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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Physicians' knowledge of inhaler devices and inha- lation techniques remains poor in Spain显示文摘 | Plaza V Sanchis J Roma P Molina J Calle M Quirce S Viejo JL Ca- ballero F Murio C | 2012 | J Aerosol Med Pulm Dm8 Deliv2012，25，1： | 1 |
| 3 | Results of laparoscopic cholecystectomy in a third-level university hospital after 17 years of experience显示文摘 | Priego P Ramiro C Molina JM | 2009 | Rev Esp Enferm Dig2009，101，1： | 1 |
| 4 | Vectorial diffraction analysis of near-field focusing of perfect black Fresnel zone plates under various polarization states显示文摘 | Lopez L C Molina M P Gonzalez P A | 2011 | Journal of Light Technology2011，29，6： | 1 |
| 5 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study显示文摘 | Keith C Bible Vera J Suman Julian R Molina Robert C Smallridge William J Maples Michael E Menefee Joseph Rubin Kostandinos Sideras John C Morris Bryan McIver Jill K Burton Kevin P Webster Carolyn Bieber Anne M Traynor Patrick J Flynn Boon Cher Goh Hui Tan | 2010 | Lancet Oncology2010，，10： | 1 |
| 6 | Lipid composition and vitamin content of wild female Litopenaeus vannamei in different stages of sexual maturation显示文摘 | Wouters R Molina C Lavens P | 2001 | Aquaculture2001，198，： | 1 |
| 7 | Mutual evaluation of global gravity models (EGM2008 and GOCE ) and terrestrial data in Amazon Basin, Brazil 显示文摘 | Bomfim E P Braitenberg C Molina E C | 2013 | Geophysical Journal International2013，195，2： | 1 |
| 8 | Lipid composition and vitamin content of wild female Litopenaeus vannamei in different stages of sexual maturation 显示文摘 | WOUTERS R MOLINA C LAVENS P | 2001 | Aquaculture2001，198，： | 1 |
| 9 | Immediate postgadolinium spoiled gradient-echo MRI for evaluating the abdominal aorta in the setting of abdominal MR examination显示文摘 | KELEKIS N L SEMELKA R C MOLINA P L | 1997 | J Magn Reson Imaging1997，7，： | 1 |
| 10 | External polyacrylate-coating as alternative material for preparation of photopolymerized sol-gel monolithic column 显示文摘 | Vaz F A S Castro P M Molina C | 2008 | Talanta2008，76，： | 1 |
| 11 | Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjogren's syndrome patients: correlation with reduced structural integrity of acini and ducts 显示文摘 | Goicovich E Molina C Perez P | 2003 | Arthritis Rheum2003，48，9： | 1 |
| 12 | Gadolinium in duce macrophage apoptosis 显示文摘 | Mizgerd J P Molina R M Stearns R C | 1996 | Journal of Leukocyte Biology1996，59，2： | 1 |
| 13 | Lipid composition and vitamin content of wild female Litopenaeus vannamei in different stages of sexual maturation 显示文摘 | WOUTERS R MOLINA C LAVENS P | 2001 | Aquaculture2001，198，： | 1 |
| 14 | Performance of QSTBC and VBLAST algorithms for MIMO channels in tunnels显示文摘 | Sanchis B C Molina G P Lienard M | 2010 | IEEE Antennas and Wireless Propagation Letters2010，9，1： | 1 |
| 15 | Lipid composition and vitamin content of wild female Litopenaeus vannamei in different stages of sexual maturation显示文摘 | Wouters R Molina C Lavens P | 2001 | Aquaculture2001，198，34： | 1 |
| 16 | Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjogren's syndrome patients: correlation with reduced structural integrity of acini and ducts 显示文摘 | Goicovich E Molina C Perez P | 2003 | Arthritis Rheum2003，48，9： | 1 |
| 17 | Involvement of endogenoussalicylic acid content, lipoxygenase and antioxidant enzymeactivities in the response of tomato cell suspension cultures to NaCl显示文摘 | Molina A Bueno P Marín M C | 2002 | New Phytologist2002，156，3： | 1 |
| 18 | Enhanced degra- dation of proteins of the basal lamina and stroma by matrix metalloproteinases from thesalivary glands of Sjogreng syndrome patients: correlation with reduced structural integrity of acini and ducts 显示文摘 | Goieovieh E Molina C Pemz P | 2003 | Arthritis Rheum2003，48，： | 1 |
| 19 | Lipid composition and vitamin content of wild female Litopenaeus vannamei in different stages of sexual maturation显示文摘 | Wouters R Molina C M Lavens P | 2001 | Aquac2001，198，： | 1 |
| 20 | Analysis of falsenegative diagnoses on endoscopic brush cytology of biliary and pancreatic duct strictures;the experience at 2 university hospitals显示文摘 | Logrono R Kurtycz D F Molina C P | 2000 | Arch Pathol Lab Med2000，124，： | 1 |
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