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| 1 | Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer显示文摘AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models.RESULTS The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ CRC.CONCLUSION In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. | Jae Hyun Kim Jun Yeop Lee Hae Koo Kim Jin Wook Lee Sung Gyu Jung Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，3： | 16 |
| 2 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 3 | Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy显示文摘AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal gastrectomy.METHODS:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer.All surgeries were performed by a single skilled surgeon.We measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after surgery.RESULTS:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36. | Hyung Hun Kim Moo In Park Sang Ho Lee Hyun Yong Hwang Sung Eun Kim Seun Ja Park Won Moon | 2012 | World Journal of Gastroenterology2012，18，30： | 6 |
| 4 | Inhibitory effects of rapamycin on the different stages of hepatic fibrosis显示文摘AIM:To investigate and compare the inhibitory effects of rapamycin in the different stages of liver fibrosis.METHODS:We performed bile duct ligation(BDL)in male Wistar rats(n=24).The experimental rats were classified into four groups:the BDL+/Rapa-group(untreated control,n=4),the BDL+/Rapa+group(treated14 d after BDL,n=8),the BDL+/Rapa++group(treated on the day after BDL,n=8),and the BDL-/Rapagroup(un-treated,sham-operated control,n=4).The BDL+/Rapa+and BDL+/Rapa++groups were administered rapamycin(2 mg/kg)for 28 d.The liver tissues were tested by immunohistochemical staining forα-smooth muscle actin(α-SMA)and cytokeratin.RESULTS:The liver mRNA levels of transforming growth factor(TGF)-β1 and platelet-derived growth factor(PDGF)were measured using the polymerase chain reaction.The protein levels of liver p70s6K and p-p70s6k were determined using Western blotting.α-SMA expression was lowest in the BDL+/Rapa++group.TGF-β1and PDGF expression levels in the rapamycin-treated group were lower than those in the un-treated group and higher than those in the control groups(TGF-β1:0.23±0.00 vs 0.34±0.01,0.23±0.0 vs 0.09±0.00,P<0.0001;PDGF:0.21±0.00 vs 0.34±0.01,0.21±0.0 vs 0.09±0.00,P<0.0001).The p70s6k and p-p70s6k levels decreased in the treated groups and were lowest in the BDL+/Rapa++group(p70s6k:1.05±0.17 vs 1.30±0.56,0.40±0.01 vs 1.30±0.56,P<0.0001;p-p70s6k:1.40±0.5 vs 1.67±0.12,0.70±0.01 vs 1.67±0.12,P<0.0001).CONCLUSION:The results of our study indicate that rapamycin has inhibitory effects on liver fibrosis,and the treatment is most effective in the early stages of fibrosis. | Yun Jeung Kim Eaum Seok Lee Seok Hyun Kim Heon Young Lee Seung Moo Noh Dae Young Kang Byung Seok Lee | 2014 | World Journal of Gastroenterology2014，20，23： | 3 |
| 5 | Assessment of cystic renal masses based on Bosniak classification: Comparison of CT and contrast-enhanced US显示文摘 | Byung Kwan Park Bohyun Kim Seung Hyup Kim Kyungran Ko Hyun Moo Lee Han Yong Choi | 2006 | European Journal of Radiology2006，，2： | 3 |
| 6 | Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes显示文摘AIM To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure.METHODS This study included 636 patients who failed firstline triple therapy and received 7d of bismuthcontaining quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and tetracycline.RESULTS The overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9%( 95% CI : 70.1 %- 77.4%) and 94.5% (95% CI : 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR=3.99, 95%CI: 1.56-10.20, P=0.004)was associated with H. pylori eradication therapy failure.CONCLUSION The second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure. | Sung Eun Kim Moo In Park Seun Ja Park Won Moon Jae Hyun Kim Kyoungwon Jung Hae Koo Kim Young Dal Lee | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 7 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 8 | Early-stage primary signet ring cell carcinoma of the colon显示文摘Primary signet ring cell carcinoma of the colorectum detected at an early stage is very rare; most cases are detected at an advanced stage. Therefore, its progno-sis is poorer than that of ordinary colorectal cancer. A 56-year-old Korean man was seen at this hospital for management of signet ring cell carcinoma of the co-lon. Colonoscopic examination revealed a Ⅱa-like, ill-defined and flatly elevated 9-mm residual tumor in the cecum. Endoscopic mucosal resection was preformed. Pathological examination of the resected specimen re-vealed signet ring cell carcinoma that had invaded the lamina propria without venous or perineural invasion. Abdominal computed tomography (CT) and positron CT showed no evidence of primary lesions or distant me-tastasis. An additional laparoscopic right-hemicolectomy was performed; no residual tumor or lymph node me-tastasis was found. We report a case of primary signet ring cell carcinoma of the colon detected at an early stage and provide a review of the literature. | Jae Hyun Kim Seun Ja Park Moo In Park Won Moon Sung Eun Kim | 2013 | World Journal of Gastroenterology2013，19，24： | 2 |
| 9 | Assessment of colon polyp morphology: Is education effective?显示文摘AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among observers.METHODS For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same participants.RESULTS The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy. | Jae Hyun Kim Kyoung Sik Nam Hye Jung Kwon Youn Jung Choi Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，34： | 2 |
| 10 | A practical method for noise reduction in a vehicle passenger compartment显示文摘 | Kim Seock Hyun Lee Jang Moo | 1998 | Journal of Vibration and Acoustics1998，120，1： | 1 |
| 11 | Vitamin D Deficiency Is Associated with Sarcopenia in Older Koreans, Regardless of Obesity: The Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009显示文摘 | Mee Kyoung Kim Ki Hyun Baek Ki-Ho Song Moo Il Kang Cheol Young Park Won Young Lee Ki Won Oh | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，10： | 1 |
| 12 | 共面转换液晶显示器中获得对比度高于1:600的新技术显示文摘薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。 | Jae Hyun Kim Joun Ho Lee Ji Chul Lim Chang Hoon Lee Moo Hyoung Song Ju Yeon Yoon Hee Dong Choi Jeom Jae Kim Chang Ho Oh Sang Deog Yeo 李路海 | 2004 | 现代显示2004，，5： | 1 |
| 13 | Wideband muttiwavelength erbium-doped fiber laser with frequency shifted feedback 显示文摘 | Chu Moo Jung Lee Jong Hyun | 2001 | Opt Commun2001，190，： | 1 |
| 14 | Bioelectrocatalytic detection of glycated hemoglobin (HbA 1c ) based on the competitive binding of target and signaling glycoproteins to a boronate-modified surface显示文摘 | Seung Yeon Song Yong Duk Han Yoo Min Park Chi Yong Jeong Yong Ju Yang Moo Sub Kim Yunhee Ku Hyun C. Yoon | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 15 | Electrospining of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Min Byung Moo Lee Gene Kim So Hyun | 2004 | Biomaterials2004，，25： | 1 |
| 16 | Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering显示文摘 | Sung In Jeong Soo Hyun Kim Young Ha Kim Youngmee Jung Jae Hyun Kwon Byung-Soo Kim Young Moo Lee | 2004 | Journal of Biomaterials Science Polymer Edition2004，，5： | 1 |
| 17 | Fluid-Structure Interaction Analysis of 3-D Rectangular Tanks by a Varationally Coupled BEM-FEM and Comparison with Test Results 显示文摘 | Hyun Moo Koh Jea Kwan Kim Jang Ho Park | 1998 | Earthquake Engineer and Structural Dynamics1998，27，： | 1 |
| 18 | Protective effect of nectandrin B , a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation显示文摘 | Sung Hwan Ki Jung‐Woon Lee Sung Chul Lim Tran Thi Hien Ji Hye Im Won Keun Oh Moo Yeol Lee Young Hyun Ji Yoon Gyoon Kim Keon Wook Kang | 2013 | Br J Pharmacol2013，，： | 1 |
| 19 | Lesion Localization in Patients With a Previous Negative Transrectal Ultrasound Biopsy and Persistently Elevated Prostate Specific Antigen Level Using Diffusion-Weighted Imaging at Three Tesla Before Rebiopsy显示文摘 | Byung Kwan Park Hyun Moo Lee Chan Kyo Kim Han Yong Choi Jong Wook Park | 2008 | Investigative Radiology2008，，： | 1 |
| 20 | Experimental study of flow boiling heat transfer and dryout characteristics at low mass flux in helically-coiled tubes显示文摘 | Kyung Won Hwang Dong Eok Kim Ki Hoon Yang Jin Man Kim Moo Hwan Kim Hyun Sun Park | 2014 | Nuclear Engineering and Design2014，，： | 1 |
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