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| 1 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 2 | Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis显示文摘AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours. | Sophie E Moore Rosana E Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott | 2017 | World Journal of Psychiatry2017，7，1： | 12 |
| 3 | Small bowel perforation after duodenal stent migration:An interesting case of a rare complication显示文摘Duodenal stents are frequently used for palliating malignant gastric outlet obstruction.Successful stent placement relieves obstructive symptoms,is cost effective,and has a relatively low complication rate.However,enteral stents have the potential of migrating distally and rarely,even lead to bowel perforation.We present a rare case of a duodenal stent placed as a palliative measure for gastric outlet obstruction due to unresectable pancreatic cancer that migrated distally after a gastrojejunostomy resulting in small bowel perforation. | Peter HU Lee Robert Moore Akshay Raizada Richard Grotz | 2011 | World Journal of Radiology2011，3，6： | 3 |
| 4 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 5 | A unifying theorem for three subspace system identification algorithms 显示文摘 | van Overschee Peter de Moor Bart | 1995 | Automotica1995，31，12： | 1 |
| 6 | Subspace state space system identification for industrial processes 显示文摘 | Favoreel Wouter de Moor Bart van Overschee Peter | 2000 | Journal of Process Control2000，10，23： | 1 |
| 7 | Design methodology for optimized die coatings used in aluminum pressure diecasting显示文摘 | RIED Peter JOHN J Moore JIAN Lin | 2005 | Die Casting Engineer2005，49，5： | 1 |
| 8 | Vaccinia vi- rus A17L open reading frame encodes an essential component of nascent viral membranes that is re- quired to initiate morphogenesis 显示文摘 | Wolffe Moore D M Peters P J | 1996 | J Virol1996，70，5： | 1 |
| 9 | Influence of moisture content and temperature on methane adsorption isotherm analysis for coals from a low-rank, biogenically-sourced gas reservoir显示文摘 | Peter J. Crosdale Tim A. Moore Tennille E. Mares | 2008 | International Journal of Coal Geology2008，，1： | 1 |
| 10 | Sensitive and semiquantitative TaqMan real-time polymerase chain reation systems for the detection of beef( Bos taurus) and the detection of the family Mammalia in food and feed 显示文摘 | Peter d Brodmann Dominik Moor | 2003 | Meat Science2003，65，： | 1 |
| 11 | Thyroid Nodule Size and Prediction of Cancer显示文摘 | Sophia C. Kamran Ellen Marqusee Mathew I. Kim Mary C. Frates Julie Ritner Hope Peters Carol B. Benson Peter M. Doubilet Edmund S. Cibas Justine Barletta Nancy Cho Atul Gawande Daniel Ruan Francis D. Moore Karla Pou P. Reed Larsen Erik K. Alexander | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，2： | 1 |
| 12 | Sensitive and semi-quantitative TaqMan? real-time polymerase chain reaction systems for the detection of beef ( Bos taurus ) and the detection of the family Mammalia in food and feed显示文摘 | Peter D. Brodmann Dominik Moor | 2003 | Meat Science2003，，1： | 1 |
| 13 | Reece Estimating stand transpiration in a Eucalyptus populnea woodland with the heat pulse method:measurement errors and sampling strategies显示文摘 | Thomas J Hatton Stepen J Moore Peter H | 1995 | Tree Physiology1995，15，2： | 1 |
| 14 | Quantitative peptide binding motifs for 19 human and mouse MHCclass I molecules derived using positional scanning combinatorialpeptide libraries显示文摘 | Sidney J Assarsson E Moore C Ngo S Pinilla C Sette A Peters B | 2008 | Immunome Res2008，4，1： | 1 |
| 15 | Prospective study ofphysical activity and risk of postmenopausal breast cancer 显示文摘 | Leitzmann MF Moore SC Peters TM | 2008 | Breast Cancer Res2008，10，5： | 1 |
| 16 | Crack propagation by differential insolation on desert surface clasts显示文摘 | John E. Moores Jon D. Pelletier Peter H. Smith | 2008 | Geomorphology2008，，3： | 1 |
| 17 | Practice parameters for the treatment of sigmoid diverticulitis—Supporting documentation显示文摘 | Drs. W. Douglas Wong Steven D. Wexner Ann Lowry Anthony Vernava Marcus Burnstein Frederick Denstman Victor Fazio Bruce Kerner Richard Moore Gregory Oliver Walter Peters Theodore Ross Peter Senatore Clifford Simmang | 2000 | Diseases of the Colon & Rectum2000，，3： | 1 |
| 18 | Transanal Endoscopic Microsurgery is more Effective than Traditional Transanal Excision for Resection of Rectal Masses显示文摘 | Jesse S. Moore Peter A. Cataldo Turner Osler Neil H. Hyman | 2008 | Diseases of the Colon & Rectum2008，，7： | 1 |
| 19 | A novel calmodulin-like protein from the liver fluke, Fasciola hepatica显示文摘 | Sean L. Russell Neil V. McFerran Catherine M. Moore Yvonne Tsang Peter Glass Elizabeth M. Hoey Alan Trudgett David J. Timson | 2012 | Biochimie2012，，11： | 1 |
| 20 | Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel 1 1 Edited by P. E. Wright显示文摘 | Richard C Moore Inyoul Y Lee Gregory L Silverman Paul M Harrison Robert Strome Cornelia Heinrich Amila Karunaratne Stephen H Pasternak M.Azhar Chishti Yan Liang Peter Mastrangelo Kai Wang Arian F.A Smit Shigeru Katamine George A Carlson Fred E Cohen Stanl | 1999 | Journal of Molecular Biology1999，，4： | 1 |
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