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| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | New multiplex PCR fo r rapid detection of isoniazid resistant M ycobacterium tuberculosis clinical isolates显示文摘 | Herrera-Leon L Molina T Saiz P | 2005 | Antimicrob Agents Chemother2005，49，： | 1 |
| 4 | Primary infection of goats with Eimeria ninakohlyakimovae does not provide protective immunity against high challenge infections显示文摘 | A. Ruiz M.C. Mu?oz J.M. Molina C. Hermosilla F. Rodríguez M. Andrada S. Martín A.Guedes D. Pérez L. Matos A.M. López A. Taubert | 2013 | Small Ruminant Research2013，，1： | 1 |
| 5 | The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel显示文摘 | Lovato T L Nguyen T P Molina M R | 2002 | Devel- opment2002，129，21： | 1 |
| 6 | Antimicrobial Agent Detection in Ewes' Milk by the Microbial Inhibitor Test BrilliantBlack Reduction TestBRT AiMm显示文摘 | MolinaM P Althaus R L Molina A | 2003 | Int Dairy J2003，13，10： | 1 |
| 7 | Characterization of tomato cycling Dof factors reveals conserved and new functions in the control of flowering time and abiotic stress responses 显示文摘 | Corrales A R Nebauer S G Carrillo L Fernandez-Nohales P Marques J Renau-Morata B Granell A Pollmann S Vicente- Carbajosa J Molina R V Medina J | 2014 | Journal of Experimental Botany2014，65，4： | 1 |
| 8 | Vectorial diffraction analysis of near-field focusing of perfect black Fresnel zone plates under various polarization states显示文摘 | Lopez L C Molina M P Gonzalez P A | 2011 | Journal of Light Technology2011，29，6： | 1 |
| 9 | New multiplex PCR for rap- id detection of isoniazid-resistant Mycobacterium tuberculosis clinical isolates显示文摘 | Herrera-Leon L Molina T Saiz P | 2005 | Antimicrob Agents Chemother2005，49，1： | 1 |
| 10 | Residue persistence in sheep milk following antibiotic therapy显示文摘 | MOLINA A MOLINA M P ALTHAUS R L | 2003 | The Veterinary Journal2003，165，1： | 1 |
| 11 | Moisture diffusion in eementitious materials: Adsorption isotherm 显示文摘 | XI Yun-ping BAZANT Z P MOLINA L | 1994 | Advanced Cement Based Materials1994，1，6： | 1 |
| 12 | Antimicrobial Agent Detection in Ewes' Milk by the Microbial Inhibitor Test Brilliant Black Reduction Test-BRT AiM(R)显示文摘 | Molina M P Althaus R L Molina A | 2003 | Int Dairy J2003，13，10： | 1 |
| 13 | Analysis Time and Lactation Stage Influence on Lactoperoxidase System Components in Dairy Ewe Milk 显示文摘 | ALTHAUS R L MOLINA M P | 2001 | J Dairy Sci2001，84，： | 1 |
| 14 | Evaluation of the BRT(R) Method for Detection of β-lactam Antibiotics in Ewe Milk显示文摘 | Althaus R L Molina M P Rodríguez | 2001 | Milchwissenschaft2001，56，10： | 1 |
| 15 | Immediate postgadolinium spoiled gradient-echo MRI for evaluating the abdominal aorta in the setting of abdominal MR examination显示文摘 | KELEKIS N L SEMELKA R C MOLINA P L | 1997 | J Magn Reson Imaging1997，7，： | 1 |
| 16 | Residue Persistence in Sheep Milk Following Antibiotic Therapy显示文摘 | Molina A Molina M P Althaus R L | 2003 | Vet J2003，165，1： | 1 |
| 17 | n-3 PUFA productivity in chemostat cultures of microalgae显示文摘 | E. Molina Grima J. A. Sánchez Pérez F. Garcia Camacho J. L. Garcia Sánchez D. López Alonso | 1993 | Applied Microbiology and Biotechnology1993，，5： | 1 |
| 18 | Detection Limits of Beta-lactam Antibiotics in Ewe Milk by Penzym Enzymatic Test显示文摘 | Althaus R L Molina M P Rodriguez M | 2001 | J Food Prot2001，64，11： | 1 |
| 19 | Promoting and Poisoning Effects of Na and C1 Coadsorption on CO Oxidation over MgO-Supported Au Nanoparticles 显示文摘 | Broqvist P Molina L M Grfinbeck H | 2004 | J Catal2004，227，1： | 1 |
| 20 | New multiplex PCR for rapid detection of isoniazid-resistant Mycobacterium tuberculosis clinical isolates显示文摘 | Lerrera L Molina T Saiz P | 2005 | Antimicrob Agents Chemother2005，49，1： | 1 |
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