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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Experimental study of radiation and free convection in an enclosure with under-floor heating system 显示文摘 | MOSTAFA R AMIR S | 2011 | Energy Convection and Managemen2011，52，： | 1 |
| 3 | City Develop- ment strategies (CDS) and sustainable urbanization in develo- ping world 显示文摘 | MOSTAFA S R NURWATI B MASTURA J | 2012 | Social and Behavioral Sciences2012，，36： | 1 |
| 4 | Modification of polyethylene by radiation-induced graft copolymerization of N-phenylmaleimide and p-hydroxy N-phenylmaleimide显示文摘 | Aly R O Mostafa T B Mokhtar S M | 2002 | Polym Test2002，21，： | 1 |
| 5 | Effect of different starter cultures on the biogenic amines production as a critical control point in fresh fermented sausages 显示文摘 | Mokhtar S Mostafa G Taha R | 2012 | Eu- ropeam Food Researoh and Technology2012，235，3： | 1 |
| 6 | Empirical Bayes quadratic estimators of variance components in normal linear models 显示文摘 | MOSTAFA S M AHMAD R | 1986 | Statistics1986，17，： | 1 |
| 7 | Assessment of persistent organochlorine residues in sediments of Hadramout coastal area, Gulf of Aden, Yemen显示文摘 | Mostafa A R Wade T L Sweet S T | 2007 | Marine Pollution Bulletin2007，54，7： | 1 |
| 8 | Charac- terization and phenols sorptive properties of carbons activated by sulphuric acid显示文摘 | MOHAMED F S KHATER W A MOSTAFA M R | 2006 | Chemical Engineering Journal2006，116，1： | 1 |
| 9 | Distribution and characteristics of polycyclic aromatic hydrocarbons(PAHs) in sediments of Hadhramout coastal area, Gulf of Aden, Yemen显示文摘 | Mostafa A R Wade T L Sweet S T | 2009 | Journal of Marine System2009，78，1： | 1 |
| 10 | Source character- ization and the environmental impact of urban street dusts from E- gypt based on hydrocarbon distributions显示文摘 | Mostafa A R Hegezi A H EI - Gayar M S | 2009 | Fuel2009，88，1： | 1 |
| 11 | Distribution and characteristics of polycyclic aromatic hydrocarbons (PAHs) in sediments of Hadhramout coastal area, Gulf of Aden, Yemen 显示文摘 | Mostafa A R Wade T L Sweet S T | 2009 | Journal of Marine Systems2009，78，1： | 1 |
| 12 | Do Liquid-Based Preparations of Urinary Cytology Perform Differently Than Classically Prepared Cases? Observations From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology显示文摘 | Laucirica Rodolfo Bentz Joel S Souers Rhona J Wasserman Patricia G Crothers Barbara A Clayton Amy C Henry Michael R Chmara Beth Anne Clary Karen M Fraig Mostafa M Moriarty Ann T | 2010 | Archives of Pathology & Laboratory Medicine2010，，1： | 1 |
| 13 | Distribution and characteristics of polycyclic aromatic hydrocarbons (PAHs) in sediments of Hadhramout coastal area,Gulf of Aden,Yemen显示文摘 | MOSTAFA A R WADE T L SWEET S T | 2009 | J Marine Syst2009，78，： | 1 |
| 14 | The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt显示文摘 | Christina Frank Mostafa K Mohamed G Thomas Strickland Daniel Lavanchy Ray R Arthur Laurence S Magder Taha El Khoby Yehia Abdel-Wahab El Said Aly Ohn Wagida Anwar Ismail Sallam | 2000 | The Lancet . 2000 (9207)2000，，9207： | 1 |
| 15 | Utilization of electroflotation in remediation of oily wastewater显示文摘 | Ibranhim M Y Mostafa S R Fahmy M F | 2001 | Separation Science and Technology2001，，36： | 1 |
| 16 | Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis?显示文摘 | PERRY S E MOSTAFA S M WENSTONE R | 2003 | Intensive Care Med2003，29，8： | 1 |
| 17 | Application of geochemical parameters for clas- sification of crude oils from egypt into source - related types显示文摘 | E1 - Gayar M S Mostafa A R Abdelfattah A E Bara- kat A O | 2002 | Fuel Process Technol2002，79，： | 1 |
| 18 | Distribution and characteristics of polycyclic aromatic hydrocarbons (PAHs) in sediments of Hadhramout coastal area, gulf of Aden, Yemen显示文摘 | MOSTAFA A R WADE T L SWEET S T | 2009 | Journal of Marine Systems2009，78，1： | 1 |
| 19 | Effect of trans- verse reinforcement on the flexural behavior of contin- uous concrete beams reinforced with FRP 显示文摘 | MOSTAFA E M AMR E R EHAB E S | 2011 | Journal of Composites for Construction2011，15，5： | 1 |
| 20 | A case study of orange juice concentration by recompression evaporation techniques显示文摘 | SOROUR M A MOSTAFA S R BO SAMRI S M | 2013 | Journal of Food Process Engineering2013，36，3： | 1 |
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