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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘 | Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter | 2014 | Cell Host & Microbe2014，，： | 3 |
| 3 | Regional cerebral activation in irritable bowel syndrome and control sllbjeets with painful and nonpaiof-ul rectaldis tentiend 显示文摘 | Mortz H Morgan V Tamer G | 2010 | Gastroenterolog)2010，118，： | 1 |
| 4 | Loss of Bmp7 and Fgf8 signaling in Hoxal3-mutant mice causes hypospadia显示文摘 | Morgan EA Nguyen SB Scott V | 2003 | Development2003，130，14： | 1 |
| 5 | Extracellular BCL2 proteins are danger - associated molecular patterns that re- duce tissue damage in routine models of ischemia - reperfusion injury显示文摘 | Iwata A Morgan - Stevenson V Schwartz B | 2010 | PLoS One2010，5，2： | 1 |
| 6 | The use of neutron activation analy- sis to determine the composition of blended samples of asbestos显示文摘 | Morgan A Timbrell V | 1971 | The International Journal of Applied Radiation and Isotopes1971，22，12： | 1 |
| 7 | Differential effects of human papillomavirus type 6,16,and 18 DNAs on immortalization and transformation of human cervical epithelial cells显示文摘 | PECORARO G MORGAN D Defendi V | 1989 | Proc Natl Acad Sci USA1989，86，2： | 1 |
| 8 | Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome显示文摘 | Morgan V Pickens D Gautam S | 2005 | Gut2005，54，5： | 1 |
| 9 | Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention 显示文摘 | Mertz H Morgan V Tanner G | 2000 | Gastroenterology2000，118，5： | 1 |
| 10 | Rating of bare overhead conductors forcontinuous currents 显示文摘 | Morgan V T | 1967 | Proceedings of the IEEE1967，114，10： | 1 |
| 11 | Efficacy and safety of Sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26- week trim in patients with type 2 diabetes 显示文摘 | Fonseca V Staels B Morgan JD 2nd | 2013 | J Diabetes Complicatians2013，27，2： | 1 |
| 12 | Topological determinants of epileptogenesis in large -scale structural and functional models of the dentate gyrus derived from experimental data显示文摘 | Dyhrfjeld -Johnsen J Santhakumar V Morgan RJ | 2007 | J Neurophysiol2007，97，： | 1 |
| 13 | Effects of osmotic potential and temperature on growth of two pathogens of figs and a biocontrol agent显示文摘 | Subbarao K V Miehailides T J Morgan D P | 1993 | Phytopathology1993，83，12： | 1 |
| 14 | The thermal rating of overhead-lineconductors一Part 1 : The steady-state thermal model显示文摘 | Morgan V T | 1982 | Electric Power System Research1982，5，： | 1 |
| 15 | The use of neutron activation analysis to determine the composition of blended samples of asbestos显示文摘 | Morgan A Timbrell V | 1971 | The International Journal of Applied Radiation and Isotopes1971，22，12： | 1 |
| 16 | An analysis of the war of attrition and the all-pay auction显示文摘 | Krishna V Morgan J | 2011 | Journal of Economic Theory2011，92，1： | 1 |
| 17 | Regional cerebral activation in irritablebowel syndrome and control subjects with painful and nonpainful rectal distention显示文摘 | MERTZ H MORGAN V TANNER G | 2000 | Gastroenterology2000，118，5： | 1 |
| 18 | Surgery for cerebral arteriovenous malformation:risks related to lenticuostriate arterial supply 显示文摘 | Morgan MK Drummond KJ Grinnell V | 1997 | J Neurosurgery1997，86，5： | 1 |
| 19 | Jump height of overhead - lineeond - uetors after the sudden release of ice loads 显示文摘 | Morgan V T Swift D A | 1964 | Proceedings lEE1964，111，10： | 1 |
| 20 | Targeting vascular endothelial growth factor (VEGF)-recep- tor-signaling in renal cell carcinoma 显示文摘 | Reuter C W Morgan M A Grunwald V | 2007 | World J Urol2007，25，1： | 1 |
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