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| 1 | Use of second generation contrast-enhanced ultrasound in the assessment of focal liver lesions显示文摘Ultrasound (US) is often the first imaging modality employed in patients with suspected focal liver lesions. The role of US in the characterisation of focal liver lesions has been transformed with the introduction of specific contrast media and the development of specialized imaging techniques. Ultrasound now can fully characterise the enhancement pattern of hepatic lesions, similar to that achieved with contrast enhanced multiphasic computed tomography (CT) and magnetic resonance imaging (MRI). US contrast agents are safe, well-tolerated and have very few contraindications. Furthermore, real-time evaluation of the vascularity of focal liver lesions has become possible with the use of the newer microbubble contrast agents. This article reviews the enhancement pattern of the most frequent liver lesions seen, using the second generation US contrast media. The common pitfalls for each type of lesion are discussed. The recent developments in US contrast media and specific imaging techniques have been a major advance and this technique, in view of the intrinsic advantages of US, will undoubtedly gain popularity in the years to come. | Stanislas HX Morin Adrian KP Lim eremy FL Cobbold Simon D Taylor-Robinson | 2007 | World Journal of Gastroenterology2007，13，45： | 16 |
| 2 | Transient elastography for the assessment of chronic liver disease: Ready for the clinic?显示文摘Transient elastography is a recently developed non- invasive technique for the assessment of hepatic fi brosis. The technique has been subject to rigorous evaluation in a number of studies in patients with chronic liver disease of varying aetiology. Transient elastography has been compared with histological assessment of percutaneous liver biopsy, with high sensitivity and specificity for the diagnosis of cirrhosis, and has also been used to assess pre-cirrhotic disease. However, the cut-off values between different histological stages vary substantially in different studies, patient groups and aetiology of liver disease. More recent studies have examined the possible place of transient elastography in clinical practice, including risk stratifi cation for the development of complications of cirrhosis. This review describes the technique of transient elastography and discusses the interpretation of recent studies, emphasizing its applicability in the clinical setting. | JFL Cobbold S Morin SD Taylor-Robinson | 2007 | World Journal of Gastroenterology2007，13，36： | 11 |
| 3 | Telomerase catalytic subunit homologs from fission yeast and human显示文摘 | Nakamura TM Morin GB Chapman KB | | 0，，： | 10 |
| 4 | 兆伏级锥形束CT:系统说明及IGRT临床应用介绍显示文摘阐述临床用兆伏级锥形束CT(MV CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以非晶硅平板型EPID,能够适合兆伏级光子射线。一体化的计算机工作平台能够支持投照图像的自动采集,图像重建,CT到锥形束CT图像的注册,以及治疗床的移动计算。系统具有亚毫米级的定位精度和足够的软组织分辨率,能够显示前列腺等软组织结构。在我院,已经使用兆伏级锥形束CT系统检测脊髓的非刚性形变,监控肿瘤的生长和消退,以及肺内固定肿瘤的定位等。对于受到金属伪影干扰的结构,兆伏级锥形束CT还提高了其勾画的准确性。在过去的几年中,兆伏级锥形束CT有了较快的发展。现在的图像质量完全可以满足IGRT应用的需要。此外,我们希望兆伏级锥形束CT在临床上的应用将随着影像技术的发展而不断扩大。 | Olivier Morin Amy Gillis Josephine Chen Michèle Aubin M.Kara Bucci Jean Pouliot 索京涛 陆嘉德 | 2006 | 中国癌症杂志2006，16，6： | 9 |
| 5 | 黄芪多糖对过氧化氢刺激皮肤成纤维细胞中线粒体和溶酶体的保护作用(英文)显示文摘目的:证明黄芪多糖对氧化应激皮肤细胞的保护作用。方法:原代培养皮肤成纤维细胞在过氧化氢0.5 mmol/L中,孵育30 min造成急性氧化损伤的模型。MTT法测黄芪多糖的剂量反应,DAPI染色法检测黄芪多糖对细胞死亡的作用;激光共聚焦法检测黄芪多糖对线粒体、线粒体膜电位以及溶酶体稳定性的保护作用。结果:经过黄芪多糖的治疗,能够明显提高细胞存活率,其作用浓度从0.5 mg/L开始,到1 mg/L达最大效果,呈剂量依赖性。而且,黄芪多糖能够抑制线粒体膜电位崩解保护线粒体形态,保护溶酶体膜。结论:这些结果证明了黄芪多糖在线粒体和溶酶体水平存在1个新的调节凋亡的途径。这个途径可以成为一些氧化应激以及溶酶体缺陷疾病的1个新的治疗靶点。 | 岳晓莉 李萍 刘欣 黄启福 BARBIER-CHASSEFIERE Veronique MORIN Christophe PAPY-GARCIA Dulce | 2008 | 中国病理生理杂志2008，24，4： | 9 |
| 6 | Assessment of the Bemisia tabaci C YP6CM l vQ transcript and protein levels in laboratory and field-derived imidacloprid-resistant insects and cross-metabolism potential of the recombinant enzyme显示文摘 | Emmanouil Roditakis Evangelia Morou Anastasia Tsagkarakou Maria Riga Ralf Nauen Mark Paine Shai Morin John Vontas | 2011 | Insect Science2011，18，1： | 7 |
| 7 | Leveraging Metabolomics to Assess the Next Generation of Temozolomide-based Therapeutic Approaches for Glioblastomas显示文摘Glioblastoma multiforme(GBM) is the most common adult primary tumor of the central nervous system.The current standard of care for glioblastoma patients involves a combination of surgery,radiotherapy and chemotherapy with the alkylating agent temozolomide.Several mechanisms underlying the inherent and acquired temozolomide resistance have been identifed and contribute to treatment failure.Early identifcation of temozolomide-resistant GBM patients and improvement of the therapeutic strategies available to treat this malignancy are of uttermost importance.This review initially looks at the molecular pathways underlying GBM formation and development with a particular emphasis placed on recent therapeutic advances made in the feld.Our focus will next be directed toward the molecular mechanisms modulating temozolomide resistance in GBM patients and the strategies envisioned to circumvent this resistance.Finally,we highlight the diagnostic and prognostic value of metabolomics in cancers and assess its potential usefulness in improving the current standard of care for GBM patients. | Patrick-Denis St-Coeur Mohamed Touaibia Miroslava Cuperlovic-Culf Pier Jr Morin | 2013 | Genomics, Proteomics & Bioinformatics2013，11，4： | 5 |
| 8 | Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway显示文摘Sclareol,an antifungal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide.Sclareol is mainly produced in clary sage flower calyces;however,the cellular localization of the sclareol biosynthesis remains unknown.To elucidate the site of sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–FTICR-MSI)and investigated the expression profile of sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specifically accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly expressed.We next isolated a glabrous beardless mutant and demonstrate that more than 90%of the sclareol is produced by the large capitate GTs.Feeding experiments,using 1-13 C-glucose,and specific enzyme inhibitors further revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of isopentenyl diphosphate(IPP)precursor used for the biosynthesis of sclareol.Our findings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of GTs as biofactories dedicated to the production of specialized metabolites. | Camille Chalvin Stephanie Drevensek Françoise Gilard Caroline Mauve Christel Chollet Halima Morin Edith Nicol Eva Heripre Lucie Kriegshauser Bertrand Gakiere Michel Dron Abdelhafid Bendahmane Adnane Boualem | 2021 | Horticulture Research2021，8，1： | 2 |
| 9 | ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography显示文摘 | Daniel B. Mark Daniel S. Berman Matthew J. Budoff J. Jeffrey Carr Thomas C. Gerber Harvey S. Hecht Mark A. Hlatky John McB. Hodgson Michael S. Lauer Julie M. Miller Richard L. Morin Debabrata Mukherjee Michael Poon Geoffrey D. Rubin Robert S. Schwartz | 2010 | Journal of the American College of Cardiology2010，，23： | 2 |
| 10 | Mitochondria as target for antiischemic drugs显示文摘 | Morin D Hauet T Spedding M Tillement J | 2001 | Adv Drug Deliv Rev2001，49，12： | 2 |
| 11 | Telomerase catalytic subunit homologs from fission yeast and human显示文摘 | Nakamura TM Morin GB Chapman KB | 1997 | Science1997，277，5328： | 2 |
| 12 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 13 | 梨花女子大学 校园谷显示文摘"校园谷"项目场地紧邻一个更大的校园和南边的新村,复杂的场地环境要求建筑"大于基地"。建筑师以一种全球化的地景式设计策略将梨花大学校园的组织结构融入到城市中。"校园谷"与"运动带相结合,创造出新型地貌,以一系列方式影响着周围环境。运动带和校园谷一样是多重事物的结合体。它是进入梨花大学校园的新大门,是日常运动消闲的新去处,是年度节庆或盛典的举办地,还是名副其实的将大学带入城市的纽带。 | André Morin Luca Reale Gaёlle Lauriot-Prévost Frederico de Matteis | 2013 | 城市环境设计2013，，9： | 2 |
| 14 | Modeling and implementation of tandem polymer solar cells using wide-bandgap front cells显示文摘Tandem device architectures offer a route to greatly increase the maximum possible power conversion efficiencies(PCEs)of polymer solar cells,however,the complexity of tandem cell device fabrication(such as selecting bandgaps of the front and back cells,current matching,thickness,and recombination layer optimization)often result in lower PCEs than are observed in single-junction devices.In this study,we analyze the influence of front cell and back cell bandgaps and use transfer matrix modeling to rationally design and optimize effective tandem solar cell structures before actual device fabrication.Our approach allows us to estimate tandem device parameters based on known absorption coefficients and open-circuit voltages of different active layer materials and design devices without wasting valuable time and materials.Using this approach,we have investigated a series of wide bandgap,high voltage photovoltaic polymers as front cells in tandem devices with PTB7-Th as a back cell.In this way,we have been able to demonstrate tandem devices with PCE of up to 12.8%with minimal consumption of valuable photoactive materials in tandem device optimization.This value represents one of the highest PCE values to date for fullerene-based tandem solar cells. | Seo-Jin Ko Hyosung Choi Quoc Viet Hoang Chang Eun Song Pierre-Olivier Morin Jungwoo Heo Mario Leclerc Sung Cheol Yoon Han Young Woo Won Suk Shin Bright Walker Jin Young Kim | 2020 | Carbon Energy2020，2，1： | 2 |
| 15 | MicroRNAs as promising biomarkers for gastric cancer显示文摘 | Pier Jr Morin Fang Wang Guo-Ping Sun Yan-Feng Zou Ji-Qing Hao Fei Zhong Wen-Jun Ren | 2012 | Cancer Biomarkers2012，，6： | 2 |
| 16 | The effect of ultrasonic salting on protein and water–protein interactions in meat显示文摘 | C.K. McDonnell P. Allen C. Morin J.G. Lyng | 2014 | Food Chemistry2014，，： | 2 |
| 17 | Mechanisms underlying nonsteroidal anti inflammatory drug-mediated apoptosis显示文摘 | Chan TA Morin PJ Vogelstein B | | 0，，： | 2 |
| 18 | 骨密度变化可作为抗骨折治疗效果的预测指标显示文摘骨质疏松症伴骨折对个人及社会均造成沉重负担,双能X线评定骨密度是目前诊断骨质疏松症的金标准。本研究旨在探究在临床实践中,常规骨密度检测作为骨折风险干预预测指标的效果。自1997年,加拿大曼尼托巴省便对本省年龄大于65岁的老年女性或者存在其它骨折风险的年轻女性进行常规的骨密度检查。研究者对大多数患者进行三年随访,而对有低骨折风险患者则进行至少为期5年的随访。数据显示,年龄大于或等于40岁的女性完成了至少一次的随访检查。 | Leslie WD Majumdar SR Morin SN 何成奇 | 2017 | 中国康复2017，32，1： | 2 |
| 19 | Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity显示文摘BACKGROUND Benzylamine and methylamine activate glucose uptake in adipocytes.For tyramine,this effect has even been extended to cardiomyocytes.AIM To investigate the effects of catecholamines and other amines on glucose uptake.METHODS A screening compared 25 biogenic amines on 2-deoxyglucose(2-DG)uptake activation in rat adipocytes.Pharmacological approaches and transgenic mouse models were then used to decipher the mode of action of several hits.RESULTS In rat adipocytes,insulin stimulation of 2-DG uptake was reproduced with catecholamines.100μmol/L or 1 mmol/L adrenaline,noradrenaline,dopamine and deoxyepinephrine,maximally activated hexose transport only when sodium orthovanadate was added at 100μmol/L.Such activation was similar to that already reported for benzylamine,methylamine and tyramine,well-recognized substrates of semicarbazide-sensitive amine oxidase(SSAO)and monoamine oxidase(MAO).Several,but not all,tested agonists ofβ-adrenoreceptors(β-ARs)also activated glucose transport whileα-AR agonists were inactive.Lack of blockade byα-andβ-AR antagonists indicated that catecholamine-induced 2-DG uptake was not mediated by AR stimulation.Adipocytes from mice lackingβ1-,β2-andβ3-ARs(triple KO)also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100μmol/L vanadate.The MAO blocker pargyline,and SSAO inhibitors did not block the effects of adrenaline or noradrenaline plus vanadate,which were blunted by antioxidants.CONCLUSION Catecholamines exert unexpected insulin-like actions in adipocytes when combined with vanadium.For limiting insulin resistance by activating glucose consumption at least in fat stores,we propose that catecholamine derivatives combined with vanadium can generate novel complexes that may have low toxicity and promising anti-diabetic properties. | Jessica Fontaine Geneviève Tavernier Nathalie Morin Christian Carpéné | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 20 | Detection rates of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, and swine influenza virus in porcine proliferative and necrotizing pneumonia显示文摘 | DROLET R LAROCHELLE R MORIN M | 2003 | Vet Pathol2003，40，2： | 1 |
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