composite of NUL-Gr/CFs with polyvinylidene fluoride matrix shows outstanding performance in heat management.Owing to the unique structure of NUL-Gr/CFs,an unprecedented value of┴TC(~7.96 W·m^–1·K^–1)is achieved at a low filler fraction of 13.8 wt.%which translates into an improvement of^3,980%of pristine polymer.The achieved outcomes elucidate the significance of the covalent interaction between graphene sheets as well as strong bonding among graphene and matrix in the composites and manifest the potential of proposed NUL-Gr/CFs architecture for practical applications. | Muhammad Maqbool Haichang Guo Akbar Bashir Ali Usman Adeel YAbid Guansong He Yanjuan Ren Zeeshan Ali Shulin Bai | 2020 | Nano Research2020，13，10： | 3 |
| 5 | Surfactant-decorated graphite nanoplatelets(GNPs) reinforced aluminum nanocomposites: sintering effects on hardness and wear显示文摘The exceptional properties of graphene make it ideal as a reinforcement to enhance the properties of aluminum matrices and this critically depends on uniform dispersion. In this study, the dispersion issue was addressed by sonication and non-covalent surface functionalization of graphite nanoplatelets(GNPs) using two types of surfactant: anionic(sodium dodecyl benzene sulfate(SDBS)) and non-ionic polymeric(ethyl cellulose(EC)). After colloidal mixing with Al powder, consolidation was performed at two sintering temperatures(550 and 620°C). The structure, density, mechanical and wear properties of the nanocomposite samples were investigated and compared with a pure Al and a pure GNPs/Al nanocomposite sample. Noticeably, EC-based 0.5 wt% GNPs/Al samples showed the highest increment of 31% increase in hardness with reduced wear rate of 98.25% at 620°C, while a 22% increase in hardness with reduced wear rate of 96.98% at 550°C was observed, as compared to pure Al. Microstructural analysis and the overall results validate the use of EC-based GNPs/Al nanocomposites as they performed better than pure Al and pure GNPs/Al nanocomposite at both sintering temperatures. | Zeeshan Baig Othman Mamat Mazli Mustapha Asad Mumtaz Sadaqat Ali Mansoor Sarfraz | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，6： | 3 |
| 6 | Diabetes mellitus and decompensated cirrhosis: Risk of hepatic encephalopathy in different age groups (糖尿病与失代偿性肝硬化:不同年龄组的肝性脑病风险)显示文摘 | Zeeshan Butt Nauman A. Jadoon Osman N. Salaria Kamran Mushtaq Irbaz B. Riaz Ahmed Shahzad Ali M. Hashmi Shahid Sarwar | 2013 | Journal of Diabetes2013，，4： | 3 |
| 7 | Hyper Heuristic Approach for Design and Optimization of Satellite Launch Vehicle显示文摘Satellite launch vehicle lies at the cross-road of multiple challenging technologies and its design and optimization present a typical example of multidisciplinary design and optimization(MDO) process.The complexity of problem demands highly effi-cient and effective algorithm that can optimize the design.Hyper heuristic approach(HHA) based on meta-heuristics is applied to the optimization of air launched satellite launch vehicle(ASLV).A non-learning random function(NLRF) is proposed to con-trol low-level meta-heuristics(LLMHs) that increases certainty of global solution,an essential ingredient required in product conceptual design phase of aerospace systems.Comprehensive empirical study is performed to evaluate the performance advan-tages of proposed approach over popular non-gradient based optimization methods.Design of ASLV encompasses aerodynamics,propulsion,structure,stages layout,mass distribution,and trajectory modules connected by multidisciplinary feasible design approach.This approach formulates explicit system-level goals and then forwards the design optimization process entirely over to optimizer.This distinctive approach for launch vehicle system design relieves engineers from tedious,iterative task and en-ables them to improve their component level models.Mass is an impetus on vehicle performance and cost,and so it is considered as the core of vehicle design process.Therefore,gross launch mass is to be minimized in HHA. | Amer Farhan RAFIQUE HE Linshu Ali KAMRAN Qasim ZEESHAN | 2011 | Chinese Journal of Aeronautics2011，24，2： | 3 |
| 8 | 无表面活性剂条件下大规模可控制备单分散Fe3O4及其化学动力学过程研究(英文)显示文摘Fe3O4微球被广泛应用于生物医药、催化和环境工程领域.理解Fe3O4微球的化学动力学过程并发展一种通用的、无表面活性剂的大规模合成Fe3O4微球的方法成为当前的迫切需求.本文提出了一种简单的无表面活性剂的方法用于大规模合成Fe3O4微球,通过调节溶液中Fe^3+/COO^-的比例,合成了直径为107到450 nm的Fe3O4微球.研究表明,反应物通过氧化还原反应、沉淀溶解平衡和配位过程形成最终反应产物.其中,二羧基基团和铁离子的配位促进了Fe3O4微球的形成.本文不仅提供了一种在大规模合成反应过程中调控产物尺寸的方法,而且详细研究了在无表面活性剂条件下合成Fe3O4微球过程中醇起到的特殊作用. | 李雅娜 汪志义 Zeeshan Ali 田克松 徐俊杰 李巍 侯仰龙 | 2019 | Science China Materials2019，62，10： | 2 |
| 9 | Synthesis of aptamer-functionalized Ag nanoclusters for MCF-7 breast cancer cells imaging显示文摘Aptamer-functionalized silver nanoclusters(Ag NCs) have been attracting a lot of interest as label-free probes which have been successfully applied to both cell imaging and molecular detection.MUCl aptamer is an ssDNA aptamer that specifically binds to MUCl mucin which is a large transmembrane glycoprotein whose expression level increases at least 10-fold in primary and metastatic breast cancers.Using C4A4C3-linker-MUCl as template,the Ag NCs were synthesized through one-pot process.The fluorescence intensity of Ag NCs was found to be closely related to the length and type(poly adenine or thymine) of the linker,the optimum linker being-AAAAA-.Using the C4A4C3-A5-MUC1 as the scaffold,the synthesized Ag NCs emitted fluorescence with high quantum yield(QY) of 66.5%.Based on the specific interaction between the MUCl aptamer and MUCl mucin,the C4A4C3-A5-MUC1-stabilized Ag NCs could recognize and differentiate the MCF-7 breast cancer cells from MDA-MB-231 breast cancer and A549 human lung cancer cells. | Taotao Li Jingjing Yang Zeeshan Ali Zunliang Wang Xianbo Mou Nongyue He Zhifei Wang | 2017 | Science China Chemistry2017，60，3： | 2 |
| 10 | 基于PCR-化学发光的HBV/HCV/HIV并行核酸检测试剂盒的评价显示文摘目的:评价一种基于PCR与化学发光技术并行检测血液中HBV/HCV/HIV的试剂盒。方法:使用自制的磁珠及试剂提取病毒核酸,利用多重PCR、特异性探针及化学发光法检测目标病毒核酸的信息,评价试剂盒的灵敏度、特异性及稳定性等。结果:本试剂盒灵敏度高,特异性和稳定性好,能够同时检测出HBV、HCV和HIV的极限值分别为2.0、3.7和166.6 U/m L,对于可能产生干扰的10种病毒和2种细菌的病原体无交叉反应,有效期约12个月。在健康献血者10 422例酶免疫分析法合格标本中,筛查出HBV DNA核酸阳性标本12例和HCV RNA核酸阳性标本2例,与国家批准的血液筛查核酸试剂平行检测结果一致。结论:该试剂盒快速、准确、高灵敏、低成本,适用于基因诊断及流行病学调查。 | 张若洋 范恩勇 王明元 Zeeshan Ali 汪久海 冯晨晨 吴敏慧 史丽莉 李智洋 梁文飚 | 2017 | 南京医科大学学报(自然科学版)2017，37，3： | 2 |
| 11 | Evaluation of immune re-sponse to Hepatitis B vaccine in health care workers at a tertiarycare hospital in Pakistan:an observational prospective study显示文摘 | Zeeshan M Jabeen K Ali AN | 2007 | BMC Infect Dis2007，7，： | 1 |
| 12 | Breeding for pre-harvest sprouting resistance in bread wheat under rainfed conditions显示文摘Pre-harvest sprouting in wheat is the germination of seeds within the spikes when rains occur after or during grain ripening, which occurs commonly in the barani tract of Pakistan. Therefore, 10 cultivars and five advanced lines of spring bread wheat were evaluated for pre-harvest sprouting resistance. After natural rainfall,seeds were immediately collected from the wet spikes and tested for germinating ability. Three different germination tests were applied to hand-threshed seed:(1) spikes threshed on the day of sampling and germination tested immediately,(2) spikes threshed on the day of sampling and germination tested 1 week later, and(3) spikes threshed 1 week after sampling and germination test immediately after threshing. Seeds and spikes kept for 1 week were place on blotting paper at room temperature.Cultivars BARS-09, 09 FJ17, Doukkala-12, NARC-09 and Ouassou-20 exhibited higher sprouting resistance while other genotypes were susceptible to pre-harvest sprouting in each of the three tests. A diallel crossing was conducted with six susceptible and two resistant genotypes to assess the genetic behavior of pre-harvest sprouting resistance.The combining ability(CA) demonstrated a higher proportion of additive genetic effects for sprouting resistance, because of higher variance of general and specific CA for both parameters under study. Doukkala-12 and BARS-09 showed increased pre-harvest sprouting resistance in their F1 descendants. | Muhammad ZEESHAN Waheed ARSHAD Muhammad Imran KHAN Shiraz ALI Ali NAWAZ Amina BATOOL Muhammad TARIQ Muhammad Imran AKRAM Muhammad Amjad ALI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 1 |
| 13 | Diabetes mellitus and decompensated cirrhosis: risk of hepatic encephalopathy in different age groups 显示文摘 | Zeeshan Butt Nauman A Jadoon Osman N Salaria Kamran Mushtaq Irbaz B Riaz Ahmed Shahzad Ali M Hashmi Shahid Sarwar | 2013 | Journal of diabetes2013，5，： | 1 |
| 14 | Unfolding the structural features of NASICON materials for sodium-ion full cells显示文摘Sodium-ion batteries(SIBs)are potential candidates for the replacement of lithium-ion batteries to meet the increasing demands of electrical storage systems due to the low cost and high abundance of sodium.Sodium superionic conductor(NASICON)structured materials have attracted enormous interest in recent years as electrode materials for safer and long-term performance of SIBs for electric energy storage smart grids.These materials have a threedimensional robust framework,high redox potential,thermal stability,and a fast Na^(+)-ion diffusion mechanism.However,NASICON has low intrinsic electronic conductivity,which limits the electrochemical performance.This review describes the structural features of NASICONs to illustrate the ion storage mechanism and electrochemical performance of SIBs.Details of the NASICON crystal structure,the affiliated Na^(+)-ion diffusion mechanism,morphology,and electrochemical performance of these materials in sodiumion half-cells as well as full cells are described.In addition to the application as electrode materials,the use of NASICONs as solid electrolytes is also elaborated in solid-state SIBs.Based on these aspects,we have provided more perspectives in terms of the commercialization of SIBs and strategies to overcome the limitations of NASICONs.Hence,this review is expected to provide the researchers of energy storage with an in-depth understanding of NASICON materials with the knowledge of structural features,which will provide a new avenue on the practicality of SIBs. | Muhammad Tayyab Ahsan Zeeshan Ali Muhammad Usman Yanglong Hou | 2022 | Carbon Energy2022，4，5： | 1 |
| 15 | Burning Regression Analysis for 3D Grain Configurations显示文摘Grain design is essentially filling a prescribed volume (chamber case) with a certain shape of propellant so as to ensure mission requirements. An infinite number of possibilities exist, covering from two dimensional to three dimensional grain designs. Accurate calculation of grain geometrical properties plays a vital role in performance prediction. In this paper a methodology has been presented for designing 3D grain configuration for Solid Rocket Motors (SRMs). The design process involves parametric modeling of the geometry in CAD software through dynamic variables that define the complex configuration. Initial geometry is defined in the form of a surface which defines the grain configuration. Grain burn back is achieved by making new surfaces at each web increment and calculating geometrical properties at each step. Geometrical calculations are based on volume and change in volume calculations. Models for Axisymetric and Finocyl grain configuration have been developed. Equilibrium pressure method is used to calculate the internal ballistics. The procedure adopted can be applied to any complex geometry in a relatively simple way for preliminary designing of grain configuration. | ALI Kamran LIANG Guozhu MUHAMMAD Zeeshan Siddiqui | 2010 | Computer Aided Drafting,Design and Manufacturing2010，20，1： | 1 |
| 16 | Seasonal variations in dissolved organic matter concentration and composition in an outdoor system for bank filtration simulation显示文摘Dissolved organic matter(DOM)in surface waters can vary markedly in character depending on seasonal variations such as rainfall intensity,UV radiations and temperature.Changes in DOM as well as temperature and rainfall intensity over the year can affect the biochemical processes occurring in bank filtration(BF).Identification and characterization of DOM in the surface water could help to optimize the water treatment and provide stable and safe drinking water.This study investigated year-long variations of DOM concentrations and compositions in a surface water of a circulated outdoor pond(research facility)connected to a BF passage.DOM was dominated by humic substances and a changing pattern of DOM in surface water was observed throughout the year.A significant increase of DOM(~38%)in surface water was noted in August compared to November.The fluorescent DOM showed that DOM in summer was enriched with the degradable fraction whilst non-degradable fraction was dominated in winter.A constant(1.7±0.1 mg/L)effluent DOM was recirculated in the system throughout the year.DOM removal through BF varied between 4%to 39%and was achieved within a few meters after infiltration and significantly correlated with influent DOM concentration(R^(2)=0.82,p<0.05).However,no significant(p>0.05)change in the removal of DOM was observed in two subsurface layers(upper and lower).This study highlights the presence of a constant non-degradable DOM in the bank filtrate,which was not affected by temperature,redox conditions and UV radiations. | Muhammad Zeeshan Omamah Ali Shamas Tabraiz Aki Sebastian Ruhl | 2024 | Journal of Environmental Sciences2024，，1： | 1 |
| 17 | On-chip classification of micro-particles using laser light scattering and machine learning显示文摘The rapid detection of microparticles exhibits a broad range of applications in the field of science and technology. The proposed method differentiates and identifies the 2 μm and 5 μm sized particles using a laser light scattering. The detection method is based on measuring forward light scattering from the particles and then classifying the acquired data using support vector machines. The device is composed of a microfluidic chip linked with photosensors and a laser device using optical fiber. Connecting the photosensors and laser device using optical fibers makes the device more diminutive in size and portable. The prepared sample containing microspheres was passed through the channel, and the surrounding photosensors measured the scattered light. The time-domain features were evaluated from the acquired scattered light, and then the SVM classifier was trained to distinguish the particle’s data. The real-time detection of the particles was performed with an overall classification accuracy of 96.06%. The optimum conditions were evaluated to detect the particles with a minimum concentration of 0.2 μg/m L. The developed system is anticipated to be helpful in developing rapid testing devices for detecting pathogens ranging between 2 μm to 10 μm. | Mubashir Hussain Xiaolong Liu Jun Zou Jian Yang Zeeshan Ali Hamood Ur Rehman Nongyue He Jianguo Dai Yongjun Tang | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 18 | Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan显示文摘Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 776) and serum (n = 1050)samples were collected from camels between November 2015 and February 2018. Samples were collected from animal markets, free-roaming herds and abattoirs. An in-house ELISA was developed to detect IgG against MERS-CoV. A total of 794 camels were found seropositive for MERS-CoV. Prevalence increased with the age and the highest seroprevalence was recorded in camels aged [ 10 years (81.37%) followed by those aged 3.1–10 years (78.65%) and B 3 years (58.19%).Higher prevalence was observed in female (78.13%) as compared to male (70.70%). Of the camel nasal swabs, 22 were found to be positive by RT-qPCR though with high Ct values. Moreover, 2,409 human serum samples were also collected from four provinces of Pakistan during 2016–2017. Among the sampled population, 840 humans were camel herders.Although we found a high rate of MERS-CoV antibody positive dromedaries (75.62%) in Pakistan, no neutralizing antibodies were detected in humans with and without contact to camels. | Ali Zohaib Muhammad Saqib Muhammad Ammar Athar Jing Chen Awais-ur-Rahman Sial Saeed Khan Zeeshan Taj Halima Sadia Usman Tahir Muhammad Haleem Tayyab Muhammad Asif Qureshi Muhammad Khalid Mansoor Muhammad Ahsan Naeem Bing-Jie Hu Bilal Ahmed Khan Ikram Din Ujjan Bei Li Wei Zhang Yun Luo Yan Zhu Cecilia Waruhiu Iahtasham Khan Xing-Lou Yang Muhammad Sohail Sajid Victor Max Corman Bing Yan Zheng-Li Shi | 2018 | Virologica Sinica2018，33，5： | 1 |
| 19 | Bedload transport from analytical and turbulence phenomenological perspectives显示文摘In this paper,we present the dynamics of bedload transport from two different perspectives.They are the analytical perspective and the turbulence phenomenological perspective.In bedload transport from the analytical perspective,we highlight the systematic advances in the analytical modelling of bedload transport over the decades.These advances are principally classified into three broad foundations,namely,the deterministic foundation,that includes the bed shear stress concept,stream power concept,force balance concept and bedform concept,and the probabilistic foundation and the turbulence phenomenological foundation of bedload transport.The bedload transport from the turbulence phenomenological perspective brings into focus the bedload-induced turbulence phenomenology,including the hydrodynamics of mobile-bed and water-worked bed flows.We also discuss the recent advances in the biofilm-coated bedload transport.Finally,conclusion is drawn,highlighting the major research challenges. | Subhasish Dey Sk Zeeshan Ali Ellora Padhi | 2019 | International Journal of Sediment Research2019，34，6： | 1 |
| 20 | A pH-responsive biomimetic drug delivery nanosystem for targeted chemo-photothermal therapy of tumors显示文摘Smart drug delivery nanosystem is significant for tumor treatments due to its possibility of temporally,spatially,and dose-controlled release.However,the therapeutic efficacy of drug delivery nanosystem is often compromised in cancer treatment as the enrichment of therapeutic agents in the reticuloendothelial system.Herein,doxorubicin(DOX)loaded biomimetic drug delivery nanosystem with macrophage cell membrane(MCM)camouflaged,MnFe_(2)O_(4)-DOX-MCM nanocube(NC),is developed for cancer treatment with tumor targeting,pH-stimuli drug release,and chemo-photothermal therapeutic effects.The nanosystem shows the capability of immune escape and enhanced cellular uptake of cancer cells due to the MCM decoration.Acid-labile bond between the MnFe2O4 NCs and DOX remains stable at physiological condition and release drugs immediately in response to the endo-/lysosome pH stimuli.Meanwhile,the photothermal effect of the nanosystem destroys tumor tissue,which further promotes chemotherapeutic efficacy.In vivo results demonstrate the tumor homing ability and produce a notable synergistic therapeutic effect of the NCs.Thus,biomimetic pH-responsive drug delivery nanosystem,MnFe_(2)O_(4)-DOX-MCM NCs,is an effective nanoplatform,which might be potential application for cancer synergistic treatment. | Yanmin Ju Zhiyi Wang Zeeshan Ali Hongchen Zhang Yazhou Wang Nuo Xu Hui Yin Fugeng Sheng Yanglong Hou | 2022 | Nano Research2022，15，5： | 1 |
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